|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Auranofin promotes the reaction [arsenite results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:36343453 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alb |
albumin |
affects binding |
ISO |
Auranofin analog binds to ALB protein |
CTD |
PMID:16791640 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions increases response to substance |
ISO |
[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein] BAK1 results in increased susceptibility to Auranofin |
CTD |
PMID:18789312 PMID:21172426 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases response to substance |
ISO |
[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein] BAX results in increased susceptibility to Auranofin |
CTD |
PMID:18789312 PMID:21172426 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein] |
CTD |
PMID:18789312 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO EXP |
Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Auranofin results in decreased expression of and results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein] BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein] |
CTD |
PMID:15159275 PMID:15191400 PMID:18789312 PMID:20542334 PMID:21699084 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein |
CTD |
PMID:20542334 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Auranofin results in decreased expression of and results in increased cleavage of CASP9 protein |
CTD |
PMID:20542334 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Auranofin results in increased expression of CDKN1A protein |
CTD |
PMID:20542334 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cebpe |
CCAAT/enhancer binding protein epsilon |
multiple interactions |
ISO |
[Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein |
CTD |
PMID:15159275 |
|
NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814
|
|
G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein] |
CTD |
PMID:10820281 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
|
|
G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
Auranofin results in decreased activity of DIO1 protein |
CTD |
PMID:34662569 |
|
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
|
|
G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein] |
CTD |
PMID:36343453 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions increases expression |
ISO |
[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein] |
CTD |
PMID:21355852 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
Auranofin promotes the reaction [arsenite results in increased activity of GSR protein] |
CTD |
PMID:36343453 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Auranofin results in increased expression of HMOX1 mRNA Auranofin results in increased expression of HMOX1 mRNA; Auranofin results in increased expression of HMOX1 protein |
CTD |
PMID:22008538 PMID:23942037 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] |
CTD |
PMID:10594346 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:20542334 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Il6st |
interleukin 6 cytokine family signal transducer |
multiple interactions |
ISO |
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein |
CTD |
PMID:20542334 |
|
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
|
|
G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
ISO |
Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein] |
CTD |
PMID:17034761 |
|
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
|
|
G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
Auranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]; Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein] |
CTD |
PMID:17034761 |
|
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
[Auranofin co-treated with Tretinoin] results in increased expression of ITGAM protein |
CTD |
PMID:15159275 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein |
CTD |
PMID:20542334 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:36343453 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:36343453 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:36343453 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions decreases expression |
ISO |
[Auranofin co-treated with SN50 peptide] results in decreased expression of MCL1 protein Auranofin results in decreased expression of MCL1 protein |
CTD |
PMID:20542334 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
Auranofin promotes the reaction [arsenite results in increased expression of NFE2L2 protein] |
CTD |
PMID:36343453 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] |
CTD |
PMID:10820281 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
ISO |
Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein] |
CTD |
PMID:10820281 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
decreases activity increases cleavage |
ISO |
Auranofin results in decreased activity of PARP1 protein Auranofin results in increased cleavage of PARP1 protein |
CTD |
PMID:15159275 PMID:21370912 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Ppif |
peptidylprolyl isomerase F |
increases oxidation multiple interactions |
ISO EXP |
Auranofin results in increased oxidation of PPIF protein Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein] |
CTD |
PMID:26975474 |
|
NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
|
|
G |
Prdx3 |
peroxiredoxin 3 |
increases oxidation multiple interactions |
ISO EXP |
Auranofin results in increased oxidation of PRDX3 protein Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein] Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein] |
CTD |
PMID:18789312 PMID:21355852 PMID:26975474 |
|
NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[lipopolysaccharide A co-treated with Auranofin] results in decreased expression of PTGS2 protein Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] |
CTD |
PMID:10594346 PMID:17034761 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
Auranofin results in decreased phosphorylation of RB1 protein |
CTD |
PMID:20542334 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
|
|
G |
Rbms3 |
RNA binding motif, single stranded interacting protein 3 |
affects response to substance |
ISO |
RBMS3 protein affects the susceptibility to Auranofin |
CTD |
PMID:36414028 |
|
NCBI chr 8:116,305,227...117,625,730
Ensembl chr 8:116,309,882...117,625,423
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin promotes the reaction [arsenite results in increased phosphorylation of RELA protein] |
CTD |
PMID:10594346 PMID:36343453 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
RT1-Ba |
RT1 class II, locus Ba |
increases response to substance |
ISO |
HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin |
CTD |
PMID:11436868 |
|
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
|
|
G |
RT1-Db1 |
RT1 class II, locus Db1 |
increases response to substance |
ISO |
HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin |
CTD |
PMID:11436868 |
|
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
|
|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Auranofin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases expression multiple interactions |
ISO |
Auranofin results in decreased expression of STAT3 protein modified form [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:20542334 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Tbk1 |
TANK-binding kinase 1 |
multiple interactions |
ISO |
Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein] |
CTD |
PMID:17034761 |
|
NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
|
|
G |
Tgfa |
transforming growth factor alpha |
multiple interactions |
ISO |
Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein] |
CTD |
PMID:36343453 |
|
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
|
|
G |
Ticam1 |
TIR domain containing adaptor molecule 1 |
multiple interactions |
ISO |
Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein] |
CTD |
PMID:17034761 |
|
NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]] |
CTD |
PMID:17034761 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein] Auranofin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] |
CTD |
PMID:10820281 PMID:18789312 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Txn1 |
thioredoxin 1 |
increases oxidation multiple interactions |
ISO |
Auranofin results in increased oxidation of TXN protein Auranofin inhibits the reaction [arsenite results in increased expression of TXN protein] |
CTD |
PMID:26975474 PMID:36343453 |
|
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
|
|
G |
Txn2 |
thioredoxin 2 |
increases oxidation multiple interactions |
ISO EXP |
Auranofin results in increased oxidation of TXN2 protein Cyclosporine promotes the reaction [Auranofin results in increased oxidation of TXN2 protein] |
CTD |
PMID:26975474 |
|
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
|
|
G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions decreases activity increases oxidation increases expression |
ISO EXP |
Auranofin inhibits the reaction [arsenite results in increased expression of and results in increased activity of TXNRD1 protein]; Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein] Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] Auranofin results in decreased activity of TXNRD1 protein Auranofin results in increased expression of TXNRD1 mRNA |
CTD |
PMID:16510263 PMID:18405881 PMID:18789312 PMID:19486940 PMID:20457604 PMID:21172426 PMID:26975474 PMID:36343453 More...
