MGST3 (microsomal glutathione S-transferase 3) - Rat Genome Database

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Gene: MGST3 (microsomal glutathione S-transferase 3) Homo sapiens
Analyze
Symbol: MGST3
Name: microsomal glutathione S-transferase 3
RGD ID: 1314953
HGNC Page HGNC:7064
Description: Enables several functions, including glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in leukotriene biosynthetic process and prostanoid metabolic process. Located in mitochondrial outer membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: glutathione peroxidase MGST3; glutathione S-transferase 3, mitochondrial; GST-3; GST-III; LTC4 synthase MGST3; microsomal glutathione S-transferase III; microsomal GST-3; microsomal GST-III
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,631,234 - 165,656,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,631,213 - 165,661,796 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,600,471 - 165,625,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,867,074 - 163,891,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341162,332,107 - 162,356,511NCBI
Celera1138,705,621 - 138,730,025 (+)NCBICelera
Cytogenetic Map1q24.1NCBI
HuRef1136,847,571 - 136,872,857 (+)NCBIHuRef
CHM1_11167,022,686 - 167,047,957 (+)NCBICHM1_1
T2T-CHM13v2.01164,977,647 - 165,002,573 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
artesunate  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlordecone  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
cholic acid  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (EXP,ISO)
dinophysistoxin 1  (EXP)
diquat  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
ethoxyquin  (ISO)
fenofibrate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
genistein  (ISO)
glafenine  (ISO)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
isoflavones  (EXP)
ivermectin  (EXP)
leflunomide  (EXP,ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
nitrogen dioxide  (EXP)
okadaic acid  (EXP,ISO)
oltipraz  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (ISO)
Rebamipide  (ISO)
resveratrol  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sulfadimethoxine  (ISO)
sulindac  (ISO)
sunitinib  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:9278457   PMID:10673221   PMID:12477932   PMID:12898215   PMID:15489334   PMID:16169070   PMID:16710414   PMID:17207965   PMID:17719568   PMID:19064610   PMID:19322201  
PMID:19343046   PMID:19536175   PMID:19946888   PMID:20360068   PMID:20379614   PMID:21116278   PMID:21873635   PMID:22939629   PMID:23376485   PMID:23874603   PMID:24623722   PMID:25280473  
PMID:25416956   PMID:25737280   PMID:25959826   PMID:25963833   PMID:26496610   PMID:26638075   PMID:27184847   PMID:28514442   PMID:28515276   PMID:29180619   PMID:29568061   PMID:29615496  
PMID:30397336   PMID:31536960   PMID:31586073   PMID:31796584   PMID:31950832   PMID:31980649   PMID:31995728   PMID:32296183   PMID:32807901   PMID:33961781   PMID:34186245   PMID:34578187  
PMID:34709727   PMID:35256949   PMID:35696571   PMID:36114006   PMID:36273042   PMID:36370807   PMID:37499664   PMID:37616343   PMID:37827155   PMID:38496616  


Genomics

Comparative Map Data
MGST3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,631,234 - 165,656,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,631,213 - 165,661,796 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,600,471 - 165,625,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,867,074 - 163,891,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341162,332,107 - 162,356,511NCBI
Celera1138,705,621 - 138,730,025 (+)NCBICelera
Cytogenetic Map1q24.1NCBI
HuRef1136,847,571 - 136,872,857 (+)NCBIHuRef
CHM1_11167,022,686 - 167,047,957 (+)NCBICHM1_1
T2T-CHM13v2.01164,977,647 - 165,002,573 (+)NCBIT2T-CHM13v2.0
Mgst3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391167,199,535 - 167,221,410 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1167,199,535 - 167,221,410 (-)EnsemblGRCm39 Ensembl
