HOXA5 (homeobox A5) - Rat Genome Database

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Gene: HOXA5 (homeobox A5) Homo sapiens
Analyze
Symbol: HOXA5
Name: homeobox A5
RGD ID: 734224
HGNC Page HGNC
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; positive regulation of macromolecule metabolic process; and regulation of myeloid cell differentiation. Located in nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: homeo box 1C; homeo box A5; homeobox protein Hox-1C; homeobox protein Hox-A5; homeobox protein HOXA5; HOX1; HOX1.3; HOX1C; MGC9376
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl727,141,052 - 27,143,681 (-)EnsemblGRCh38hg38GRCh38
GRCh38727,141,052 - 27,143,681 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37727,180,671 - 27,183,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36727,147,521 - 27,149,812 (-)NCBINCBI36hg18NCBI36
Build 34726,954,235 - 26,956,527NCBI
Celera727,169,928 - 27,172,220 (-)NCBI
Cytogenetic Map7p15.2NCBI
HuRef727,061,238 - 27,063,851 (-)NCBIHuRef
CHM1_1727,180,379 - 27,182,993 (-)NCBICHM1_1
CRA_TCAGchr7v2727,231,823 - 27,234,436 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IBA,ISO)
bronchiole development  (IEA,ISO)
cartilage morphogenesis  (ISO)
cell migration  (IEA,ISO)
cell-cell signaling involved in mammary gland development  (IEA,ISO)
embryonic skeletal system development  (ISO)
embryonic skeletal system morphogenesis  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
intestinal epithelial cell maturation  (IEA,ISO)
lobar bronchus epithelium development  (ISO)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
lung goblet cell differentiation  (IEA,ISO)
lung-associated mesenchyme development  (IEA,ISO)
mammary gland alveolus development  (IEA,ISO)
mammary gland epithelial cell differentiation  (IEA,ISO)
mesenchymal-epithelial cell signaling  (IEA,ISO)
morphogenesis of an epithelium  (ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of angiogenesis  (IMP)
negative regulation of erythrocyte differentiation  (IDA)
pattern specification process  (ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of myeloid cell differentiation  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
regulation of mammary gland epithelial cell proliferation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
respiratory gaseous exchange by respiratory system  (ISO)
respiratory system process  (IEA,ISO)
skeletal system development  (ISO)
thyroid gland development  (IEA,ISO)
trachea cartilage morphogenesis  (IEA,ISO)
trachea morphogenesis  (ISO)

Cellular Component
chromatin  (ISA)
nucleus  (IBA,IDA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:1358459   PMID:1973146   PMID:2568583   PMID:2576652   PMID:8570656   PMID:8646877   PMID:8657138   PMID:9457903   PMID:10397719   PMID:10737800   PMID:10875927   PMID:10879542  
PMID:11238043   PMID:11857506   PMID:12163409   PMID:12477932   PMID:12642491   PMID:12690205   PMID:12853948   PMID:14701762   PMID:15489334   PMID:15545268   PMID:15617687   PMID:15684390  
PMID:15757903   PMID:16379594   PMID:16756717   PMID:17167183   PMID:17785556   PMID:17804711   PMID:17957028   PMID:18538349   PMID:19274049   PMID:19322201   PMID:19453261   PMID:19554572  
PMID:19938081   PMID:20211142   PMID:20846263   PMID:20890077   PMID:21311178   PMID:21532573   PMID:21546695   PMID:21873635   PMID:22227861   PMID:22464764   PMID:22876840   PMID:23136161  
PMID:23455924   PMID:24952347   PMID:24981860   PMID:25544563   PMID:25549794   PMID:25585874   PMID:25875824   PMID:25979369   PMID:25987065   PMID:26186194   PMID:26219418   PMID:26397212  
PMID:26678341   PMID:26846409   PMID:27052693   PMID:27157614   PMID:27418136   PMID:27960137   PMID:28338293   PMID:28423732   PMID:28473536   PMID:28482119   PMID:28514442   PMID:28833816  
PMID:29174371   PMID:29229926   PMID:29412790   PMID:29532406   PMID:29632085   PMID:29844126   PMID:30015922   PMID:30046127   PMID:30201235   PMID:30267809   PMID:30483748   PMID:30521886  
PMID:30833792   PMID:31159758   PMID:31732746   PMID:31779094   PMID:31959759   PMID:32296183   PMID:32499530   PMID:32675397   PMID:32814053   PMID:33547267   PMID:34079125   PMID:34362486  


