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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628670
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppif
Name: peptidylprolyl isomerase F
Acc ID: CHEBI:2922
Term: auranofin
Definition: An S-glycosyl compound consisting of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose with the sufur atom coordinated to (triethylphosphoranylidene)gold. It is administered orally for the treatment of active progressive rheumatoid arthritis.
Chemical ID: MESH:D001310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppifincreases oxidationEXP 6480464CTDAuranofin results in increased oxidation of PPIF proteinPMID:26975474
Ppifmultiple interactionsEXP 6480464CTDAuranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]PMID:26975474
Ppifincreases oxidationISOPPIF (Homo sapiens)6480464CTDAuranofin results in increased oxidation of PPIF proteinPMID:26975474
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