GPR55 (G protein-coupled receptor 55) - Rat Genome Database

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Gene: GPR55 (G protein-coupled receptor 55) Homo sapiens
Analyze
Symbol: GPR55
Name: G protein-coupled receptor 55
RGD ID: 1348516
HGNC Page HGNC:4511
Description: Enables cannabinoid receptor activity. Involved in bone resorption; negative regulation of osteoclast differentiation; and positive regulation of intracellular signal transduction. Located in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: G-protein coupled receptor 55; LPIR1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,907,328 - 230,961,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,907,318 - 230,961,066 (-)EnsemblGRCh38hg38GRCh38
GRCh372231,772,043 - 231,789,957 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,480,287 - 231,498,185 (-)NCBINCBI36Build 36hg18NCBI36
Build 342231,597,538 - 231,615,446NCBI
Celera2225,548,449 - 225,566,348 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2223,614,400 - 223,632,298 (-)NCBIHuRef
CHM1_12231,777,847 - 231,795,746 (-)NCBICHM1_1
T2T-CHM13v2.02231,390,497 - 231,444,798 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IDA,IEA,TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9931487   PMID:12477932   PMID:15489334   PMID:16318877   PMID:16434153   PMID:16611220   PMID:17676365   PMID:17704825   PMID:17704827   PMID:17765871   PMID:17767170   PMID:17876300  
PMID:17876302   PMID:17906678   PMID:18240029   PMID:18263732   PMID:18445684   PMID:18577758   PMID:18757503   PMID:18845565   PMID:19285259   PMID:19286662   PMID:19306092   PMID:19335651  
PMID:19589225   PMID:19647110   PMID:19723626   PMID:19805329   PMID:19913121   PMID:20051382   PMID:20117132   PMID:20136841   PMID:20166924   PMID:20298715   PMID:20346144   PMID:20359546  
PMID:20370712   PMID:20506567   PMID:20549374   PMID:20590578   PMID:20628086   PMID:20649562   PMID:20649563   PMID:20735417   PMID:20818416   PMID:20838378   PMID:21057532   PMID:21072666  
PMID:21079038   PMID:21104381   PMID:21220919   PMID:21233197   PMID:21324983   PMID:21367464   PMID:21447538   PMID:21464819   PMID:21467997   PMID:21534610   PMID:21537344   PMID:21557736  
PMID:21601562   PMID:21603896   PMID:21718301   PMID:21873635   PMID:21907912   PMID:21964594   PMID:22027819   PMID:22179809   PMID:22285325   PMID:22433274   PMID:22454039   PMID:22589443  
PMID:22674489   PMID:22751111   PMID:22820167   PMID:22831390   PMID:22990678   PMID:23063456   PMID:23108553   PMID:23151004   PMID:23161546   PMID:23220281   PMID:23333304   PMID:23603203  
PMID:23639801   PMID:24274581   PMID:24602016   PMID:24652077   PMID:24942731   PMID:24972076   PMID:25048571   PMID:25233417   PMID:25344934   PMID:25545857   PMID:25869640   PMID:25889562  
PMID:25970609   PMID:25989290   PMID:26186194   PMID:26436760   PMID:26588872   PMID:27109575   PMID:27215467   PMID:27423937   PMID:27561953   PMID:28005346   PMID:28272905   PMID:28514442  
PMID:28875496   PMID:29188802   PMID:29435814   PMID:29888782   PMID:30830860   PMID:30890410   PMID:31149342   PMID:31200545   PMID:31925452   PMID:32121640   PMID:32329085   PMID:33902596  
PMID:33952459   PMID:33959968   PMID:33961781   PMID:34237432   PMID:34271437   PMID:34324032   PMID:34948125   PMID:35562947   PMID:37544935   PMID:37688769   PMID:37866808   PMID:37998380  


Genomics

Comparative Map Data
GPR55
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,907,328 - 230,961,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,907,318 - 230,961,066 (-)EnsemblGRCh38hg38GRCh38
GRCh372231,772,043 - 231,789,957 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,480,287 - 231,498,185 (-)NCBINCBI36Build 36hg18NCBI36
Build 342231,597,538 - 231,615,446NCBI
Celera2225,548,449 - 225,566,348 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2223,614,400 - 223,632,298 (-)NCBIHuRef
CHM1_12231,777,847 - 231,795,746 (-)NCBICHM1_1
T2T-CHM13v2.02231,390,497 - 231,444,798 (-)NCBIT2T-CHM13v2.0
Gpr55
