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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cabergoline
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Accession:CHEBI:3286 term browser browse the term
Definition:An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.
Synonyms:exact_synonym: (8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
 related_synonym: (8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide;   (8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide;   1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea;   1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea;   1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea;   Formula=C26H37N5O2;   InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1;   InChIKey=KORNTPPJEAJQIU-KJXAQDMKSA-N;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@H](CN2CC=C)C(=O)N(CCCN(C)C)C(=O)NCC;   cabergolina;   cabergolinum
 xref: Beilstein:6020775;   CAS:81409-90-7;   DrugBank:DB00248;   Drug_Central:460;   HMDB:HMDB0014393;   KEGG:C08187;   KEGG:D00987;   LINCS:LSM-3939
 xref_mesh: MESH:C047047
 xref: PMID:22075008;   PMID:22336848;   PMID:22740242;   PMID:23110560;   PMID:23743769;   Patent:BE888243;   Patent:US4526892;   VSDB:1830;   Wikipedia:Cabergoline



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cabergoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression ISO Cabergoline results in increased expression of BDNF protein CTD PMID:35104500 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO Cabergoline results in increased expression of CREB1 protein modified form CTD PMID:35104500 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Cabergoline binds to and results in increased activity of DRD2 protein CTD PMID:35104500 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
increases secretion
ISO cabergoline results in increased expression of GDNF mRNA
cabergoline results in increased secretion of GDNF protein
CTD PMID:12770616 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Ngf nerve growth factor increases expression
increases secretion
ISO cabergoline results in increased expression of NGF mRNA
cabergoline results in increased secretion of NGF protein
CTD PMID:12770616 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Prl prolactin decreases expression
decreases secretion
multiple interactions
ISO
EXP
cabergoline results in decreased expression of PRL protein
cabergoline results in decreased secretion of PRL protein
Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [cabergoline results in decreased secretion of PRL protein]
CTD PMID:2570719 PMID:3745407 PMID:7670571 PMID:15377706 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link

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  CHEBI ontology 19831
    role 19807
      application 19650
        pharmaceutical 19491
          drug 19491
            antineoplastic agent 17757
              cabergoline 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17549
                                            carboxamide 17549
                                              monocarboxylic acid amide 15680
                                                urea 5579
                                                  ureas 5577
                                                    N-acylurea 72
                                                      cabergoline 6
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