GRCm381167,371,966 - 167,393,841 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1167,371,966 - 167,393,841 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,302,515 - 169,323,928 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,209,059 - 169,230,472 (-)NCBIMGSCv36mm8
Celera1169,789,931 - 169,811,361 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map174.76NCBI
Mgst3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81382,059,480 - 82,080,418 (-)NCBIGRCr8
mRatBN7.21379,526,541 - 79,547,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1379,526,541 - 79,547,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1382,156,415 - 82,177,230 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01383,463,504 - 83,484,105 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01380,701,212 - 80,722,001 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01385,601,499 - 85,622,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1385,601,499 - 85,622,314 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01390,244,188 - 90,265,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41383,038,049 - 83,058,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11383,052,236 - 83,073,033 (-)NCBI
Celera1379,231,777 - 79,252,592 (-)NCBICelera
Cytogenetic Map13q24NCBI
Mgst3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546211,024,789 - 11,031,282 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546211,024,678 - 11,041,851 (-)NCBIChiLan1.0ChiLan1.0
MGST3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2184,110,120 - 84,137,066 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1183,778,739 - 83,805,682 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01141,063,051 - 141,087,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11144,852,428 - 144,876,800 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1144,868,059 - 144,876,684 (+)Ensemblpanpan1.1panPan2
MGST3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13817,670,329 - 17,691,822 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3817,668,752 - 17,718,704 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3817,726,881 - 17,748,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03817,724,958 - 17,751,927 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3817,724,911 - 17,778,579 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13817,723,864 - 17,745,307 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03818,075,030 - 18,096,456 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03818,369,309 - 18,390,981 (-)NCBIUU_Cfam_GSD_1.0
Mgst3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344101,807,586 - 101,819,050 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648119,654,441 - 19,659,291 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648119,654,335 - 19,665,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGST3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl485,069,607 - 85,094,981 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1485,069,603 - 85,095,022 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2492,725,520 - 92,750,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MGST3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12563,227,351 - 63,252,547 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2563,224,338 - 63,252,340 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605564,986,997 - 65,012,877 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgst3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248263,969,929 - 3,987,159 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248263,969,838 - 3,987,159 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MGST3
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1 copy number loss See cases [RCV000051172] Chr1:159479887..166895086 [GRCh38]
Chr1:159449677..166864323 [GRCh37]
Chr1:157716301..165130947 [NCBI36]
Chr1:1q23.2-24.1		 pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1		 pathogenic
GRCh38/hg38 1q23.3-25.2(chr1:164922655-180061589)x3 copy number gain See cases [RCV000051856] Chr1:164922655..180061589 [GRCh38]
Chr1:164891892..180030724 [GRCh37]
Chr1:163158516..178297347 [NCBI36]
Chr1:1q23.3-25.2		 pathogenic
GRCh38/hg38 1q23.3-24.1(chr1:164547546-165689403)x1 copy number loss See cases [RCV000053213] Chr1:164547546..165689403 [GRCh38]
Chr1:164516783..165658640 [GRCh37]
Chr1:162783407..163925264 [NCBI36]
Chr1:1q23.3-24.1		 uncertain significance
GRCh38/hg38 1q23.3-24.2(chr1:160789732-168617494)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|See cases [RCV000053913] Chr1:160789732..168617494 [GRCh38]
Chr1:160759522..168586732 [GRCh37]
Chr1:159026146..166853356 [NCBI36]
Chr1:1q23.3-24.2		 pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:161740907-173965154)x1 copy number loss See cases [RCV000053914] Chr1:161740907..173965154 [GRCh38]
Chr1:161710697..173934292 [GRCh37]
Chr1:159977321..172200915 [NCBI36]
Chr1:1q23.3-25.1		 pathogenic
GRCh38/hg38 1q23.3-24.2(chr1:162040050-167480663)x1 copy number loss See cases [RCV000053915] Chr1:162040050..167480663 [GRCh38]
Chr1:162009840..167449900 [GRCh37]
Chr1:160276464..165716524 [NCBI36]
Chr1:1q23.3-24.2		 pathogenic
GRCh38/hg38 1q23.3-24.3(chr1:164036599-171252077)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053916]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053916]|See cases [RCV000053916] Chr1:164036599..171252077 [GRCh38]
Chr1:164005836..171221216 [GRCh37]
Chr1:162272460..169487840 [NCBI36]
Chr1:1q23.3-24.3		 pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:163382523-175877022)x1 copy number loss See cases [RCV000143292] Chr1:163382523..175877022 [GRCh38]
Chr1:163352313..175846158 [GRCh37]
Chr1:161618937..174112781 [NCBI36]
Chr1:1q23.3-25.1		 pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
NM_004528.4(MGST3):c.216A>C (p.Leu72Phe) single nucleotide variant not specified [RCV004296392] Chr1:165652002 [GRCh38]
Chr1:165621239 [GRCh37]
Chr1:1q24.1		 uncertain significance
GRCh37/hg19 1q23.2-25.1(chr1:160369890-175796325) copy number loss not provided [RCV000767779] Chr1:160369890..175796325 [GRCh37]
Chr1:1q23.2-25.1		 pathogenic
GRCh37/hg19 1q23.3-25.3(chr1:161676893-184071723)x1 copy number loss See cases [RCV000447098] Chr1:161676893..184071723 [GRCh37]
Chr1:1q23.3-25.3		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_004528.4(MGST3):c.287G>C (p.Gly96Ala) single nucleotide variant not specified [RCV004307899] Chr1:165654316 [GRCh38]
Chr1:165623553 [GRCh37]
Chr1:1q24.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1 copy number loss not provided [RCV000736717] Chr1:159815642..177026983 [GRCh37]
Chr1:1q23.2-25.2		 pathogenic
GRCh37/hg19 1q24.1(chr1:165599804-165600923)x0 copy number loss not provided [RCV000736721] Chr1:165599804..165600923 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q24.1(chr1:165602406-165606269)x3 copy number gain not provided [RCV000736722] Chr1:165602406..165606269 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q24.1(chr1:165602452-165604789)x1 copy number loss not provided [RCV000736723] Chr1:165602452..165604789 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q24.1(chr1:165602524-165604240)x1 copy number loss not provided [RCV000736724] Chr1:165602524..165604240 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q24.1(chr1:165602524-165604277)x1 copy number loss not provided [RCV000736725] Chr1:165602524..165604277 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q24.1(chr1:165602524-165605209)x1 copy number loss not provided [RCV000736726] Chr1:165602524..165605209 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q24.1(chr1:165603289-165604240)x1 copy number loss not provided [RCV000736727] Chr1:165603289..165604240 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q24.1(chr1:165603660-165604240)x1 copy number loss not provided [RCV000736728] Chr1:165603660..165604240 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q24.1(chr1:165603677-165604789)x1 copy number loss not provided [RCV000736729] Chr1:165603677..165604789 [GRCh37]
Chr1:1q24.1		 benign
GRCh37/hg19 1q23.3-24.2(chr1:163093021-168991239)x1 copy number loss not provided [RCV000849156] Chr1:163093021..168991239 [GRCh37]
Chr1:1q23.3-24.2		 pathogenic
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2		 pathogenic
GRCh37/hg19 1q23.3-24.2(chr1:164608682-169216098)x1 copy number loss not provided [RCV001258478] Chr1:164608682..169216098 [GRCh37]
Chr1:1q23.3-24.2		 likely pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
GRCh37/hg19 1q23.3-24.3(chr1:162330810-171532331) copy number loss not specified [RCV002053680] Chr1:162330810..171532331 [GRCh37]
Chr1:1q23.3-24.3		 pathogenic
GRCh37/hg19 1q23.2-24.1(chr1:160417296-166197042) copy number loss not specified [RCV002053658] Chr1:160417296..166197042 [GRCh37]
Chr1:1q23.2-24.1		 pathogenic
NM_004528.4(MGST3):c.176G>A (p.Arg59Gln) single nucleotide variant not specified [RCV004245744] Chr1:165651072 [GRCh38]
Chr1:165620309 [GRCh37]
Chr1:1q24.1		 uncertain significance
NM_004528.4(MGST3):c.192-423G>A single nucleotide variant Pulmonary disease, chronic obstructive, susceptibility to [RCV002508838] Chr1:165651555 [GRCh38]
Chr1:165620792 [GRCh37]
Chr1:1q24.1		 association
NM_004528.4(MGST3):c.244C>T (p.His82Tyr) single nucleotide variant not specified [RCV004200340] Chr1:165652030 [GRCh38]
Chr1:165621267 [GRCh37]
Chr1:1q24.1		 uncertain significance
NM_004528.4(MGST3):c.*282G>T single nucleotide variant Pulmonary disease, chronic obstructive, susceptibility to [RCV002508826] Chr1:165655786 [GRCh38]
Chr1:165625023 [GRCh37]
Chr1:1q24.1		 protective
NM_004528.4(MGST3):c.*58G>T single nucleotide variant Pulmonary disease, chronic obstructive, susceptibility to [RCV002508825] Chr1:165655562 [GRCh38]
Chr1:165624799 [GRCh37]
Chr1:1q24.1		 association
NM_004528.4(MGST3):c.-8+936G>A single nucleotide variant Pulmonary disease, chronic obstructive, susceptibility to [RCV002508845] Chr1:165632229 [GRCh38]
Chr1:165601466 [GRCh37]
Chr1:1q24.1		 association
NM_004528.4(MGST3):c.-7-2921C>T single nucleotide variant Pulmonary disease, chronic obstructive, susceptibility to [RCV002508846] Chr1:165646920 [GRCh38]
Chr1:165616157 [GRCh37]
Chr1:1q24.1		 association
NM_004528.4(MGST3):c.-6C>T single nucleotide variant Pulmonary disease, chronic obstructive, susceptibility to [RCV002508844] Chr1:165649842 [GRCh38]
Chr1:165619079 [GRCh37]
Chr1:1q24.1		 association
NM_004528.4(MGST3):c.253A>G (p.Ile85Val) single nucleotide variant not specified [RCV004279855] Chr1:165654282 [GRCh38]
Chr1:165623519 [GRCh37]
Chr1:1q24.1		 likely benign
NM_004528.4(MGST3):c.83A>G (p.Asn28Ser) single nucleotide variant not specified [RCV004283025] Chr1:165649930 [GRCh38]
Chr1:165619167 [GRCh37]
Chr1:1q24.1		 uncertain significance
NM_004528.4(MGST3):c.110A>G (p.Lys37Arg) single nucleotide variant not specified [RCV004349622] Chr1:165649957 [GRCh38]
Chr1:165619194 [GRCh37]
Chr1:1q24.1		 uncertain significance
NM_004528.4(MGST3):c.250C>T (p.Arg84Cys) single nucleotide variant not specified [RCV004365009] Chr1:165654279 [GRCh38]
Chr1:165623516 [GRCh37]
Chr1:1q24.1		 uncertain significance
GRCh37/hg19 1q23.3-25.1(chr1:164571371-175708060)x1 copy number loss not provided [RCV003483966] Chr1:164571371..175708060 [GRCh37]
Chr1:1q23.3-25.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1686
Count of miRNA genes:799
Interacting mature miRNAs:908
Transcripts:ENST00000367883, ENST00000367884, ENST00000367885, ENST00000367886, ENST00000367888, ENST00000367889, ENST00000460632, ENST00000461308, ENST00000461759, ENST00000477450, ENST00000488688, ENST00000494074, ENST00000495447, ENST00000609263
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human
407202100GWAS851076_Hleukocyte count QTL GWAS851076 (human)3e-20leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)1165652909165652910Human
407195924GWAS844900_Hasparagine measurement QTL GWAS844900 (human)0.00001asparagine measurementblood amino acid measurement (CMO:0003730)1165645791165645792Human
407206054GWAS855030_Hneutrophil count QTL GWAS855030 (human)5e-10neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)1165652909165652910Human
407030652GWAS679628_Hbrain volume measurement QTL GWAS679628 (human)0.000007brain volume measurementbrain morphological measurement (CMO:0000136)1165647351165647352Human
407203690GWAS852666_Hleukocyte count QTL GWAS852666 (human)4e-08leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)1165652909165652910Human

Markers in Region
SHGC-89234  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,616,317 - 165,616,587UniSTSGRCh37
Build 361163,882,941 - 163,883,211RGDNCBI36
Celera1138,721,489 - 138,721,759RGD
Cytogenetic Map1q23UniSTS
HuRef1136,863,797 - 136,864,067UniSTS
TNG Radiation Hybrid Map174992.0UniSTS
STS-AA027186  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,622,501 - 165,622,680UniSTSGRCh37
Build 361163,889,125 - 163,889,304RGDNCBI36
Celera1138,727,674 - 138,727,853RGD
Cytogenetic Map1q23UniSTS
HuRef1136,869,990 - 136,870,169UniSTS
GeneMap99-GB4 RH Map1590.86UniSTS
NCBI RH Map11446.5UniSTS
RH41830  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,620,276 - 165,620,446UniSTSGRCh37
Build 361163,886,900 - 163,887,070RGDNCBI36
Celera1138,725,448 - 138,725,618RGD
Cytogenetic Map1q23UniSTS
HuRef1136,867,756 - 136,867,926UniSTS
GeneMap99-GB4 RH Map1599.31UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005245174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047421030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054336666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054336667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF026977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI591182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL356441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL451074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY388493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI666647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR450359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ185045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000367883   ⟹   ENSP00000356858
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,632,063 - 165,655,620 (+)Ensembl
Ensembl Acc Id: ENST00000367884   ⟹   ENSP00000356859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,631,255 - 165,655,620 (+)Ensembl
Ensembl Acc Id: ENST00000367885   ⟹   ENSP00000356860
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,631,240 - 165,655,620 (+)Ensembl
Ensembl Acc Id: ENST00000367888   ⟹   ENSP00000356863
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,631,213 - 165,661,796 (+)Ensembl
Ensembl Acc Id: ENST00000367889   ⟹   ENSP00000356864
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,631,234 - 165,656,136 (+)Ensembl
Ensembl Acc Id: ENST00000460632
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,631,237 - 165,637,149 (+)Ensembl
Ensembl Acc Id: ENST00000461308
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,631,226 - 165,650,774 (+)Ensembl
Ensembl Acc Id: ENST00000461759
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,645,661 - 165,648,670 (+)Ensembl
Ensembl Acc Id: ENST00000477450
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,649,838 - 165,653,801 (+)Ensembl
Ensembl Acc Id: ENST00000488688
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,631,258 - 165,651,594 (+)Ensembl
Ensembl Acc Id: ENST00000494074
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,653,833 - 165,655,620 (+)Ensembl
Ensembl Acc Id: ENST00000495447
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,631,239 - 165,655,617 (+)Ensembl
Ensembl Acc Id: ENST00000609263
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,648,792 - 165,651,892 (+)Ensembl
Ensembl Acc Id: ENST00000627653   ⟹   ENSP00000487151
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,632,240 - 165,656,133 (+)Ensembl
RefSeq Acc Id: NM_004528   ⟹   NP_004519
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,631,234 - 165,656,136 (+)NCBI
GRCh371165,600,110 - 165,625,373 (+)ENTREZGENE
GRCh371165,600,110 - 165,625,373 (+)NCBI
Build 361163,867,074 - 163,891,481 (+)NCBI Archive
Celera1138,705,621 - 138,730,025 (+)RGD
HuRef1136,847,571 - 136,872,857 (+)ENTREZGENE
CHM1_11167,022,686 - 167,047,957 (+)NCBI
T2T-CHM13v2.01164,977,647 - 165,002,573 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047421030   ⟹   XP_047276986
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,631,234 - 165,656,136 (+)NCBI
RefSeq Acc Id: XM_054336666   ⟹   XP_054192641
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01164,977,647 - 165,002,573 (+)NCBI
RefSeq Acc Id: XM_054336667   ⟹   XP_054192642
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01164,977,700 - 165,002,573 (+)NCBI
RefSeq Acc Id: NP_004519   ⟸   NM_004528
- UniProtKB: B2R592 (UniProtKB/Swiss-Prot),   Q6ICN4 (UniProtKB/Swiss-Prot),   O14880 (UniProtKB/Swiss-Prot),   Q53GB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000487151   ⟸   ENST00000627653
Ensembl Acc Id: ENSP00000356858   ⟸   ENST00000367883
Ensembl Acc Id: ENSP00000356860   ⟸   ENST00000367885
Ensembl Acc Id: ENSP00000356859   ⟸   ENST00000367884
Ensembl Acc Id: ENSP00000356864   ⟸   ENST00000367889
Ensembl Acc Id: ENSP00000356863   ⟸   ENST00000367888
RefSeq Acc Id: XP_047276986   ⟸   XM_047421030
- Peptide Label: isoform X1
- UniProtKB: Q53GB9 (UniProtKB/TrEMBL),   Q5VV89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054192641   ⟸   XM_054336666
- Peptide Label: isoform X1
- UniProtKB: Q53GB9 (UniProtKB/TrEMBL),   Q5VV89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054192642   ⟸   XM_054336667
- Peptide Label: isoform X1
- UniProtKB: Q53GB9 (UniProtKB/TrEMBL),   Q5VV89 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O14880-F1-model_v2 AlphaFold O14880 1-152 view protein structure

Promoters
RGD ID:6786032
Promoter ID:HG_KWN:5974
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000367884,   ENST00000367885,   ENST00000404549,   OTTHUMT00000083797,   OTTHUMT00000083874,   OTTHUMT00000083877,   OTTHUMT00000083878,   OTTHUMT00000083879,   OTTHUMT00000083880
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,866,596 - 163,867,096 (+)MPROMDB
RGD ID:6785256
Promoter ID:HG_KWN:5975
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000367883,   ENST00000367886
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,867,549 - 163,868,049 (+)MPROMDB
RGD ID:6786030
Promoter ID:HG_KWN:5976
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000083784
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,881,689 - 163,882,189 (+)MPROMDB
RGD ID:6857970
Promoter ID:EPDNEW_H2150
Type:initiation region
Name:MGST3_2
Description:microsomal glutathione S-transferase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2151  EPDNEW_H2152  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,630,861 - 165,630,921EPDNEW
RGD ID:6857972
Promoter ID:EPDNEW_H2151
Type:initiation region
Name:MGST3_1
Description:microsomal glutathione S-transferase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2150  EPDNEW_H2152  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,631,263 - 165,631,323EPDNEW
RGD ID:6857974
Promoter ID:EPDNEW_H2152
Type:multiple initiation site
Name:MGST3_3
Description:microsomal glutathione S-transferase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2150  EPDNEW_H2151  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,649,813 - 165,649,873EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7064 AgrOrtholog
COSMIC MGST3 COSMIC
Ensembl Genes ENSG00000143198 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000367883.3 UniProtKB/TrEMBL
  ENST00000367884.6 UniProtKB/Swiss-Prot
  ENST00000367885 ENTREZGENE
  ENST00000367885.5 UniProtKB/TrEMBL
  ENST00000367888.8 UniProtKB/TrEMBL
  ENST00000367889 ENTREZGENE
  ENST00000367889.8 UniProtKB/Swiss-Prot
  ENST00000627653.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000143198 GTEx
HGNC ID HGNC:7064 ENTREZGENE
Human Proteome Map MGST3 Human Proteome Map
InterPro MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPEG-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4259 UniProtKB/Swiss-Prot
NCBI Gene 4259 ENTREZGENE
OMIM 604564 OMIM
PANTHER MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MICROSOMAL GLUTATHIONE S-TRANSFERASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30793 PharmGKB
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R592 ENTREZGENE
  MGST3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53GB9 ENTREZGENE, UniProtKB/TrEMBL
  Q5VV87_HUMAN UniProtKB/TrEMBL
  Q5VV89 ENTREZGENE, UniProtKB/TrEMBL
  Q6ICN4 ENTREZGENE
UniProt Secondary B2R592 UniProtKB/Swiss-Prot
  Q6ICN4 UniProtKB/Swiss-Prot