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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5H-dibenzo[b,f]azepine
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Accession:CHEBI:47802 term browser browse the term
Definition:A mancude organic heterotricyclic parent that consists of a seven-membered nitrogen hetrocycle fused with two benzene rings.
Synonyms:related_synonym: 2,2'-iminostilbene;   2,3,6,7-dibenzazepine;   5H-Dibenz[b,f]azepin;   5H-dibenz[b,f]azepine;   5H-dibenzazepine;   Formula=C14H11N;   InChI=1S/C14H11N/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-10,15H;   InChIKey=LCGTWRLJTMHIQZ-UHFFFAOYSA-N;   SMILES=N1C2=C(C=CC=C2)C=CC2=C1C=CC=C2;   dibenz(b,f)azepine;   dibenzazepine;   iminostilbene;   o,o'-iminostilbene
 xref: Beilstein:1343358;   CAS:256-96-2;   Chemspider:8857;   PDBeChem:ONB;   PMID:11767950;   PMID:12052500;   PMID:12061877;   PMID:15837018;   PMID:16203183;   PMID:17236778;   PMID:18779941;   PMID:19486265;   PMID:19774656;   PMID:20922935;   PMID:21087114;   PMID:21441615;   PMID:22322005;   PMID:22751668;   PMID:2322636;   PMID:24358274;   PMID:27175105;   PMID:27389944;   PMID:27807790;   PMID:30660838;   PMID:30754023;   PMID:30823329;   PMID:31718245;   PMID:33381027;   PMID:33842007;   PMID:3680120;   PMID:4146691;   PMID:5982986;   PMID:7587936;   PMID:8385460;   PMID:870507;   Reaxys:1343358;   Wikipedia:Dibenzazepine



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clomipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Clomipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression EXP Clomipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Clomipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP Clomipramine affects the expression of ALDH1A4 mRNA CTD PMID:18355885 NCBI chr 1:218,201,443...218,241,410
Ensembl chr 1:218,201,472...218,248,906
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Clomipramine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Clomipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Clomipramine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Clomipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Clomipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP3 protein] CTD PMID:10487422 PMID:22700542 PMID:28482088 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO Clomipramine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Clomipramine results in increased activity of CASP9 protein CTD PMID:28482088 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression ISO Clomipramine results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Clomipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Clomipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Clomipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:114,422,681...114,441,034
Ensembl chr 8:114,422,921...114,441,033
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Clomipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Clomipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Clomipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Clomipramine affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression EXP Clomipramine affects the expression of CYP3A23-3A1 mRNA CTD PMID:18355885 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Clomipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Clomipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Clomipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Clomipramine results in increased expression of DRD2 protein CTD PMID:20619828 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Clomipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Clomipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Clomipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Clomipramine results in increased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fndc4 fibronectin type III domain containing 4 decreases expression
increases expression
ISO Clomipramine results in decreased expression of FNDC4 mRNA
Clomipramine results in increased expression of FNDC4 mRNA
CTD PMID:17175557 NCBI chr 6:25,077,155...25,080,812 JBrowse link
G Gckr glucokinase regulator affects expression EXP Clomipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clomipramine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
JBrowse link
G Gls2 glutaminase 2 affects expression EXP Clomipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Clomipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Clomipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Clomipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Clomipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Clomipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Clomipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hpn hepsin increases expression ISO Clomipramine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
increases expression
ISO
EXP
Clomipramine binds to HTR2C protein
Clomipramine results in increased expression of HTR2C protein
CTD PMID:18083778 PMID:20619828 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il33 interleukin 33 affects expression EXP Clomipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Clomipramine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Clomipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lox lysyl oxidase affects expression EXP Clomipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lss lanosterol synthase increases expression ISO Clomipramine results in increased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Clomipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
JBrowse link
G Manba mannosidase beta affects expression EXP Clomipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983
JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Clomipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Clomipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Clomipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clomipramine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Clomipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases phosphorylation ISO Clomipramine results in increased phosphorylation of NTRK2 protein CTD PMID:22396798 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Clomipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Oaf out at first homolog affects expression EXP Clomipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Clomipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pc pyruvate carboxylase affects expression EXP Clomipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Clomipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Clomipramine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Clomipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prl prolactin affects secretion
increases expression
multiple interactions
increases secretion
ISO Clomipramine affects the secretion of PRL protein
Clomipramine results in increased expression of PRL protein
SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein]
Clomipramine results in increased secretion of PRL protein
CTD PMID:3602989 PMID:7930386 PMID:17000009 PMID:19698552 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases expression ISO Clomipramine results in increased expression of PROC protein CTD PMID:17891354 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Clomipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Clomipramine affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Clomipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Clomipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Clomipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:136,124,502...136,255,669
Ensembl chr 1:136,124,499...136,255,584
