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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:estriol 3-O-(beta-D-glucuronide)
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Accession:CHEBI:45869 term browser browse the term
Definition:A steroid glucosiduronic acid that is the 3-beta-D-glucuronide of estriol; a steroid hormone ligand recognised by the monoclonal antibody 4155.
Synonyms:exact_synonym: (16alpha,17beta)-16,17-dihydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid
 related_synonym: 16alpha,17beta-estriol 3-(beta-D-glucuronide);   E13G;   Estriol-3-glucuronide;   Formula=C24H32O9;   InChI=1S/C24H32O9/c1-24-7-6-13-12-5-3-11(32-23-19(28)17(26)18(27)20(33-23)22(30)31)8-10(12)2-4-14(13)15(24)9-16(25)21(24)29/h3,5,8,13-21,23,25-29H,2,4,6-7,9H2,1H3,(H,30,31)/t13-,14-,15+,16-,17+,18+,19-,20+,21+,23-,24+/m1/s1;   InChIKey=UZKIAJMSMKLBQE-JRSYHJKYSA-N;   SMILES=[H][C@]12CC[C@]3(C)[C@@H](O)[C@H](O)C[C@@]3([H])[C@]1([H])CCc1cc(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)ccc21;   estra-1,3,5(10)-triene-3,16alpha,17beta-triol 3-D-glucuronide
 xref: Beilstein:5664384;   CAS:2479-91-6;   HMDB:HMDB0010335;   KEGG:C11288;   LIPID_MAPS_instance:LMST05010017
 xref_mesh: MESH:C022810
 xref: PDB:1BFV;   PDBeChem:STG;   PMID:15537867;   PMID:9261086;   Reaxys:5664384
 cyclic_relationship: is_conjugate_acid_of CHEBI:136649


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estriol 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions
increases hydrolysis		 ISO estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estriol 3-glucuronide		 CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      biological role 19894
        epitope 7032
          estriol 3-O-(beta-D-glucuronide) 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            heteroorganic entity 19547
                              organochalcogen compound 19296
                                organooxygen compound 19206
                                  carbohydrates and carbohydrate derivatives 14960
                                    carbohydrate 14960
                                      carbohydrate derivative 14229
                                        glycosyl compound 12963
                                          glycoside 11774
                                            glycosiduronic acid 180
                                              glucosiduronic acid 180
                                                steroid glucosiduronic acid 25
                                                  estriol 3-O-(beta-D-glucuronide) 1
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