Genomics

Comparative Map Data
HOXA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl727,141,052 - 27,143,681 (-)EnsemblGRCh38hg38GRCh38
GRCh38727,141,052 - 27,143,681 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37727,180,671 - 27,183,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36727,147,521 - 27,149,812 (-)NCBINCBI36hg18NCBI36
Build 34726,954,235 - 26,956,527NCBI
Celera727,169,928 - 27,172,220 (-)NCBI
Cytogenetic Map7p15.2NCBI
HuRef727,061,238 - 27,063,851 (-)NCBIHuRef
CHM1_1727,180,379 - 27,182,993 (-)NCBICHM1_1
CRA_TCAGchr7v2727,231,823 - 27,234,436 (-)NCBI
Hoxa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39652,178,734 - 52,181,567 (-)NCBIGRCm39mm39
GRCm39 Ensembl652,178,734 - 52,181,567 (-)Ensembl
GRCm38652,201,754 - 52,204,587 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl652,201,754 - 52,204,587 (-)EnsemblGRCm38mm10GRCm38
MGSCv37652,151,753 - 52,154,586 (-)NCBIGRCm37mm9NCBIm37
MGSCv36652,131,337 - 52,134,170 (-)NCBImm8
Celera652,723,406 - 52,726,239 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map625.4NCBI
Hoxa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2481,302,341 - 81,306,234 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl481,302,353 - 81,306,234 (-)Ensembl
Rnor_6.0482,170,383 - 82,174,788 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl482,170,387 - 82,173,207 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.04146,837,214 - 146,841,619 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4480,501,675 - 80,504,626 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1480,779,823 - 80,781,740 (-)NCBI
Celera476,192,532 - 76,196,931 (-)NCBICelera
Cytogenetic Map4q24NCBI
Hoxa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541028,834,127 - 28,838,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541028,835,795 - 28,838,244 (-)NCBIChiLan1.0ChiLan1.0
HOXA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1727,385,175 - 27,388,990 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl727,385,175 - 27,388,990 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0727,786,040 - 27,789,339 (-)NCBIMhudiblu_PPA_v0panPan3
HOXA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11440,315,409 - 40,319,001 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1440,315,639 - 40,317,768 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1439,746,469 - 39,750,543 (-)NCBI
ROS_Cfam_1.01440,253,687 - 40,258,302 (-)NCBI
UMICH_Zoey_3.11440,368,242 - 40,372,352 (-)NCBI
UNSW_CanFamBas_1.01440,053,309 - 40,057,416 (-)NCBI
UU_Cfam_GSD_1.01440,411,943 - 40,416,018 (-)NCBI
Hoxa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511884,557,026 - 84,560,322 (-)NCBI
SpeTri2.0NW_0049364783,768,757 - 3,771,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOXA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1845,421,663 - 45,432,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11845,429,691 - 45,432,723 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21850,062,880 - 50,065,910 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HOXA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12131,224,017 - 31,227,819 (+)NCBI
ChlSab1.1 Ensembl2131,224,977 - 31,227,994 (+)Ensembl
Vero_WHO_p1.0NW_02366604273,506,435 - 73,509,813 (-)NCBI
Hoxa5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247393,461,779 - 3,464,543 (+)NCBI

Position Markers
ECD01324  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,180,775 - 27,181,644UniSTSGRCh37
Build 36727,147,300 - 27,148,169RGDNCBI36
Celera727,169,707 - 27,170,577RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,061,339 - 27,062,208UniSTS
CRA_TCAGchr7v2727,231,924 - 27,232,793UniSTS
ECD02396  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,182,632 - 27,183,463UniSTSGRCh37
Build 36727,149,157 - 27,149,988RGDNCBI36
Celera727,171,565 - 27,172,396RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,063,196 - 27,064,027UniSTS
CRA_TCAGchr7v2727,233,781 - 27,234,612UniSTS
ECD02852  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,181,692 - 27,182,507UniSTSGRCh37
Build 36727,148,217 - 27,149,032RGDNCBI36
