Lpar4 (lysophosphatidic acid receptor 4) - Rat Genome Database

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Gene: Lpar4 (lysophosphatidic acid receptor 4) Mus musculus
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Symbol: Lpar4
Name: lysophosphatidic acid receptor 4
RGD ID: 1557960
MGI Page MGI
Description: Enables lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including branchial arch; future brain; limb; nose; and skeleton. Orthologous to human LPAR4 (lysophosphatidic acid receptor 4); INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730485F04Rik; G protein-coupled receptor 23; G-protein coupled receptor 23; Gpr; Gpr23; L; LPA receptor 4; LPA-4; LPA4; p2y; P2Y purinoceptor 9; p2y9; purinergic receptor 9
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,964,231 - 105,977,505 (+)NCBIGRCm39mm39
GRCm39 EnsemblX105,964,231 - 105,977,506 (+)Ensembl
GRCm38X106,920,625 - 106,933,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,920,625 - 106,933,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X104,115,964 - 104,129,238 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X103,123,375 - 103,135,151 (+)NCBImm8
CeleraX93,766,647 - 93,780,135 (+)NCBICelera
Cytogenetic MapXDNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12679517   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16782887   PMID:16829511  
PMID:17166850   PMID:18625716   PMID:18762810   PMID:18799693   PMID:18843048   PMID:18924241   PMID:20505096   PMID:20713964   PMID:21267068   PMID:21873635   PMID:22465231   PMID:24194600  
PMID:24602016   PMID:26090649   PMID:26714589   PMID:28854359   PMID:30026265   PMID:30796085   PMID:30804442   PMID:30847983   PMID:31335323   PMID:31633020  


Genomics

Comparative Map Data
Lpar4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,964,231 - 105,977,505 (+)NCBIGRCm39mm39
GRCm39 EnsemblX105,964,231 - 105,977,506 (+)Ensembl
GRCm38X106,920,625 - 106,933,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,920,625 - 106,933,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X104,115,964 - 104,129,238 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X103,123,375 - 103,135,151 (+)NCBImm8
CeleraX93,766,647 - 93,780,135 (+)NCBICelera
Cytogenetic MapXDNCBI
LPAR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX78,747,709 - 78,758,714 (+)EnsemblGRCh38hg38GRCh38
GRCh38X78,747,658 - 78,758,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X78,003,217 - 78,012,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,896,957 - 77,899,249 (+)NCBINCBI36hg18NCBI36
Build 34X77,816,445 - 77,818,733NCBI
CeleraX78,243,611 - 78,252,993 (+)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX71,584,019 - 71,593,185 (+)NCBIHuRef
CHM1_1X77,896,235 - 77,905,616 (+)NCBICHM1_1
Lpar4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X72,033,486 - 72,046,978 (+)NCBI
Rnor_6.0 EnsemblX78,042,859 - 78,056,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X78,042,859 - 78,056,347 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X78,237,912 - 78,251,631 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X95,180,476 - 95,194,380 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX73,333,463 - 73,346,943 (+)NCBICelera
Cytogenetic MapXq22NCBI
LPAR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X77,997,762 - 78,007,810 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0X67,887,929 - 67,899,287 (+)NCBIMhudiblu_PPA_v0panPan3
LPAR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,828,462 - 60,840,053 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,838,170 - 60,839,282 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,840,269 - 51,852,543 (+)NCBI
ROS_Cfam_1.0X62,081,200 - 62,093,456 (+)NCBI
UMICH_Zoey_3.1X59,772,817 - 59,785,084 (+)NCBI
UNSW_CanFamBas_1.0X61,377,993 - 61,390,257 (+)NCBI
UU_Cfam_GSD_1.0X60,976,943 - 60,989,213 (+)NCBI
Lpar4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X54,501,599 - 54,514,883 (+)NCBI
SpeTri2.0NW_004936547821,950 - 834,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPAR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX62,862,213 - 62,873,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X62,862,158 - 62,876,184 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X71,950,203 - 71,962,681 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232244
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X67,755,081 - 67,770,690 (+)NCBI
ChlSab1.1 EnsemblX67,764,914 - 67,766,026 (+)Ensembl
Vero_WHO_p1.0NW_0236679094,274 - 10,125 (-)NCBI

Position Markers
RH131472  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X106,931,876 - 106,932,046UniSTSGRCm38
MGSCv37X104,127,215 - 104,127,385UniSTSGRCm37
CeleraX93,778,112 - 93,778,282UniSTS
Cytogenetic MapXDUniSTS
UniSTS:238065  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X106,932,186 - 106,932,423UniSTSGRCm38
MGSCv37X104,127,525 - 104,127,762UniSTSGRCm37
CeleraX93,778,422 - 93,778,659UniSTS
Cytogenetic MapXDUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7360056151324042Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined48090244130864007Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X55000000150000000Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined72410246140302463Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX76263065110263152Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X81146308115146453Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined86019000120019114Mouse
13208552Wght12_mweight 12 (mouse)X95000000151000000Mouse
13208556Lgth14_mbody length 14 (mouse)X95000000151000000Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX103012242163975945Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1093
Count of miRNA genes:509
Interacting mature miRNAs:664
Transcripts:ENSMUST00000060576
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000060576   ⟹   ENSMUSP00000053986
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX106,920,625 - 106,933,900 (+)Ensembl
RefSeq Acc Id: NM_175271   ⟹   NP_780480
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X105,964,231 - 105,977,505 (+)NCBI
GRCm38X106,920,625 - 106,933,899 (+)ENTREZGENE
MGSCv37X104,115,964 - 104,129,238 (+)RGD
CeleraX93,766,647 - 93,780,135 (+)RGD
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_780480   ⟸   NM_175271
- UniProtKB: Q8BLG2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000053986   ⟸   ENSMUST00000060576
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6845918
Promoter ID:MM_KWN:61546
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000044364
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X104,115,729 - 104,116,229 (+)MPROMDB
RGD ID:13681208
Promoter ID:EPDNEW_M24753
Type:initiation region
Name:Lpar4_1
Description:Mus musculus lysophosphatidic acid receptor 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X106,920,675 - 106,920,735EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925384 AgrOrtholog
Ensembl Genes ENSMUSG00000049929 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000053986 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000060576 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78134 UniProtKB/Swiss-Prot
MGD MGI:1925384 ENTREZGENE
NCBI Gene 78134 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lpar4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt LPAR4_MOUSE UniProtKB/Swiss-Prot
  Q80UD5_MOUSE UniProtKB/TrEMBL
  Q8BLG2 ENTREZGENE
UniProt Secondary A2ADM5 UniProtKB/Swiss-Prot
  Q8BKK1 UniProtKB/Swiss-Prot
  Q8VE54 UniProtKB/Swiss-Prot