nitrogen dioxide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nitrogen dioxide	go back to main search page
Accession:	CHEBI:33101	browse the term
Definition:	A nitrogen oxide that has formula NO2.
Synonyms:	exact_synonym:	dioxidonitrogen(.); nitrogen(IV) oxide; nitrosooxidanyl
	related_synonym:	Formula=NO2; InChI=1S/NO2/c2-1-3; InChIKey=JCXJVPUVTGWSNB-UHFFFAOYSA-N; NO2; ONO(.); SMILES=O=[N]=O; Stickstoffdioxid; nitryl
	alt_id:	CHEBI:29332; CHEBI:29784; CHEBI:39851
	xref:	CAS:10102-44-0; Gmelin:976
	xref_mesh:	MESH:D009585
	xref:	MolBase:939; PDBeChem:2NO

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Genes (141)

nitrogen dioxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adipogenesis associated Mth938 domain containing

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of AAMDC 5' UTR

NCBI chr11:77,821,144...77,906,024
Ensembl chr11:77,821,109...77,918,432

G

ATP binding cassette subfamily C member 2

multiple interactions

ABCC2 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Nitrogen Dioxide]

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

adhesion G protein-coupled receptor A1

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of ADGRA1 gene

NCBI chr10:133,087,924...133,131,675
Ensembl chr10:133,087,924...133,131,675

G

adenosine A2b receptor

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of ADORA2B gene

NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746

G

albumin

increases expression

Nitrogen Dioxide results in increased expression of ALB mRNA

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

ankyrin repeat domain 45

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of ANKRD45 gene

NCBI chr 1:173,608,336...173,715,185
Ensembl chr 1:173,608,336...173,669,851

G

aldehyde oxidase 1

increases expression

Nitrogen Dioxide results in increased expression of AOX1 mRNA

NCBI chr 2:200,586,014...200,682,241
Ensembl chr 2:200,586,014...200,677,064

G

aquaporin 1 (Colton blood group)

decreases expression

Nitrogen Dioxide results in decreased expression of AQP1 mRNA

NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517

G

ATP1A1 antisense RNA 1

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of ATP1A1-AS1 gene

NCBI chr 1:116,392,865...116,418,622
Ensembl chr 1:116,378,437...116,421,301

G

aurora kinase C

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of AURKC gene

NCBI chr19:57,231,023...57,235,548
Ensembl chr19:57,231,009...57,235,548

G

beta-1,3-galactosyltransferase 4

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of B3GALT4 gene

NCBI chr 6:33,277,123...33,278,825
Ensembl chr 6:33,277,123...33,284,832

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Nitrogen Dioxide results in increased expression of BAX mRNA; Nitrogen Dioxide results in increased expression of BAX protein
[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of BAX protein

PMID:22621880 PMID:27521637

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 binding component 3

increases expression

Nitrogen Dioxide results in increased expression of BBC3 mRNA

NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766

G

BCL2 interacting protein 3

increases expression

Nitrogen Dioxide results in increased expression of BNIP3 mRNA

NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CACNA2D1 gene

NCBI chr 7:81,946,444...82,443,956
Ensembl chr 7:81,946,444...82,443,956

G

catalase

increases expression
multiple interactions

Nitrogen Dioxide results in increased expression of CAT mRNA
CAT protein inhibits the reaction [Nitrogen Dioxide results in decreased expression of CCND1 mRNA]
[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of CAT mRNA; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CAT gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased expression of CAT mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CAT gene

PMID:12600834 PMID:15336314 PMID:27448387

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cystathionine beta-synthase

decreases activity

Nitrogen Dioxide results in decreased activity of CBS protein

NCBI chr21:43,053,191...43,076,873
Ensembl chr21:43,053,191...43,076,943

G

C-C motif chemokine ligand 11

increases expression

Nitrogen Dioxide results in increased expression of CCL11 mRNA

NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334

G

C-C motif chemokine ligand 2

increases expression
decreases expression

Nitrogen Dioxide results in increased expression of CCL2 mRNA; Nitrogen Dioxide results in increased expression of CCL2 protein
Nitrogen Dioxide results in decreased expression of CCL2 mRNA

