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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mancude organic heterotricyclic parent
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Accession:CHEBI:36416 term browser browse the term
Synonyms:related_synonym: mancude organic heterotricyclic parents;   mancude-ring organic heterotricyclic parents


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1,10-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression ISO 1,10-phenanthroline results in decreased expression of ACE mRNA CTD PMID:19502547 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ahr aryl hydrocarbon receptor decreases activity
multiple interactions
EXP
ISO
1,10-phenanthroline results in decreased activity of AHR protein
[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; resveratrol inhibits the reaction [[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]
1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; 1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Zinc inhibits the reaction [1,10-phenanthroline results in decreased activity of AHR protein]
CTD PMID:1322109, PMID:2160969, PMID:27180721 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO 1,10-phenanthroline results in decreased expression of AK1 mRNA CTD PMID:19502547 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Akap9 A-kinase anchoring protein 9 increases expression ISO 1,10-phenanthroline results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO 1,10-phenanthroline results in decreased activity of AKR1C4 protein CTD PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO 1,10-phenanthroline results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO 1,10-phenanthroline results in decreased activity of AKR1C3 protein CTD PMID:12604236 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO 1,10-phenanthroline results in increased expression of ALDOA mRNA CTD PMID:19502547 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression ISO 1,10-phenanthroline results in increased expression of ALDOC mRNA CTD PMID:19502547 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO 1,10-phenanthroline results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases activity
multiple interactions
ISO 1,10-phenanthroline results in decreased activity of ANPEP protein
Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]
CTD PMID:17109655 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression ISO 1,10-phenanthroline results in decreased expression of AQP3 mRNA CTD PMID:19641517 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Aspa aspartoacylase decreases activity ISO 1,10-phenanthroline results in decreased activity of ASPA protein CTD PMID:17027983 NCBI chr10:59,839,693...59,888,244
Ensembl chr10:59,839,852...59,892,960
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein CTD PMID:21355074 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bnip3l BCL2 interacting protein 3 like decreases expression ISO 1,10-phenanthroline results in decreased expression of BNIP3L mRNA CTD PMID:19502547 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Ca9 carbonic anhydrase 9 increases expression ISO 1,10-phenanthroline results in increased expression of CA9 mRNA CTD PMID:19502547 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Cat catalase decreases expression ISO 1,10-phenanthroline results in decreased expression of CAT mRNA CTD PMID:19502547 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd83 CD83 molecule increases expression ISO 1,10-phenanthroline results in increased expression of CD83 mRNA CTD PMID:19641517 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions
ISO 1,10-phenanthroline results in increased expression of CD86 mRNA
Acetylcysteine inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]; SB 203580 inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]
CTD PMID:19641517 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO 1,10-phenanthroline results in increased activity of CFTR protein CTD PMID:15921678 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases stability
ISO
EXP
1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; zinc chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA
1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
1,10-phenanthroline results in increased stability of CYP1A1 mRNA
CTD PMID:1322109, PMID:19896525, PMID:27180721 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression ISO 1,10-phenanthroline results in increased expression of EGLN1 mRNA CTD PMID:19502547 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 decreases expression ISO 1,10-phenanthroline results in decreased expression of EGLN2 mRNA CTD PMID:19502547 NCBI chr 1:83,969,456...83,977,665
Ensembl chr 1:83,969,457...83,977,236
JBrowse link
G Egr1 early growth response 1 increases expression ISO 1,10-phenanthroline results in increased expression of EGR1 mRNA CTD PMID:19502547 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eno1 enolase 1 increases expression ISO 1,10-phenanthroline results in increased expression of ENO1 mRNA CTD PMID:19502547 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Eno2 enolase 2 increases expression ISO 1,10-phenanthroline results in increased expression of ENO2 mRNA CTD PMID:19502547 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO 1,10-phenanthroline results in decreased expression of ERCC2 mRNA CTD PMID:19502547 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO 1,10-phenanthroline results in increased expression of GAPDH mRNA CTD PMID:19502547 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO 1,10-phenanthroline results in decreased expression of GPX3 mRNA CTD PMID:19502547 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Copper binds to phthalic acid binds to 1,10-phenanthroline] which results in increased expression of H2AX protein modified form CTD PMID:22659117 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO 1,10-phenanthroline results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 1,10-phenanthroline results in increased expression of HBEGF mRNA CTD PMID:26800359 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
ISO 4'-O-methylalpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]
HIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]
1,10-phenanthroline results in increased activity of HIF1A protein
CTD PMID:19091749, PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha decreases expression ISO 1,10-phenanthroline results in decreased expression of HIF3A mRNA CTD PMID:19502547 NCBI chr 1:78,976,318...78,997,869
Ensembl chr 1:78,976,318...78,997,869
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression ISO 1,10-phenanthroline results in increased expression of HILPDA mRNA CTD PMID:19502547 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hk1 hexokinase 1 increases expression ISO 1,10-phenanthroline results in increased expression of HK1 mRNA CTD PMID:19502547 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hk2 hexokinase 2 increases expression ISO 1,10-phenanthroline results in increased expression of HK2 mRNA CTD PMID:19502547 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of HMOX1 protein]; 1,10-phenanthroline inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA] CTD PMID:9747510, PMID:15629867, PMID:20888885 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 1,10-phenanthroline affects the reaction [Smoke results in increased expression of ICAM1 protein] CTD PMID:15560890 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases degradation EXP 1,10-phenanthroline results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO 1,10-phenanthroline results in decreased expression of IL1R1 mRNA CTD PMID:19502547 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [Mustard Gas results in increased degradation of LAMC2 protein] CTD PMID:18095945 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO 1,10-phenanthroline results in increased expression of LDHA mRNA CTD PMID:19502547 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 multiple interactions ISO [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein CTD PMID:21355074 NCBI chr  X:40,258,933...40,309,047
Ensembl chr  X:40,258,493...40,310,563
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO 1,10-phenanthroline results in increased expression of MDM2 mRNA CTD PMID:19502547 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO 1,10-phenanthroline results in increased expression of MIF mRNA CTD PMID:19502547 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO 1,10-phenanthroline results in decreased activity of MMP8 protein CTD PMID:15057751 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein]
1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]
CTD PMID:20177776, PMID:20195827 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nppb natriuretic peptide B increases expression ISO 1,10-phenanthroline results in increased expression of NPPB mRNA CTD PMID:19502547 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nub1 negative regulator of ubiquitin-like proteins 1 increases expression ISO 1,10-phenanthroline results in increased expression of NUB1 mRNA CTD PMID:19502547 NCBI chr 4:6,950,870...6,981,400
Ensembl chr 4:6,951,478...6,978,073
JBrowse link
G Ocln occludin multiple interactions ISO 1,10-phenanthroline inhibits the reaction [Patulin results in increased degradation of OCLN protein] CTD PMID:19013514 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 increases expression ISO 1,10-phenanthroline results in increased expression of P4HA2 mRNA CTD PMID:19502547 NCBI chr10:39,435,227...39,464,134
Ensembl chr10:39,435,227...39,464,188
