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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:estriol
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Accession:CHEBI:27974 term browser browse the term
Definition:A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer).
Synonyms:exact_synonym: estra-1,3,5(10)-triene-3,16alpha,17beta-triol
 related_synonym: (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol;   1,3,5(10)-Estratriene-3,16-alpha,17beta-triol;   16alpha,17beta-estriol;   16alpha-hydroxyestradiol;   3,16alpha,17beta-trihydroxy-Delta(1,3,5)-estratriene;   Estriel;   Formula=C18H24O3;   InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1;   InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N;   SMILES=[H][C@]12CC[C@]3(C)[C@@H](O)[C@H](O)C[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21;   oestriol;   trihydroxyestrin
 alt_id: CHEBI:23969;   CHEBI:42467;   CHEBI:4869
 xref: Beilstein:2508172;   CAS:50-27-1;   DrugBank:DB04573;   Drug_Central:3187;   HMDB:HMDB0000153;   KEGG:C05141;   KEGG:D00185;   LINCS:LSM-2368;   LIPID_MAPS_instance:LMST02010003
 xref_mesh: MESH:D004964
 xref: MetaCyc:ESTRIOL;   PDBeChem:ESL;   PMID:11133265;   PMID:23777262;   PMID:9373313;   Reaxys:2508172;   VSDB:1907;   Wikipedia:Estriol


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estriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression
multiple interactions
increases export		 ISO Estriol results in increased expression of ABCB1 mRNA; Estriol results in increased expression of ABCB1 protein
Elacridar inhibits the reaction [ABCB1 protein results in increased export of Estriol]		 CTD PMID:15290871 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 mRNA]; fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 protein]
Estriol results in increased expression of ABCG2 mRNA; Estriol results in increased expression of ABCG2 protein		 CTD PMID:16849015 PMID:17823853 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acrbp proacrosin binding protein decreases expression EXP Estriol results in decreased expression of ACRBP mRNA CTD PMID:25575267 NCBI chr 6:125,026,890...125,040,228
Ensembl chr 6:125,026,652...125,040,230 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression ISO Estriol affects the expression of ACTC1 mRNA CTD PMID:23184660 NCBI chr 2:113,877,763...113,883,356
Ensembl chr 2:113,877,763...113,884,029 		JBrowse link
G Afp alpha fetoprotein increases expression
affects binding		 ISO
EXP		 Estriol results in increased expression of AFP protein
Estriol binds to AFP protein		 CTD PMID:2470397 PMID:18497072 PMID:23013281 PMID:25349334 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Estriol results in increased expression of AGER protein CTD PMID:15878629 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Estriol results in decreased expression of AGTR1 mRNA CTD PMID:15159206 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Akap17b A kinase anchor protein 17B decreases expression EXP Estriol results in decreased expression of AKAP17B mRNA CTD PMID:25575267 NCBI chr  X:35,871,832...35,909,021
Ensembl chr  X:35,871,967...35,909,048 		JBrowse link
G Akirin1 akirin 1 increases expression EXP Estriol results in increased expression of AKIRIN1 mRNA CTD PMID:25575267 NCBI chr 4:123,628,988...123,644,092
Ensembl chr 4:123,628,352...123,644,138 		JBrowse link
G Alb albumin decreases expression EXP Estriol results in decreased expression of ALB protein CTD PMID:2470397 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Amer1 APC membrane recruitment 1 decreases expression EXP Estriol results in decreased expression of AMER1 mRNA CTD PMID:25575267 NCBI chr  X:94,463,919...94,488,446
Ensembl chr  X:94,463,924...94,488,478 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 ISO Estriol binds to AR protein
Estriol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Estriol inhibits the reaction [Metribolone results in increased activity of AR protein]		 CTD PMID:14565775 PMID:18324785 PMID:28803809 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO Estriol results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450 		JBrowse link
G Aurkb aurora kinase B increases expression EXP Estriol results in increased expression of AURKB mRNA CTD PMID:25575267 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490 		JBrowse link
G B3gntl1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 decreases expression EXP Estriol results in decreased expression of B3GNTL1 mRNA CTD PMID:25575267 NCBI chr11:121,507,023...121,563,985
Ensembl chr11:121,507,023...121,563,979 		JBrowse link
G B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 increases expression ISO Estriol results in increased expression of B4GALT1 mRNA CTD PMID:14605097 NCBI chr 4:40,804,602...40,855,711
Ensembl chr 4:40,804,602...40,854,005 		JBrowse link