PMID:10715624 PMID:11498801 PMID:27206323

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 3

increases expression

Nitrogen Dioxide results in increased expression of CCL3 mRNA

NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169

G

C-C motif chemokine ligand 5

increases expression

Nitrogen Dioxide results in increased expression of CCL5 mRNA

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

cyclin D1

multiple interactions
decreases expression

CAT protein inhibits the reaction [Nitrogen Dioxide results in decreased expression of CCND1 mRNA]
Nitrogen Dioxide results in decreased expression of CCND1 mRNA; Nitrogen Dioxide results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

CD72 molecule

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CD72 3' UTR

NCBI chr 9:35,609,982...35,646,857
Ensembl chr 9:35,609,982...35,646,810

G

cyclin dependent kinase inhibitor 2A

multiple interactions

[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CDKN2A gene

NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301

G

C-reactive protein

increases expression

Nitrogen Dioxide results in increased expression of CRP protein

PMID:18629312 PMID:22306530

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

cold shock domain containing E1

increases expression

Nitrogen Dioxide results in increased expression of CSDE1 mRNA

NCBI chr 1:114,716,916...114,757,984
Ensembl chr 1:114,716,913...114,758,676

G

colony stimulating factor 2

increases secretion

Nitrogen Dioxide results in increased secretion of CSF2 protein

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

C-X-C motif chemokine ligand 2

multiple interactions
increases expression

[Ozone co-treated with Nitrogen Dioxide] results in increased expression of CXCL2 mRNA
Nitrogen Dioxide results in increased expression of CXCL2 mRNA; Nitrogen Dioxide results in increased expression of CXCL2 protein

PMID:10715624 PMID:10986008 PMID:11498801

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

C-X-C motif chemokine ligand 8

increases expression
increases secretion

Nitrogen Dioxide results in increased expression of CXCL8 mRNA
Nitrogen Dioxide results in increased secretion of CXCL8 protein

PMID:8398164 PMID:8584542 PMID:22331494 PMID:27206323

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

diacylglycerol kinase kappa

increases expression

Nitrogen Dioxide results in increased expression of DGKK mRNA

NCBI chr X:50,365,409...50,470,825
Ensembl chr X:50,365,409...50,470,825

G

dynamin 1 like

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of DNM1L protein

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

G

dopamine receptor D2

increases expression

Nitrogen Dioxide results in increased expression of DRD2 mRNA

NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691

G

E2F transcription factor 2

decreases activity

Nitrogen Dioxide results in decreased activity of E2F2 protein

NCBI chr 1:23,505,212...23,531,233
Ensembl chr 1:23,506,438...23,531,233

G

endothelin 1

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of EDN1 protein

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

EPH receptor B2

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of EPHB2 gene

NCBI chr 1:22,710,838...22,921,500
Ensembl chr 1:22,710,839...22,921,500

G

ezrin

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which results in decreased expression of EZR protein

NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368

G

FA core complex associated protein 20

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of FAAP20 gene

NCBI chr 1:2,184,477...2,212,720
Ensembl chr 1:2,184,461...2,212,720

G

family with sequence similarity 124 member B

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of FAM124B gene

NCBI chr 2:224,378,698...224,402,107
Ensembl chr 2:224,378,698...224,402,107

G

fission, mitochondrial 1

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of FIS1 protein

NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316

G

fms related receptor tyrosine kinase 1

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the expression of FLT1 protein; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of FLT1 protein

NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145

G

fibronectin 1

decreases expression

Nitrogen Dioxide results in decreased expression of FN1 mRNA

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Nitrogen Dioxide results in increased expression of FOS protein

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190

G

forkhead box M1

increases expression

Nitrogen Dioxide results in increased expression of FOXM1 mRNA

NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,680...2,877,174

G

forkhead box P3

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of FOXP3 promoter

NCBI chr X:49,250,438...49,264,710
Ensembl chr X:49,250,438...49,264,800

G

glutamate-cysteine ligase modifier subunit

decreases expression

Nitrogen Dioxide results in decreased expression of GCLM mRNA

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

gamma-glutamyltransferase 1

increases expression
multiple interactions

Nitrogen Dioxide results in increased expression of GGT1 mRNA
Nitrogen Dioxide results in increased expression of and results in increased activity of GGT1 protein

PMID:9144455 PMID:16049373

NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005

G

G protein-coupled receptor 55

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA

NCBI chr 2:230,907,328...230,961,201
Ensembl chr 2:230,907,318...230,961,066

G

G protein-coupled receptor 75

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of GPR75 gene

NCBI chr 2:53,852,912...53,859,967
Ensembl chr 2:53,852,912...53,859,967

G

glutathione peroxidase 3

increases expression
decreases expression

Nitrogen Dioxide results in increased expression of GPX3 mRNA
Nitrogen Dioxide results in decreased expression of GPX3 mRNA

