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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-acylurea
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Accession:CHEBI:74266 term browser browse the term
Definition:A member of the class of ureas that has the general formula R-CO-NH-CO-NH2 or R-CO-NH-CO-NH-CO-R', formally derived by the acylation of one or both of the nitrogens of a urea moiety.
Synonyms:related_synonym: N-acylureas;   ureide;   ureides


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cabergoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression ISO Cabergoline results in increased expression of BDNF protein CTD PMID:35104500 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO Cabergoline results in increased expression of CREB1 protein modified form CTD PMID:35104500 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Cabergoline binds to and results in increased activity of DRD2 protein CTD PMID:35104500 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
increases secretion		 ISO cabergoline results in increased expression of GDNF mRNA
cabergoline results in increased secretion of GDNF protein		 CTD PMID:12770616 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Ngf nerve growth factor increases expression
increases secretion		 ISO cabergoline results in increased expression of NGF mRNA
cabergoline results in increased secretion of NGF protein		 CTD PMID:12770616 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Prl prolactin decreases expression
multiple interactions
decreases secretion		 ISO
EXP		 cabergoline results in decreased expression of PRL protein
Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [cabergoline results in decreased secretion of PRL protein]		 CTD PMID:2570719 PMID:3745407 PMID:7670571 PMID:15377706 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
chlorfluazuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases activity		 ISO chlorfluazuron results in increased expression of CYP2B6 mRNA
chlorfluazuron results in increased activity of CYP2B6 protein		 CTD PMID:22310298 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 ISO chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
chlorfluazuron results in decreased activity of CYP2E1 protein		 CTD PMID:22634058 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO chlorfluazuron results in increased expression of CYP3A4 mRNA CTD PMID:22310298 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
diflubenzuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Diflubenzuron results in increased expression of CYP1A1 protein CTD PMID:8812189 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO Diflubenzuron binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects binding ISO Diflubenzuron binds to CYP3A4 protein CTD PMID:32278787 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Diflubenzuron results in increased expression of CYP3A23-3A1 protein CTD PMID:8812189 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Diflubenzuron results in increased activity of NR1I2 protein CTD PMID:16565514 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
dihydroorotic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
increases metabolic processing
increases oxidation		 ISO
EXP		 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
DHODH protein results in increased metabolism of 4,5-dihydroorotic acid
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; azastene inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; HR 325 inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; toltrazuril inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]		 CTD PMID:9776318 PMID:9802339 PMID:11248707 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
flufenoxuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO flufenoxuron results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]		 CTD PMID:33771252 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor decreases expression ISO flufenoxuron results in decreased expression of AR mRNA CTD PMID:33771252 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation ISO flufenoxuron results in decreased phosphorylation of BAD protein CTD PMID:33771252 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO flufenoxuron results in increased expression of BAK1 protein CTD PMID:33771252 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO flufenoxuron results in decreased expression of BCL2L1 protein CTD PMID:33771252 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO flufenoxuron results in increased expression of CYP17A1 mRNA CTD PMID:33771252 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO flufenoxuron results in increased expression of CYP19A1 mRNA CTD PMID:33771252 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO flufenoxuron results in increased expression of DDIT3 protein CTD PMID:33771252 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO flufenoxuron results in increased phosphorylation of EIF2S1 protein CTD PMID:33771252 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO flufenoxuron results in increased expression of ERN1 protein CTD PMID:33771252 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression ISO flufenoxuron results in decreased expression of HSD17B1 mRNA CTD PMID:33771252 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 increases expression ISO flufenoxuron results in increased expression of HSD17B3 mRNA CTD PMID:33771252 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO flufenoxuron results in increased expression of HSPA9 protein CTD PMID:33771252 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO flufenoxuron results in decreased expression of JUN mRNA CTD PMID:33771252 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO flufenoxuron results in decreased expression of JUND mRNA CTD PMID:33771252 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO flufenoxuron results in increased phosphorylation of MAPK1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]		 CTD PMID:33771252 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein] CTD PMID:33771252 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO flufenoxuron results in increased phosphorylation of MAPK8 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]		 CTD PMID:33771252 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO flufenoxuron results in decreased expression of PCNA protein CTD PMID:33771252 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rmdn3 regulator of microtubule dynamics 3 increases expression ISO flufenoxuron results in increased expression of RMDN3 protein CTD PMID:33771252 NCBI chr 3:106,125,961...106,146,568
