FIS1 (fission, mitochondrial 1) - Rat Genome Database

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Gene: FIS1 (fission, mitochondrial 1) Homo sapiens
Analyze
Symbol: FIS1
Name: fission, mitochondrial 1
RGD ID: 1315413
HGNC Page HGNC
Description: Exhibits identical protein binding activity. Involved in several processes, including cellular calcium ion homeostasis; mitochondrion organization; and regulation of anion transport. Localizes to integral component of mitochondrial outer membrane; integral component of peroxisomal membrane; and protein-containing complex. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CGI-135; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog; H_NH0132A01.6; hFis1; mitochondrial fission 1 protein; mitochondrial fission molecule; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7101,239,458 - 101,252,316 (-)EnsemblGRCh38hg38GRCh38
GRCh387101,239,472 - 101,245,081 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,882,753 - 100,888,362 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,669,613 - 100,675,091 (-)NCBINCBI36hg18NCBI36
Build 347100,476,327 - 100,481,801NCBI
Celera795,892,051 - 95,897,529 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,475,936 - 95,481,415 (-)NCBIHuRef
CHM1_17100,813,303 - 100,818,781 (-)NCBICHM1_1
CRA_TCAGchr7v27100,241,280 - 100,246,758 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4-DAMP(1+)  (ISO)
aldehydo-D-glucose  (ISO)
Aroclor 1254  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
Brodifacoum  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (ISO)
carnosic acid  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
curcumin  (ISO)
cytochalasin B  (ISO)
D-glucose  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (EXP)
elemental selenium  (EXP)
flutamide  (ISO)
folpet  (ISO)
gallic acid  (EXP)
gallocatechin  (EXP)
glafenine  (ISO)
glucose  (ISO)
hexadecanoic acid  (EXP)
hydralazine  (EXP)
hydrogen peroxide  (EXP)
isoprenaline  (ISO)
melatonin  (ISO)
metformin  (ISO)
mitomycin C  (EXP)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
nitrogen dioxide  (ISO)
nocodazole  (ISO)
okadaic acid  (ISO)
oleic acid  (EXP)
oxidopamine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
phlorizin  (ISO)
rac-lactic acid  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
spermine  (ISO)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
tert-butyl hydroperoxide  (EXP)
thapsigargin  (EXP)
trans-cinnamic acid  (ISO)
trichloroethene  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy of mitochondrion  (IBA,IDA)
calcium-mediated signaling using intracellular calcium source  (IMP)
cellular response to glucose stimulus  (ISO)
cellular response to lipid  (ISO)
cellular response to peptide  (ISO)
cellular response to thapsigargin  (ISO)
cellular response to toxic substance  (ISO)
mitochondrial fission  (IBA,IDA,IMP)
mitochondrial fragmentation involved in apoptotic process  (IBA,IDA,IMP,ISO)
mitochondrial fusion  (IMP)
mitochondrion morphogenesis  (IMP)
negative regulation of ATP metabolic process  (IMP)
negative regulation of endoplasmic reticulum calcium ion concentration  (IMP)
negative regulation of fatty acid transport  (IMP)
peroxisome fission  (IBA,IDA,IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of intrinsic apoptotic signaling pathway  (IMP)
positive regulation of mitochondrial calcium ion concentration  (IMP)
positive regulation of mitochondrial fission  (IDA,ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein targeting to membrane  (IDA)
protein import into peroxisome membrane  (TAS)
protein targeting to mitochondrion  (IMP)
regulation of mitochondrion organization  (IMP)
release of cytochrome c from mitochondria  (IMP)
response to flavonoid  (ISO)
response to fluoride  (ISO)
response to hypobaric hypoxia  (ISO)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Aparicio-Trejo OE, etal., Biofactors. 2016 Nov 1. doi: 10.1002/biof.1338.
2. Chitra L and Boopathy R, Br J Pharmacol. 2013 Jul;169(5):1035-47. doi: 10.1111/bph.12179.
3. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
4. GOA_HUMAN data from the GO Consortium
5. Guo Z, etal., Int J Environ Res Public Health. 2017 Jan 29;14(2). pii: E134. doi: 10.3390/ijerph14020134.
6. Jannig PR, etal., PLoS One. 2014 Jan 10;9(1):e85820. doi: 10.1371/journal.pone.0085820. eCollection 2014.
7. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
8. Li R, etal., J Hazard Mater. 2015 Apr 28;287:392-401. doi: 10.1016/j.jhazmat.2015.02.006. Epub 2015 Feb 4.
9. Lionetti L, etal., PLoS One. 2014 Mar 24;9(3):e92753. doi: 10.1371/journal.pone.0092753. eCollection 2014.
10. Liu Q, etal., PLoS One. 2015 Oct 19;10(10):e0140906. doi: 10.1371/journal.pone.0140906. eCollection 2015.
11. O'Leary MF, etal., Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30. doi: 10.1152/ajpcell.00240.2012. Epub 2012 Dec 5.
12. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
13. Qin SL, etal., J Trace Elem Med Biol. 2015 Jan;29:263-8. doi: 10.1016/j.jtemb.2014.06.001. Epub 2014 Jun 9.
14. RGD automated import pipeline for gene-chemical interactions
15. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
16. Wang Y, etal., Neuroscience. 2015 Mar 19;289:224-32. doi: 10.1016/j.neuroscience.2014.12.061. Epub 2015 Jan 13.
17. Zhang ZY, etal., Neurosci Lett. 2015 Sep 14;604:18-23. doi: 10.1016/j.neulet.2015.06.021. Epub 2015 Jun 12.
Additional References at PubMed
PMID:10810093   PMID:12477932   PMID:12783892   PMID:12853948   PMID:12861026   PMID:14561759   PMID:14623186   PMID:14705031   PMID:14996942   PMID:15024001   PMID:15356267   PMID:15489334  
PMID:16010987   PMID:16107562   PMID:16118244   PMID:16874301   PMID:16883569   PMID:16914522   PMID:17207965   PMID:17408615   PMID:17545159   PMID:17884824   PMID:18029348   PMID:18353969  
PMID:18515060   PMID:18782765   PMID:18832378   PMID:18845145   PMID:19864424   PMID:19946888   PMID:20178365   PMID:20179104   PMID:20428767   PMID:20451243   PMID:20826455   PMID:20877624  
PMID:21103663   PMID:21149567   PMID:21163940   PMID:21183955   PMID:21516116   PMID:21699783   PMID:21701560   PMID:21873635   PMID:21890626   PMID:22340708   PMID:22595523   PMID:22789569  
PMID:22939629   PMID:23077178   PMID:23283981   PMID:23503661   PMID:23713734   PMID:23907611   PMID:23921378   PMID:24416201   PMID:25416956   PMID:25822260   PMID:25843291   PMID:26936603  
PMID:27497958   PMID:27499296   PMID:28380382   PMID:29117863   PMID:29335339   PMID:29464060   PMID:29509190   PMID:29910151   PMID:30404157   PMID:30555023   PMID:30566949   PMID:30894073  
PMID:31053718   PMID:31318583   PMID:31482366   PMID:31536960   PMID:31723608   PMID:32296183   PMID:32521232   PMID:32694731   PMID:32877691  


Genomics

Comparative Map Data
FIS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7101,239,458 - 101,252,316 (-)EnsemblGRCh38hg38GRCh38
GRCh387101,239,472 - 101,245,081 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,882,753 - 100,888,362 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,669,613 - 100,675,091 (-)NCBINCBI36hg18NCBI36
Build 347100,476,327 - 100,481,801NCBI
Celera795,892,051 - 95,897,529 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,475,936 - 95,481,415 (-)NCBIHuRef
CHM1_17100,813,303 - 100,818,781 (-)NCBICHM1_1
CRA_TCAGchr7v27100,241,280 - 100,246,758 (-)NCBI
Fis1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395136,982,129 - 136,995,088 (+)NCBIGRCm39mm39
GRCm39 Ensembl5136,982,129 - 136,995,088 (+)Ensembl
GRCm385136,953,275 - 136,966,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5136,953,275 - 136,966,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv375137,429,145 - 137,442,104 (+)NCBIGRCm37mm9NCBIm37
MGSCv365137,246,713 - 137,250,859 (+)NCBImm8
Celera5133,969,492 - 133,982,284 (+)NCBICelera
Cytogenetic Map5G2NCBI
Fis1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21219,708,558 - 19,723,392 (-)NCBI
Rnor_6.0 Ensembl1222,750,485 - 22,765,308 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01222,750,485 - 22,765,324 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,760,051 - 24,774,751 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,806,840 - 20,821,766 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11220,807,273 - 20,811,373 (+)NCBI
Celera1221,483,983 - 21,498,749 (-)NCBICelera
Cytogenetic Map12q12NCBI
Fis1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,038,221 - 16,060,623 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545616,057,158 - 16,060,623 (+)NCBIChiLan1.0ChiLan1.0
FIS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17106,621,211 - 106,626,612 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,621,211 - 106,626,683 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0793,381,058 - 93,386,483 (-)NCBIMhudiblu_PPA_v0panPan3
FIS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,642,014 - 8,645,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,642,039 - 8,648,851 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,339,369 - 10,343,166 (+)NCBI