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39185,860,927 - 85,924,781 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl185,866,039 - 85,888,729 (-)EnsemblGRCm39 Ensembl
GRCm38185,933,221 - 85,991,583 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl185,938,318 - 85,961,007 (-)EnsemblGRCm38mm10GRCm38
MGSCv37187,836,112 - 87,857,630 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36187,770,708 - 87,792,178 (-)NCBIMGSCv36mm8
Celera188,904,892 - 88,926,362 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.94NCBI
Gpr55
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,037,748 - 94,081,426 (-)NCBIGRCr8
mRatBN7.2986,584,906 - 86,640,601 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,590,885 - 86,640,613 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0992,961,431 - 93,011,157 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl992,962,738 - 92,963,697 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0992,690,726 - 92,740,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,657,975 - 84,658,934 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera984,012,133 - 84,061,885 (-)NCBICelera
Cytogenetic Map9q35NCBI
Gpr55
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554534,470,602 - 4,520,036 (+)NCBIChiLan1.0ChiLan1.0
GPR55
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213133,530,894 - 133,585,350 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B133,545,859 - 133,600,315 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B118,159,511 - 118,163,334 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B236,955,534 - 236,973,443 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B236,958,210 - 236,959,169 (-)Ensemblpanpan1.1panPan2
GPR55
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12542,864,869 - 42,931,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2542,866,416 - 42,908,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2543,423,433 - 43,492,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,119,993 - 43,188,752 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,125,851 - 43,137,553 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,048,843 - 43,117,310 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02542,891,570 - 42,960,149 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,046,922 - 43,115,784 (-)NCBIUU_Cfam_GSD_1.0
Gpr55
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,053,427 - 185,098,555 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365255,869,416 - 5,888,789 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365255,869,416 - 5,888,789 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR55
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15131,655,663 - 131,673,693 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115131,655,655 - 131,674,816 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215145,334,233 - 145,406,104 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR55
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110116,945,216 - 116,967,559 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10116,947,905 - 116,948,864 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604082,498,705 - 82,516,906 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr55
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248434,263,659 - 4,282,131 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248434,263,818 - 4,311,348 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPR55
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q32.3-37.3(chr2:194898783-236473913)x3 copy number gain See cases [RCV000051119] Chr2:194898783..236473913 [GRCh38]
Chr2:195763507..237382556 [GRCh37]
Chr2:195471752..237047295 [NCBI36]
Chr2:2q32.3-37.3		 pathogenic
GRCh38/hg38 2q36.3-37.3(chr2:226978129-236886599)x1 copy number loss See cases [RCV000052637] Chr2:226978129..236886599 [GRCh38]
Chr2:227842845..237795242 [GRCh37]
Chr2:227551089..237459981 [NCBI36]
Chr2:2q36.3-37.3		 pathogenic
GRCh38/hg38 2q36.3-37.2(chr2:227343278-235339168)x1 copy number loss See cases [RCV000052638] Chr2:227343278..235339168 [GRCh38]