G Bmf BCL2 modifying factor decreases expression EXP Estriol results in decreased expression of BMF mRNA CTD PMID:25575267 NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168 		JBrowse link
G Btbd10 BTB domain containing 10 increases expression EXP Estriol results in increased expression of BTBD10 mRNA CTD PMID:25575267 NCBI chr 7:112,914,838...112,970,734
Ensembl chr 7:112,914,833...112,968,599 		JBrowse link
G C2cd2l C2 calcium-dependent domain containing 2-like increases expression EXP Estriol results in increased expression of C2CD2L mRNA CTD PMID:25575267 NCBI chr 9:44,220,534...44,231,579
Ensembl chr 9:44,220,534...44,231,582 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression EXP Estriol results in increased expression of CCN1 mRNA CTD PMID:25575267 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Ccnb1 cyclin B1 increases expression EXP Estriol results in increased expression of CCNB1 mRNA CTD PMID:25575267 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnb2 cyclin B2 increases expression EXP Estriol results in increased expression of CCNB2 mRNA CTD PMID:25575267 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Estriol inhibits the reaction [Estradiol results in increased cleavage of CCNE1 protein] CTD PMID:23624423 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cd274 CD274 antigen increases expression EXP Estriol results in increased expression of CD274 protein CTD PMID:21317386 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd276 CD276 antigen increases expression EXP Estriol results in increased expression of CD276 protein CTD PMID:21317386 NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720 		JBrowse link
G Cd80 CD80 antigen increases expression EXP Estriol results in increased expression of CD80 protein CTD PMID:21317386 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697 		JBrowse link
G Cd86 CD86 antigen increases expression EXP Estriol results in increased expression of CD86 protein CTD PMID:21317386 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cd99l2 CD99 antigen-like 2 decreases expression EXP Estriol results in decreased expression of CD99L2 mRNA CTD PMID:25575267 NCBI chr  X:70,463,666...70,536,467
Ensembl chr  X:70,463,666...70,536,455 		JBrowse link
G Cdc42se1 CDC42 small effector 1 increases expression EXP Estriol results in increased expression of CDC42SE1 mRNA CTD PMID:25575267 NCBI chr 3:95,135,735...95,143,735
Ensembl chr 3:95,136,043...95,143,720 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression EXP Estriol results in increased expression of CDKN1A mRNA CTD PMID:25575267 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Chst8 carbohydrate sulfotransferase 8 increases expression EXP Estriol results in increased expression of CHST8 mRNA CTD PMID:25575267 NCBI chr 7:34,373,893...34,512,136
Ensembl chr 7:34,373,893...34,512,136 		JBrowse link
G Ckb creatine kinase, brain increases expression ISO Estriol results in increased expression of CKB CTD PMID:10030690 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772 		JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 decreases expression EXP Estriol results in decreased expression of CNRIP1 mRNA CTD PMID:25575267 NCBI chr11:17,001,859...17,029,372
Ensembl chr11:17,001,586...17,029,371 		JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 increases expression EXP Estriol results in increased expression of CRISPLD2 mRNA CTD PMID:25575267 NCBI chr 8:120,719,177...120,779,533
Ensembl chr 8:120,719,177...120,779,532 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO Estriol inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]
Estriol results in decreased expression of CYP19A1 mRNA		 CTD PMID:21296134 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:12093619 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression EXP Estriol results in increased expression of CYP2B10 mRNA CTD PMID:7771797 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 multiple interactions ISO Estriol inhibits the reaction [imidacloprid results in increased expression of CYP3A7]; Estriol inhibits the reaction [thiacloprid results in increased expression of CYP3A7]; Estriol inhibits the reaction [Thiamethoxam results in increased expression of CYP3A7] CTD PMID:28750898 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Dennd2a DENN domain containing 2A increases expression EXP Estriol results in increased expression of DENND2A mRNA CTD PMID:25575267 NCBI chr 6:39,439,308...39,535,067
Ensembl chr 6:39,439,312...39,534,801 		JBrowse link
G Dtx4 deltex 4, E3 ubiquitin ligase decreases expression EXP Estriol results in decreased expression of DTX4 mRNA CTD PMID:25575267 NCBI chr19:12,443,700...12,479,509
Ensembl chr19:12,443,702...12,478,818 		JBrowse link
G Eeig1 estrogen-induced osteoclastogenesis regulator 1 increases expression ISO Estriol results in increased expression of EEIG1 mRNA CTD PMID:14605097 NCBI chr 2:32,425,344...32,459,763