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO 1,10-phenanthroline results in increased expression of PDK1 mRNA CTD PMID:19502547 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO 1,10-phenanthroline results in increased expression of PDK3 mRNA CTD PMID:19502547 NCBI chr  X:62,836,131...62,904,114
Ensembl chr  X:62,836,131...62,903,554
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO 1,10-phenanthroline results in increased expression of PGK1 mRNA CTD PMID:19502547 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO 1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein] CTD PMID:20177776 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO 1,10-phenanthroline results in increased expression of PLOD3 mRNA CTD PMID:19502547 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta decreases expression ISO 1,10-phenanthroline results in decreased expression of PPP2R1B mRNA CTD PMID:19502547 NCBI chr 8:55,279,278...55,311,768
Ensembl chr 8:55,279,373...55,301,320
JBrowse link
G Psph phosphoserine phosphatase decreases expression ISO 1,10-phenanthroline results in decreased expression of PSPH mRNA CTD PMID:19502547 NCBI chr12:30,514,128...30,526,551
Ensembl chr12:30,514,112...30,526,557
JBrowse link
G Sele selectin E multiple interactions ISO 1,10-phenanthroline affects the reaction [Smoke results in increased expression of SELE protein] CTD PMID:15560890 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO 1,10-phenanthroline results in increased expression of SERPINE1 mRNA CTD PMID:19502547 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of SOD1 protein]; 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in decreased expression of SOD1 protein] CTD PMID:15629867, PMID:20674559 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein] CTD PMID:20674559 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein CTD PMID:21355074 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide affects the localization of STAT3 protein] CTD PMID:10364193 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tfrc transferrin receptor increases expression ISO 1,10-phenanthroline results in increased expression of TFRC mRNA CTD PMID:19502547 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Timm17a translocase of inner mitochondrial membrane 17A multiple interactions ISO 1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in decreased expression of TIMM17A protein] CTD PMID:24315374 NCBI chr13:52,124,641...52,136,127
Ensembl chr13:52,124,635...52,136,127
JBrowse link
G Tp53 tumor protein p53 affects folding ISO 1,10-phenanthroline affects the folding of TRP53 protein CTD PMID:8467489 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO 1,10-phenanthroline results in increased expression of VEGFA mRNA; 1,10-phenanthroline results in increased expression of VEGFA protein
HIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]
CTD PMID:19502547 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
1,7-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP 1,7-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; 1,7-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP 1,7-phenanthroline results in increased expression of CYP1A1 protein
1,7-phenanthroline inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP1A1 protein]; 1,7-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
CTD PMID:1322109, PMID:17967931 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP 1,7-phenanthroline inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP1A2 protein]
1,7-phenanthroline results in increased expression of CYP1A2 protein
CTD PMID:17967931 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO 1,7-phenanthroline results in decreased expression of POU5F1 protein CTD PMID:21111795 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases expression
EXP 1,7-phenanthroline promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A6 protein]
1,7-phenanthroline results in increased expression of UGT1A6 protein
CTD PMID:17967931 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
10H-phenothiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects localization
multiple interactions
ISO phenothiazine analog affects the localization of AR protein
phenothiazine analog binds to and results in decreased activity of AR protein
CTD PMID:17606915 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO phenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein] CTD PMID:26735014 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO phenothiazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO phenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein] CTD PMID:26735014 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
1H-imidazo[2,1-i]purine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase increases metabolic processing ISO ALKBH2 protein results in increased metabolism of 1,N(6)-ethenoadenine CTD PMID:32293880 NCBI chr12:48,257,575...48,262,244
Ensembl chr12:48,257,609...48,262,243
JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases metabolic processing ISO MPG protein results in increased metabolism of 1,N(6)-ethenoadenine CTD PMID:10626224, PMID:32293880 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
4,7-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases activity
multiple interactions
ISO
EXP
4,7-phenanthroline results in decreased activity of AHR protein
4,7-phenanthroline inhibits the reaction [AHR promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]]
4,7-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; 4,7-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
CTD PMID:1322109, PMID:8738555 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP 4,7-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
9H-carbazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP
ISO
carbazole binds to and results in increased activity of AHR protein CTD PMID:21431309, PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
acetophenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO acetophenazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
annomontine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO annomontine results in increased expression of AHR mRNA CTD PMID:20449727 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO annomontine results in increased expression of AHRR mRNA CTD PMID:20449727 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO annomontine results in increased expression of CYP1A1 mRNA CTD PMID:20449727 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
bathocuproine disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA] CTD PMID:15477007 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ARHGDIA mRNA CTD PMID:15477007 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA] CTD PMID:15477007 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions ISO ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 mRNA]; ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein] CTD PMID:20194531 NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760, PMID:21242307 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO bathocuproine sulfonate results in decreased expression of BCL2 protein CTD PMID:24614111 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL2A1 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL2A1 mRNA]] CTD PMID:15477007 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Casp3 caspase 3 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of CASP3 protein] CTD PMID:10941151, PMID:11239917, PMID:18056745 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]] CTD PMID:15477007 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]] CTD PMID:11006087 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL3 mRNA] CTD PMID:15477007 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCT5 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCT5 mRNA]] CTD PMID:15477007 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790
JBrowse link
G Cd200 Cd200 molecule multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA] CTD PMID:15477007 NCBI chr11:60,371,617...60,398,450
Ensembl chr11:60,371,684...60,403,196
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNA] CTD PMID:15477007 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh17 cadherin 17 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CDH17 mRNA]; [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CDH17 mRNA CTD PMID:15477007 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Clu clusterin multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cntnap1 contactin associated protein 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CNTNAP1 mRNA CTD PMID:15477007 NCBI chr10:89,087,904...89,103,615
Ensembl chr10:89,089,646...89,103,614
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] CTD PMID:15477007 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cp ceruloplasmin multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein] CTD PMID:17032174 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpsf1 cleavage and polyadenylation specific factor 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CPSF1 mRNA CTD PMID:15477007 NCBI chr 7:117,661,779...117,672,373
Ensembl chr 7:117,661,661...117,672,373
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CREB1 mRNA CTD PMID:15477007 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crem cAMP responsive element modulator multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA] CTD PMID:15477007 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Cul5 cullin 5 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA] CTD PMID:15477007 NCBI chr 8:58,199,992...58,255,149
Ensembl chr 8:58,202,821...58,253,688
