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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:16alpha-hydroxy steroid
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Accession:CHEBI:16799 term browser browse the term
Definition:A 16-hydroxy steroid in which the hydroxy group at position 16 has alpha-configuration.
Synonyms:related_synonym: 16alpha-Hydroxysteroid;   16alpha-hydroxy steroids;   Formula=C19H31OR;   SMILES=C12C(C3C(C([C@@H](C3)O)*)(C)CC1)CCC4C2(CCCC4)C;   a 16alpha-hydroxysteroid
 alt_id: CHEBI:11333;   CHEBI:13584;   CHEBI:19165;   CHEBI:778
 xref: KEGG:C01090



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16alpha-hydroxytestosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [ABCC1 gene mutant form results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 16-hydroxytestosterone CTD PMID:22522787 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
estriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export
increases expression
multiple interactions
ISO ABCB1 protein results in increased export of Estriol
Estriol results in increased expression of ABCB1 mRNA; Estriol results in increased expression of ABCB1 protein
Elacridar inhibits the reaction [ABCB1 protein results in increased export of Estriol]
CTD PMID:15290871 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 mRNA]; fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 protein]
Estriol results in increased expression of ABCG2 mRNA; Estriol results in increased expression of ABCG2 protein
CTD PMID:16849015 PMID:17823853 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acrbp acrosin binding protein decreases expression ISO Estriol results in decreased expression of ACRBP mRNA CTD PMID:25575267 NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression ISO Estriol affects the expression of ACTC1 mRNA CTD PMID:23184660 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
JBrowse link
G Afp alpha-fetoprotein increases expression
affects binding
ISO
EXP
Estriol results in increased expression of AFP protein
Estriol binds to AFP protein
CTD PMID:2470397 PMID:18497072 PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Estriol results in increased expression of AGER protein CTD PMID:15878629 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Estriol results in decreased expression of AGTR1 mRNA CTD PMID:15159206 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Akap17a A-kinase anchoring protein 17A decreases expression ISO Estriol results in decreased expression of AKAP17B mRNA CTD PMID:25575267 NCBI chr12:16,310,427...16,315,166
Ensembl chr12:16,310,437...16,314,479
JBrowse link
G Akirin1 akirin 1 increases expression ISO Estriol results in increased expression of AKIRIN1 mRNA CTD PMID:25575267 NCBI chr 5:135,989,378...136,004,782
Ensembl chr 5:135,989,465...136,004,762
JBrowse link
G Alb albumin decreases expression ISO Estriol results in decreased expression of ALB protein CTD PMID:2470397 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Amer1 APC membrane recruitment protein 1 decreases expression ISO Estriol results in decreased expression of AMER1 mRNA CTD PMID:25575267 NCBI chr  X:60,300,595...60,316,480
Ensembl chr  X:60,295,751...60,316,440
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
Estriol binds to AR protein
Estriol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Estriol inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD PMID:14565775 PMID:18324785 PMID:28803809 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO Estriol results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Aurkb aurora kinase B increases expression ISO Estriol results in increased expression of AURKB mRNA CTD PMID:25575267 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G B3gntl1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 decreases expression ISO Estriol results in decreased expression of B3GNTL1 mRNA CTD PMID:25575267 NCBI chr10:106,870,237...106,933,723
Ensembl chr10:106,873,169...106,933,637
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression ISO Estriol results in increased expression of B4GALT1 mRNA CTD PMID:14605097 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G Bmf Bcl2 modifying factor decreases expression ISO Estriol results in decreased expression of BMF mRNA CTD PMID:25575267 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Btbd10 BTB domain containing 10 increases expression ISO Estriol results in increased expression of BTBD10 mRNA CTD PMID:25575267 NCBI chr 1:167,431,320...167,489,320
Ensembl chr 1:167,431,329...167,489,916
JBrowse link
G C2cd2l C2CD2-like increases expression ISO Estriol results in increased expression of C2CD2L mRNA CTD PMID:25575267 NCBI chr 8:44,648,074...44,658,856
Ensembl chr 8:44,648,079...44,658,340
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Estriol results in increased expression of CCN1 mRNA CTD PMID:25575267 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Estriol results in increased expression of CCNB1 mRNA CTD PMID:25575267 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Estriol results in increased expression of CCNB2 mRNA CTD PMID:25575267 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Estriol inhibits the reaction [Estradiol results in increased cleavage of CCNE1 protein] CTD PMID:23624423 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd274 CD274 molecule increases expression ISO Estriol results in increased expression of CD274 protein CTD PMID:21317386 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd276 Cd276 molecule increases expression ISO Estriol results in increased expression of CD276 protein CTD PMID:21317386 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Estriol results in increased expression of CD80 protein CTD PMID:21317386 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd86 CD86 molecule increases expression ISO Estriol results in increased expression of CD86 protein CTD PMID:21317386 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cd99l2 CD99 molecule-like 2 decreases expression ISO Estriol results in decreased expression of CD99L2 mRNA CTD PMID:25575267
G Cdc42se1 CDC42 small effector 1 increases expression ISO Estriol results in increased expression of CDC42SE1 mRNA CTD PMID:25575267 NCBI chr 2:182,805,691...182,813,520
Ensembl chr 2:182,804,925...182,814,028
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Estriol results in increased expression of CDKN1A mRNA CTD PMID:25575267 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chst8 carbohydrate sulfotransferase 8 increases expression ISO Estriol results in increased expression of CHST8 mRNA CTD PMID:25575267 NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900
JBrowse link
G Ckb creatine kinase B increases expression EXP Estriol results in increased expression of CKB CTD PMID:10030690 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 decreases expression ISO Estriol results in decreased expression of CNRIP1 mRNA CTD PMID:25575267 NCBI chr14:91,463,046...91,492,736
Ensembl chr14:91,462,647...91,492,735
JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 increases expression ISO Estriol results in increased expression of CRISPLD2 mRNA CTD PMID:25575267 NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO Estriol inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]
Estriol results in decreased expression of CYP19A1 mRNA
CTD PMID:21296134 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:12093619 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Estriol results in increased expression of CYP2B10 mRNA CTD PMID:7771797 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Dennd2a DENN domain containing 2A increases expression ISO Estriol results in increased expression of DENND2A mRNA CTD PMID:25575267 NCBI chr 4:68,233,016...68,332,235
Ensembl chr 4:68,233,958...68,332,105
JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 decreases expression ISO Estriol results in decreased expression of DTX4 mRNA CTD PMID:25575267 NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818
JBrowse link
G Egr1 early growth response 1 increases expression EXP Estriol results in increased expression of EGR1 mRNA CTD PMID:1717835 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr3 early growth response 3 increases expression ISO Estriol results in increased expression of EGR3 mRNA CTD PMID:15159206 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta increases expression ISO Estriol results in increased expression of EIF2S2 mRNA CTD PMID:25575267 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
JBrowse link
G Eno2 enolase 2 decreases expression ISO Estriol results in decreased expression of ENO2 mRNA CTD PMID:15159206 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
increases activity
affects localization
increases expression
ISO
EXP
Estriol binds to and results in increased activity of ESR1 protein; Estriol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estriol inhibits the reaction [Estradiol binds to ESR1 protein]; Estriol promotes the reaction [ESR1 protein binds to ESR1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased activity of ESR1 protein]
Estriol binds to ESR1 protein
Estriol affects the localization of ESR1 protein
Estriol results in increased expression of ESR1 mRNA
CTD PMID:9048584 PMID:11162928 PMID:11518614 PMID:12127041 PMID:12598185 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO
EXP
Estriol binds to and results in increased activity of ESR2 protein; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]
Estriol binds to Esr2 protein
Estriol binds to ESR2 protein
Estriol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]
CTD
RGD
PMID:8650195 PMID:9048584 PMID:9492041 PMID:9751507 PMID:11518614 More... RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Etf1 eukaryotic translation termination factor 1 increases expression ISO Estriol results in increased expression of ETF1 mRNA CTD PMID:25575267 NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810
JBrowse link
G F10 coagulation factor X increases expression ISO Estriol results in increased expression of F10 protein CTD PMID:614942 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G Fam102a family with sequence similarity 102, member A increases expression ISO Estriol results in increased expression of FAM102A mRNA CTD PMID:14605097 NCBI chr 3:15,823,147...15,854,651
Ensembl chr 3:15,823,144...15,854,643
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Estriol results in increased expression of FOS mRNA CTD PMID:2118345 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxa2 forkhead box A2 increases expression ISO Estriol results in increased expression of FOXA2 mRNA CTD PMID:23184660 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Gh1 growth hormone 1 increases expression EXP Estriol results in increased expression of GH1 mRNA CTD PMID:15240998 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO Estriol results in decreased expression of HNF4A mRNA CTD PMID:23184660 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hoxa10 homeobox A10 decreases expression ISO Estriol results in decreased expression of HOXA10 mRNA CTD PMID:16402032
G Hoxa11 homeobox A11 decreases expression ISO Estriol results in decreased expression of HOXA11 mRNA CTD PMID:16402032 NCBI chr 4:81,342,527...81,346,189
Ensembl chr 4:81,342,528...81,346,232
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO Estriol results in decreased expression of IFNG protein
Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]
CTD PMID:11063824 PMID:21317386 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Estriol results in increased expression of IGF1 mRNA CTD PMID:15969240 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO Estriol results in decreased expression of IGFBP5 mRNA CTD PMID:15159206 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Il10 interleukin 10 increases expression ISO Estriol results in increased expression of IL10 mRNA CTD PMID:21317386 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A increases expression ISO Estriol results in increased expression of IL12A mRNA CTD PMID:21317386 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B decreases expression ISO Estriol results in decreased expression of IL12B mRNA CTD PMID:21317386 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Estriol results in decreased expression of IL1A mRNA CTD PMID:10731640 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Estriol results in decreased expression of IL23A mRNA CTD PMID:21317386 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 increases expression ISO Estriol results in increased expression of IL4 protein CTD PMID:21317386 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO Estriol results in decreased expression of IL6 mRNA
Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Estriol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tamoxifen inhibits the reaction [Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
CTD PMID:8979148 PMID:10731640 PMID:21317386 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO Estriol results in increased expression of INHBB mRNA CTD PMID:25575267 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 decreases expression ISO Estriol results in decreased expression of IP6K2 mRNA CTD PMID:25575267 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Estriol results in increased expression of JUN mRNA CTD PMID:2118345 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO Estriol results in decreased expression of LPAR4 mRNA CTD PMID:25575267 NCBI chr  X:72,033,486...72,046,978
Ensembl chr  X:72,033,486...72,046,977
JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated decreases expression ISO Estriol results in decreased expression of LSM10 mRNA CTD PMID:25575267 NCBI chr 5:138,365,983...138,375,856
Ensembl chr 5:138,373,119...138,377,505
JBrowse link
G Mak16 MAK16 homolog increases expression ISO Estriol results in increased expression of RBM13 mRNA CTD PMID:25575267 NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO Estriol results in increased expression of MAP2K1 mRNA CTD PMID:25575267 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation
ISO
EXP
4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-propylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]
Estriol affects the phosphorylation of MAPK1 protein
4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-propylphenol affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]
CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
affects phosphorylation
ISO
EXP
4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-propylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]
Estriol affects the phosphorylation of MAPK3 protein
4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-propylphenol affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]
CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Estriol results in increased expression of MYC mRNA CTD PMID:2118345 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression
multiple interactions
ISO Estriol results in increased expression of NAMPT mRNA
[Estradiol co-treated with Progesterone] promotes the reaction [Estriol results in increased expression of NAMPT mRNA]
CTD PMID:20004694 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Estriol results in decreased expression of NOS2 mRNA
CTD PMID:11063824 PMID:21317386 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Estriol results in increased expression of NOS3 mRNA; Estriol results in increased expression of NOS3 protein CTD PMID:12547825 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppc natriuretic peptide C increases expression ISO Estriol results in increased expression of NPPC protein CTD PMID:9435603 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Estriol binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nup50 nucleoporin 50 increases expression ISO Estriol results in increased expression of NUP50 mRNA CTD PMID:25575267 NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 increases expression ISO Estriol results in increased expression of PDCD1LG2 protein CTD PMID:21317386 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938
JBrowse link
G Pde12 phosphodiesterase 12 increases expression ISO Estriol results in increased expression of PDE12 mRNA CTD PMID:25575267 NCBI chr16:1,915,386...1,925,427
Ensembl chr16:1,915,386...1,925,887
JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO Estriol results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Estriol results in increased expression of PDZK1 mRNA CTD PMID:14605097 PMID:15159206 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514
JBrowse link
G Pgr progesterone receptor increases expression ISO Estriol results in increased expression of PGR mRNA CTD PMID:19820872 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 decreases expression ISO Estriol results in decreased expression of PIK3IP1 mRNA CTD PMID:25575267 NCBI chr14:78,203,539...78,216,616
Ensembl chr14:78,204,053...78,216,608
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit decreases expression ISO Estriol results in decreased expression of POLG2 mRNA CTD PMID:25575267 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B increases expression ISO Estriol results in increased expression of PPP1R15B mRNA CTD PMID:25575267 NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737
JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Estriol results in increased expression of PPP4R1 mRNA CTD PMID:25575267 NCBI chr 9:105,391,271...105,450,626
Ensembl chr 9:105,391,412...105,450,633
JBrowse link
G Prl prolactin multiple interactions
increases expression
increases secretion
EXP
ISO
Estriol promotes the reaction [Estradiol results in increased expression of PRL mRNA]
Estriol results in increased expression of PRL mRNA; Estriol results in increased expression of PRL protein
Estriol results in increased secretion of PRL protein
4-ethylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-nonylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-octylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-propylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; bisphenol A affects the reaction [Estriol results in increased secretion of PRL protein]
CTD PMID:3780563 PMID:3996322 PMID:7306549 PMID:20950447 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prrx2 paired related homeobox 2 increases expression ISO Estriol results in increased expression of PRRX2 mRNA CTD PMID:25575267 NCBI chr 3:14,132,511...14,168,535
Ensembl chr 3:14,094,004...14,168,535
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Estriol inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:12547825 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rrp1b ribosomal RNA processing 1B increases expression ISO Estriol results in increased expression of RRP1B mRNA CTD PMID:25575267 NCBI chr20:10,123,111...10,148,704
Ensembl chr20:10,123,125...10,147,928
JBrowse link
G Sdc3 syndecan 3 increases expression EXP Estriol results in increased expression of SDC3 mRNA CTD PMID:11024013 NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Estriol results in decreased expression of SELENBP1 mRNA CTD PMID:15159206
G Shbg sex hormone binding globulin affects binding ISO Estriol binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Sirt3 sirtuin 3 decreases expression ISO Estriol results in decreased expression of SIRT3 mRNA CTD PMID:25575267 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases expression ISO Estriol results in decreased expression of SLC12A2 mRNA CTD PMID:15159206 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Estriol results in increased expression of SLC7A11 mRNA CTD PMID:15159206 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slc7a6 solute carrier family 7 member 6 increases expression ISO Estriol results in increased expression of SLC7A6 mRNA CTD PMID:25575267 NCBI chr19:34,073,472...34,100,268
Ensembl chr19:34,074,286...34,100,268
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Estriol results in increased expression of SOCS3 mRNA CTD PMID:25575267 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression ISO Estriol results in increased expression of STAT5A mRNA CTD PMID:25575267 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Estriol results in decreased activity of SULT1E1 protein CTD PMID:16914110 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Synpo synaptopodin increases expression ISO Estriol results in increased expression of SYNPO mRNA CTD PMID:25575267 NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126
JBrowse link
G Tbx19 T-box transcription factor 19 decreases abundance ISO TBX19 gene mutant form results in decreased abundance of Estriol CTD PMID:16390921 NCBI chr13:77,450,848...77,484,475
Ensembl chr13:77,450,849...77,504,163
JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions
ISO Estriol results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Estriol results in increased expression of TFF1 mRNA]
CTD PMID:22562034 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Estriol results in increased expression of TGFB1 mRNA CTD PMID:21317386 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thra thyroid hormone receptor alpha decreases expression ISO Estriol results in decreased expression of THRA mRNA CTD PMID:25575267 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tmem183a transmembrane protein 183A increases expression ISO Estriol results in increased expression of TMEM183A mRNA CTD PMID:25575267 NCBI chr13:45,803,641...45,820,409
Ensembl chr13:45,803,639...45,820,375
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Estriol inhibits the reaction [TNF protein affects the localization of RELA protein]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]
estriol enhances the reaction [lipopolysaccharide increases expression of Tnf mRNA in liver and protein in serum]
Estriol affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Estriol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tamoxifen inhibits the reaction [Estriol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
CTD
RGD
PMID:8979148 PMID:11063824 PMID:12547825 PMID:9575848 RGD:15017096 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO Estriol results in decreased expression of TXNIP mRNA CTD PMID:25575267 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Tyr tyrosinase multiple interactions ISO Estriol inhibits the reaction [imidazole results in increased expression of TYR protein] CTD PMID:3127403 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) increases expression ISO Estriol results in increased expression of UBE2F mRNA CTD PMID:25575267 NCBI chr 9:91,845,954...91,881,145
Ensembl chr 9:91,845,987...91,880,594
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Estriol; UGT1A1 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Estriol; UGT1A3 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Estriol CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO
EXP
UGT1A8 protein results in increased glucuronidation of Estriol; UGT1A8 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 PMID:15502008 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of Estriol; UGT2B7 protein results in increased glucuronidation of Estriol CTD PMID:8423545 PMID:8517101 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Utp6 UTP6 small subunit processome component increases expression ISO Estriol results in increased expression of UTP6 mRNA CTD PMID:25575267 NCBI chr10:64,897,321...64,928,105
Ensembl chr10:64,897,328...64,927,997
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:12547825 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vdr vitamin D receptor increases expression ISO Estriol results in increased expression of VDR mRNA CTD PMID:14992164 PMID:15775415 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Estriol results in increased expression of VEGFA mRNA alternative form CTD PMID:8344219 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 increases expression ISO Estriol results in increased expression of VTCN1 protein CTD PMID:21317386 NCBI chr 2:188,253,594...188,321,658
Ensembl chr 2:188,253,594...188,321,658
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO Estriol results in increased expression of WARS1 mRNA CTD PMID:15159206 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
JBrowse link
G Zfp688 zinc finger protein 688 decreases expression ISO Estriol results in decreased expression of ZFP688 mRNA CTD PMID:25575267 Ensembl chr 1:182,039,931...182,043,103 JBrowse link
estriol 16-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:9794924 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
estriol 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions
increases hydrolysis
ISO estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estriol 3-glucuronide
CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
triamcinolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Triamcinolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:15365089 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Triamcinolone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Triamcinolone results in decreased phosphorylation of AKT1 protein CTD PMID:15187100 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ar androgen receptor multiple interactions ISO Triamcinolone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Casp9 caspase 9 increases activity ISO Triamcinolone results in increased activity of CASP9 protein CTD PMID:11734450 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Triamcinolone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Triamcinolone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO Triamcinolone results in increased expression of and results in increased activity of HPGD protein CTD PMID:15680906 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Triamcinolone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [Triamcinolone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Mb myoglobin increases secretion EXP Triamcinolone results in increased secretion of MB protein CTD PMID:19628585 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity
ISO NR3C1 protein alternative form inhibits the reaction [Triamcinolone results in increased activity of NR3C1 protein alternative form]; Triamcinolone binds to and results in increased activity of NR3C1 protein CTD PMID:11956172 PMID:15362971 PMID:15755863 PMID:21543282 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases activity
increases activity
ISO Triamcinolone results in decreased activity of NR3C2 protein
Triamcinolone results in increased activity of NR3C2 protein
CTD PMID:15362971 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Triamcinolone binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pomc proopiomelanocortin decreases response to substance ISO Triamcinolone results in decreased susceptibility to POMC protein modified form CTD PMID:7788158 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Triamcinolone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
triamcinolone acetonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of Triamcinolone Acetonide CTD PMID:16105236 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein] CTD PMID:23751068 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP Triamcinolone Acetonide results in increased expression of BAD protein CTD PMID:15987869 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Triamcinolone Acetonide results in increased expression of BAX protein CTD PMID:15987869 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Triamcinolone Acetonide results in increased expression of BID protein CTD PMID:15987869 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp8 caspase 8 increases activity EXP Triamcinolone Acetonide results in increased activity of CASP8 protein CTD PMID:15987869 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein] CTD PMID:10903220 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Triamcinolone Acetonide promotes the reaction [Paraquat results in increased expression of CCN2 mRNA] CTD PMID:15728566 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases secretion
ISO Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Triamcinolone Acetonide results in decreased secretion of CSF2 protein
CTD PMID:10460758 PMID:10868704 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Triamcinolone Acetonide results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions
ISO Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA
Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA]