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clomipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Clomipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Clomipramine binds to and results in decreased activity of SLC6A4 protein; SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein] CTD PMID:16272152 PMID:17000009 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Clomipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Clomipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Clomipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Clomipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Clomipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:112,891,007...112,925,727 JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Clomipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Clomipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Clomipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tagln transgelin decreases expression ISO Clomipramine results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tex261 testis expressed 261 affects expression EXP Clomipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Clomipramine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Clomipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Clomipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:18,918,614...18,920,807 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Clomipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Clomipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:20,521,018...20,545,060
Ensembl chr14:20,517,951...20,545,531
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 affects expression EXP Clomipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Clomipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
JBrowse link
imipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Imipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression EXP Imipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Imipramine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
decreases activity
ISO Imipramine inhibits the reaction [asoxime chloride inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]]; Imipramine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Imipramine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Imipramine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
Imipramine results in increased activity of ACHE protein
Imipramine results in decreased activity of ACHE protein
CTD PMID:25522658 PMID:29614332 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
decreases activity
EXP [Imipramine co-treated with Idazoxan] results in decreased activity of ADRB1 protein; [Imipramine co-treated with Yohimbine] results in decreased activity of ADRB1 protein
Imipramine results in decreased activity of ADRB1 protein
CTD PMID:2868116 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases expression ISO Imipramine results in decreased expression of ADRB2 protein CTD PMID:10618463 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Alb albumin affects binding ISO Imipramine binds to ALB protein CTD PMID:20956006 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Imipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP Imipramine affects the expression of ALDH1A4 mRNA CTD PMID:18355885 NCBI chr 1:218,201,443...218,241,410
Ensembl chr 1:218,201,472...218,248,906
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Imipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Arg1 arginase 1 multiple interactions ISO Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ARG1 protein]] CTD PMID:30620895 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Imipramine results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Imipramine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
affects expression
ISO
EXP
Imipramine results in increased expression of BDNF mRNA
Rolipram promotes the reaction [Imipramine results in increased expression of BDNF mRNA]
Imipramine affects the expression of BDNF protein
CTD PMID:8601816 PMID:15157811 PMID:17617388 PMID:17950272 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Imipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Imipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP3 protein] CTD PMID:10487422 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Imipramine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Imipramine inhibits the reaction [lead acetate results in increased activity of CASP8 protein] CTD PMID:22033380 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase affects activity ISO Imipramine affects the activity of CAT protein CTD PMID:19798453 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Imipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Imipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Imipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:114,422,681...114,441,034
Ensembl chr 8:114,422,921...114,441,033
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression EXP Imipramine results in decreased expression of CNR1 protein CTD PMID:28866072 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression EXP Imipramine results in increased expression of CNR2 protein CTD PMID:28866072 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Imipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
increases phosphorylation
multiple interactions
EXP
ISO
Imipramine results in increased expression of CREB1 mRNA
Imipramine results in increased phosphorylation of CREB1 protein
Rolipram promotes the reaction [Imipramine results in increased expression of CREB1 mRNA]
CTD PMID:8601816 PMID:22396798 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Imipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crh corticotropin releasing hormone affects activity EXP Imipramine affects the activity of CRH protein CTD PMID:2553044 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP1A2 protein affects the metabolism of Imipramine
CYP1A2 protein results in increased metabolism of Imipramine
CYP1A2 protein results in decreased methylation of and results in increased activity of Imipramine; Imipramine inhibits the reaction [resveratrol results in decreased activity of CYP1A2 protein]; Organophosphorus Compounds inhibits the reaction [CYP1A2 protein results in decreased methylation of and results in increased activity of Imipramine]
CTD PMID:11714871 PMID:15286053 PMID:15922009 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Imipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Imipramine affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing
multiple interactions
ISO CYP2C19 protein affects the metabolism of Imipramine
CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine; Organophosphorus Compounds inhibits the reaction [CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine]
CTD PMID:15286053 PMID:15922009 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Imipramine CTD PMID:15286053 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine; Organophosphorus Compounds inhibits the reaction [CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine] CTD PMID:15922009 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression EXP Imipramine affects the expression of CYP3A23-3A1 mRNA CTD PMID:18355885 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Imipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Imipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Imipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 increases expression ISO Imipramine results in increased expression of DNAJC5 mRNA; Imipramine results in increased expression of DNAJC5 protein CTD PMID:11257428 NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Imipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Imipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Imipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Imipramine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Imipramine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:25,077,155...25,080,812 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Imipramine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP Imipramine results in decreased expression of GAP43 mRNA CTD PMID:17950272 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gckr glucokinase regulator affects expression EXP Imipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Imipramine results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
JBrowse link