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which affects the localization of CYCS protein] CTD PMID:18056745 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of DNAJB1 mRNA CTD PMID:15477007 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dusp4 dual specificity phosphatase 4 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]] CTD PMID:15477007 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Egr2 early growth response 2 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA] CTD PMID:15477007 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Egr3 early growth response 3 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of EGR3 mRNA CTD PMID:15477007 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO bathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of FASN mRNA] CTD PMID:24170205 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:22842628 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOS protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]] CTD PMID:15477007, PMID:17032174 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fyb1 FYN binding protein 1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA] CTD PMID:15477007 NCBI chr 2:55,834,904...55,983,805
Ensembl chr 2:55,835,151...55,983,804
JBrowse link
G Gfra2 GDNF family receptor alpha 2 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GFRA2 mRNA] CTD PMID:15477007 NCBI chr15:52,557,004...52,648,984
Ensembl chr15:52,557,607...52,648,972
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GNAS mRNA CTD PMID:15477007 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GTF2H2C mRNA CTD PMID:15477007 NCBI chr 2:30,494,718...30,522,716
Ensembl chr 2:30,494,825...30,522,727
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HADHA mRNA] CTD PMID:15477007 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA] CTD PMID:15477007 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein CTD PMID:21242307 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HNRNPUL1 mRNA CTD PMID:15477007 NCBI chr 1:82,512,745...82,548,446
Ensembl chr 1:82,512,745...82,546,937
JBrowse link
G Hpx hemopexin multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]; bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HSPA8 mRNA; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA8 mRNA]] CTD PMID:15477007 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hyal3 hyaluronidase 3 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HYAL3 mRNA CTD PMID:15477007 NCBI chr 8:116,336,512...116,342,147
Ensembl chr 8:116,336,512...116,342,146
JBrowse link
G Il2 interleukin 2 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]] CTD PMID:15477007 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO bathocuproine sulfonate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]] CTD PMID:23134680 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il2rb interleukin 2 receptor subunit beta multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RB mRNA] CTD PMID:15477007 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN protein]] CTD PMID:15477007, PMID:17032174 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA] CTD PMID:15477007 NCBI chr15:57,170,566...57,277,811
Ensembl chr15:57,221,292...57,277,811
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO bathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of LDLR mRNA] CTD PMID:24170205 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Ltbp4 latent transforming growth factor beta binding protein 4 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA] CTD PMID:15477007 NCBI chr 1:84,118,046...84,152,095
Ensembl chr 1:84,118,046...84,150,084
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of MAPK1 protein]]
bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]
bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]
CTD PMID:10658192, PMID:15477007, PMID:22842628 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of MAPK3 protein]]
bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK3 protein]
CTD PMID:10941151, PMID:15477007, PMID:22842628 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK8 protein] CTD PMID:10941151, PMID:11239917, PMID:18056745 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mta1 metastasis associated 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MTA1 mRNA CTD PMID:15477007 NCBI chr 6:137,911,302...137,950,066
Ensembl chr 6:137,924,293...137,950,075
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]; bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MYC mRNA] CTD PMID:15477007 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Naa80 N(alpha)-acetyltransferase 80, NatH catalytic subunit multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NAA80 mRNA] CTD PMID:15477007 NCBI chr 8:116,336,441...116,339,691
Ensembl chr 8:116,336,441...116,339,690
JBrowse link
G Nell1 neural EGFL like 1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA] CTD PMID:15477007 NCBI chr 1:105,348,577...106,218,970
Ensembl chr 1:105,349,069...106,218,958
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of NFE2L2 mRNA CTD PMID:15477007 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] CTD PMID:11006087 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] CTD PMID:11006087 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nmi N-myc (and STAT) interactor multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NMI mRNA] CTD PMID:15477007 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NR4A3 mRNA] CTD PMID:15477007 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ODC1 mRNA CTD PMID:15477007 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pax8 paired box 8 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of PAX8 mRNA] CTD PMID:11108245 NCBI chr 3:1,527,316...1,586,019
Ensembl chr 3:1,527,279...1,584,946
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO bathocuproine sulfonate results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of PPP1R10 mRNA CTD PMID:15477007 NCBI chr20:3,329,677...3,344,286
Ensembl chr20:3,329,677...3,344,286
JBrowse link
G Prnp prion protein multiple interactions EXP bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein] CTD PMID:16148034 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA] CTD PMID:15477007 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 increases oxidation ISO bathocuproine sulfonate results in increased oxidation of SCO1 protein CTD PMID:23345593 NCBI chr10:53,595,854...53,608,437
Ensembl chr10:53,595,854...53,608,435
JBrowse link
G Sla src-like adaptor multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLA mRNA] CTD PMID:15477007 NCBI chr 7:107,585,055...107,604,950
Ensembl chr 7:107,584,118...107,634,335
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO [bathocuproine sulfonate results in decreased abundance of Copper] which results in increased expression of SLC31A1 mRNA; bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] CTD PMID:18483225 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc31a2 solute carrier family 31 member 2 multiple interactions
affects localization
ISO [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein] which results in increased uptake of and results in increased susceptibility to Cisplatin; [bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein
bathocuproine sulfonate affects the localization of SLC31A2 protein
ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 mRNA]; ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein]
CTD PMID:20194531 NCBI chr 5:78,120,606...78,131,111
Ensembl chr 5:78,120,607...78,131,114
JBrowse link
G Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SNRNP70 mRNA CTD PMID:15477007 NCBI chr 1:101,367,470...101,388,153
Ensembl chr 1:101,367,471...101,388,129
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SOD1 mRNA CTD PMID:15477007 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] CTD PMID:18483225 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Srgn serglycin multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SRGN mRNA CTD PMID:15477007 NCBI chr20:32,120,317...32,158,071
Ensembl chr20:32,120,320...32,139,789
JBrowse link
G Srpra SRP receptor subunit alpha multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRPRA mRNA] CTD PMID:15477007 NCBI chr 8:36,410,683...36,416,766
Ensembl chr 8:36,410,683...36,416,296
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]] CTD PMID:11006087 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA] CTD PMID:15477007 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid results in increased abundance of Copper] which results in increased oxidation of and results in increased expression of TP53 protein] CTD PMID:11964141 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpo thyroid peroxidase multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA] CTD PMID:11108245 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]] CTD PMID:15477007 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Tyr tyrosinase multiple interactions ISO bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TYROBP mRNA] CTD PMID:15477007 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303
JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of UBE2L6 mRNA CTD PMID:15477007 NCBI chr 3:72,191,533...72,206,190
Ensembl chr 3:72,191,533...72,206,188
JBrowse link
G Ubl4a ubiquitin-like 4A multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of UBL4A mRNA CTD PMID:15477007 NCBI chr  X:156,340,919...156,343,771
Ensembl chr  X:156,340,925...156,343,777
JBrowse link
G Vim vimentin multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VIM mRNA] CTD PMID:15477007 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
beta-carboline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO norharman inhibits the reaction [Lipids metabolite results in increased activity of AHR protein]
norharman results in increased activity of AHR protein
