CCL11 (C-C motif chemokine ligand 11) - Rat Genome Database

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Gene: CCL11 (C-C motif chemokine ligand 11) Homo sapiens
Analyze
Symbol: CCL11
Name: C-C motif chemokine ligand 11
RGD ID: 1351854
HGNC Page HGNC:10610
Description: Enables CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including eosinophil chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular region. Implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Biomarker of several diseases, including cystic fibrosis; hyperglycemia; lung disease (multiple); nephrotic syndrome type 1; and ureteral obstruction.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-C motif chemokine 11; chemokine (C-C motif) ligand 11; eosinophil chemotactic protein; eotaxin; eotaxin-1; MGC22554; SCYA11; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); small-inducible cytokine A11
RGD Orthologs
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,285,742 - 34,288,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,285,742 - 34,288,334 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,612,761 - 32,615,353 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,636,800 - 29,639,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,636,799 - 29,639,312NCBI
Celera1729,522,500 - 29,525,011 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,797,991 - 28,800,502 (+)NCBIHuRef
CHM1_11732,676,549 - 32,679,061 (+)NCBICHM1_1
T2T-CHM13v2.01735,232,017 - 35,234,610 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,4-benzoquinone  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chlorophenol  (EXP)
6-propyl-2-thiouracil  (ISO)
9,10-phenanthroquinone  (ISO)
actinomycin D  (EXP)
aluminium sulfate (anhydrous)  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
apocynin  (EXP)
arsenous acid  (ISO)
asbestos  (EXP)
Bardoxolone methyl  (ISO)
barium sulfate  (ISO)
beclomethasone  (EXP)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
budesonide  (EXP)
cadmium dichloride  (EXP)
Calcimycin  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
catechol  (EXP)
ceric oxide  (ISO)
CGP 52608  (EXP)
chloroquine  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
clopidogrel  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (ISO)
diethylstilbestrol  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
emamectin benzoate  (EXP)
ethanol  (EXP)
ferric oxide  (ISO)
Fexofenadine hydrochloride  (EXP)
flutamide  (ISO)
fluticasone  (EXP)
Fulvic acid  (EXP)
fumaric acid  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
graphene oxide  (ISO)
heparin  (ISO)
hydroquinone  (EXP)
indole-3-methanol  (ISO)
ionomycin  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
mercury dichloride  (ISO)
metam  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
MK 571  (ISO)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nitrogen dioxide  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phthalic anhydride  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
prednisolone  (ISO)
prednisone  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salmeterol xinafoate  (EXP)
SB 203580  (ISO)
serpentine asbestos  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
synephrine  (EXP,ISO)
syringin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
zileuton  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IDA,IEA,TAS)
extracellular space  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy. Andres-Hernando A, etal., Nephrol Dial Transplant. 2012 Dec;27(12):4339-47. doi: 10.1093/ndt/gfs256. Epub 2012 Jul 9.
2. Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis. Bocchino V, etal., Allergy. 2002 Jan;57(1):17-22.
3. Eotaxin and capping protein in experimental vasculopathy. Chen J, etal., Am J Pathol. 1998 Jul;153(1):81-90.
4. The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines/chemokines in uncomplicated type 1 diabetes: a pilot study. Cherney DZ, etal., Diabetes Care. 2011 Jan;34(1):177-80. doi: 10.2337/dc10-1219. Epub 2010 Sep 14.
5. The effect of aliskiren on urinary cytokine/chemokine responses to clamped hyperglycaemia in type 1 diabetes. Cherney DZ, etal., Diabetologia. 2013 Jul 28.
6. Intrinsic expression of Th2 cytokines in urothelium of congenital ureteropelvic junction obstruction. Chiou YY, etal., Kidney Int. 2005 Feb;67(2):638-46.
7. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. Chiu BC, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):106-16. Epub 2003 Jan 10.
8. Eosinophil and T cell markers predict functional decline in COPD patients. D'Armiento JM, etal., Respir Res. 2009 Nov 19;10:113.
9. Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. Emad A and Emad Y, J Clin Immunol. 2007 Nov;27(6):605-12. Epub 2007 Jul 10.
10. Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. Firoved AM, etal., Am J Pathol. 2005 Nov;167(5):1309-20.
11. T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice. Forbes E, etal., Gastroenterology. 2004 Jul;127(1):105-18.
12. A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Fulkerson PC, etal., Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16418-23. Epub 2006 Oct 23.
13. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
14. Eotaxin expression in Sephadex-induced lung injury in rats. Guo RF, etal., Am J Pathol. 1999 Dec;155(6):2001-8.
15. Regulatory effects of eotaxin on acute lung inflammatory injury. Guo RF, etal., J Immunol. 2001 Apr 15;166(8):5208-18.
16. mRNA differential display analysis of nephrotic kidney glomeruli. Haltia A, etal., Exp Nephrol. 1999 Jan-Feb;7(1):52-8.
17. Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate. Harris MT, etal., Prostate. 2000 Jun 15;44(1):19-25.
18. Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Huaux F, etal., Am J Pathol. 2005 Dec;167(6):1485-96.
19. Quantitative expression levels of regulated on activation, normal T cell expressed and secreted and eotaxin transcripts in toluene diisocyanate-induced allergic rats. Im GJ, etal., Acta Otolaryngol. 2005 Apr;125(4):370-7.
20. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. Jahnsen FL, etal., J Immunol. 1999 Aug 1;163(3):1545-51.
21. A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. Katoh S, etal., J Clin Invest. 2003 May;111(10):1563-70.
22. Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis. Kim HH, etal., J Korean Med Sci. 2007 Feb;22(1):37-42.
23. Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. Klein A, etal., Br J Pharmacol. 2002 Mar;135(5):1213-8.
24. HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection. Lamoury FM, etal., BMC Infect Dis. 2016 Jun 1;16:241. doi: 10.1186/s12879-016-1567-2.
25. The migration of T cells in response to influenza virus is altered in neonatal mice. Lines JL, etal., J Immunol. 2010 Sep 1;185(5):2980-8. Epub 2010 Jul 23.
26. [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models] Liu CT, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Aug;29(8):558-62.
27. Multiplex bead analysis of urinary cytokines of type 2 diabetic patients with normo- and microalbuminuria. Liu J, etal., J Immunoassay Immunochem. 2010 Oct;31(4):279-89.
28. Zinc suppressed the airway inflammation in asthmatic rats: effects of zinc on generation of eotaxin, MCP-1, IL-8, IL-4, and IFN-gamma. Lu H, etal., Biol Trace Elem Res. 2012 Dec;150(1-3):314-21. doi: 10.1007/s12011-012-9493-7. Epub 2012 Aug 30.
29. Immune profile and Epstein-Barr virus infection in acute interstitial nephritis: an immunohistochemical study in 78 patients. Mansur A, etal., Nephron Clin Pract. 2011;119(4):c293-300. doi: 10.1159/000329671. Epub 2011 Sep 21.
30. Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers. Martell L, etal., Orphanet J Rare Dis. 2011 Dec 16;6:84. doi: 10.1186/1750-1172-6-84.
31. Differential cytokine mRNA expression in Dermatophagoides farinae allergen-sensitized and respiratory syncytial virus-infected mice. Matsuse H, etal., Microbes Infect. 2000 Jun;2(7):753-9.
32. Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection. Matthews SP, etal., J Virol. 2005 Feb;79(4):2050-7.
33. Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema. Miller M, etal., J Allergy Clin Immunol. 2007 Nov;120(5):1118-25.
34. Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients. Min JW, etal., Chest. 2005 Nov;128(5):3127-32.
35. Production of granulomatous inflammation in lungs of rat pups and adults by Sephadex beads. Miyake M, etal., Pediatr Res. 2004 Aug;56(2):205-11. Epub 2004 Jun 4.
36. Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages. Nagarkar DR, etal., J Immunol. 2010 Aug 15;185(4):2525-35. Epub 2010 Jul 19.
37. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. Ockinger J, etal., Genes Immun. 2010 Mar;11(2):142-54. Epub 2009 Oct 29.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. Comparison of the cytokine and chemokine dynamics of the early inflammatory response in models of burn injury and infection. Orman MA, etal., Cytokine. 2011 Sep;55(3):362-71. doi: 10.1016/j.cyto.2011.05.010. Epub 2011 Jun 8.
40. Mast-cell activation augments the late phase reaction in experimental immune-mediated blepharoconjunctivitis. Ozaki A, etal., Graefes Arch Clin Exp Ophthalmol. 2003 May;241(5):394-402. Epub 2003 Apr 4.
41. Influence of murine Toxocara canis infection on plasma and bronchoalveolar lavage fluid eosinophil numbers and its correlation with cytokine levels. Pecinali NR, etal., Vet Parasitol. 2005 Nov 25;134(1-2):121-30. Epub 2005 Sep 15.