Chr2:228207994..236247812 [GRCh37]
Chr2:227916238..235912551 [NCBI36]
Chr2:2q36.3-37.2		 pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:188818195-242065208)x3 copy number gain See cases [RCV000052958] Chr2:188818195..242065208 [GRCh38]
Chr2:189682921..243007359 [GRCh37]
Chr2:189391166..242656032 [NCBI36]
Chr2:2q32.2-37.3		 pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:190310736-241892770)x3 copy number gain See cases [RCV000052959] Chr2:190310736..241892770 [GRCh38]
Chr2:191175462..242834921 [GRCh37]
Chr2:190883707..242483594 [NCBI36]
Chr2:2q32.2-37.3		 pathogenic
GRCh38/hg38 2q32.3-37.3(chr2:193122313-241074980)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]|See cases [RCV000052960] Chr2:193122313..241074980 [GRCh38]
Chr2:193987039..242014395 [GRCh37]
Chr2:193695284..241663068 [NCBI36]
Chr2:2q32.3-37.3		 pathogenic
GRCh38/hg38 2q36.1-37.3(chr2:223992431-242126245)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052972]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052972]|See cases [RCV000052972] Chr2:223992431..242126245 [GRCh38]
Chr2:224857148..243059659 [GRCh37]
Chr2:224565392..242717069 [NCBI36]
Chr2:2q36.1-37.3		 pathogenic
GRCh38/hg38 2q36.3-37.3(chr2:227803148-242086301)x3 copy number gain See cases [RCV000052973] Chr2:227803148..242086301 [GRCh38]
Chr2:228667864..243028452 [GRCh37]
Chr2:228376108..242677125 [NCBI36]
Chr2:2q36.3-37.3		 pathogenic
NM_005683.3(GPR55):c.93C>T (p.Phe31=) single nucleotide variant Malignant melanoma [RCV000065465] Chr2:230910870 [GRCh38]
Chr2:231775585 [GRCh37]
Chr2:231483829 [NCBI36]
Chr2:2q37.1		 not provided
NM_005683.4(GPR55):c.941C>T (p.Thr314Ile) single nucleotide variant Malignant tumor of prostate [RCV000149174] Chr2:230910022 [GRCh38]
Chr2:231774737 [GRCh37]
Chr2:2q37.1		 uncertain significance
GRCh37/hg19 2q36.3-37.1(chr2:230411764-232019784)x1 copy number loss not specified [RCV000515677] Chr2:230411764..232019784 [GRCh37]
Chr2:2q36.3-37.1		 uncertain significance
GRCh38/hg38 2q36.3-37.3(chr2:228723579-241404867)x3 copy number gain See cases [RCV000134169] Chr2:228723579..241404867 [GRCh38]
Chr2:229588295..242344282 [GRCh37]
Chr2:229296539..241992955 [NCBI36]
Chr2:2q36.3-37.3		 pathogenic
GRCh38/hg38 2q34-37.3(chr2:210579676-242126245)x3 copy number gain See cases [RCV000135934] Chr2:210579676..242126245 [GRCh38]
Chr2:211444400..243059659 [GRCh37]
Chr2:211152645..242717069 [NCBI36]
Chr2:2q34-37.3		 pathogenic
GRCh38/hg38 2q36.3-37.2(chr2:228014149-234976424)x3 copy number gain See cases [RCV000136967] Chr2:228014149..234976424 [GRCh38]
Chr2:228878865..235885068 [GRCh37]
Chr2:228587109..235549807 [NCBI36]
Chr2:2q36.3-37.2		 pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:189436149-241841232)x3 copy number gain See cases [RCV000142307] Chr2:189436149..241841232 [GRCh38]
Chr2:190300875..242783384 [GRCh37]
Chr2:190009120..242432057 [NCBI36]
Chr2:2q32.2-37.3		 pathogenic
GRCh38/hg38 2q35-37.3(chr2:218101759-242126245)x3 copy number gain See cases [RCV000143216] Chr2:218101759..242126245 [GRCh38]
Chr2:218966482..243059659 [GRCh37]
Chr2:218674727..242717069 [NCBI36]
Chr2:2q35-37.3		 pathogenic
NC_000002.12:g.230940164C>T single nucleotide variant Lung cancer [RCV000091949] Chr2:230940164 [GRCh38]
Chr2:231804879 [GRCh37]
Chr2:2q37.1		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q35-37.3(chr2:219966808-237815985)x3 copy number gain See cases [RCV000448049] Chr2:219966808..237815985 [GRCh37]
Chr2:2q35-37.3		 pathogenic
GRCh37/hg19 2q36.1-37.1(chr2:223378640-232061074)x1 copy number loss See cases [RCV000448773] Chr2:223378640..232061074 [GRCh37]
Chr2:2q36.1-37.1		 likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q36.1-37.3(chr2:222077224-239394441)x3 copy number gain See cases [RCV000511816] Chr2:222077224..239394441 [GRCh37]
Chr2:2q36.1-37.3		 pathogenic
GRCh37/hg19 2q34-37.3(chr2:213518431-242783384)x3 copy number gain See cases [RCV000512009] Chr2:213518431..242783384 [GRCh37]