CTD PMID:27020609, PMID:28336214 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO CYP1A1 protein affects the metabolism of [norharman co-treated with aniline]
norharman results in increased expression of CYP1A1 mRNA; norharman results in increased expression of CYP1A1 protein
CTD PMID:15279827, PMID:28336214 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO norharman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity
ISO norharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
norharman results in decreased activity of MAOB protein
CTD PMID:21554916 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions
ISO norharman results in decreased activity of SLC22A1 protein
norharman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
CTD PMID:30189235 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions
ISO norharman results in decreased activity of SLC22A2 protein
norharman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
CTD PMID:30189235 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions
ISO norharman results in decreased activity of SLC22A3 protein
norharman inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
CTD PMID:30189235 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
carbazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP
ISO
carbazole binds to and results in increased activity of AHR protein CTD PMID:21431309, PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
clomipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Clomipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression EXP Clomipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Clomipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP Clomipramine affects the expression of ALDH1A4 mRNA CTD PMID:18355885 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Clomipramine results in decreased expression of AP1S1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Clomipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Clomipramine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Clomipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Clomipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP3 protein] CTD PMID:10487422, PMID:22700542, PMID:28482088 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO Clomipramine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Clomipramine results in increased activity of CASP9 protein CTD PMID:28482088 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression ISO Clomipramine results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Clomipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Clomipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Clomipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:122,789,208...122,807,560
Ensembl chr 8:122,789,453...122,807,560
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Clomipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,655,038...3,774,887
Ensembl chr10:3,655,038...3,774,884
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Clomipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Clomipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Clomipramine affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression EXP Clomipramine affects the expression of CYP3A23-3A1 mRNA CTD PMID:18355885 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Clomipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:14,891,062...14,907,250
Ensembl chr 7:14,891,001...14,907,305
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Clomipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:90,532,153...90,587,542
Ensembl chr13:90,532,326...90,591,796
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Clomipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Clomipramine results in increased expression of DRD2 protein CTD PMID:20619828 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Clomipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:143,679,656...143,701,452
Ensembl chr 7:143,679,617...143,701,452
JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Clomipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Clomipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Clomipramine results in increased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Gckr glucokinase regulator affects expression EXP Clomipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clomipramine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gls2 glutaminase 2 affects expression EXP Clomipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:2,605,679...2,621,853
Ensembl chr 7:2,605,719...2,621,852
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Clomipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Clomipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Clomipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Clomipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Clomipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Clomipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hpn hepsin increases expression ISO Clomipramine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
increases expression
ISO
EXP
Clomipramine binds to HTR2C protein
Clomipramine results in increased expression of HTR2C protein
CTD PMID:18083778, PMID:20619828 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il33 interleukin 33 affects expression EXP Clomipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Clomipramine results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Clomipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lox lysyl oxidase affects expression EXP Clomipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Lss lanosterol synthase increases expression ISO Clomipramine results in increased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Clomipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678
JBrowse link
G Manba mannosidase beta affects expression EXP Clomipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:240,668,213...240,760,264
Ensembl chr 2:240,668,195...240,760,261
JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Clomipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:88,997,011...89,002,154
Ensembl chr10:88,997,399...89,002,152
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Clomipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:3,344,870...3,350,929
Ensembl chr20:3,344,870...3,350,927
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Clomipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clomipramine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Clomipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases phosphorylation ISO Clomipramine results in increased phosphorylation of NTRK2 protein CTD PMID:22396798 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Clomipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oaf out at first homolog affects expression EXP Clomipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Clomipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pc pyruvate carboxylase affects expression EXP Clomipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Clomipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Clomipramine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Clomipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prl prolactin affects secretion
increases expression
multiple interactions
increases secretion
ISO Clomipramine affects the secretion of PRL protein
Clomipramine results in increased expression of PRL protein
SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein]
Clomipramine results in increased secretion of PRL protein
CTD PMID:3602989, PMID:7930386, PMID:17000009, PMID:19698552 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases expression ISO Clomipramine results in increased expression of PROC protein CTD PMID:17891354 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Clomipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Clomipramine affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Clomipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Clomipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Clomipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:144,069,641...144,200,402
Ensembl chr 1:144,069,638...144,200,397
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clomipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Clomipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Clomipramine binds to and results in decreased activity of SLC6A4 protein; SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein] CTD PMID:16272152, PMID:17000009 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Clomipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Clomipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Clomipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Clomipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Clomipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Clomipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:16,976,355...16,979,760
Ensembl chr14:16,976,356...16,979,760
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Clomipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Clomipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tagln transgelin decreases expression ISO Clomipramine results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tex261 testis expressed 261 affects expression EXP Clomipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:115,446,830...115,454,035
Ensembl chr 4:115,448,708...115,453,659
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Clomipramine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Clomipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:170,471,265...170,474,111
Ensembl chr 1:170,471,238...170,474,113