42. Invariant natural killer T cell agonist modulates experimental focal and segmental glomerulosclerosis. Pereira RL, etal., PLoS One. 2012;7(3):e32454. doi: 10.1371/journal.pone.0032454. Epub 2012 Mar 12.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
48. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. Rothenberg ME, etal., J Exp Med. 1997 Feb 17;185(4):785-90.
49. Nasal lavage fluid concentrations of eotaxin-1 (CCL11) in naturally occurring allergic rhinitis: relationship to disease activity, nasal luminal eosinophil influx, and plasma protein exudation. Salib RJ, etal., Clin Exp Allergy. 2005 Aug;35(8):995-1002.
50. Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme. Silva PM, etal., Br J Pharmacol. 2001 Sep;134(2):283-94.
51. Innate and adaptive mediators in cystic fibrosis and allergic fungal rhinosinusitis. Skinner ML, etal., Am J Rhinol. 2007 Sep-Oct;21(5):538-41.
52. Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation. Su YC, etal., J Immunol. 2008 Feb 15;180(4):2600-7.
53. Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model. Tirgan N, etal., Exp Diabetes Res. 2012;2012:349320. doi: 10.1155/2012/349320. Epub 2012 Sep 20.
54. Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. Umezawa M, etal., Cytokine. 2008 Aug;43(2):105-9. Epub 2008 Jul 1.
55. The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan. Wang TN, etal., Allergy. 2007 Oct;62(10):1125-30.
56. Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia. Wohlleben G, etal., J Immunol. 2003 May 1;170(9):4601-11.
57. Effects of cryptoporus polysaccharide on rat allergic rhinitis associated with inhibiting eotaxin mRNA expression. Xie QM, etal., J Ethnopharmacol. 2006 Oct 11;107(3):424-30. Epub 2006 Apr 18.
58. Effect of Tong Qiao drops on the expression of eotaxin, IL-13 in the nasal mucosa of rats with allergic rhinitis. Xu YY, etal., J Chin Med Assoc. 2012 Oct;75(10):524-9. doi: 10.1016/j.jcma.2012.07.003. Epub 2012 Oct 2.
59. Eotaxin-1, -2, and -3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients. Yao T, etal., Laryngoscope. 2009 Jun;119(6):1053-9.
60. Functional consequences of inhibiting exocytosis of Weibel-Palade bodies in acute renal ischemia. Yasuda K, etal., Am J Physiol Renal Physiol. 2012 Mar 15;302(6):F713-21. doi: 10.1152/ajprenal.00541.2011. Epub 2011 Dec 7.
61. Eotaxin-1 in exhaled breath condensate of stable and unstable asthma patients. Zietkowski Z, etal., Respir Res. 2010 Aug 12;11:110.
62. Eotaxin/CCL11 levels correlate with myocardial fibrosis and mast cell density in native and transplanted rat hearts. Zweifel M, etal., Transplant Proc. 2010 Sep;42(7):2763-6.
Additional References at PubMed
PMID:8597956   PMID:8609214   PMID:8631813   PMID:8642344   PMID:8674119   PMID:8676064   PMID:8780731   PMID:9169149   PMID:9299399   PMID:9405404   PMID:9558100   PMID:9578468  
PMID:9712872   PMID:10072545   PMID:10201960   PMID:10477718   PMID:10642580   PMID:10706854   PMID:10708591   PMID:10734104   PMID:11264152   PMID:11390394   PMID:11425309   PMID:11742272  
PMID:11884459   PMID:11966763   PMID:12065904   PMID:12082592   PMID:12192108   PMID:12193745   PMID:12234713   PMID:12370400   PMID:12392390   PMID:12393570   PMID:12477932   PMID:12884299  
PMID:12915771   PMID:12916705   PMID:12949249   PMID:14571188   PMID:14725564   PMID:14733956   PMID:15067078   PMID:15186951   PMID:15207712   PMID:15223611   PMID:15389872   PMID:15489334  
PMID:15537425   PMID:15661912   PMID:16029496   PMID:16169070   PMID:16184405   PMID:16391516   PMID:16461130   PMID:16510147   PMID:16517749   PMID:16864713   PMID:16872505   PMID:16874958  
PMID:16879311   PMID:17016617   PMID:17220216   PMID:17438849   PMID:17438850   PMID:17541284   PMID:17672898   PMID:17703412   PMID:17827376   PMID:18055844   PMID:18203973   PMID:18275857  
PMID:18312459   PMID:18312691   PMID:18380907   PMID:18398743   PMID:18515987   PMID:18523302   PMID:18699931   PMID:18712274   PMID:18714023   PMID:18844613   PMID:18950617   PMID:18971287  
PMID:18974840   PMID:18981162   PMID:19028820   PMID:19056482   PMID:19131662   PMID:19247692   PMID:19258923   PMID:19263529   PMID:19264973   PMID:19338989   PMID:19351767   PMID:19423540  
PMID:19479237   PMID:19522186   PMID:19525930   PMID:19559392   PMID:19578796   PMID:19729601   PMID:19913121   PMID:19937162   PMID:19948975   PMID:20041150   PMID:20056178   PMID:20227754  