ROS_Cfam_1.068,461,512 - 8,465,308 (+)NCBI
UMICH_Zoey_3.168,417,290 - 8,421,077 (+)NCBI
UNSW_CanFamBas_1.068,392,322 - 8,396,123 (+)NCBI
UU_Cfam_GSD_1.068,557,014 - 8,560,797 (+)NCBI
Fis1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,919,990 - 132,923,784 (+)NCBI
SpeTri2.0NW_0049365431,112,746 - 1,116,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FIS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,931,104 - 8,941,865 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,938,250 - 8,942,102 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FIS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12811,934,848 - 11,940,230 (+)NCBI
ChlSab1.1 Ensembl2811,934,821 - 11,941,901 (+)Ensembl
Fis1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474016,052,777 - 16,056,438 (+)NCBI

Position Markers
WI-11506  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377100,882,901 - 100,883,029UniSTSGRCh37
Build 367100,669,621 - 100,669,749RGDNCBI36
Celera795,892,059 - 95,892,187RGD
Cytogenetic Map7q11.22UniSTS
Cytogenetic Map7q22.1UniSTS
HuRef795,475,944 - 95,476,072UniSTS
CRA_TCAGchr7v27100,241,288 - 100,241,416UniSTS
GeneMap99-GB4 RH Map7517.11UniSTS
Whitehead-RH Map7487.9UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR484hsa-miR-484Mirtarbaseexternal_infoChIP-seq//Immunoblot//LacZ reporter assay//qRT-PCRFunctional MTI22510686

Predicted Target Of
Summary Value
Count of predictions:3401
Count of miRNA genes:703
Interacting mature miRNAs:824
Transcripts:ENST00000223136, ENST00000435848, ENST00000442303, ENST00000449367, ENST00000463406, ENST00000473527, ENST00000474120, ENST00000480497, ENST00000482199
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 7
Medium 2432 2978 1723 622 1948 464 4355 2187 3718 416 1441 1608 171 1204 2788 4
Low 7 11 3 2 3 1 1 10 16 3 12 5 4 1 2 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000223136   ⟹   ENSP00000223136
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,472 - 101,245,081 (-)Ensembl
RefSeq Acc Id: ENST00000435848   ⟹   ENSP00000413500
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,661 - 101,252,133 (-)Ensembl
RefSeq Acc Id: ENST00000442303   ⟹   ENSP00000395964
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,607 - 101,245,048 (-)Ensembl
RefSeq Acc Id: ENST00000449367   ⟹   ENSP00000411442
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,458 - 101,245,075 (-)Ensembl
RefSeq Acc Id: ENST00000463406
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,612 - 101,241,177 (-)Ensembl
RefSeq Acc Id: ENST00000473527   ⟹   ENSP00000444771
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,612 - 101,252,291 (-)Ensembl
RefSeq Acc Id: ENST00000474120   ⟹   ENSP00000442056
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,594 - 101,252,316 (-)Ensembl
RefSeq Acc Id: ENST00000480497
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,732 - 101,244,731 (-)Ensembl
RefSeq Acc Id: ENST00000482199
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7101,239,552 - 101,241,785 (-)Ensembl
RefSeq Acc Id: NM_016068   ⟹   NP_057152
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387101,239,472 - 101,245,081 (-)NCBI
GRCh377100,882,893 - 100,889,009 (-)NCBI
Build 367100,669,613 - 100,675,091 (-)NCBI Archive
HuRef795,475,936 - 95,481,415 (-)ENTREZGENE
CHM1_17100,813,303 - 100,818,781 (-)NCBI
CRA_TCAGchr7v27100,241,280 - 100,246,758 (-)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057152   ⟸   NM_016068
- UniProtKB: Q9Y3D6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000395964   ⟸   ENST00000442303
RefSeq Acc Id: ENSP00000223136   ⟸   ENST00000223136
RefSeq Acc Id: ENSP00000444771   ⟸   ENST00000473527
RefSeq Acc Id: ENSP00000442056   ⟸   ENST00000474120
RefSeq Acc Id: ENSP00000411442   ⟸   ENST00000449367
RefSeq Acc Id: ENSP00000413500   ⟸   ENST00000435848

Promoters
RGD ID:6814782
Promoter ID:HG_XEF:7643
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001096647,   NM_001105919,   NM_001130206,   NM_001163243
Position:
Human AssemblyChrPosition (strand)Source