Celera727,170,625 - 27,171,440RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,062,256 - 27,063,071UniSTS
CRA_TCAGchr7v2727,232,841 - 27,233,656UniSTS
ECD04652  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,184,307 - 27,185,065UniSTSGRCh37
Build 36727,150,832 - 27,151,590RGDNCBI36
Celera727,173,240 - 27,173,998RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,064,690 - 27,065,448UniSTS
CRA_TCAGchr7v2727,235,456 - 27,236,214UniSTS
ECD09662  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,183,592 - 27,184,215UniSTSGRCh37
Build 36727,150,117 - 27,150,740RGDNCBI36
Celera727,172,525 - 27,173,148RGD
Cytogenetic Map7p15.2UniSTS
CRA_TCAGchr7v2727,234,741 - 27,235,364UniSTS
REN100510  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,180,562 - 27,180,801UniSTSGRCh37
Build 36727,147,087 - 27,147,326RGDNCBI36
Celera727,169,497 - 27,169,733RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,061,129 - 27,061,365UniSTS
CRA_TCAGchr7v2727,231,714 - 27,231,950UniSTS
REN100511  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,180,781 - 27,181,051UniSTSGRCh37
Build 36727,147,306 - 27,147,576RGDNCBI36
Celera727,169,713 - 27,169,983RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,061,345 - 27,061,615UniSTS
CRA_TCAGchr7v2727,231,930 - 27,232,200UniSTS
REN100512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,181,037 - 27,181,274UniSTSGRCh37
Build 36727,147,562 - 27,147,799RGDNCBI36
Celera727,169,969 - 27,170,207RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,061,601 - 27,061,838UniSTS
CRA_TCAGchr7v2727,232,186 - 27,232,423UniSTS
REN100513  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,181,251 - 27,181,510UniSTSGRCh37
Build 36727,147,776 - 27,148,035RGDNCBI36
Celera727,170,184 - 27,170,443RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,061,815 - 27,062,074UniSTS
CRA_TCAGchr7v2727,232,400 - 27,232,659UniSTS
REN100514  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,181,484 - 27,181,733UniSTSGRCh37
Build 36727,148,009 - 27,148,258RGDNCBI36
Celera727,170,417 - 27,170,666RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,062,048 - 27,062,297UniSTS
CRA_TCAGchr7v2727,232,633 - 27,232,882UniSTS
REN100519  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,182,558 - 27,182,824UniSTSGRCh37
Build 36727,149,083 - 27,149,349RGDNCBI36
Celera727,171,491 - 27,171,757RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,063,122 - 27,063,388UniSTS
CRA_TCAGchr7v2727,233,707 - 27,233,973UniSTS
REN100520  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,182,692 - 27,182,946UniSTSGRCh37
Build 36727,149,217 - 27,149,471RGDNCBI36
Celera727,171,625 - 27,171,879RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,063,256 - 27,063,510UniSTS
CRA_TCAGchr7v2727,233,841 - 27,234,095UniSTS
REN100521  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,182,935 - 27,183,179UniSTSGRCh37
Build 36727,149,460 - 27,149,704RGDNCBI36
Celera727,171,868 - 27,172,112RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,063,499 - 27,063,743UniSTS
CRA_TCAGchr7v2727,234,084 - 27,234,328UniSTS
REN100522  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,183,134 - 27,183,380UniSTSGRCh37
Build 36727,149,659 - 27,149,905RGDNCBI36
Celera727,172,067 - 27,172,313RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,063,698 - 27,063,944UniSTS
CRA_TCAGchr7v2727,234,283 - 27,234,529UniSTS
REN100523  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,183,234 - 27,183,463UniSTSGRCh37
Build 36727,149,759 - 27,149,988RGDNCBI36
Celera727,172,167 - 27,172,396RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,063,798 - 27,064,027UniSTS
CRA_TCAGchr7v2727,234,383 - 27,234,612UniSTS
REN100524  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,183,441 - 27,183,681UniSTSGRCh37
Build 36727,149,966 - 27,150,206RGDNCBI36
Celera727,172,374 - 27,172,614RGD
Cytogenetic Map7p15.2UniSTS
CRA_TCAGchr7v2727,234,590 - 27,234,830UniSTS
REN100525  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,183,658 - 27,183,895UniSTSGRCh37
Build 36727,150,183 - 27,150,420RGDNCBI36
Celera727,172,591 - 27,172,828RGD
Cytogenetic Map7p15.2UniSTS
CRA_TCAGchr7v2727,234,807 - 27,235,044UniSTS