Ensembl chr 2:32,425,344...32,459,768 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Estriol results in increased expression of EGR1 mRNA CTD PMID:1717835 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Egr3 early growth response 3 increases expression ISO Estriol results in increased expression of EGR3 mRNA CTD PMID:15159206 NCBI chr14:70,314,766...70,320,062
Ensembl chr14:70,314,652...70,320,063 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit 2 beta increases expression EXP Estriol results in increased expression of EIF2S2 mRNA CTD PMID:25575267 NCBI chr 2:154,713,330...154,734,826
Ensembl chr 2:154,713,330...154,734,855 		JBrowse link
G Eno2 enolase 2, gamma neuronal decreases expression ISO Estriol results in decreased expression of ENO2 mRNA CTD PMID:15159206 NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
increases expression
affects localization
affects binding
increases activity		 ISO
EXP		 Estriol binds to and results in increased activity of ESR1 protein; Estriol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estriol inhibits the reaction [Estradiol binds to ESR1 protein]; Estriol promotes the reaction [ESR1 protein binds to ESR1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased activity of ESR1 protein]
Estriol results in increased expression of ESR1 mRNA
Estriol affects the localization of ESR1 protein
Estriol binds to ESR1 protein		 CTD PMID:9048584 PMID:11162928 PMID:11518614 PMID:12127041 PMID:12598185 More... NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
affects binding		 ISO
EXP		 Estriol binds to and results in increased activity of ESR2 protein; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]
Estriol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]
Estriol binds to ESR2 protein
Estriol binds to Esr2 protein		 CTD
RGD		 PMID:8650195 PMID:9048584 PMID:9492041 PMID:9751507 PMID:11518614 More... RGD:8694130 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Etf1 eukaryotic translation termination factor 1 increases expression EXP Estriol results in increased expression of ETF1 mRNA CTD PMID:25575267 NCBI chr18:35,035,838...35,065,060
Ensembl chr18:35,035,838...35,065,060 		JBrowse link
G F10 coagulation factor X increases expression ISO Estriol results in increased expression of F10 protein CTD PMID:614942 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Estriol results in increased expression of FOS mRNA CTD PMID:2118345 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Foxa2 forkhead box A2 increases expression ISO Estriol results in increased expression of FOXA2 mRNA CTD PMID:23184660 NCBI chr 2:147,884,797...147,888,889
Ensembl chr 2:147,884,797...147,888,889 		JBrowse link
G Gh growth hormone increases expression ISO Estriol results in increased expression of GH1 mRNA CTD PMID:15240998 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691 		JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha decreases expression ISO Estriol results in decreased expression of HNF4A mRNA CTD PMID:23184660 NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830 		JBrowse link
G Hoxa10 homeobox A10 decreases expression EXP Estriol results in decreased expression of HOXA10 mRNA CTD PMID:16402032 NCBI chr 6:52,208,177...52,217,658
Ensembl chr 6:52,208,177...52,217,834 		JBrowse link
G Hoxa11 homeobox A11 decreases expression EXP Estriol results in decreased expression of HOXA11 mRNA CTD PMID:16402032 NCBI chr 6:52,219,086...52,222,784
Ensembl chr 6:52,219,086...52,222,790 		JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions		 EXP Estriol results in decreased expression of IFNG protein
Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]		 CTD PMID:11063824 PMID:21317386 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Estriol results in increased expression of IGF1 mRNA CTD PMID:15969240 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO Estriol results in decreased expression of IGFBP5 mRNA CTD PMID:15159206 NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043 		JBrowse link
G Il10 interleukin 10 increases expression EXP Estriol results in increased expression of IL10 mRNA CTD PMID:21317386 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12a interleukin 12a increases expression EXP Estriol results in increased expression of IL12A mRNA CTD PMID:21317386 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880 		JBrowse link
G Il12b interleukin 12b decreases expression EXP Estriol results in decreased expression of IL12B mRNA CTD PMID:21317386 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Estriol results in decreased expression of IL1A mRNA CTD PMID:10731640 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 decreases expression EXP Estriol results in decreased expression of IL23A mRNA CTD PMID:21317386 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Il4 interleukin 4 increases expression EXP Estriol results in increased expression of IL4 protein CTD PMID:21317386 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO
EXP		 Estriol results in decreased expression of IL6 mRNA
Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Estriol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tamoxifen inhibits the reaction [Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]		 CTD PMID:8979148 PMID:10731640 PMID:21317386 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Inhbb inhibin beta-B increases expression EXP Estriol results in increased expression of INHBB mRNA CTD PMID:25575267 NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978 		JBrowse link
G Ip6k2 inositol hexaphosphate kinase 2 decreases expression EXP Estriol results in decreased expression of IP6K2 mRNA CTD PMID:25575267 NCBI chr 9:108,660,928...108,683,532
Ensembl chr 9:108,660,995...108,683,536 		JBrowse link
G Jun jun proto-oncogene increases expression ISO Estriol results in increased expression of JUN mRNA CTD PMID:2118345 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression EXP Estriol results in decreased expression of LPAR4 mRNA CTD PMID:25575267 NCBI chr  X:105,964,231...105,977,505
Ensembl chr  X:105,964,231...105,977,506 		JBrowse link
G Lsm10 U7 snRNP-specific Sm-like protein LSM10 decreases expression EXP Estriol results in decreased expression of LSM10 mRNA CTD PMID:25575267 NCBI chr 4:125,990,350...125,992,375
Ensembl chr 4:125,990,416...125,992,377 		JBrowse link
G Mak16 MAK16 homolog increases expression EXP Estriol results in increased expression of RBM13 mRNA CTD PMID:25575267 NCBI chr 8:31,649,496...31,658,752
Ensembl chr 8:31,649,491...31,658,792 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 increases expression EXP Estriol results in increased expression of MAP2K1 mRNA CTD PMID:25575267 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation		 EXP
ISO		 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-propylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]
4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-propylphenol affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
affects phosphorylation		 EXP
ISO		 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-propylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]
4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-propylphenol affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO Estriol results in increased expression of MYC mRNA CTD PMID:2118345 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression
multiple interactions		 EXP Estriol results in increased expression of NAMPT mRNA
[Estradiol co-treated with Progesterone] promotes the reaction [Estriol results in increased expression of NAMPT mRNA]		 CTD PMID:20004694 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases expression		 EXP Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Estriol results in decreased expression of NOS2 mRNA		 CTD PMID:11063824 PMID:21317386 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO Estriol results in increased expression of NOS3 mRNA; Estriol results in increased expression of NOS3 protein CTD PMID:12547825 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nppc natriuretic peptide type C increases expression EXP Estriol results in increased expression of NPPC protein CTD PMID:9435603 NCBI chr 1:86,594,015...86,598,295
Ensembl chr 1:86,594,013...86,598,293 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Estriol binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nup50 nucleoporin 50 increases expression EXP Estriol results in increased expression of NUP50 mRNA CTD PMID:25575267 NCBI chr15:84,800,100...84,827,164
Ensembl chr15:84,807,612...84,827,164 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 increases expression EXP Estriol results in increased expression of PDCD1LG2 protein CTD PMID:21317386 NCBI chr19:29,388,319...29,450,327
Ensembl chr19:29,388,319...29,448,561 		JBrowse link
G Pde12 phosphodiesterase 12 increases expression EXP Estriol results in increased expression of PDE12 mRNA CTD PMID:25575267 NCBI chr14:26,381,113...26,390,823
Ensembl chr14:26,381,113...26,391,038 		JBrowse link
G Pdgfa platelet derived growth factor, alpha decreases expression ISO Estriol results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125 		JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Estriol results in increased expression of PDZK1 mRNA CTD PMID:14605097 PMID:15159206 NCBI chr 3:96,736,772...96,778,242
Ensembl chr 3:96,736,600...96,778,242 		JBrowse link
G Pgr progesterone receptor increases expression ISO Estriol results in increased expression of PGR mRNA CTD PMID:19820872 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 decreases expression EXP Estriol results in decreased expression of PIK3IP1 mRNA CTD PMID:25575267 NCBI chr11:3,280,731...3,292,971