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Clomipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Clomipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Clomipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 affects expression EXP Clomipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Clomipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
dibenzofuran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 increases expression EXP dibenzofuran analog results in increased expression of ACKR3 mRNA CTD PMID:20566336 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression EXP dibenzofuran analog results in increased expression of ADH7 mRNA CTD PMID:20566336 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
affects localization
EXP
ISO
AHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1A mRNA]; AHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1B mRNA]; AHR protein promotes the reaction [dibenzofuran analog results in increased expression of GSTA2 mRNA]; AHR protein promotes the reaction [dibenzofuran analog results in increased expression of PLA2G2A mRNA]; AHR protein promotes the reaction [dibenzofuran analog results in increased expression of PTGS2 mRNA]; dibenzofuran binds to and results in increased activity of AHR protein
dibenzofuran analog results in increased activity of AHR protein
dibenzofuran analog affects the localization of AHR protein
CTD PMID:20566336, PMID:21431309, PMID:28186253, PMID:28669845 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP dibenzofuran analog results in increased expression of AHRR mRNA CTD PMID:20566336 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression EXP dibenzofuran analog results in increased expression of ALDH3A1 mRNA CTD PMID:20566336 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression EXP dibenzofuran analog results in increased expression of ALDH3A2 mRNA CTD PMID:20566336 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Aurkb aurora kinase B decreases expression EXP dibenzofuran analog results in decreased expression of AURKB mRNA CTD PMID:20566336 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression EXP dibenzofuran analog results in decreased expression of BARD1 mRNA CTD PMID:20566336 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression EXP dibenzofuran analog results in decreased expression of BRCA1 mRNA CTD PMID:20566336 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression EXP dibenzofuran analog results in decreased expression of BRCA2 mRNA CTD PMID:20566336 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP dibenzofuran analog results in increased expression of CCL20 mRNA CTD PMID:20566336 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccna2 cyclin A2 decreases expression EXP dibenzofuran analog results in decreased expression of CCNA2 mRNA CTD PMID:20566336 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression EXP dibenzofuran analog results in decreased expression of CCNB1 mRNA CTD PMID:20566336 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
EXP dibenzofuran analog results in increased expression of CDKN1A mRNA
AHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1A mRNA]
CTD PMID:20566336 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
EXP dibenzofuran analog results in increased expression of CDKN1B mRNA; dibenzofuran analog results in increased expression of CDKN1B protein
AHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1B mRNA]
CTD PMID:20566336 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP dibenzofuran analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein] CTD PMID:21880487 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO dibenzofuran analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein] CTD PMID:21880487 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 decreases expression EXP dibenzofuran analog results in decreased expression of COX4I2 mRNA CTD PMID:20566336 NCBI chr 3:148,234,546...148,245,424
Ensembl chr 3:148,234,193...148,245,416
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 mRNA]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 mRNA]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 protein]
dibenzofuran analog results in increased expression of CYP1A1 mRNA; dibenzofuran analog results in increased expression of CYP1A1 protein
CTD PMID:20566336 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions
ISO dibenzofuran results in increased activity of CYP1A2 protein
dibenzofuran metabolite results in increased activity of CYP1A2 protein
[acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA
CTD PMID:7750161, PMID:8001243, PMID:26032510 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases expression EXP dibenzofuran analog results in increased expression of CYP2F4 mRNA CTD PMID:20566336 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 increases expression EXP dibenzofuran analog results in increased expression of ENTPD1 mRNA CTD PMID:20566336 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
increases expression
EXP AHR protein promotes the reaction [dibenzofuran analog results in increased expression of GSTA2 mRNA] CTD PMID:20566336 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP dibenzofuran analog results in increased expression of JUN mRNA CTD PMID:20566336 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta affects localization
increases expression
ISO dibenzofuran affects the localization of MAP1LC3B protein
dibenzofuran results in increased expression of MAP1LC3B protein modified form
CTD PMID:22173198 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nptxr neuronal pentraxin receptor increases expression EXP dibenzofuran analog results in increased expression of NPTXR mRNA CTD PMID:20566336 NCBI chr 7:121,011,678...121,029,754
Ensembl chr 7:121,011,680...121,029,754
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP dibenzofuran analog results in increased expression of NQO1 mRNA CTD PMID:20566336 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP dibenzofuran analog results in increased expression of NR1D2 mRNA CTD PMID:20566336 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions
increases expression
EXP AHR protein promotes the reaction [dibenzofuran analog results in increased expression of PLA2G2A mRNA] CTD PMID:20566336 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Ptges prostaglandin E synthase increases expression EXP dibenzofuran analog results in increased expression of PTGES mRNA CTD PMID:20566336 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP dibenzofuran analog results in increased expression of PTGS2 mRNA
AHR protein promotes the reaction [dibenzofuran analog results in increased expression of PTGS2 mRNA]
CTD PMID:20566336 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad51 RAD51 recombinase decreases expression EXP dibenzofuran analog results in decreased expression of RAD51 mRNA CTD PMID:20566336 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rbp4 retinol binding protein 4 increases expression EXP dibenzofuran analog results in increased expression of RBP4 mRNA CTD PMID:20566336 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP dibenzofuran analog results in increased expression of SERPINE1 mRNA CTD PMID:20566336 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sim2 SIM bHLH transcription factor 2 increases expression EXP dibenzofuran analog results in increased expression of SIM2 mRNA CTD PMID:20566336 NCBI chr11:34,315,739...34,355,183
Ensembl chr11:34,316,295...34,354,027
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO dibenzofuran results in decreased expression of SQSTM1 protein CTD PMID:22173198 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP dibenzofuran analog results in increased expression of TIPARP mRNA CTD PMID:20566336 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Tmem150a transmembrane protein 150A increases expression EXP dibenzofuran analog results in increased expression of TMEM150A mRNA CTD PMID:20566336 NCBI chr 4:100,217,986...100,222,131
Ensembl chr 4:100,218,661...100,222,130
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression EXP dibenzofuran analog results in decreased expression of TOP2A mRNA CTD PMID:20566336 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
dibenzothiophene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP dibenzothiophene binds to and results in increased activity of AHR protein CTD PMID:21431309 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
ethidium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:15897899 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] CTD PMID:15897899 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] CTD PMID:15897899 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA] CTD PMID:15897899 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd59 CD59 molecule increases mutagenesis ISO Ethidium results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Gja1 gap junction protein, alpha 1 increases uptake EXP GJA1 protein results in increased uptake of Ethidium CTD PMID:26926986 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:8875956, PMID:10571731 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression ISO Ethidium results in decreased expression of COX1 protein CTD PMID:18823003 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Ethidium results in decreased expression of COX2 mRNA CTD PMID:22712077 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO Ethidium results in decreased expression of CYTB mRNA CTD PMID:22712077 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 decreases expression ISO Ethidium results in decreased expression of ND1 mRNA CTD PMID:22712077 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 decreases expression ISO Ethidium results in decreased expression of ND4 mRNA CTD PMID:22712077 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Ethidium results in increased expression of NRF1 mRNA CTD PMID:22712077 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases transport