Chr2:2q34-37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q35-37.3(chr2:219225872-242016876)x3 copy number gain not provided [RCV000682170] Chr2:219225872..242016876 [GRCh37]
Chr2:2q35-37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q34-37.3(chr2:210779657-239879183)x3 copy number gain See cases [RCV000790568] Chr2:210779657..239879183 [GRCh37]
Chr2:2q34-37.3		 pathogenic
GRCh37/hg19 2q36.3-37.3(chr2:230814690-242783384)x3 copy number gain not provided [RCV001007519] Chr2:230814690..242783384 [GRCh37]
Chr2:2q36.3-37.3		 pathogenic
NM_005683.4(GPR55):c.323G>A (p.Ser108Asn) single nucleotide variant Inborn genetic diseases [RCV003272682] Chr2:230910640 [GRCh38]
Chr2:231775355 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.307G>A (p.Val103Ile) single nucleotide variant not provided [RCV000956054] Chr2:230910656 [GRCh38]
Chr2:231775371 [GRCh37]
Chr2:2q37.1		 benign
NM_005683.4(GPR55):c.74C>T (p.Ala25Val) single nucleotide variant Inborn genetic diseases [RCV003253148] Chr2:230910889 [GRCh38]
Chr2:231775604 [GRCh37]
Chr2:2q37.1		 uncertain significance
GRCh37/hg19 2q31.2-37.3(chr2:178397959-243007457)x3 copy number gain See cases [RCV001263052] Chr2:178397959..243007457 [GRCh37]
Chr2:2q31.2-37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q36.3-37.1(chr2:229968217-231883182) copy number loss not specified [RCV002053293] Chr2:229968217..231883182 [GRCh37]
Chr2:2q36.3-37.1		 pathogenic
GRCh37/hg19 2q36.3-37.1(chr2:228807574-235475892) copy number loss not specified [RCV002053291] Chr2:228807574..235475892 [GRCh37]
Chr2:2q36.3-37.1		 pathogenic
GRCh37/hg19 2q36.1-37.1(chr2:223378640-232061074) copy number loss not specified [RCV002053287] Chr2:223378640..232061074 [GRCh37]
Chr2:2q36.1-37.1		 pathogenic
GRCh37/hg19 2q35-37.3(chr2:219606537-239217703) copy number loss not specified [RCV002053285] Chr2:219606537..239217703 [GRCh37]
Chr2:2q35-37.3		 pathogenic
NC_000002.11:g.(?_231033840)_(234978657_?)dup duplication Joubert syndrome 22 [RCV001877690]|Perlman syndrome [RCV001877689] Chr2:231033840..234978657 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.773T>C (p.Val258Ala) single nucleotide variant Inborn genetic diseases [RCV002684624] Chr2:230910190 [GRCh38]
Chr2:231774905 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.635G>A (p.Arg212Gln) single nucleotide variant Inborn genetic diseases [RCV002902097] Chr2:230910328 [GRCh38]
Chr2:231775043 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.835G>A (p.Val279Ile) single nucleotide variant Inborn genetic diseases [RCV002779457] Chr2:230910128 [GRCh38]
Chr2:231774843 [GRCh37]
Chr2:2q37.1		 likely benign
NM_005683.4(GPR55):c.655G>A (p.Val219Met) single nucleotide variant Inborn genetic diseases [RCV002951973] Chr2:230910308 [GRCh38]
Chr2:231775023 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.501G>A (p.Met167Ile) single nucleotide variant Inborn genetic diseases [RCV002998533] Chr2:230910462 [GRCh38]
Chr2:231775177 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.668C>T (p.Ala223Val) single nucleotide variant Inborn genetic diseases [RCV002984490] Chr2:230910295 [GRCh38]
Chr2:231775010 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.454G>A (p.Gly152Arg) single nucleotide variant Inborn genetic diseases [RCV002804441] Chr2:230910509 [GRCh38]
Chr2:231775224 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.761A>G (p.Asn254Ser) single nucleotide variant Inborn genetic diseases [RCV002697191] Chr2:230910202 [GRCh38]
Chr2:231774917 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.389G>T (p.Ser130Ile) single nucleotide variant Inborn genetic diseases [RCV002696480] Chr2:230910574 [GRCh38]
Chr2:231775289 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.347G>A (p.Ser116Asn) single nucleotide variant Inborn genetic diseases [RCV002719467] Chr2:230910616 [GRCh38]
Chr2:231775331 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.571C>T (p.Leu191Phe) single nucleotide variant Inborn genetic diseases [RCV002897794] Chr2:230910392 [GRCh38]
Chr2:231775107 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.908G>A (p.Arg303Gln) single nucleotide variant Inborn genetic diseases [RCV003189827] Chr2:230910055 [GRCh38]
Chr2:231774770 [GRCh37]
Chr2:2q37.1		 uncertain significance
NM_005683.4(GPR55):c.668C>G (p.Ala223Gly) single nucleotide variant Inborn genetic diseases [RCV003194149] Chr2:230910295 [GRCh38]
Chr2:231775010 [GRCh37]
Chr2:2q37.1		 uncertain significance
GRCh37/hg19 2q36.2-37.3(chr2:225995545-237594511)x3 copy number gain not provided [RCV003484091] Chr2:225995545..237594511 [GRCh37]
Chr2:2q36.2-37.3		 pathogenic
GRCh37/hg19 2q35-37.3(chr2:218376403-242783384)x3 copy number gain not provided [RCV003484087] Chr2:218376403..242783384 [GRCh37]
Chr2:2q35-37.3		 pathogenic
Single allele duplication not provided [RCV003448672] Chr2:230077026..243049549 [GRCh37]
Chr2:2q36.3-37.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2431
Count of miRNA genes:870
Interacting mature miRNAs:1026
Transcripts:ENST00000392039, ENST00000392040, ENST00000438398, ENST00000444078
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SGC38350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372231,774,399 - 231,774,685UniSTSGRCh37
Build 362231,482,643 - 231,482,929RGDNCBI36
Celera2225,550,806 - 225,551,092RGD
Cytogenetic Map2q37UniSTS
HuRef2223,616,756 - 223,617,042UniSTS
GeneMap99-GB4 RH Map2713.52UniSTS
Whitehead-RH Map21057.2UniSTS
NCBI RH Map21877.6UniSTS
L17684  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373184,258,602 - 184,258,852UniSTSGRCh37
Build 363185,741,296 - 185,741,546RGDNCBI36
Celera3182,706,463 - 182,706,713RGD
Cytogenetic Map2q37UniSTS
HuRef2223,628,873 - 223,629,736UniSTS
HuRef3181,670,181 - 181,670,431UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 3 2 1 426 5 1 88
Low 796 572 252 77 1134 20 351 215 1249 78 482 318 56 29 108 2
Below cutoff 1525 1892 1267 444 329 338 3159 1444 2150 259 741 1124 111 1110 2001 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_050956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005246952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC012507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF096786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ348259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000392039   ⟹   ENSP00000375893
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2230,909,866 - 230,961,066 (-)Ensembl
RefSeq Acc Id: ENST00000392040   ⟹   ENSP00000375894
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2230,907,328 - 230,925,226 (-)Ensembl
RefSeq Acc Id: ENST00000438398   ⟹   ENSP00000412768
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2230,910,237 - 230,925,226 (-)Ensembl
RefSeq Acc Id: ENST00000444078   ⟹   ENSP00000410267
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2230,907,318 - 230,925,226 (-)Ensembl
RefSeq Acc Id: ENST00000622008   ⟹   ENSP00000482381
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2230,907,319 - 230,925,226 (-)Ensembl
RefSeq Acc Id: ENST00000650999   ⟹   ENSP00000498258
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2230,907,328 - 230,925,242 (-)Ensembl
RefSeq Acc Id: NM_005683   ⟹   NP_005674
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,907,328 - 230,925,242 (-)NCBI
GRCh372231,772,043 - 231,789,953 (-)NCBI
Build 362231,480,287 - 231,498,185 (-)NCBI Archive
HuRef2223,614,400 - 223,632,298 (-)ENTREZGENE
CHM1_12231,777,847 - 231,795,746 (-)NCBI
T2T-CHM13v2.02231,390,497 - 231,408,407 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005246952   ⟹   XP_005247009
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,907,328 - 230,925,242 (-)NCBI
GRCh372231,772,043 - 231,789,953 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011512175   ⟹   XP_011510477
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,907,328 - 230,961,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011512176   ⟹   XP_011510478
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,907,328 - 230,927,744 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054344567   ⟹   XP_054200542