REN100526  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,183,883 - 27,184,132UniSTSGRCh37
Build 36727,150,408 - 27,150,657RGDNCBI36
Celera727,172,816 - 27,173,065RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,064,266 - 27,064,515UniSTS
CRA_TCAGchr7v2727,235,032 - 27,235,281UniSTS
REN100527  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,184,107 - 27,184,375UniSTSGRCh37
Build 36727,150,632 - 27,150,900RGDNCBI36
Celera727,173,040 - 27,173,308RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,064,490 - 27,064,758UniSTS
CRA_TCAGchr7v2727,235,256 - 27,235,524UniSTS
REN100528  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,184,370 - 27,184,612UniSTSGRCh37
Build 36727,150,895 - 27,151,137RGDNCBI36
Celera727,173,303 - 27,173,545RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,064,753 - 27,064,995UniSTS
CRA_TCAGchr7v2727,235,519 - 27,235,761UniSTS
REN100529  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,184,584 - 27,184,821UniSTSGRCh37
Build 36727,151,109 - 27,151,346RGDNCBI36
Celera727,173,517 - 27,173,754RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,064,967 - 27,065,204UniSTS
CRA_TCAGchr7v2727,235,733 - 27,235,970UniSTS
REN100530  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,184,798 - 27,185,030UniSTSGRCh37
Build 36727,151,323 - 27,151,555RGDNCBI36
Celera727,173,731 - 27,173,963RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,065,181 - 27,065,413UniSTS
CRA_TCAGchr7v2727,235,947 - 27,236,179UniSTS
REN100531  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,184,997 - 27,185,250UniSTSGRCh37
Build 36727,151,522 - 27,151,775RGDNCBI36
Celera727,173,930 - 27,174,184RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,065,380 - 27,065,638UniSTS
CRA_TCAGchr7v2727,236,146 - 27,236,399UniSTS
UniSTS:57649  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,181,035 - 27,181,360UniSTSGRCh37
Build 36727,147,560 - 27,147,885RGDNCBI36
Celera727,169,967 - 27,170,293RGD
HuRef727,061,599 - 27,061,924UniSTS
CRA_TCAGchr7v2727,232,184 - 27,232,509UniSTS
MARC_6217-6218:992007117:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,180,894 - 27,181,124UniSTSGRCh37
Build 36727,147,419 - 27,147,649RGDNCBI36
Celera727,169,826 - 27,170,056RGD
HuRef727,061,458 - 27,061,688UniSTS
CRA_TCAGchr7v2727,232,043 - 27,232,273UniSTS
Hoxa5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,181,475 - 27,181,625UniSTSGRCh37
Build 36727,148,000 - 27,148,150RGDNCBI36
Celera727,170,408 - 27,170,558RGD
HuRef727,062,039 - 27,062,189UniSTS
CRA_TCAGchr7v2727,232,624 - 27,232,774UniSTS
stSG609349  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,180,860 - 27,181,073UniSTSGRCh37
Build 36727,147,385 - 27,147,598RGDNCBI36
Celera727,169,792 - 27,170,005RGD
Cytogenetic Map7p15.2UniSTS
HuRef727,061,424 - 27,061,637UniSTS
CRA_TCAGchr7v2727,232,009 - 27,232,222UniSTS
HOXA5_3307  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37727,180,813 - 27,181,634UniSTSGRCh37
Build 36727,147,338 - 27,148,159RGDNCBI36
Celera727,169,745 - 27,170,567RGD
HuRef727,061,377 - 27,062,198UniSTS
CRA_TCAGchr7v2727,231,962 - 27,232,783UniSTS
HOX1  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7p15.2UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR19Ahsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI14697198
MIR19Ahsa-miR-19a-3pMirtarbaseexternal_infoReporter assay;OtherNon-Functional MTI21271217
MIR196A1hsa-miR-196a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22876840
MIR196A1hsa-miR-196a-5pOncomiRDBexternal_infoNANA22876840
MIR196A2hsa-miR-196a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22876840
MIR196A2hsa-miR-196a-5pOncomiRDBexternal_infoNANA22876840
MIR130Ahsa-miR-130a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI17957028
MIR130Ahsa-miR-130a-5pMirecordsexternal_infoNANA17957028

Predicted Target Of
Summary Value
Count of predictions:600
Count of miRNA genes:397
Interacting mature miRNAs:452
Transcripts:ENST00000222726, ENST00000520854
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1
Medium 1957 514 283 16 270 18 2037 854 763 355 587 724 1 693 1327
Low 467 780 917 216 581 216 2146 902 164 60 805 839 8 511 1459 1
