Chst8 (carbohydrate sulfotransferase 8) - Rat Genome Database

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Gene: Chst8 (carbohydrate sulfotransferase 8) Mus musculus
Analyze
Symbol: Chst8
Name: carbohydrate sulfotransferase 8
RGD ID: 1319068
MGI Page MGI
Description: Enables N-acetylgalactosamine 4-O-sulfotransferase activity. Acts upstream of or within proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including foregut; genitourinary system; heart; nervous system; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human CHST8 (carbohydrate sulfotransferase 8); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1500011J21Rik; AI426009; carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; GalNAc; galNAc-4-O-sulfotransferase 1; galNAc-4-ST1; GalNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39734,373,893 - 34,512,136 (-)NCBIGRCm39mm39
GRCm39 Ensembl734,373,893 - 34,512,136 (-)Ensembl
GRCm38734,674,468 - 34,812,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl734,674,468 - 34,812,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37735,459,487 - 35,597,730 (-)NCBIGRCm37mm9NCBIm37
MGSCv36734,383,519 - 34,521,436 (-)NCBImm8
Celera729,810,004 - 29,947,409 (-)NCBICelera
Cytogenetic Map7B2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:10988300   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:12944377   PMID:14610273   PMID:15489334   PMID:16079414   PMID:16141072   PMID:16141073  
PMID:17967808   PMID:18431515   PMID:18799693   PMID:19136628   PMID:21267068   PMID:21491433   PMID:21873635   PMID:21982770   PMID:22280990   PMID:24194600   PMID:25556833   PMID:27626380  
PMID:30228991  


Genomics

Comparative Map Data
Chst8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39734,373,893 - 34,512,136 (-)NCBIGRCm39mm39
GRCm39 Ensembl734,373,893 - 34,512,136 (-)Ensembl
GRCm38734,674,468 - 34,812,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl734,674,468 - 34,812,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37735,459,487 - 35,597,730 (-)NCBIGRCm37mm9NCBIm37
MGSCv36734,383,519 - 34,521,436 (-)NCBImm8
Celera729,810,004 - 29,947,409 (-)NCBICelera
Cytogenetic Map7B2NCBI
CHST8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1933,621,953 - 33,773,509 (+)EnsemblGRCh38hg38GRCh38
GRCh381933,621,953 - 33,773,509 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371934,112,859 - 34,264,414 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361938,867,274 - 38,956,254 (+)NCBINCBI36hg18NCBI36
Build 341938,867,273 - 38,956,253NCBI
Celera1930,806,474 - 30,958,041 (+)NCBI
Cytogenetic Map19q13.11NCBI
HuRef1930,612,378 - 30,763,394 (+)NCBIHuRef
CHM1_11934,114,228 - 34,265,711 (+)NCBICHM1_1
Chst8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2187,294,144 - 87,435,900 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl190,542,096 - 90,685,257 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0190,542,095 - 90,685,257 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0191,681,356 - 91,822,788 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4187,152,490 - 87,311,536 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1187,230,992 - 87,232,087 (-)NCBI
Celera181,658,173 - 81,797,008 (-)NCBICelera
Cytogenetic Map1q21NCBI
Chst8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554683,356,679 - 3,488,222 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554683,357,368 - 3,486,195 (+)NCBIChiLan1.0ChiLan1.0
CHST8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11939,338,488 - 39,445,592 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1939,354,974 - 39,445,592 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01930,549,667 - 30,705,452 (+)NCBIMhudiblu_PPA_v0panPan3
CHST8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11118,458,636 - 118,551,610 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1118,458,625 - 118,524,104 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1117,861,417 - 117,990,971 (-)NCBI
ROS_Cfam_1.01119,058,922 - 119,188,616 (-)NCBI
UMICH_Zoey_3.11118,619,785 - 118,749,190 (-)NCBI
UNSW_CanFamBas_1.01118,245,888 - 118,375,705 (-)NCBI
UU_Cfam_GSD_1.01119,304,573 - 119,434,387 (-)NCBI
Chst8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093499,403,690 - 9,520,771 (+)NCBI
SpeTri2.0NW_0049365702,125,111 - 2,242,172 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHST8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl643,371,531 - 43,493,246 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1643,371,436 - 43,493,250 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CHST8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1628,657,639 - 28,808,906 (+)NCBI
ChlSab1.1 Ensembl628,722,901 - 28,808,904 (+)Ensembl
Vero_WHO_p1.0NW_0236660736,389,650 - 6,556,430 (+)NCBI
Chst8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247949,403,216 - 9,526,633 (-)NCBI