G Gls2 glutaminase 2 affects expression EXP Imipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Imipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Imipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Imipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Imipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hdac5 histone deacetylase 5 increases expression ISO Imipramine results in increased expression of HDAC5 mRNA CTD PMID:17988634 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Imipramine results in decreased activity of HMBS protein CTD PMID:10416826 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Imipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Imipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hpn hepsin increases expression ISO Imipramine results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases activity ISO Imipramine results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Imipramine results in increased expression of HSPA8 mRNA alternative form; Imipramine results in increased expression of HSPA8 protein alternative form CTD PMID:10425221 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A affects expression EXP Imipramine affects the expression of HTR1A mRNA CTD PMID:17617388 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP Imipramine results in decreased expression of HTR2A CTD PMID:2553044 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Imipramine affects the reaction [caryophyllene promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL10 protein]] CTD PMID:30620895 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]]; Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein] CTD PMID:30620895 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il33 interleukin 33 affects expression EXP Imipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Imipramine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO Imipramine binds to and results in decreased activity of KCNH1 protein CTD PMID:18497958 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
decreases localization
ISO
EXP
Imipramine binds to and results in decreased activity of KCNH2 protein; Imipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Imipramine results in decreased activity of KCNH2 protein
Imipramine results in decreased localization of KCNH2 protein
CTD PMID:15272206 PMID:19583963 PMID:21158687 PMID:21525004 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Imipramine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
JBrowse link
G Lox lysyl oxidase affects expression EXP Imipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lss lanosterol synthase increases expression ISO Imipramine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Imipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
JBrowse link
G Manba mannosidase beta affects expression EXP Imipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Imipramine binds to and results in increased activity of MAPK1 protein]; Imipramine binds to and results in increased activity of MAPK1 protein CTD PMID:20484120 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Imipramine binds to and results in increased activity of MAPK3 protein]; Imipramine binds to and results in increased activity of MAPK3 protein CTD PMID:20484120 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Imipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Imipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Imipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Imipramine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Imipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
increases phosphorylation
ISO Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]; Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form]; Imipramine results in increased phosphorylation of and results in increased activity of NTRK2 protein
Imipramine results in increased phosphorylation of NTRK2 protein
CTD PMID:21666748 PMID:22396798 PMID:31631060 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Imipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Oaf out at first homolog affects expression EXP Imipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Imipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pc pyruvate carboxylase affects expression EXP Imipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Imipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions ISO Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form] CTD PMID:22396798 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO Imipramine inhibits the reaction [Buspirone results in increased expression of POMC protein] CTD PMID:19762159 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Imipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions EXP Imipramine inhibits the reaction [Ethanol results in increased activity of PPP2CA protein] CTD PMID:20224005 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Imipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Imipramine affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Imipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Imipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Serpini1 serpin family I member 1 increases expression EXP Imipramine results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Imipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:136,124,502...136,255,669
Ensembl chr 1:136,124,499...136,255,584
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:24947867 PMID:25106415 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Imipramine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Imipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:10966924 PMID:21697722 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Imipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases activity
multiple interactions
ISO Imipramine results in decreased activity of SLC47A1 protein
Imipramine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:16928787 PMID:21599003 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases activity EXP Imipramine results in decreased activity of SLC6A4 protein CTD PMID:18561912 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Imipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Imipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Imipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Imipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Imipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:112,891,007...112,925,727 JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Imipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Imipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Imipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tagln transgelin decreases expression ISO Imipramine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tex261 testis expressed 261 affects expression EXP Imipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253
JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Imipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Imipramine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]; Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Imipramine promotes the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]
CTD PMID:15946935 PMID:30529211 PMID:30620895 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Imipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:18,918,614...18,920,807 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Imipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases glucuronidation
affects metabolic processing
ISO Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine]
UGT1A4 protein results in increased glucuronidation of Imipramine; UGT1A4 protein SNP results in increased glucuronidation of Imipramine
UGT1A4 protein affects the metabolism of Imipramine
CTD PMID:9264550 PMID:14570768 PMID:15286053 PMID:15708967 PMID:25448279 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Imipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:20,521,018...20,545,060
Ensembl chr14:20,517,951...20,545,531
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 affects expression EXP Imipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Imipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
JBrowse link
trimipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Trimipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        mancude ring 8564
          organic mancude parent 8564
            mancude organic heterocyclic parent 8564
              mancude organic heterotricyclic parent 360
                5H-dibenzo[b,f]azepine 132
                  5H-dibenzo[b,f]azepin-2-ol + 0
                  imipramine + 132
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterotricyclic compound 14639
                                      mancude organic heterotricyclic parent 360
                                        5H-dibenzo[b,f]azepine 132
                                          5H-dibenzo[b,f]azepin-2-ol + 0
                                          imipramine + 132
paths to the root