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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:33101
Term: nitrogen dioxide
Definition: A nitrogen oxide that has formula NO2.
Chemical ID: MESH:D009585
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFaffects response to substanceEXP 6480464CTDTNF gene polymorphism affects the susceptibility to Nitrogen DioxidePMID:20049212
TNFdecreases secretionEXP 6480464CTDNitrogen Dioxide results in decreased secretion of TNF proteinPMID:9363475
TNFincreases expressionEXP 6480464CTDNitrogen Dioxide results in increased expression of TNF mRNAPMID:28669936
TNFincreases secretionEXP 6480464CTDNitrogen Dioxide results in increased secretion of TNF proteinPMID:8398164
TNFmultiple interactionsEXP 6480464CTDTNF gene SNP results in increased susceptibility to [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide]PMID:29624745
TNFmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD[Ozone co-treated with Nitrogen Dioxide] results in increased expression of TNF proteinPMID:10986008
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