PMID:20236835   PMID:20237496   PMID:20306659   PMID:20406964   PMID:20438785   PMID:20444156   PMID:20503287   PMID:20505746   PMID:20536507   PMID:20603037   PMID:20628086   PMID:20628624  
PMID:20934424   PMID:21052690   PMID:21077277   PMID:21314817   PMID:21368236   PMID:21406396   PMID:21601544   PMID:21825098   PMID:21873635   PMID:21900206   PMID:22114952   PMID:22271279  
PMID:22412388   PMID:22773402   PMID:22775568   PMID:22846146   PMID:23049769   PMID:23059958   PMID:23061798   PMID:23114905   PMID:23128233   PMID:23149666   PMID:23180368   PMID:23477905  
PMID:23496801   PMID:23532518   PMID:23597562   PMID:23679817   PMID:23820464   PMID:23904440   PMID:24273921   PMID:24482230   PMID:24600981   PMID:24604010   PMID:24647150   PMID:25080789  
PMID:25111027   PMID:25237944   PMID:25393692   PMID:25450766   PMID:25620704   PMID:25645983   PMID:26241961   PMID:26270578   PMID:26306920   PMID:26324103   PMID:26341115   PMID:26359802  
PMID:26491210   PMID:26699196   PMID:26861136   PMID:26874691   PMID:26907493   PMID:27119233   PMID:27525354   PMID:27621211   PMID:27664933   PMID:27681294   PMID:28381538   PMID:28634890  
PMID:28873081   PMID:28950005   PMID:29138487   PMID:29477870   PMID:30021884   PMID:30308289   PMID:30583236   PMID:31364439   PMID:32147601   PMID:32450244   PMID:32560958   PMID:32694731  
PMID:32929618   PMID:33452453   PMID:33528280   PMID:33846499   PMID:33849248   PMID:34086364   PMID:34288108   PMID:34571176   PMID:34830041   PMID:35254015   PMID:35690992   PMID:36398464  
PMID:36576886   PMID:37860000   PMID:38195933   PMID:38305920   PMID:38394497  


Genomics

Comparative Map Data
CCL11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,285,742 - 34,288,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,285,742 - 34,288,334 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,612,761 - 32,615,353 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,636,800 - 29,639,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,636,799 - 29,639,312NCBI
Celera1729,522,500 - 29,525,011 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,797,991 - 28,800,502 (+)NCBIHuRef
CHM1_11732,676,549 - 32,679,061 (+)NCBICHM1_1
T2T-CHM13v2.01735,232,017 - 35,234,610 (+)NCBIT2T-CHM13v2.0
Ccl11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,948,658 - 81,953,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,948,649 - 81,953,781 (+)EnsemblGRCm39 Ensembl
GRCm381182,057,832 - 82,062,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,057,823 - 82,062,955 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,871,334 - 81,876,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,874,117 - 81,879,148 (+)NCBIMGSCv36mm8
Celera1191,671,281 - 91,676,404 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1149.84NCBI
Ccl11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,525,975 - 67,530,576 (+)NCBIGRCr8
mRatBN7.21067,028,328 - 67,032,929 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,028,328 - 67,032,926 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,649,521 - 71,654,122 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,154,872 - 71,159,475 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,615,995 - 66,620,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,434,965 - 69,439,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,434,941 - 69,439,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,069,783 - 69,074,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,279,161 - 70,283,762 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11070,292,783 - 70,297,384 (+)NCBI
Celera1065,975,844 - 65,980,445 (+)NCBICelera
Cytogenetic Map10q26NCBI
LOC100980531
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21930,175,125 - 30,195,199 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11732,056,452 - 32,076,467 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01722,495,737 - 22,515,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,806,311 - 22,808,330 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,806,076 - 22,808,345 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl1722,787,541 - 22,791,604 (-)Ensemblpanpan1.1panPan2
LOC101968920