increases transport
ISO P2RX7 gene polymorphism results in decreased transport of Ethidium
P2RX7 protein results in increased transport of Ethidium
CTD PMID:16263709 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
affects uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
SLC22A1 protein affects the uptake of Ethidium
CTD PMID:19357179 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 affects uptake
multiple interactions
increases uptake
ISO SLC22A2 protein affects the uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Ethidium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Ethidium results in increased expression of TFAM mRNA CTD PMID:22712077 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
fluphenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions
decreases activity
EXP [Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein
Fluphenazine results in decreased activity of ALAD protein
CTD PMID:19486337 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Ar androgen receptor multiple interactions ISO Fluphenazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein] CTD PMID:19486337 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Fluphenazine results in decreased activity of CYP2C19 protein CTD PMID:15135088 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Fluphenazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Fluphenazine binds to DRD2 protein CTD PMID:17606915 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding ISO Fluphenazine binds to HTR2A protein CTD PMID:17606915 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Fluphenazine binds to HTR2C protein CTD PMID:17606915 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Fluphenazine inhibits the reaction [NGF protein results in increased uptake of Calcium] CTD PMID:1374475 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Prl prolactin increases secretion ISO Fluphenazine results in increased secretion of PRL protein CTD PMID:9989566 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fluphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO Fluphenazine results in decreased expression of TAC1 mRNA CTD PMID:15845098 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tfeb transcription factor EB affects localization ISO Fluphenazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
imipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Imipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression EXP Imipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
decreases activity
ISO Imipramine inhibits the reaction [asoxime chloride inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]]; Imipramine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Imipramine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Imipramine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
Imipramine results in increased activity of ACHE protein
Imipramine results in decreased activity of ACHE protein
CTD PMID:25522658, PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
decreases activity
EXP [Imipramine co-treated with Idazoxan] results in decreased activity of ADRB1 protein; [Imipramine co-treated with Yohimbine] results in decreased activity of ADRB1 protein
Imipramine results in decreased activity of ADRB1 protein
CTD PMID:2868116 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases expression ISO Imipramine results in decreased expression of ADRB2 protein CTD PMID:10618463 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Alb albumin affects binding ISO Imipramine binds to ALB protein CTD PMID:20956006 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Imipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP Imipramine affects the expression of ALDH1A4 mRNA CTD PMID:18355885 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Imipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Imipramine results in increased expression of ASAH1 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Imipramine results in increased expression of ASNS mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
affects expression
ISO
EXP
Imipramine results in increased expression of BDNF mRNA
Rolipram promotes the reaction [Imipramine results in increased expression of BDNF mRNA]
Imipramine affects the expression of BDNF protein
CTD PMID:8601816, PMID:15157811, PMID:17617388, PMID:17950272 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Imipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Imipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP3 protein] CTD PMID:10487422, PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Imipramine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Imipramine inhibits the reaction [lead acetate results in increased activity of CASP8 protein] CTD PMID:22033380 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase affects activity ISO Imipramine affects the activity of CAT protein CTD PMID:19798453 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Imipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Imipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Imipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:122,789,208...122,807,560
Ensembl chr 8:122,789,453...122,807,560
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression EXP Imipramine results in decreased expression of CNR1 protein CTD PMID:28866072 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression EXP Imipramine results in increased expression of CNR2 protein CTD PMID:28866072 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Imipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,655,038...3,774,887
Ensembl chr10:3,655,038...3,774,884
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
increases phosphorylation
multiple interactions
EXP
ISO
Imipramine results in increased expression of CREB1 mRNA
Imipramine results in increased phosphorylation of CREB1 protein
Rolipram promotes the reaction [Imipramine results in increased expression of CREB1 mRNA]
CTD PMID:8601816, PMID:22396798 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Imipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crh corticotropin releasing hormone affects activity EXP Imipramine affects the activity of CRH protein CTD PMID:2553044 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP1A2 protein affects the metabolism of Imipramine
CYP1A2 protein results in increased metabolism of Imipramine
CYP1A2 protein results in decreased methylation of and results in increased activity of Imipramine; Imipramine inhibits the reaction [resveratrol results in decreased activity of CYP1A2 protein]; Organophosphorus Compounds inhibits the reaction [CYP1A2 protein results in decreased methylation of and results in increased activity of Imipramine]
CTD PMID:11714871, PMID:15286053, PMID:15922009 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Imipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Imipramine affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing
multiple interactions
ISO CYP2C19 protein affects the metabolism of Imipramine
CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine; Organophosphorus Compounds inhibits the reaction [CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine]
CTD PMID:15286053, PMID:15922009 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Imipramine CTD PMID:15286053 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression EXP Imipramine affects the expression of CYP3A23-3A1 mRNA CTD PMID:18355885 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Imipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:14,891,062...14,907,250
Ensembl chr 7:14,891,001...14,907,305
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Imipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:90,532,153...90,587,542
Ensembl chr13:90,532,326...90,591,796
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Imipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 increases expression ISO Imipramine results in increased expression of DNAJC5 mRNA; Imipramine results in increased expression of DNAJC5 protein CTD PMID:11257428 NCBI chr 3:177,012,714...177,047,787
Ensembl chr 3:177,013,604...177,043,902
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Imipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:143,679,656...143,701,452
Ensembl chr 7:143,679,617...143,701,452
JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Imipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Imipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Imipramine results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Imipramine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP Imipramine results in decreased expression of GAP43 mRNA CTD PMID:17950272 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gckr glucokinase regulator affects expression EXP Imipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Imipramine results in increased expression of GDPD3 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gls2 glutaminase 2 affects expression EXP Imipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:2,605,679...2,621,853
Ensembl chr 7:2,605,719...2,621,852