Ensembl chr 3:106,125,951...106,146,586 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions
decreases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KA1 protein]; U 0126 inhibits the reaction [flufenoxuron results in decreased phosphorylation of RPS6KA1 protein] CTD PMID:33771252 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; pyrazolanthrone affects the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; U 0126 inhibits the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:33771252 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sqstm1 sequestosome 1 increases phosphorylation ISO flufenoxuron results in increased phosphorylation of SQSTM1 protein CTD PMID:33771252 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO flufenoxuron results in increased expression of STAR mRNA CTD PMID:33771252 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Vapb VAMP associated protein B and C increases expression ISO flufenoxuron results in increased expression of VAPB protein CTD PMID:33771252 NCBI chr 3:162,535,974...162,578,747
Ensembl chr 3:162,535,905...162,573,763 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression ISO flufenoxuron results in increased expression of VDAC1 protein CTD PMID:33771252 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
glimepiride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO glimepiride results in decreased activity of ABCB11 protein
glimepiride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride CTD PMID:22209866 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO glimepiride results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO glimepiride results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Capn1 calpain 1 increases expression ISO glimepiride results in increased expression of CAPN1 mRNA CTD PMID:33652124 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn10 calpain 10 increases expression ISO glimepiride results in increased expression of CAPN10 mRNA CTD PMID:33652124 NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494 		JBrowse link
G Capn2 calpain 2 increases expression ISO glimepiride results in increased expression of CAPN2 mRNA CTD PMID:33652124 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO glimepiride results in increased activity of CASP3 protein
glimepiride results in increased expression of CASP3 mRNA		 CTD PMID:33652124 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [glimepiride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP [Plant Extracts co-treated with glimepiride] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; glimepiride inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:26721197 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 decreases expression ISO glimepiride results in decreased expression of INS protein CTD PMID:15642492 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride CTD PMID:22209866 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO glimepiride results in increased activity of NR1I2 protein
[glimepiride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO glimepiride affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO glimepiride results in increased expression of TP53 mRNA CTD PMID:33652124 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
hexaflumuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases expression EXP hexafluoron results in decreased expression of ALB protein CTD PMID:34993831 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP hexafluoron results in increased expression of BAX mRNA CTD PMID:35773501 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP hexafluoron results in decreased expression of BCL2 mRNA CTD PMID:35773501 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression EXP hexafluoron results in increased expression of CASP3 mRNA; hexafluoron results in increased expression of CASP3 protein CTD PMID:34993831 PMID:35773501 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity EXP hexafluoron results in decreased activity of CAT protein CTD PMID:35773501 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression		 ISO hexafluoron results in increased activity of CYP2B6 protein
hexafluoron results in increased expression of CYP2B6 mRNA		 CTD PMID:22310298 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO hexafluoron results in increased expression of CYP3A4 mRNA CTD PMID:22310298 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP hexafluoron results in increased expression of GPT protein CTD PMID:34993831 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP hexafluoron results in increased expression of HMOX1 mRNA CTD PMID:34993831 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP hexafluoron results in decreased expression of KEAP1 mRNA CTD PMID:34993831 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression EXP hexafluoron results in increased expression of MAPK8 mRNA CTD PMID:34993831 PMID:35773501 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP hexafluoron results in increased expression of TNF protein CTD PMID:34993831 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
imidapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 increases response to substance ISO ACE2 gene SNP results in increased susceptibility to imidapril CTD PMID:27121444 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO CES1 protein results in increased hydrolysis of and results in increased activity of imidapril; CES1 protein results in increased metabolism of and results in increased activity of imidapril; Dust inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; tert-butylphenyl diphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; triphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril] CTD PMID:9300133 PMID:31268531 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to imidapril CTD PMID:16765146 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
imidaprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] CTD PMID:16257180 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] CTD PMID:16257180 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
triflumuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity ISO triflumuron results in increased activity of CAT protein CTD PMID:32312157 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing		 ISO furafylline inhibits the reaction [CYP1A2 protein results in increased metabolism of triflumuron] CTD PMID:31082524 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing ISO CYP2C18 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
increases metabolic processing		 ISO Sulfaphenazole inhibits the reaction [CYP2C19 protein results in increased metabolism of triflumuron] CTD PMID:31082524 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of triflumuron CTD PMID:31082524
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of triflumuron CTD PMID:31082524 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing		 ISO Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of triflumuron] CTD PMID:31082524 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        agrochemical 16259
          fertilizer 13804
            urea 5571
              ureas 5569
                N-acylurea 72
                  2-bromo-N-carbamoyl-3-methylbutanamide + 0
                  2-cyano-3-[2,5-dimethyl-1-(2-methylpropyl)-3-pyrrolyl]-2-propenoic acid [2-oxo-2-[[oxo-(prop-2-enylamino)methyl]amino]ethyl] ester 0
                  3-Oxo-3-ureidoisobutyrate 0
                  5-N-Methyloxaluric acid 0
                  Buthidazole 0
                  Cutin-1 0
                  N-[(1-adamantylamino)-oxomethyl]-2-chloroacetamide 0
                  N-[(2-methoxyanilino)-oxomethyl]benzamide 0
                  N-[(3-chloro-4-fluoroanilino)-oxomethyl]-4-methyl-5-thiadiazolecarboxamide 0
                  N-[anilino(oxo)methyl]-2-methoxy-4-(trifluoromethyl)-3-pyridinecarboxamide 0
                  N-benzoylurea + 46
                  N-carbamoyl-2-[4-oxo-2-[(2-oxo-5H-thiazol-4-yl)hydrazo]-5-thiazolyl]acetamide 0
                  acecarbromal 0
                  apronal 0
                  benzoylurea insecticide + 46
                  cabergoline 6
                  capuride 0
                  carbromal 0
                  dihydroorotic acid + 1
                  ectylurea 0
                  fluazuron 0
                  glimepiride 17
                  hexaflumuron 12
                  imidapril + 5
                  imidaprilat 2
                  lufenuron 0
                  tarocin A2 0
                  teflubenzuron 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                urea 5571
                                                  ureas 5569
                                                    N-acylurea 72
                                                      2-bromo-N-carbamoyl-3-methylbutanamide + 0
                                                      2-cyano-3-[2,5-dimethyl-1-(2-methylpropyl)-3-pyrrolyl]-2-propenoic acid [2-oxo-2-[[oxo-(prop-2-enylamino)methyl]amino]ethyl] ester 0
                                                      3-Oxo-3-ureidoisobutyrate 0
                                                      5-N-Methyloxaluric acid 0
                                                      Buthidazole 0
                                                      Cutin-1 0
                                                      N-[(1-adamantylamino)-oxomethyl]-2-chloroacetamide 0
                                                      N-[(2-methoxyanilino)-oxomethyl]benzamide 0
                                                      N-[(3-chloro-4-fluoroanilino)-oxomethyl]-4-methyl-5-thiadiazolecarboxamide 0
                                                      N-[anilino(oxo)methyl]-2-methoxy-4-(trifluoromethyl)-3-pyridinecarboxamide 0
                                                      N-benzoylurea + 46
                                                      N-carbamoyl-2-[4-oxo-2-[(2-oxo-5H-thiazol-4-yl)hydrazo]-5-thiazolyl]acetamide 0
                                                      acecarbromal 0
                                                      apronal 0
                                                      benzoylurea insecticide + 46
                                                      cabergoline 6
                                                      capuride 0
                                                      carbromal 0
                                                      dihydroorotic acid + 1
                                                      ectylurea 0
                                                      fluazuron 0
                                                      glimepiride 17
                                                      hexaflumuron 12
                                                      imidapril + 5
                                                      imidaprilat 2
                                                      lufenuron 0
                                                      tarocin A2 0
                                                      teflubenzuron 0
paths to the root