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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clomipramine
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Accession:CHEBI:47780 term browser browse the term
Definition:A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Synonyms:exact_synonym: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
 related_synonym: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE;   3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine;   3-chloroimipramine;   Formula=C19H23ClN2;   G 34586;   InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;   InChIKey=GDLIGKIOYRNHDA-UHFFFAOYSA-N;   SMILES=CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12;   chlorimipramine;   monochlorimipramine
 alt_id: CHEBI:3754;   CHEBI:47359
 xref: Beilstein:1323477;   CAS:303-49-1;   DrugBank:DB01242;   Drug_Central:701;   KEGG:C06918;   KEGG:D07727;   LINCS:LSM-3171
 xref_mesh: MESH:D002997
 xref: PDBeChem:CXX;   PMID:12007764;   PMID:12084414;   PMID:16085036;   PMID:17471183;   PMID:19747949;   PMID:19810911;   Patent:CH371799;   Patent:US3467650;   Reaxys:1323477;   Wikipedia:Clomipramine
 cyclic_relationship: is_conjugate_base_of CHEBI:64209


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clomipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Clomipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression EXP Clomipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Clomipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Clomipramine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713 		JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Clomipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Clomipramine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Clomipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Clomipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP3 protein] CTD PMID:10487422 PMID:22700542 PMID:28482088 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Clomipramine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Clomipramine results in increased activity of CASP9 protein CTD PMID:28482088 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression ISO Clomipramine results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Clomipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Clomipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Clomipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033 		JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Clomipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054 		JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Clomipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Clomipramine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Clomipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Clomipramine affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression EXP Clomipramine affects the expression of CYP3A23-3A1 mRNA CTD PMID:18355885 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Clomipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506 		JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Clomipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Clomipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Clomipramine results in increased expression of DRD2 protein CTD PMID:20619828 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Clomipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Clomipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Clomipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Clomipramine results in increased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fh fumarate hydratase multiple interactions EXP Clomipramine results in increased activity of and results in increased secretion of FH protein CTD PMID:37217012 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 decreases expression
increases expression		 ISO Clomipramine results in decreased expression of FNDC4 mRNA
Clomipramine results in increased expression of FNDC4 mRNA		 CTD PMID:17175557 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675 		JBrowse link
G Gckr glucokinase regulator affects expression EXP Clomipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clomipramine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063 		JBrowse link
G Gls2 glutaminase 2 affects expression EXP Clomipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Clomipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases export		 EXP Clomipramine results in increased activity of and results in increased secretion of GPT protein
Clomipramine results in increased export of GPT protein		 CTD PMID:37217012 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Clomipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Clomipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hal histidine ammonia lyase affects expression EXP Clomipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701 		JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Clomipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Clomipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hpn hepsin increases expression ISO Clomipramine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
increases expression		 ISO
EXP		 Clomipramine binds to HTR2C protein
Clomipramine results in increased expression of HTR2C protein		 CTD PMID:18083778 PMID:20619828 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il33 interleukin 33 affects expression EXP Clomipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Clomipramine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Clomipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lox lysyl oxidase affects expression EXP Clomipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lss lanosterol synthase increases expression ISO Clomipramine results in increased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Clomipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072 		JBrowse link
G Manba mannosidase beta affects expression EXP Clomipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983 		JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Clomipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350 		JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Clomipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Clomipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clomipramine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Clomipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases phosphorylation ISO Clomipramine results in increased phosphorylation of NTRK2 protein CTD PMID:22396798 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Clomipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Oaf out at first homolog affects expression EXP Clomipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Clomipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pc pyruvate carboxylase affects expression EXP Clomipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Clomipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Clomipramine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Clomipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prl prolactin affects secretion
increases expression
multiple interactions
increases secretion		 ISO Clomipramine affects the secretion of PRL protein
Clomipramine results in increased expression of PRL protein
SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein]
Clomipramine results in increased secretion of PRL protein		 CTD PMID:3602989 PMID:7930386 PMID:17000009 PMID:19698552 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases expression ISO Clomipramine results in increased expression of PROC protein CTD PMID:17891354 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Clomipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Clomipramine affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Clomipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Clomipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Clomipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:136,124,500...136,255,669
Ensembl chr 1:136,124,499...136,255,584 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clomipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Clomipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Clomipramine binds to and results in decreased activity of SLC6A4 protein; SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein] CTD PMID:16272152 PMID:17000009 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Clomipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Clomipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Clomipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Clomipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Clomipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945 		JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Clomipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443 		JBrowse link
G Stmn1 stathmin 1 affects expression EXP Clomipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Clomipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tagln transgelin decreases expression ISO Clomipramine results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tex261 testis expressed 261 affects expression EXP Clomipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Clomipramine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Clomipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Clomipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Clomipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Clomipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 affects expression EXP Clomipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Clomipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          antiviral agent 11074
            anticoronaviral agent 9662
              clomipramine 93
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  organic heteropolycyclic compound 18301
                                    organic heterotricyclic compound 15642
                                      mancude organic heterotricyclic parent 374
                                        5H-dibenzo[b,f]azepine 135
                                          imipramine 135
                                            clomipramine 93
paths to the root