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Imipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Imipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Imipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Imipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hdac5 histone deacetylase 5 increases expression ISO Imipramine results in increased expression of HDAC5 mRNA CTD PMID:17988634 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Imipramine results in decreased activity of HMBS protein CTD PMID:10416826 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Imipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Imipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hpn hepsin increases expression ISO Imipramine results in increased expression of HPN mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Imipramine results in increased expression of HSPA8 mRNA alternative form; Imipramine results in increased expression of HSPA8 protein alternative form CTD PMID:10425221 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A affects expression EXP Imipramine affects the expression of HTR1A mRNA CTD PMID:17617388 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP Imipramine results in decreased expression of HTR2A CTD PMID:2553044 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Il33 interleukin 33 affects expression EXP Imipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Imipramine results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO Imipramine binds to and results in decreased activity of KCNH1 protein CTD PMID:18497958 NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
decreases localization
ISO
EXP
Imipramine binds to and results in decreased activity of KCNH2 protein; Imipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Imipramine results in decreased activity of KCNH2 protein
Imipramine results in decreased localization of KCNH2 protein
CTD PMID:15272206, PMID:19583963, PMID:21158687, PMID:21525004, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Imipramine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Lox lysyl oxidase affects expression EXP Imipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Lss lanosterol synthase increases expression ISO Imipramine results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17567588 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Imipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678
JBrowse link
G Manba mannosidase beta affects expression EXP Imipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:240,668,213...240,760,264
Ensembl chr 2:240,668,195...240,760,261
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Imipramine binds to and results in increased activity of MAPK1 protein]; Imipramine binds to and results in increased activity of MAPK1 protein CTD PMID:20484120 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Imipramine binds to and results in increased activity of MAPK3 protein]; Imipramine binds to and results in increased activity of MAPK3 protein CTD PMID:20484120 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Imipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:88,997,011...89,002,154
Ensembl chr10:88,997,399...89,002,152
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Imipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:3,344,870...3,350,929
Ensembl chr20:3,344,870...3,350,927
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Imipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Imipramine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Imipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
increases phosphorylation
ISO Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]; Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form]; Imipramine results in increased phosphorylation of and results in increased activity of NTRK2 protein
Imipramine results in increased phosphorylation of NTRK2 protein
CTD PMID:21666748, PMID:22396798, PMID:31631060 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Imipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oaf out at first homolog affects expression EXP Imipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Imipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pc pyruvate carboxylase affects expression EXP Imipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Imipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions ISO Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form] CTD PMID:22396798 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO Imipramine inhibits the reaction [Buspirone results in increased expression of POMC protein] CTD PMID:19762159 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Imipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions EXP Imipramine inhibits the reaction [Ethanol results in increased activity of PPP2CA protein] CTD PMID:20224005 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Imipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Imipramine affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Imipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Imipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Serpini1 serpin family I member 1 increases expression EXP Imipramine results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 2:174,013,058...174,111,693
Ensembl chr 2:174,013,288...174,111,752
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Imipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:144,069,641...144,200,402
Ensembl chr 1:144,069,638...144,200,397
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:24947867, PMID:25106415 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Imipramine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Imipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:10966924, PMID:21697722 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Imipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases activity
multiple interactions
ISO Imipramine results in decreased activity of SLC47A1 protein
Imipramine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:16928787, PMID:21599003 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases activity EXP Imipramine results in decreased activity of SLC6A4 protein CTD PMID:18561912 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Imipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Imipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Imipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Imipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Imipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Imipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:16,976,355...16,979,760
Ensembl chr14:16,976,356...16,979,760
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Imipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Imipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tagln transgelin decreases expression ISO Imipramine results in decreased expression of TAGLN mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tex261 testis expressed 261 affects expression EXP Imipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:115,446,830...115,454,035
Ensembl chr 4:115,448,708...115,453,659
JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Imipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:170,471,265...170,474,111
Ensembl chr 1:170,471,238...170,474,113
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:15946935 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Imipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Imipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases glucuronidation
affects metabolic processing
ISO Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine]
UGT1A4 protein results in increased glucuronidation of Imipramine; UGT1A4 protein SNP results in increased glucuronidation of Imipramine
UGT1A4 protein affects the metabolism of Imipramine
CTD PMID:9264550, PMID:14570768, PMID:15286053, PMID:15708967, PMID:25448279 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Imipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 affects expression EXP Imipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Imipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
oxanthrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects abundance ISO CYP1A1 gene polymorphism affects the abundance of dibenzo(1,4)dioxin CTD PMID:23528250 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
perazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of Perazine CTD PMID:11026737 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
periciazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO periciazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO periciazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
perphenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D multiple interactions ISO Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Perphenazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Perphenazine results in decreased expression of FSHB protein CTD PMID:6770916 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Perphenazine results in decreased activity of KCNH2 protein
CTD PMID:21158687, PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Perphenazine results in decreased expression of LHB protein CTD PMID:6770916 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Prl prolactin increases expression ISO
EXP
Perphenazine results in increased expression of PRL protein CTD PMID:6770916, PMID:7262630, PMID:17335319 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Perphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression ISO Perphenazine results in increased expression of TNNI3 protein CTD PMID:14742781 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
prochlorperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Prochlorperazine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Prochlorperazine binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Tfeb transcription factor EB affects localization ISO Prochlorperazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
quinacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of Quinacrine
Elacridar inhibits the reaction [ABCB1 protein results in increased transport of Quinacrine]
CTD PMID:16581945 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Agt angiotensinogen multiple interactions ISO Quinacrine inhibits the reaction [AGT protein results in increased metabolism of and results in increased abundance of Arachidonic Acid] CTD PMID:16257180 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
increases expression
multiple interactions
ISO BAX protein results in increased susceptibility to Quinacrine
Quinacrine results in increased expression of BAX mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of BAX mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of BAX protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of BAX protein]; mithramycin A inhibits the reaction [Quinacrine results in increased expression of BAX mRNA]; mithramycin A inhibits the reaction [Quinacrine results in increased expression of BAX protein]; Quinacrine promotes the reaction [SP1 protein binds to BAX promoter]; Quinacrine results in increased expression of and affects the localization of BAX protein
CTD PMID:16177561, PMID:28867437 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase decreases expression
multiple interactions
ISO Quinacrine results in decreased expression of BTRC protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased expression of BTRC protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of BAX protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; FOXP3 protein affects the reaction [Quinacrine results in decreased expression of BTRC protein]; MIR183 mRNA affects the reaction [Quinacrine results in decreased expression of BTRC protein]; Quinacrine results in decreased expression of and results in decreased stability of BTRC mRNA
CTD PMID:28867437 NCBI chr 1:265,100,094...265,270,263
Ensembl chr 1:265,157,379...265,269,837
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO Quinacrine results in increased cleavage of CASP3 protein
GSK3B protein affects the reaction [Quinacrine results in increased activity of CASP3 protein]
CTD PMID:28720477, PMID:28867437 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Quinacrine results in increased cleavage of CASP9 protein CTD PMID:28867437 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Quinacrine results in decreased expression of CCND1 protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of CCND1 protein]
CTD PMID:28720477 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 increases expression
multiple interactions
ISO Quinacrine results in increased expression of CSNK1A1 protein
GSK3B protein affects the reaction [Quinacrine results in increased expression of CSNK1A1 protein]
CTD PMID:28720477 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO GSK3B protein affects the reaction [Quinacrine results in decreased expression of CTNNB1 protein] CTD PMID:28720477 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of Quinacrine CTD PMID:16581945 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
EXP Quinacrine binds to and results in decreased activity of CYP2E1 protein
Quinacrine results in decreased expression of CYP2E1 protein
CTD PMID:18754103 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of Quinacrine CTD PMID:16581945 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Foxp3 forkhead box P3 increases expression
multiple interactions
ISO Quinacrine results in increased expression of FOXP3 mRNA; Quinacrine results in increased expression of FOXP3 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 protein]; FOXP3 protein affects the reaction [Quinacrine results in decreased expression of BTRC protein]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of MIR183 mRNA]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of SP1 protein]
CTD PMID:28867437 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression
multiple interactions
ISO Quinacrine results in decreased expression of GLI1 protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein]
CTD PMID:28720477 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO Quinacrine results in increased expression of GSK3B mRNA
GSK3B protein affects the reaction [Quinacrine results in decreased expression of CCND1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of CTNNB1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of MYC protein]; GSK3B protein affects the reaction [Quinacrine results in increased activity of CASP3 protein]; GSK3B protein affects the reaction [Quinacrine results in increased expression of CSNK1A1 protein]; Quinacrine results in increased expression of and results in decreased phosphorylation of GSK3B protein
CTD PMID:28720477 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Quinacrine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO Quinacrine results in decreased phosphorylation of MAPK1 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]
CTD PMID:28867437 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Quinacrine results in decreased phosphorylation of MAPK3 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK3 protein]
CTD PMID:28867437 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir183 microRNA 183 multiple interactions
increases expression
ISO FOXP3 protein affects the reaction [Quinacrine results in increased expression of MIR183 mRNA]; MIR183 mRNA affects the reaction [Quinacrine results in decreased expression of BTRC protein]; MIR183 mRNA affects the reaction [Quinacrine results in increased expression of SP1 protein] CTD PMID:28867437 NCBI chr 4:57,463,569...57,463,678
Ensembl chr 4:57,463,569...57,463,678
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO Quinacrine results in decreased expression of MYC protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of MYC protein]
CTD PMID:28720477 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO Quinacrine binds to and results in decreased activity of NQO2 protein CTD PMID:15078100 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Otc ornithine carbamoyltransferase multiple interactions EXP Quinacrine inhibits the reaction [PRL protein results in increased activity of OTC protein]; Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Quinacrine results in increased cleavage of PARP1 protein CTD PMID:28867437 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prl prolactin multiple interactions EXP Quinacrine inhibits the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of SP1 protein]; MIR183 mRNA affects the reaction [Quinacrine results in increased expression of SP1 protein]; Quinacrine promotes the reaction [SP1 protein binds to BAX promoter]; Quinacrine results in increased expression of and results in increased stability of SP1 protein CTD PMID:28867437 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:21398612 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tp53 tumor protein p53 increases activity
multiple interactions
ISO Quinacrine results in increased activity of TP53 protein
Quinacrine results in increased stability of and results in increased activity of TP53 protein
CTD PMID:12082016, PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
triflupromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Triflupromazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
trimipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Trimipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        mancude ring 8105
          organic mancude parent 8105
            mancude organic heterocyclic parent 8105
              mancude organic heterotricyclic parent 347
                1H-imidazo[4,5-c]quinoline 0
                5H-dibenzo[b,f]azepine + 123
                acridine + 28
                benzo[de]isoquinoline + 0
                benzo[g]pteridine 0
                beta-carboline + 13
                carbazole + 1
                dibenzofuran + 39
                dibenzothiophene + 1
                imidazo[2,1-i]purine + 2
                oxanthrene 1
                perimidine + 0
                phenanthridine + 18
                phenanthroline + 157
                phenazine + 0
                phenothiazine + 26
                thianthrene + 0
                thioxanthene + 0
                tri-s-triazine 0
                xanthene + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterotricyclic compound 14571
                                      mancude organic heterotricyclic parent 347
                                        1H-imidazo[4,5-c]quinoline 0
                                        5H-dibenzo[b,f]azepine + 123
                                        acridine + 28
                                        benzo[de]isoquinoline + 0
                                        benzo[g]pteridine 0
                                        beta-carboline + 13
                                        carbazole + 1
                                        dibenzofuran + 39
                                        dibenzothiophene + 1
                                        imidazo[2,1-i]purine + 2
                                        oxanthrene 1
                                        perimidine + 0
                                        phenanthridine + 18
                                        phenanthroline + 157
                                        phenazine + 0
                                        phenothiazine + 26
                                        thianthrene + 0
                                        thioxanthene + 0
                                        tri-s-triazine 0
                                        xanthene + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.