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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lincomycin
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Accession:CHEBI:6472 term browser browse the term
Definition:A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.
Synonyms:exact_synonym: methyl 6,8-dideoxy-6-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
 related_synonym: Cillimycin;   Formula=C18H34N2O6S;   InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11?,12-,13+,14-,15-,16-,18-/m1/s1;   InChIKey=OJMMVQQUTAEWLP-KIDUDLJLSA-N;   Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside;   SMILES=CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O;   lincomicina;   lincomycine;   lincomycinum
 xref: CAS:154-21-2;   DrugBank:DB01627;   Drug_Central:1582;   HMDB:HMDB0015564;   KEGG:C06812;   KEGG:C14002;   KEGG:D00223;   KEGG:D02346;   LINCS:LSM-5602
 xref_mesh: MESH:D008034
 xref: PMID:24324587;   Reaxys:707677;   Wikipedia:Lincomycin



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lincomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related affects expression ISO Lincomycin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Lincomycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
clindamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO Clindamycin results in increased expression of and results in increased activity of CYP3A4 protein
Clindamycin results in increased expression of CYP3A4 mRNA
CTD PMID:18505790 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Clindamycin results in increased expression of MMP13 mRNA CTD PMID:20338993 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Clindamycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Clindamycin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
clindamycin phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 decreases activity ISO clindamycin phosphate results in decreased activity of PON1 protein CTD PMID:16880604 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        antimicrobial agent 17818
          lincomycin 6
            clindamycin + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                monocarboxylic acid amide 15534
                                                  pyrrolidinecarboxamide 33
                                                    lincomycin 6
                                                      clindamycin + 5
paths to the root