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Gene: P2RX4 (purinergic receptor P2X 4) Homo sapiens
Symbol: P2RX4
Name: purinergic receptor P2X 4
Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP receptor; ATP-gated cation channel protein; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; P2X4R; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel, 4; purinergic receptor P2X4; purinoceptor P2X4
Mus musculus (house mouse) : P2rx4 (purinergic receptor P2X, ligand-gated ion channel 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : P2rx4 (purinergic receptor P2X 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2rx4 (purinergic receptor P2X 4)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RX4 (purinergic receptor P2X 4)
Canis lupus familiaris (dog) : P2RX4 (purinergic receptor P2X 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2rx4 (purinergic receptor P2X 4)
Sus scrofa (pig) : P2RX4 (purinergic receptor P2X 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812121,209,861 - 121,234,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712121,647,664 - 121,671,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,132,047 - 120,156,292 (+)NCBINCBI36hg18NCBI36
Build 3412120,110,383 - 120,134,627NCBI
Celera12121,285,420 - 121,309,664 (+)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12118,657,246 - 118,681,512 (+)NCBIHuRef
CHM1_112121,616,508 - 121,640,746 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on P2RX4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732285
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.