PMID:15336314 PMID:16049373

NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988

G

glutathione peroxidase 4

affects expression

Nitrogen Dioxide affects the expression of GPX4 mRNA

NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791

G

glutathione peroxidase 5

increases expression

Nitrogen Dioxide results in increased expression of GPX5 mRNA

NCBI chr 6:28,525,881...28,534,955
Ensembl chr 6:28,525,881...28,534,955

G

glutathione-disulfide reductase

increases activity
increases expression

Nitrogen Dioxide results in increased activity of GSR protein
Nitrogen Dioxide results in increased expression of GSR mRNA

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione synthetase

decreases expression

Nitrogen Dioxide results in decreased expression of GSS mRNA

NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027

G

glutathione S-transferase mu 1

affects response to substance

GSTM1 gene polymorphism affects the susceptibility to Nitrogen Dioxide

NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039

G

glutathione S-transferase pi 1

affects response to substance
multiple interactions

GSTP1 gene polymorphism affects the susceptibility to Nitrogen Dioxide
GSTP1 gene SNP results in increased susceptibility to [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide]

PMID:22732554 PMID:29624745

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

glutathione S-transferase theta 1

affects response to substance

GSTT1 gene polymorphism affects the susceptibility to Nitrogen Dioxide

G

3-hydroxyisobutyrate dehydrogenase

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene

NCBI chr 7:27,525,442...27,662,883
Ensembl chr 7:27,525,442...27,662,883

G

heme oxygenase 1

increases expression
decreases expression

Nitrogen Dioxide results in increased expression of HMOX1 mRNA
Nitrogen Dioxide results in decreased expression of HMOX1 mRNA

PMID:10715624 PMID:20197249 PMID:27206323

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

homeobox A11

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of HOXA11 gene

NCBI chr 7:27,181,157...27,185,232
Ensembl chr 7:27,181,157...27,185,232

G

HOXA11 antisense RNA

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of HOXA11-AS gene

NCBI chr 7:27,185,408...27,189,293
Ensembl chr 7:27,184,507...27,189,298

G

homeobox A4

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of HOXA4 gene

NCBI chr 7:27,128,525...27,130,757
Ensembl chr 7:27,128,507...27,130,780

G

homeobox A5

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of HOXA5 gene

NCBI chr 7:27,141,052...27,143,681
Ensembl chr 7:27,141,052...27,143,681

G

homeobox A6

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of HOXA6 gene

NCBI chr 7:27,145,396...27,147,774
Ensembl chr 7:27,145,396...27,150,603

G

homeobox B6

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of HOXB6 gene

NCBI chr17:48,595,751...48,604,986
Ensembl chr17:48,595,751...48,604,992

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of HSP90AA1 gene

NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699

G

intercellular adhesion molecule 1

increases expression

Nitrogen Dioxide results in increased expression of ICAM1 mRNA

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interferon gamma

multiple interactions
decreases expression

[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrogen Dioxide
Nitrogen Dioxide results in decreased expression of IFNG protein

PMID:22303861 PMID:28935613

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 10

increases expression

Nitrogen Dioxide results in increased expression of IL10 mRNA; Nitrogen Dioxide results in increased expression of IL10 protein

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 13

increases expression
decreases methylation

Nitrogen Dioxide results in increased expression of IL13 protein
Nitrogen Dioxide results in decreased methylation of IL13 promoter
Nitrogen Dioxide results in increased expression of IL13 mRNA

PMID:28669936 PMID:28935613

NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110

G

interleukin 1 beta

multiple interactions
decreases expression

[Ozone co-treated with Nitrogen Dioxide] results in increased expression of IL1B protein
Nitrogen Dioxide results in decreased expression of IL1B mRNA
IL1B gene SNP results in increased susceptibility to [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased abundance of Nitrogen Dioxide]

PMID:9363475 PMID:10986008 PMID:27640071

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 32

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of IL32 gene

NCBI chr16:3,065,403...3,069,530
Ensembl chr16:3,065,297...3,082,192

G

interleukin 4

decreases methylation
multiple interactions
increases expression

Nitrogen Dioxide results in decreased methylation of IL4 promoter
[Nitrogen Dioxide results in decreased methylation of IL4 gene] which results in increased expression of IL4 promoter
Nitrogen Dioxide results in increased expression of IL4 protein