Ensembl chr11:3,280,401...3,292,971 		JBrowse link
G Polg2 polymerase (DNA directed), gamma 2, accessory subunit decreases expression EXP Estriol results in decreased expression of POLG2 mRNA CTD PMID:25575267 NCBI chr11:106,659,030...106,670,363
Ensembl chr11:106,659,079...106,670,363 		JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B increases expression EXP Estriol results in increased expression of PPP1R15B mRNA CTD PMID:25575267 NCBI chr 1:133,058,904...133,067,538
Ensembl chr 1:133,058,881...133,067,521 		JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression EXP Estriol results in increased expression of PPP4R1 mRNA CTD PMID:25575267 NCBI chr17:66,089,253...66,148,921
Ensembl chr17:66,089,568...66,148,921 		JBrowse link
G Prl prolactin increases expression
multiple interactions
increases secretion		 ISO
EXP		 Estriol results in increased expression of PRL mRNA; Estriol results in increased expression of PRL protein
Estriol promotes the reaction [Estradiol results in increased expression of PRL mRNA]
4-ethylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-nonylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-octylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-propylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; bisphenol A affects the reaction [Estriol results in increased secretion of PRL protein]		 CTD PMID:3780563 PMID:3996322 PMID:7306549 PMID:20950447 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Prrx2 paired related homeobox 2 increases expression EXP Estriol results in increased expression of PRRX2 mRNA CTD PMID:25575267 NCBI chr 2:30,735,076...30,771,263
Ensembl chr 2:30,724,984...30,771,263 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Estriol inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:12547825 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rrp1b ribosomal RNA processing 1B increases expression EXP Estriol results in increased expression of RRP1B mRNA CTD PMID:25575267 NCBI chr17:32,255,087...32,281,839
Ensembl chr17:32,255,074...32,281,839 		JBrowse link
G Sdc3 syndecan 3 increases expression ISO Estriol results in increased expression of SDC3 mRNA CTD PMID:11024013 NCBI chr 4:130,519,855...130,553,629
Ensembl chr 4:130,519,848...130,553,630 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Estriol results in decreased expression of SELENBP1 mRNA CTD PMID:15159206 NCBI chr 3:94,840,394...94,852,069
Ensembl chr 3:94,840,367...94,852,069 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Estriol binds to SHBG protein CTD PMID:25349334 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731 		JBrowse link
G Sirt3 sirtuin 3 decreases expression EXP Estriol results in decreased expression of SIRT3 mRNA CTD PMID:25575267 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Slc12a2 solute carrier family 12, member 2 decreases expression ISO Estriol results in decreased expression of SLC12A2 mRNA CTD PMID:15159206 NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO Estriol results in increased expression of SLC7A11 mRNA CTD PMID:15159206 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 increases expression EXP Estriol results in increased expression of SLC7A6 mRNA CTD PMID:25575267 NCBI chr 8:106,894,718...106,925,346
Ensembl chr 8:106,895,489...106,925,338 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Estriol results in increased expression of SOCS3 mRNA CTD PMID:25575267 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression EXP Estriol results in increased expression of STAT5A mRNA CTD PMID:25575267 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 decreases activity ISO Estriol results in decreased activity of SULT1E1 protein CTD PMID:16914110 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
G Synpo synaptopodin increases expression EXP Estriol results in increased expression of SYNPO mRNA CTD PMID:25575267 NCBI chr18:60,727,053...60,793,241
Ensembl chr18:60,727,045...60,793,214 		JBrowse link
G Tbx19 T-box 19 decreases abundance ISO TBX19 gene mutant form results in decreased abundance of Estriol CTD PMID:16390921 NCBI chr 1:164,965,403...164,988,342
Ensembl chr 1:164,965,424...164,988,342 		JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions		 ISO Estriol results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Estriol results in increased expression of TFF1 mRNA]		 CTD PMID:22562034 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Estriol results in increased expression of TGFB1 mRNA CTD PMID:21317386 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thra thyroid hormone receptor alpha decreases expression EXP Estriol results in decreased expression of THRA mRNA CTD PMID:25575267 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Tmem183a transmembrane protein 183A increases expression EXP Estriol results in increased expression of TMEM183A mRNA CTD PMID:25575267 NCBI chr 1:134,273,834...134,289,765