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,957,463 - 37,971,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538847,464 - 848,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936538835,859 - 837,710 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538835,436 - 848,907 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,779,173 - 40,782,893 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,779,906 - 40,782,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,424,321 - 42,427,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,792,699 - 27,796,437 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,794,033 - 27,796,460 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660752,223,450 - 2,226,274 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCL11
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000017.11:g.34284427= single nucleotide variant Susceptibility to HIV infection [RCV000008872] Chr17:34284427 [GRCh38]
Chr17:32611446 [GRCh37]
Chr17:17q12		 pathogenic|protective
NC_000017.11:g.34274816GAGAAG[9] microsatellite Inherited susceptibility to asthma [RCV000008873] Chr17:34274815..34274816 [GRCh38]
Chr17:32601834..32601835 [GRCh37]
Chr17:17q12		 risk factor
GRCh38/hg38 17q12(chr17:33642695-34549211)x3 copy number gain See cases [RCV000054013] Chr17:33642695..34549211 [GRCh38]
Chr17:31969714..32876230 [GRCh37]
Chr17:28993827..29900343 [NCBI36]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:33670906-34596087)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|See cases [RCV000054042] Chr17:33670906..34596087 [GRCh38]
Chr17:31997925..32923106 [GRCh37]
Chr17:29022038..29947219 [NCBI36]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:33715517-34301601)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|See cases [RCV000054043] Chr17:33715517..34301601 [GRCh38]
Chr17:32042536..32628620 [GRCh37]
Chr17:29066649..29652733 [NCBI36]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:33777728-34301601)x3 copy number gain See cases [RCV000135956] Chr17:33777728..34301601 [GRCh38]
Chr17:32104747..32628620 [GRCh37]
Chr17:29128860..29652733 [NCBI36]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:33671097-34595982)x3 copy number gain See cases [RCV000139003] Chr17:33671097..34595982 [GRCh38]
Chr17:31998116..32923001 [GRCh37]
Chr17:29022229..29947114 [NCBI36]
Chr17:17q12		 likely benign
GRCh38/hg38 17q12(chr17:33671106-34595887)x3 copy number gain See cases [RCV000140285] Chr17:33671106..34595887 [GRCh38]
Chr17:31998125..32922906 [GRCh37]
Chr17:29022238..29947019 [NCBI36]
Chr17:17q12		 likely benign
GRCh37/hg19 17q12(chr17:31982779-32917705)x3 copy number gain See cases [RCV000449299] Chr17:31982779..32917705 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000445952] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000511904] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:32064314-32643063)x3 copy number gain See cases [RCV000511568] Chr17:32064314..32643063 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_002986.3(CCL11):c.206C>A (p.Ala69Asp) single nucleotide variant not specified [RCV004315249] Chr17:34287602 [GRCh38]
Chr17:32614621 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q12(chr17:32351496-34455576)x1 copy number loss not provided [RCV000683918] Chr17:32351496..34455576 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_002986.3(CCL11):c.227C>A (p.Pro76His) single nucleotide variant not specified [RCV004296093] Chr17:34287623 [GRCh38]
Chr17:32614642 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2		 pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787392] Chr17:31889285..33557612 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:31957257-32944153)x3 copy number gain not provided [RCV000846469] Chr17:31957257..32944153 [GRCh37]
Chr17:17q12		 uncertain significance
NM_002986.3(CCL11):c.257A>C (p.Lys86Thr) single nucleotide variant not provided [RCV000957583] Chr17:34287653 [GRCh38]
Chr17:32614672 [GRCh37]
Chr17:17q12		 benign
GRCh37/hg19 17q12(chr17:31959226-32937658) copy number gain not specified [RCV002052595] Chr17:31959226..32937658 [GRCh37]
Chr17:17q12		 uncertain significance
NM_002986.3(CCL11):c.56C>A (p.Pro19His) single nucleotide variant not specified [RCV004236238] Chr17:34285864 [GRCh38]
Chr17:32612883 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q11.2-12(chr17:30572862-35843988) copy number loss Chromosome 17q12 deletion syndrome [RCV003319594] Chr17:30572862..35843988 [GRCh37]