Position Markers
AI426009  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38734,675,002 - 34,675,083UniSTSGRCm38
MGSCv37735,460,021 - 35,460,102UniSTSGRCm37
Celera729,810,538 - 29,810,619UniSTS
Cytogenetic Map7B3-B5UniSTS
D7Mit156  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38734,801,081 - 34,801,224UniSTSGRCm38
MGSCv37735,586,100 - 35,586,243UniSTSGRCm37
Celera729,935,800 - 29,935,925UniSTS
Cytogenetic Map7B3-B5UniSTS
cM Map716.0UniSTS
Whitehead Genetic713.1UniSTS
Whitehead/MRC_RH7444.07UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7269777136697919Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360000072900000Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined71028944244289559Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71060637344606511Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71278145246781452Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71278145246781452Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1333306047333196Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71343577947435779Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71360000047700000Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71690336849509583Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71899486940024609Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71958059053580679Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined72014282554142942Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72302446357024609Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72323914857239292Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72341710757417107Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72719819161202351Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72760637337142942Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72789112561891125Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3033306081485905Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73206509766065329Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73274478466744933Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3379830258499217Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3379830258499217Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3379830258499217Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3379830258499217Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73379830258499217Mouse
1357731Lvrq6_mliver weight QTL 6 (mouse)Not determined73379830258499217Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73379830258499217Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73379830258499217Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73379830258499217Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73440327768403475Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73450000051500000Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73466713968667295Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73479812168798270Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1142
Count of miRNA genes:558
Interacting mature miRNAs:696
Transcripts:ENSMUST00000078686, ENSMUST00000135295, ENSMUST00000154629
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000078686   ⟹   ENSMUSP00000077752
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl734,674,468 - 34,812,686 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135295
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl734,675,819 - 34,812,711 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154629   ⟹   ENSMUSP00000123498
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl734,674,759 - 34,812,686 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205259   ⟹   ENSMUSP00000145646
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl734,674,468 - 34,812,686 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205390
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl734,695,122 - 34,812,672 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl734,694,272 - 34,697,450 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238947   ⟹   ENSMUSP00000159050
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl734,674,468 - 34,753,812 (-)Ensembl
RefSeq Acc Id: NM_175140   ⟹   NP_780349
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39734,373,893 - 34,512,136 (-)NCBI
GRCm38734,674,468 - 34,812,711 (-)ENTREZGENE
MGSCv37735,459,487 - 35,597,730 (-)RGD
Celera729,810,004 - 29,947,409 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540337   ⟹   XP_006540400
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39734,374,184 - 34,453,314 (-)NCBI
GRCm38734,674,759 - 34,753,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540340   ⟹   XP_006540403
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39734,374,184 - 34,458,247 (-)NCBI
GRCm38734,674,759 - 34,758,828 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242955   ⟹   XP_030098815
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39734,374,184 - 34,512,117 (-)NCBI
GRCm38734,674,759 - 34,812,692 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_780349   ⟸   NM_175140
- UniProtKB: Q8BQ86 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540403   ⟸   XM_006540340
- Peptide Label: isoform X1
- UniProtKB: Q8BQ86 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540400   ⟸   XM_006540337
- Peptide Label: isoform X1
- UniProtKB: Q8BQ86 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030098815   ⟸   XM_030242955
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000145646   ⟸   ENSMUST00000205259
RefSeq Acc Id: ENSMUSP00000159050   ⟸   ENSMUST00000238947
RefSeq Acc Id: ENSMUSP00000123498   ⟸   ENSMUST00000154629
RefSeq Acc Id: ENSMUSP00000077752   ⟸   ENSMUST00000078686

Promoters
RGD ID:8663641
Promoter ID:EPDNEW_M9852
Type:initiation region
Name:Chst8_2
Description:Mus musculus carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9853  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38734,748,291 - 34,748,351EPDNEW
RGD ID:8663643
Promoter ID:EPDNEW_M9853
Type:single initiation site
Name:Chst8_1
Description:Mus musculus carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9852  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38734,812,686 - 34,812,746EPDNEW
RGD ID:6840835
Promoter ID:MM_KWN:50005
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Lung
Transcripts:NM_175140,   OTTMUST00000072159
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36735,597,489 - 35,597,989 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916197 AgrOrtholog
Ensembl Genes ENSMUSG00000060402 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000077752 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000123498 UniProtKB/TrEMBL
  ENSMUSP00000145646 UniProtKB/Swiss-Prot
  ENSMUSP00000159050 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000078686 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000154629 UniProtKB/TrEMBL
  ENSMUST00000205259 UniProtKB/Swiss-Prot
  ENSMUST00000238947 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Carb_sulfotrans_8-10 UniProtKB/Swiss-Prot
  Sulfotransferase UniProtKB/Swiss-Prot
KEGG Report mmu:68947 UniProtKB/Swiss-Prot
MGD MGI:1916197 ENTREZGENE
NCBI Gene 68947 ENTREZGENE
PANTHER PTHR12137 UniProtKB/Swiss-Prot
Pfam Sulfotransfer_2 UniProtKB/Swiss-Prot
PhenoGen Chst8 PhenoGen
UniProt CHST8_MOUSE UniProtKB/Swiss-Prot
  D6RCV4_MOUSE UniProtKB/TrEMBL
  Q8BQ86 ENTREZGENE
UniProt Secondary Q76EC6 UniProtKB/Swiss-Prot
  Q80XD4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-09 Chst8  carbohydrate sulfotransferase 8    carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8  Symbol and/or name change 5135510 APPROVED