Ensembl chr 1:134,273,835...134,289,717 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Estriol inhibits the reaction [TNF protein affects the localization of RELA protein]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]
Estriol affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Estriol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tamoxifen inhibits the reaction [Estriol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
estriol enhances the reaction [lipopolysaccharide increases expression of Tnf mRNA in liver and protein in serum]		 CTD
RGD		 PMID:8979148 PMID:11063824 PMID:12547825 PMID:9575848 RGD:15017096 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression EXP Estriol results in decreased expression of TXNIP mRNA CTD PMID:25575267 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199 		JBrowse link
G Tyr tyrosinase multiple interactions EXP Estriol inhibits the reaction [imidazole results in increased expression of TYR protein] CTD PMID:3127403 NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720 		JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) increases expression EXP Estriol results in increased expression of UBE2F mRNA CTD PMID:25575267 NCBI chr 1:91,177,412...91,214,243
Ensembl chr 1:91,178,026...91,218,059 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Estriol; UGT1A1 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of Estriol; UGT1A10 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Estriol; UGT1A3 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of Estriol; UGT2B7 protein results in increased glucuronidation of Estriol CTD PMID:8423545 PMID:8517101 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
G Utp6 UTP6 small subunit processome component increases expression EXP Estriol results in increased expression of UTP6 mRNA CTD PMID:25575267 NCBI chr11:79,824,782...79,853,213
Ensembl chr11:79,823,147...79,853,216 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:12547825 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor increases expression ISO Estriol results in increased expression of VDR mRNA CTD PMID:14992164 PMID:15775415 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Estriol results in increased expression of VEGFA mRNA alternative form CTD PMID:8344219 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 increases expression EXP Estriol results in increased expression of VTCN1 protein CTD PMID:21317386 NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase1 increases expression ISO Estriol results in increased expression of WARS1 mRNA CTD PMID:15159206 NCBI chr12:108,825,956...108,860,095
Ensembl chr12:108,825,956...108,860,100 		JBrowse link
G Zfp688 zinc finger protein 688 decreases expression EXP Estriol results in decreased expression of ZFP688 mRNA CTD PMID:25575267 NCBI chr 7:127,018,138...127,023,786
Ensembl chr 7:127,018,139...127,021,240 		JBrowse link
estriol 16-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:9794924 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
estriol 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl klotho multiple interactions
increases hydrolysis		 EXP estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estriol 3-glucuronide		 CTD PMID:14701853 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      biological role 22166
        molecular messenger 19390
          hormone 18922
            sex hormone 18735
              estrogen 18662
                estriol 126
                  3-(allyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol 0
                  6-ketoestriol 0
                  estriol 16-O-(beta-D-glucuronide) 1
                  estriol 3-O-(beta-D-glucuronide) 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      carbon group element atom 21909
                        carbon atom 21835
                          organic molecular entity 21835
                            organic molecule 21652
                              organic cyclic compound 21261
                                organic polycyclic compound 17919
                                  steroid 14873
                                    hydroxy steroid 14607
                                      16-hydroxy steroid 157
                                        16alpha-hydroxy steroid 153
                                          estriol 126
                                            3-(allyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol 0
                                            6-ketoestriol 0
                                            estriol 16-O-(beta-D-glucuronide) 1
                                            estriol 3-O-(beta-D-glucuronide) 1
paths to the root