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02231,390,497 - 231,408,613 (-)NCBI
RefSeq Acc Id: XM_054344568   ⟹   XP_054200543
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02231,390,497 - 231,444,798 (-)NCBI
RefSeq Acc Id: XM_054344569   ⟹   XP_054200544
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02231,390,497 - 231,410,898 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_005674   ⟸   NM_005683
- UniProtKB: Q8N580 (UniProtKB/Swiss-Prot),   Q9Y2T6 (UniProtKB/Swiss-Prot),   A8K858 (UniProtKB/TrEMBL),   A0A024R484 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005247009   ⟸   XM_005246952
- Peptide Label: isoform X1
- UniProtKB: Q8N580 (UniProtKB/Swiss-Prot),   Q9Y2T6 (UniProtKB/Swiss-Prot),   A8K858 (UniProtKB/TrEMBL),   A0A024R484 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011510477   ⟸   XM_011512175
- Peptide Label: isoform X1
- UniProtKB: Q8N580 (UniProtKB/Swiss-Prot),   Q9Y2T6 (UniProtKB/Swiss-Prot),   A8K858 (UniProtKB/TrEMBL),   A0A024R484 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011510478   ⟸   XM_011512176
- Peptide Label: isoform X1
- UniProtKB: Q8N580 (UniProtKB/Swiss-Prot),   Q9Y2T6 (UniProtKB/Swiss-Prot),   A8K858 (UniProtKB/TrEMBL),   A0A024R484 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000412768   ⟸   ENST00000438398
RefSeq Acc Id: ENSP00000482381   ⟸   ENST00000622008
RefSeq Acc Id: ENSP00000498258   ⟸   ENST00000650999
RefSeq Acc Id: ENSP00000410267   ⟸   ENST00000444078
RefSeq Acc Id: ENSP00000375893   ⟸   ENST00000392039
RefSeq Acc Id: ENSP00000375894   ⟸   ENST00000392040
RefSeq Acc Id: XP_054200543   ⟸   XM_054344568
- Peptide Label: isoform X1
- UniProtKB: Q9Y2T6 (UniProtKB/Swiss-Prot),   Q8N580 (UniProtKB/Swiss-Prot),   A0A024R484 (UniProtKB/TrEMBL),   A8K858 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054200544   ⟸   XM_054344569
- Peptide Label: isoform X1
- UniProtKB: Q9Y2T6 (UniProtKB/Swiss-Prot),   Q8N580 (UniProtKB/Swiss-Prot),   A0A024R484 (UniProtKB/TrEMBL),   A8K858 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054200542   ⟸   XM_054344567
- Peptide Label: isoform X1
- UniProtKB: Q9Y2T6 (UniProtKB/Swiss-Prot),   Q8N580 (UniProtKB/Swiss-Prot),   A0A024R484 (UniProtKB/TrEMBL),   A8K858 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y2T6-F1-model_v2 AlphaFold Q9Y2T6 1-319 view protein structure

Promoters
RGD ID:6863052
Promoter ID:EPDNEW_H4691
Type:initiation region
Name:GPR55_1
Description:G protein-coupled receptor 55
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,925,242 - 230,925,302EPDNEW
RGD ID:6797541
Promoter ID:HG_KWN:37660
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC010FXT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362231,483,306 - 231,484,567 (-)MPROMDB
RGD ID:6797538
Promoter ID:HG_KWN:37661
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005683,   OTTHUMT00000256959
Position:
Human AssemblyChrPosition (strand)Source
Build 362231,497,846 - 231,498,897 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4511 AgrOrtholog
COSMIC GPR55 COSMIC
Ensembl Genes ENSG00000135898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000392039 ENTREZGENE
  ENST00000392039.2 UniProtKB/Swiss-Prot
  ENST00000392040.5 UniProtKB/Swiss-Prot
  ENST00000438398.1 UniProtKB/TrEMBL
  ENST00000444078.5 UniProtKB/Swiss-Prot
  ENST00000622008.4 UniProtKB/Swiss-Prot
  ENST00000650999 ENTREZGENE
  ENST00000650999.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000135898 GTEx
HGNC ID HGNC:4511 ENTREZGENE
Human Proteome Map GPR55 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 9290 ENTREZGENE
OMIM 604107 OMIM
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24232:SF56 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28900 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R484 ENTREZGENE
  A8K858 ENTREZGENE, UniProtKB/TrEMBL
  C9J1P7_HUMAN UniProtKB/TrEMBL
  GPR55_HUMAN UniProtKB/Swiss-Prot
  Q8N580 ENTREZGENE
  Q9Y2T6 ENTREZGENE
UniProt Secondary A0A024R484 UniProtKB/TrEMBL
  Q8N580 UniProtKB/Swiss-Prot