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 6

multiple interactions
increases expression
increases secretion
decreases expression

[Ozone co-treated with Nitrogen Dioxide] results in increased expression of IL6 protein
Nitrogen Dioxide results in increased expression of IL6 mRNA; Nitrogen Dioxide results in increased expression of IL6 protein
Nitrogen Dioxide results in increased secretion of IL6 protein
Nitrogen Dioxide results in decreased expression of IL6 mRNA
IL6 gene SNP affects the susceptibility to [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased abundance of Nitrogen Dioxide]

PMID:8584542 PMID:10986008 PMID:18629312 PMID:19750100 PMID:24056475 More...

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interaction protein for cytohesin exchange factors 1

decreases expression

Nitrogen Dioxide results in decreased expression of IPCEF1 mRNA

NCBI chr 6:154,154,496...154,356,803
Ensembl chr 6:154,154,496...154,356,803

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Nitrogen Dioxide results in increased expression of JUN protein

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

kelch like family member 35

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of KLHL35 gene

NCBI chr11:75,422,394...75,433,203
Ensembl chr11:75,422,394...75,433,203

G

lipase maturation factor 1

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of LMF1 gene

NCBI chr16:853,634...981,613
Ensembl chr16:853,634...981,318

G

lon peptidase 1, mitochondrial

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA

NCBI chr19:5,691,834...5,720,452
Ensembl chr19:5,691,834...5,720,572

G

leucine zipper transcription factor like 1

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of LZTFL1 gene

NCBI chr 3:45,823,316...45,915,724
Ensembl chr 3:45,823,316...45,916,042

G

MCF.2 cell line derived transforming sequence like

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of MCF2L gene

NCBI chr13:112,894,335...113,099,742
Ensembl chr13:112,894,378...113,099,742

G

Meis homeobox 2

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of MEIS2 gene

NCBI chr15:36,889,204...37,101,311
Ensembl chr15:36,889,204...37,101,299

G

mitofusin 1

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MFN1 protein

NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936

G

mitofusin 2

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MFN2 protein

NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211

G

microsomal glutathione S-transferase 3

increases expression

Nitrogen Dioxide results in increased expression of MGST3 mRNA

NCBI chr 1:165,631,234...165,656,136
Ensembl chr 1:165,631,213...165,661,796

G

microRNA 1249

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR1249 mRNA

NCBI chr22:45,200,954...45,201,019
Ensembl chr22:45,200,954...45,201,019

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microRNA 185

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR185 mRNA

NCBI chr22:20,033,139...20,033,220
Ensembl chr22:20,033,139...20,033,220

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microRNA 205

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR205 mRNA

NCBI chr 1:209,432,133...209,432,242
Ensembl chr 1:209,432,133...209,432,242

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microRNA 30e

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR30E mRNA

NCBI chr 1:40,754,355...40,754,446
Ensembl chr 1:40,754,355...40,754,446

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microRNA 338

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR338 mRNA

NCBI chr17:81,125,883...81,125,949
Ensembl chr17:81,125,883...81,125,949

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microRNA 34b

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR34B mRNA

NCBI chr11:111,512,938...111,513,021
Ensembl chr11:111,512,938...111,513,021

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microRNA 374c

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR374C mRNA

NCBI chr X:74,218,549...74,218,618
Ensembl chr X:74,218,549...74,218,618

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microRNA 375

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR375 mRNA

NCBI chr 2:219,001,645...219,001,708
Ensembl chr 2:219,001,645...219,001,708

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microRNA 425

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR425 mRNA

NCBI chr 3:49,020,148...49,020,234
Ensembl chr 3:49,020,148...49,020,234

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microRNA 450b

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR450B mRNA

NCBI chr X:134,540,185...134,540,262
Ensembl chr X:134,540,185...134,540,262

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microRNA 502

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR500 mRNA

NCBI chr X:50,014,598...50,014,683
Ensembl chr X:50,014,598...50,014,683

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microRNA 504

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR504 mRNA

NCBI chr X:138,667,711...138,667,793
Ensembl chr X:138,667,711...138,667,793

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microRNA let-7e

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIRLET7E mRNA

NCBI chr19:51,692,786...51,692,864
Ensembl chr19:51,692,786...51,692,864

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myeloperoxidase

increases expression

Nitrogen Dioxide results in increased expression of MPO mRNA

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

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metallothionein 3

increases expression

Nitrogen Dioxide results in increased expression of MT3 mRNA

NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088

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myelin transcription factor 1 like

