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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727780
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx2
Name: glutathione peroxidase 2
Acc ID: CHEBI:79311
Term: glucoraphanin
Definition: A thia-glucosinolic acid that is glucoerucin in which the sulfur atom of the methyl thioether group has been oxidised to the corresponding sulfoxide.
Chemical ID: MESH:C119494
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx2increases expression EXP 152998882RGDGlucoraphanin increases expression of Gpx2 mRNA in the jejunum 
Gpx2increases expressionISOGPX2 (Homo sapiens)6480464CTDglucoraphanin analog results in increased expression of GPX2 mRNA; glucoraphanin analog results in increased expression of GPX2 proteinPMID:20868228
Gpx2multiple interactionsISOGPX2 (Homo sapiens)6480464CTDBenzo(a)pyrene inhibits the reaction [glucoraphanin results in increased expression of GPX2 mRNA]; glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA]PMID:20868228
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