Below cutoff 7 1534 470 365 798 225 67 375 1621 2 63 36 141 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000222726   ⟹   ENSP00000222726
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl727,141,052 - 27,143,681 (-)Ensembl
RefSeq Acc Id: ENST00000520854
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl727,141,807 - 27,142,775 (-)Ensembl
RefSeq Acc Id: NM_019102   ⟹   NP_061975
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38727,141,052 - 27,143,681 (-)NCBI
GRCh37727,180,671 - 27,192,309 (-)NCBI
Build 36727,147,521 - 27,149,812 (-)NCBI Archive
HuRef727,061,238 - 27,063,851 (-)ENTREZGENE
CHM1_1727,180,379 - 27,182,993 (-)NCBI
CRA_TCAGchr7v2727,231,823 - 27,234,436 (-)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061975   ⟸   NM_019102
- UniProtKB: P20719 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000222726   ⟸   ENST00000222726
Protein Domains
Homeobox

Promoters
RGD ID:7210169
Promoter ID:EPDNEW_H10830
Type:initiation region
Name:HOXA5_4
Description:homeobox A5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10832  EPDNEW_H10831  EPDNEW_H10835  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38727,143,142 - 27,143,202EPDNEW
RGD ID:7210173
Promoter ID:EPDNEW_H10831
Type:initiation region
Name:HOXA5_3
Description:homeobox A5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10830  EPDNEW_H10832  EPDNEW_H10835  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38727,143,397 - 27,143,457EPDNEW
RGD ID:7210171
Promoter ID:EPDNEW_H10832
Type:initiation region
Name:HOXA5_2
Description:homeobox A5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10830  EPDNEW_H10831  EPDNEW_H10835  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38727,143,681 - 27,143,741EPDNEW
RGD ID:6805775
Promoter ID:HG_KWN:56675
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000059535,   OTTHUMT00000134420
Position:
Human AssemblyChrPosition (strand)Source
Build 36727,149,246 - 27,149,746 (-)MPROMDB
RGD ID:7210179
Promoter ID:EPDNEW_H10835
Type:initiation region
Name:HOXA5_1
Description:homeobox A5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10830  EPDNEW_H10832  EPDNEW_H10831  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38727,152,581 - 27,152,641EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p15.2-14.3(chr7:25511691-30421133)x1 copy number loss See cases [RCV000052310] Chr7:25511691..30421133 [GRCh38]
Chr7:25551310..30460749 [GRCh37]
Chr7:25517835..30427274 [NCBI36]
Chr7:7p15.2-14.3
pathogenic
GRCh38/hg38 7p15.2(chr7:27107301-27314586)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053436]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053436]|See cases [RCV000053436] Chr7:27107301..27314586 [GRCh38]
Chr7:27146920..27354205 [GRCh37]
Chr7:27113445..27320730 [NCBI36]
Chr7:7p15.2
uncertain significance
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3 copy number gain See cases [RCV000053530] Chr7:54185..37089712 [GRCh38]
Chr7:54185..37129317 [GRCh37]
Chr7:149268..37095842 [NCBI36]
Chr7:7p22.3-14.2
pathogenic
NM_019102.3(HOXA5):c.563-53C>T single nucleotide variant Lung cancer [RCV000105979] Chr7:27142138 [GRCh38]
Chr7:27181757 [GRCh37]
Chr7:7p15.2
uncertain significance
GRCh38/hg38 7p21.1-15.2(chr7:20210912-27849400)x1 copy number loss See cases [RCV000134333] Chr7:20210912..27849400 [GRCh38]
Chr7:20250535..27889019 [GRCh37]
Chr7:20217060..27855544 [NCBI36]
Chr7:7p21.1-15.2
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p21.1-14.3(chr7:20561456-32005143)x1 copy number loss See cases [RCV000136775] Chr7:20561456..32005143 [GRCh38]
Chr7:20601079..32044755 [GRCh37]
Chr7:20567604..32011280 [NCBI36]
Chr7:7p21.1-14.3
pathogenic
GRCh38/hg38 7p22.1-15.2(chr7:5682209-27230311)x3 copy number gain See cases [RCV000136649] Chr7:5682209..27230311 [GRCh38]
Chr7:5721840..27269930 [GRCh37]
Chr7:5688366..27236455 [NCBI36]
Chr7:7p22.1-15.2
pathogenic
GRCh38/hg38 7p22.3-15.2(chr7:1698124-27207295)x3 copy number gain See cases [RCV000143060] Chr7:1698124..27207295 [GRCh38]
Chr7:1737760..27246914 [GRCh37]
Chr7:1704286..27213439 [NCBI36]
Chr7:7p22.3-15.2
pathogenic
GRCh38/hg38 7p22.3-15.2(chr7:43360-27196404)x3 copy number gain See cases [RCV000143586] Chr7:43360..27196404 [GRCh38]