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of MYT1L gene

NCBI chr 2:1,789,113...2,331,275
Ensembl chr 2:1,789,113...2,331,664

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nitric oxide synthase 2

increases expression
multiple interactions

Nitrogen Dioxide results in increased expression of NOS2 mRNA
[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of NOS2 gene

PMID:10715624 PMID:26778509

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

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nitric oxide synthase 3

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of NOS3 protein

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

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NADPH oxidase 5

decreases expression

Nitrogen Dioxide results in decreased expression of NOX5 mRNA

NCBI chr15:69,014,695...69,062,762
Ensembl chr15:69,014,695...69,062,762

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NPHP3 antisense RNA 1

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of NPHP3-AS1 gene

NCBI chr 3:132,721,750...132,874,211
Ensembl chr 3:132,721,750...132,895,230

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NAD(P)H quinone dehydrogenase 1

affects response to substance

NQO1 gene polymorphism affects the susceptibility to Nitrogen Dioxide

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

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nudix hydrolase 1

increases expression

Nitrogen Dioxide results in increased expression of NUDT1 mRNA

NCBI chr 7:2,242,226...2,251,145
Ensembl chr 7:2,242,226...2,251,146

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OPA1 mitochondrial dynamin like GTPase

multiple interactions

[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of OPA1 protein

NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811

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olfactory receptor family 2 subfamily L member 13

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of OR2L13 gene

NCBI chr 1:247,937,177...248,101,163
Ensembl chr 1:248,095,184...248,101,163

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purinergic receptor P2X 4

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of P2RX4 gene

NCBI chr12:121,210,129...121,234,106
Ensembl chr12:121,210,065...121,234,106

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proliferating cell nuclear antigen

decreases expression

Nitrogen Dioxide results in decreased expression of PCNA protein

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

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placental growth factor

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the expression of PGF protein; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of PGF protein

NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626

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piezo type mechanosensitive ion channel component 1 (Er blood group)

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of PIEZO1 gene

NCBI chr16:88,715,338...88,785,220
Ensembl chr16:88,715,338...88,785,220

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piwi like RNA-mediated gene silencing 2

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of PIWIL2 gene

NCBI chr 8:22,275,316...22,357,568
Ensembl chr 8:22,275,316...22,357,568

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phospholipase A2 group VII

affects expression

Nitrogen Dioxide affects the expression of PLA2G7

NCBI chr 6:46,704,201...46,735,721
Ensembl chr 6:46,704,201...46,735,693

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DNA polymerase delta 4, accessory subunit

increases expression

Nitrogen Dioxide results in increased expression of POLD4 mRNA

NCBI chr11:67,350,765...67,353,596
Ensembl chr11:67,350,772...67,356,972

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PPARG coactivator 1 alpha

decreases expression

Nitrogen Dioxide results in decreased expression of PPARGC1A mRNA

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

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phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1

increases expression

Nitrogen Dioxide results in increased expression of PREX1 mRNA

NCBI chr20:48,624,252...48,888,185
Ensembl chr20:48,624,252...48,827,999

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prostaglandin-endoperoxide synthase 2

increases expression

Nitrogen Dioxide results in increased expression of PTGS2 mRNA

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

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RB transcriptional corepressor 1

decreases phosphorylation

Nitrogen Dioxide results in decreased phosphorylation of RB1 protein

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

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ring finger protein 2

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of RNF2 5' UTR

NCBI chr 1:185,045,558...185,102,603
Ensembl chr 1:185,045,497...185,102,603

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selectin P

increases expression

Nitrogen Dioxide results in increased expression of SELP protein modified form

NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193

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surfactant protein D

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which results in increased expression of SFTPD protein

NCBI chr10:79,937,740...79,982,383
Ensembl chr10:79,937,467...79,982,614

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src kinase associated phosphoprotein 2

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of SKAP2 gene

NCBI chr 7:26,654,770...26,864,590
Ensembl chr 7:26,667,068...26,995,239

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solute carrier family 25 member 28

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of SLC25A28 gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of SLC25A28 gene

NCBI chr10:99,610,522...99,659,286
Ensembl chr10:99,610,519...99,622,793

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solute carrier organic anion transporter family member 1B1

multiple interactions

SLCO1B1 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Nitrogen Dioxide]

NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796

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superoxide dismutase 1

increases expression
multiple interactions
decreases expression
decreases activity

Nitrogen Dioxide results in increased expression of SOD1 mRNA
[[SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites] which results in increased chemical synthesis of Nitrogen Dioxide
Nitrogen Dioxide results in decreased expression of SOD1 protein
Nitrogen Dioxide results in decreased activity of SOD1 protein

PMID:15336314 PMID:18629312 PMID:19243126 PMID:22621880

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

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superoxide dismutase 2

decreases activity
multiple interactions

Nitrogen Dioxide results in decreased activity of SOD2 protein
[[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of SOD2 promoter] which affects the methylation of SOD2 promoter; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of SOD2 promoter

PMID:22621880 PMID:31220783

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

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splA/ryanodine receptor domain and SOCS box containing 4

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of SPSB4 gene

NCBI chr 3:141,051,347...141,148,611
Ensembl chr 3:141,051,347...141,148,611

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transforming growth factor beta 1

multiple interactions

[Ozone co-treated with Nitrogen Dioxide] results in increased expression of TGFB1 mRNA

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

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THAP domain containing 1

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of THAP1 3' UTR

NCBI chr 8:42,836,674...42,843,325
Ensembl chr 8:42,836,674...42,843,325

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tumor necrosis factor

multiple interactions
affects response to substance
decreases secretion
increases secretion
increases expression

[Ozone co-treated with Nitrogen Dioxide] results in increased expression of TNF protein
TNF gene polymorphism affects the susceptibility to Nitrogen Dioxide
Nitrogen Dioxide results in decreased secretion of TNF protein
Nitrogen Dioxide results in increased secretion of TNF protein
Nitrogen Dioxide results in increased expression of TNF mRNA
TNF gene SNP results in increased susceptibility to [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide]

PMID:8398164 PMID:9363475 PMID:10986008 PMID:20049212 PMID:28669936 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

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TNF receptor superfamily member 1B

increases expression

Nitrogen Dioxide results in increased expression of TNFRSF1B protein modified form

NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228

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tumor protein p53

increases expression
multiple interactions

Nitrogen Dioxide results in increased expression of TP53 mRNA; Nitrogen Dioxide results in increased expression of TP53 protein
[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of TRP53 protein

PMID:22621880 PMID:27521637

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

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thyroid peroxidase

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of TPO gene; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased expression of TPO mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of TPO gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased expression of TPO mRNA

NCBI chr 2:1,374,047...1,543,673
Ensembl chr 2:1,374,066...1,543,711

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tRNA methyltransferase 10A

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of TRMT10A

NCBI chr 4:99,546,711...99,564,039
Ensembl chr 4:99,546,709...99,564,039

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titin

increases expression

Nitrogen Dioxide results in increased expression of TTN mRNA

NCBI chr 2:178,525,989...178,807,423
Ensembl chr 2:178,525,989...178,830,802

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thioredoxin

multiple interactions

[Ozone co-treated with Nitrogen Dioxide] results in increased expression of TXN1 mRNA

NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507

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thioredoxin domain containing 2

increases expression

Nitrogen Dioxide results in increased expression of TXNDC2 mRNA

NCBI chr18:9,885,973...9,889,275
Ensembl chr18:9,885,766...9,889,275

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thioredoxin reductase 1

increases expression

Nitrogen Dioxide results in increased expression of TXNRD1 mRNA

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

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vascular cell adhesion molecule 1

increases expression

Nitrogen Dioxide results in increased expression of VCAM1 mRNA

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

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zinc finger protein 563

multiple interactions

[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of ZNF563 gene

NCBI chr19:12,317,477...12,347,390
Ensembl chr19:12,317,477...12,333,720

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26504
chemical entity	26484
molecular entity	26466
inorganic molecular entity	25620
inorganic oxide	8467
nitrogen oxide	438
nitrogen dioxide	141
Path 2
Term	Annotations
CHEBI ontology	26504
subatomic particle	26480
composite particle	26480
hadron	26480
baryon	26480
nucleon	26480
atomic nucleus	26480
atom	26480
main group element atom	26217
p-block element atom	26217
chalcogen	25124
oxygen atom	24931
oxygen molecular entity	24931
oxide	13908
inorganic oxide	8467
nitrogen oxide	438
nitrogen dioxide	141

paths to the root