|
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
|
|
G |
Txnrd2 |
thioredoxin reductase 2 |
multiple interactions decreases activity |
ISO EXP |
Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]; Auranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA] Auranofin results in decreased activity of TXNRD2 protein |
CTD |
PMID:15458826 PMID:19486940 PMID:21172426 PMID:21355852 |
|
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
|
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases expression |
ISO |
Clindamycin results in increased expression of and results in increased activity of CYP3A4 protein Clindamycin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:18505790 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Mmp13 |
matrix metallopeptidase 13 |
increases expression |
ISO |
Clindamycin results in increased expression of MMP13 mRNA |
CTD |
PMID:20338993 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
|
|
G |
RT1-A2 |
RT1 class Ia, locus A2 |
affects expression |
ISO |
Clindamycin affects the expression of HLA-E mRNA |
CTD |
PMID:25811541 |
|
NCBI chr20:4,870,939...4,910,183
|
|
G |
RT1-Db1 |
RT1 class II, locus Db1 |
affects expression |
ISO |
Clindamycin affects the expression of HLA-DRB1 mRNA |
CTD |
PMID:25811541 |
|
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
|
|
|
G |
Pon1 |
paraoxonase 1 |
decreases activity |
ISO |
clindamycin phosphate results in decreased activity of PON1 protein |
CTD |
PMID:16880604 |
|
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
|
|
|
G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions decreases expression |
ISO |
glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA] glucobrassicin analog results in decreased expression of GPX2 protein |
CTD |
PMID:20868228 |
|
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions decreases activity |
ISO |
glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein] glucobrassicin analog results in decreased activity of NQO1 protein |
CTD |
PMID:20868228 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1A1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1A2 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1B1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
glucoerucin results in increased expression of EPHX1 protein |
CTD |
PMID:21132492 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity |
EXP |
glucoerucin results in increased activity of NQO1 protein |
CTD |
PMID:20833222 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1A1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1A2 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1B1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of EPHX1 protein |
CTD |
PMID:21132492 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression |
EXP |
Glucoraphanin decreases expression of Gpx1 mRNA in the jejunum |
RGD |
PMID:23271678 |
RGD:152998882 |
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gpx2 |
glutathione peroxidase 2 |
increases expression increases expression multiple interactions |
ISO EXP |
glucoraphanin analog results in increased expression of GPX2 mRNA; glucoraphanin analog results in increased expression of GPX2 protein Glucoraphanin increases expression of Gpx2 mRNA in the jejunum Benzo(a)pyrene inhibits the reaction [glucoraphanin results in increased expression of GPX2 mRNA]; glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA] |
CTD RGD |
PMID:20868228 PMID:23271678 |
RGD:152998882 |
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization |
ISO |
glucoraphanin analog affects the localization of NFE2L2 protein |
CTD |
PMID:20868228 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases activity |
ISO EXP |
glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein] glucoraphanin analog results in increased activity of NQO1 protein |
CTD |
PMID:20833222 PMID:20868228 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Isopropyl Thiogalactoside results in increased expression of CDKN1A protein |
CTD |
PMID:15190207 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
|
G |
Mr1 |
major histocompatibility complex, class I-related |
affects expression |
ISO |
Lincomycin affects the expression of MR1 mRNA |
CTD |
PMID:25811541 |
|
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
|
|
G |
RT1-A2 |
RT1 class Ia, locus A2 |
affects expression |
ISO |
Lincomycin affects the expression of HLA-E mRNA |
CTD |
PMID:25811541 |
|
NCBI chr20:4,870,939...4,910,183
|
|
|
G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
increases mutagenesis |
ISO |
1-methoxy-3-indolylmethylglucosinolate metabolite results in increased mutagenesis of HPRT1 gene |
CTD |
PMID:20846518 |
|
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
|
|
G |
Sult1a1 |
sulfotransferase family 1A member 1 |
increases response to substance |
ISO |
SULT1A1 protein results in increased susceptibility to 1-methoxy-3-indolylmethylglucosinolate metabolite |
CTD |
PMID:20846518 |
|
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
|
|
|
G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases activity |
EXP |
sinigrin results in increased activity of AKR7A3 protein |
CTD |
PMID:9328168 |
|
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
|
|
G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases activity |
EXP |
sinigrin results in increased activity of GSTA5 protein |
CTD |
PMID:9328168 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
sinigrin inhibits the reaction [TNF protein affects the localization of RELA protein] |
CTD |
PMID:28483571 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
sinigrin inhibits the reaction [TNF protein affects the localization of RELA protein]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:28483571 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:28483571 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|