Build 367100,674,301 - 100,674,801 (-)MPROMDB
RGD ID:6805666
Promoter ID:HG_KWN:59032
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_016068,   OTTHUMT00000347450,   OTTHUMT00000347451,   OTTHUMT00000347452
Position:
Human AssemblyChrPosition (strand)Source
Build 367100,674,759 - 100,675,259 (-)MPROMDB
RGD ID:6806382
Promoter ID:HG_KWN:59033
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000347453,   OTTHUMT00000347457,   UC010LHT.1,   UC010LHV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367100,680,551 - 100,682,387 (-)MPROMDB
RGD ID:7211467
Promoter ID:EPDNEW_H11479
Type:initiation region
Name:FIS1_1
Description:fission, mitochondrial 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11480  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387101,245,081 - 101,245,141EPDNEW
RGD ID:7211469
Promoter ID:EPDNEW_H11480
Type:initiation region
Name:FIS1_2
Description:fission, mitochondrial 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11479  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387101,252,304 - 101,252,364EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1
pathogenic
GRCh38/hg38 7q22.1(chr7:100419914-102482826)x1 copy number loss See cases [RCV000054155] Chr7:100419914..102482826 [GRCh38]
Chr7:100017537..102123273 [GRCh37]
Chr7:99855473..101910278 [NCBI36]
Chr7:7q22.1
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1
pathogenic|uncertain significance
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q22.1(chr7:101130561-101255628)x3 copy number gain See cases [RCV000136835] Chr7:101130561..101255628 [GRCh38]
Chr7:100773842..100898909 [GRCh37]
Chr7:100560562..100685629 [NCBI36]
Chr7:7q22.1
benign
GRCh38/hg38 7q22.1(chr7:99932610-102473188)x3 copy number gain See cases [RCV000138109] Chr7:99932610..102473188 [GRCh38]
Chr7:99530233..102113635 [GRCh37]
Chr7:99368169..101900640 [NCBI36]
Chr7:7q22.1
uncertain significance
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:100884470-101699764)x1 copy number loss See cases [RCV000511666] Chr7:100884470..101699764 [GRCh37]
Chr7:7q22.1
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Speech-language disorder 1 [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:99593346-102470275)x1 copy number loss See cases [RCV001195072] Chr7:99593346..102470275 [GRCh37]
Chr7:7q22.1
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21689 AgrOrtholog
COSMIC FIS1 COSMIC
Ensembl Genes ENSG00000214253 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000223136 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000395964 UniProtKB/TrEMBL
  ENSP00000411442 UniProtKB/TrEMBL
  ENSP00000413500 UniProtKB/TrEMBL
  ENSP00000442056 UniProtKB/TrEMBL
  ENSP00000444771 UniProtKB/TrEMBL
Ensembl Transcript ENST00000223136 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000435848 UniProtKB/TrEMBL
  ENST00000442303 UniProtKB/TrEMBL
  ENST00000449367 UniProtKB/TrEMBL
  ENST00000473527 UniProtKB/TrEMBL
  ENST00000474120 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000214253 GTEx
HGNC ID HGNC:21689 ENTREZGENE
Human Proteome Map FIS1 Human Proteome Map
InterPro Fis1 UniProtKB/Swiss-Prot
  Fis1_cytosol UniProtKB/Swiss-Prot
  Fis1_TPR_C UniProtKB/Swiss-Prot
  Fis1_TPR_N UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:51024 UniProtKB/Swiss-Prot
NCBI Gene 51024 ENTREZGENE
OMIM 609003 OMIM
PANTHER PTHR13247 UniProtKB/Swiss-Prot
Pfam Fis1_TPR_C UniProtKB/Swiss-Prot
  Fis1_TPR_N UniProtKB/Swiss-Prot
PharmGKB PA134984211 PharmGKB
PIRSF TPR_repeat_11_Fis1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniProt C9JXH1_HUMAN UniProtKB/TrEMBL
  F5H509_HUMAN UniProtKB/TrEMBL
  F5H8A8_HUMAN UniProtKB/TrEMBL
  F8WBT1_HUMAN UniProtKB/TrEMBL
  F8WD11_HUMAN UniProtKB/TrEMBL
  FIS1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9BTP3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-30 FIS1  fission, mitochondrial 1    fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED
2011-08-16 FIS1  fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)  FIS1  fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED