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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:33101
Term: nitrogen dioxide
Definition: A nitrogen oxide that has formula NO2.
Chemical ID: MESH:D009585
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1decreases expressionEXP 6480464CTDNitrogen Dioxide results in decreased expression of SOD1 proteinPMID:18629312
SOD1multiple interactionsEXP 6480464CTD[[SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites] which results in increased chemical synthesis of Nitrogen DioxidePMID:19243126
SOD1decreases activityISOSod1 (Rattus norvegicus)6480464CTDNitrogen Dioxide results in decreased activity of SOD1 proteinPMID:22621880
SOD1increases expressionISOSod1 (Rattus norvegicus)6480464CTDNitrogen Dioxide results in increased expression of SOD1 mRNAPMID:15336314
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