CTD PMID:24555085 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Fadd Fas associated via death domain increases expression EXP Triamcinolone Acetonide results in increased expression of FADD protein CTD PMID:15987869 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased abundance of Thromboxane B2]; Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Triamcinolone Acetonide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:10460758 PMID:15337628 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of IL4 mRNA] CTD PMID:23751068 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of IL5 mRNA] CTD PMID:23751068 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA] CTD PMID:27916735 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA] CTD PMID:23751068 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Triamcinolone Acetonide results in decreased expression of MKI67 protein CTD PMID:16029572 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA] CTD PMID:27916735 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
decreases expression
ISO
EXP
[Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide binds to and affects the localization of NR3C1 protein
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]; Triamcinolone Acetonide binds to and affects the activity of NR3C1 protein
Triamcinolone Acetonide results in decreased expression of NR3C1 protein
Triamcinolone Acetonide analog binds to NR3C1 protein; Triamcinolone Acetonide binds to NR3C1 protein
CTD PMID:926113 PMID:15250541 PMID:15705660 PMID:15976447 PMID:16029572 More... NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases activity ISO Triamcinolone Acetonide results in decreased activity of PLA2G4A protein CTD PMID:15337628 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of PTGS2 protein] CTD PMID:23751068 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions EXP
ISO
Triamcinolone Acetonide results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1A protein modified form
Triamcinolone Acetonide results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form
CTD PMID:25447644 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Triamcinolone Acetonide results in increased expression of SULT1A1 mRNA; Triamcinolone Acetonide results in increased expression of SULT1A1 protein CTD PMID:10799342 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:15728566 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]
CTD PMID:10100995 PMID:10903220 PMID:15337628 PMID:27916735 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA]
Triamcinolone Acetonide results in decreased expression of VEGFA protein
CTD PMID:15728566 PMID:16029572 PMID:16249516 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        polyatomic entity 19721
          heteroatomic molecular entity 19662
            hydroxides 19158
              organic hydroxy compound 18656
                hydroxy steroid 12976
                  16-hydroxy steroid 163
                    16alpha-hydroxy steroid 159
                      16alpha,17alpha-dihydroxypregnenolone 0
                      16alpha-hydroxyandrost-4-ene-3,17-dione 0
                      16alpha-hydroxydehydroepiandrosterone 0
                      16alpha-hydroxydehydroepiandrosterone 3-sulfate 0
                      16alpha-hydroxyestrone + 0
                      16alpha-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                      16alpha-hydroxypregnenolone 0
                      16alpha-hydroxyprogesterone 0
                      16alpha-hydroxytestosterone 1
                      17-epiestriol + 0
                      3-(allyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol 0
                      6-ketoestriol 0
                      6beta,16alpha,17alpha-trihydroxyprogesterone 0
                      algestone + 0
                      avicholic acid 0
                      estetrol 0
                      estriol + 126
                      estriol 3-O-(beta-D-glucuronide) 1
                      homoavicholic acid 0
                      triamcinolone + 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic polycyclic compound 16570
                                  steroid 13347
                                    hydroxy steroid 12976
                                      16-hydroxy steroid 163
                                        16alpha-hydroxy steroid 159
                                          16alpha,17alpha-dihydroxypregnenolone 0
                                          16alpha-hydroxyandrost-4-ene-3,17-dione 0
                                          16alpha-hydroxydehydroepiandrosterone 0
                                          16alpha-hydroxydehydroepiandrosterone 3-sulfate 0
                                          16alpha-hydroxyestrone + 0
                                          16alpha-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                          16alpha-hydroxypregnenolone 0
                                          16alpha-hydroxyprogesterone 0
                                          16alpha-hydroxytestosterone 1
                                          17-epiestriol + 0
                                          3-(allyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol 0
                                          6-ketoestriol 0
                                          6beta,16alpha,17alpha-trihydroxyprogesterone 0
                                          algestone + 0
                                          avicholic acid 0
                                          estetrol 0
                                          estriol + 126
                                          estriol 3-O-(beta-D-glucuronide) 1
                                          homoavicholic acid 0
                                          triamcinolone + 42
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