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Gene: P2RX4 (purinergic receptor P2X 4) Homo sapiens
Symbol: P2RX4
Name: purinergic receptor P2X 4
RGD ID: 732285
Description: Exhibits several functions, including cadherin binding activity; ligand-gated cation channel activity; and purinergic nucleotide receptor activity. Involved in several processes, including cellular response to ATP; positive regulation of endothelial cell migration; and regulation of muscle system process. Localizes to cell junction; integral component of plasma membrane; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP receptor; ATP-gated cation channel protein; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; P2X4R; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel, 4; purinergic receptor P2X4; purinoceptor P2X4
Mus musculus (house mouse) : P2rx4 (purinergic receptor P2X, ligand-gated ion channel 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : P2rx4 (purinergic receptor P2X 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2rx4 (purinergic receptor P2X 4)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RX4 (purinergic receptor P2X 4)
Canis lupus familiaris (dog) : P2RX4 (purinergic receptor P2X 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2rx4 (purinergic receptor P2X 4)
Sus scrofa (pig) : P2RX4 (purinergic receptor P2X 4)
Chlorocebus sabaeus (African green monkey) : P2RX4 (purinergic receptor P2X 4)
Heterocephalus glaber (naked mole-rat) : P2rx4 (purinergic receptor P2X 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl12121,209,861 - 121,234,106 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl12121,209,857 - 121,234,106 (+)EnsemblGRCh38hg38GRCh38
GRCh3812121,210,096 - 121,234,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712121,647,664 - 121,671,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,132,047 - 120,156,292 (+)NCBINCBI36hg18NCBI36
Build 3412120,110,383 - 120,134,627NCBI
Celera12121,285,420 - 121,309,664 (+)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12118,657,246 - 118,681,512 (+)NCBIHuRef
CHM1_112121,616,508 - 121,640,746 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on P2RX4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732285
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.