Chr7:43360..27236023 [GRCh37]
Chr7:138443..27202548 [NCBI36]
Chr7:7p22.3-15.2
pathogenic
GRCh37/hg19 7p15.3-14.3(chr7:22935369-32621975)x1 copy number loss See cases [RCV000240125] Chr7:22935369..32621975 [GRCh37]
Chr7:7p15.3-14.3
pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p21.3-14.2(chr7:11562624-36395416)x3 copy number gain See cases [RCV000446478] Chr7:11562624..36395416 [GRCh37]
Chr7:7p21.3-14.2
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p15.3-15.2(chr7:25448425-27578387)x3 copy number gain See cases [RCV000447735] Chr7:25448425..27578387 [GRCh37]
Chr7:7p15.3-15.2
likely pathogenic
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 copy number gain See cases [RCV000512091] Chr7:11048840..52863626 [GRCh37]
Chr7:7p21.3-12.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-14.3(chr7:704573-29257946)x3 copy number gain See cases [RCV000510275] Chr7:704573..29257946 [GRCh37]
Chr7:7p22.3-14.3
pathogenic
GRCh37/hg19 7p15.3-14.3(chr7:24344104-28879357)x1 copy number loss See cases [RCV000510695] Chr7:24344104..28879357 [GRCh37]
Chr7:7p15.3-14.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Speech-language disorder 1 [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p15.2(chr7:27026872-27322106)x3 copy number gain not provided [RCV000746569] Chr7:27026872..27322106 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p15.2(chr7:27065705-27286796)x1 copy number loss not provided [RCV000746570] Chr7:27065705..27286796 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p15.2(chr7:27089764-27322106)x3 copy number gain not provided [RCV000746571] Chr7:27089764..27322106 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p15.2(chr7:27118974-27264337)x3 copy number gain not provided [RCV000746572] Chr7:27118974..27264337 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p15.2(chr7:27118974-27286796)x3 copy number gain not provided [RCV000746573] Chr7:27118974..27286796 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p15.2(chr7:27123880-27286796)x1 copy number loss not provided [RCV000746574] Chr7:27123880..27286796 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p15.2(chr7:27130276-27286796)x3 copy number gain not provided [RCV000746575] Chr7:27130276..27286796 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p15.2(chr7:27135314-27264337)x3 copy number gain not provided [RCV000746576] Chr7:27135314..27264337 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p15.2(chr7:27135314-27286796)x3 copy number gain not provided [RCV000746577] Chr7:27135314..27286796 [GRCh37]
Chr7:7p15.2
benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p15.3-14.3(chr7:23877135-33139446)x1 copy number loss not provided [RCV001005924] Chr7:23877135..33139446 [GRCh37]
Chr7:7p15.3-14.3
pathogenic
NC_000007.13:g.23236782_30690453del7453672 deletion Silver Russell Syndrome-related disorder [RCV000785664] Chr7:23236782..30690453 [GRCh37]
Chr7:7p15.3-14.3
pathogenic
NM_019102.4(HOXA5):c.81T>C (p.His27=) single nucleotide variant not provided [RCV000954264] Chr7:27143527 [GRCh38]
Chr7:27183146 [GRCh37]
Chr7:7p15.2
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5106 AgrOrtholog
COSMIC HOXA5 COSMIC
Ensembl Genes ENSG00000106004 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000222726 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000222726 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000106004 GTEx
HGNC ID HGNC:5106 ENTREZGENE
Human Proteome Map HOXA5 Human Proteome Map
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_antennapedia UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_Antennapedia_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3202 UniProtKB/Swiss-Prot
NCBI Gene 3202 ENTREZGENE
OMIM 142952 OMIM
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29383 PharmGKB
PRINTS ANTENNAPEDIA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANTENNAPEDIA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HXA5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6FG31_HUMAN UniProtKB/TrEMBL
UniProt Secondary A4D179 UniProtKB/Swiss-Prot
  O43367 UniProtKB/Swiss-Prot
  Q96CY6 UniProtKB/Swiss-Prot