Chr17:17q11.2-12		 pathogenic
NM_002986.3(CCL11):c.119A>T (p.Lys40Met) single nucleotide variant not specified [RCV004355459] Chr17:34287138 [GRCh38]
Chr17:32614157 [GRCh37]
Chr17:17q12		 uncertain significance
NM_002986.3(CCL11):c.84C>G (p.Val28=) single nucleotide variant CCL11-related disorder [RCV003907367] Chr17:34287103 [GRCh38]
Chr17:32614122 [GRCh37]
Chr17:17q12		 likely benign
NM_002986.3(CCL11):c.67G>A (p.Ala23Thr) single nucleotide variant CCL11-related disorder [RCV003974708] Chr17:34285875 [GRCh38]
Chr17:32612894 [GRCh37]
Chr17:17q12		 benign
NM_002986.3(CCL11):c.124C>A (p.Pro42Thr) single nucleotide variant not specified [RCV004430530] Chr17:34287143 [GRCh38]
Chr17:32614162 [GRCh37]
Chr17:17q12		 uncertain significance
NM_002986.3(CCL11):c.47C>T (p.Ala16Val) single nucleotide variant not specified [RCV004430531] Chr17:34285855 [GRCh38]
Chr17:32612874 [GRCh37]
Chr17:17q12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:240
Interacting mature miRNAs:252
Transcripts:ENST00000305869
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298406BP16_HBlood pressure QTL 16 (human)0.0004Blood pressurehypertension susceptibility171477864740778647Human

Markers in Region
RH75873  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,614,722 - 32,614,954UniSTSGRCh37
Build 361729,638,835 - 29,639,067RGDNCBI36
Celera1729,524,535 - 29,524,766RGD
Cytogenetic Map17q21.1-q21.2UniSTS
HuRef1728,800,026 - 28,800,257UniSTS
CCL11_2928  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,614,555 - 32,615,115UniSTSGRCh37
Build 361729,638,668 - 29,639,228RGDNCBI36
Celera1729,524,368 - 29,524,927RGD
HuRef1728,799,859 - 28,800,418UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
819 2316 1348 1496 1565 1137 1565 2 412 640 339 885 4453 3997 8 1267 734 1294 968 75

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB063614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB063616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI446061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF197516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U46572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U46573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z69291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z75668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z75669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z92709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000305869   ⟹   ENSP00000302234
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,285,742 - 34,288,334 (+)Ensembl
RefSeq Acc Id: NM_002986   ⟹   NP_002977
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,285,742 - 34,288,334 (+)NCBI
GRCh371732,612,687 - 32,615,199 (+)ENTREZGENE
Build 361729,636,800 - 29,639,312 (+)NCBI Archive
HuRef1728,797,991 - 28,800,502 (+)ENTREZGENE
CHM1_11732,676,549 - 32,679,061 (+)NCBI
T2T-CHM13v2.01735,232,017 - 35,234,610 (+)NCBI
Sequence:
RefSeq Acc Id: NP_002977   ⟸   NM_002986
- Peptide Label: precursor
- UniProtKB: Q92490 (UniProtKB/Swiss-Prot),   P50877 (UniProtKB/Swiss-Prot),   Q92491 (UniProtKB/Swiss-Prot),   P51671 (UniProtKB/Swiss-Prot),   Q6I9T4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000302234   ⟸   ENST00000305869
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51671-F1-model_v2 AlphaFold P51671 1-97 view protein structure

Promoters
RGD ID:7234587
Promoter ID:EPDNEW_H23039
Type:multiple initiation site
Name:CCL11_1
Description:C-C motif chemokine ligand 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,285,742 - 34,285,802EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10610 AgrOrtholog
COSMIC CCL11 COSMIC
Ensembl Genes ENSG00000172156 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000305869 ENTREZGENE
  ENST00000305869.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000172156 GTEx
HGNC ID HGNC:10610 ENTREZGENE
Human Proteome Map CCL11 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 6356 ENTREZGENE
OMIM 601156 OMIM
PANTHER EOTAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA35543 PharmGKB
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCL11_HUMAN UniProtKB/Swiss-Prot
  P50877 ENTREZGENE
  P51671 ENTREZGENE
  Q6I9T4 ENTREZGENE, UniProtKB/TrEMBL
  Q92490 ENTREZGENE
  Q92491 ENTREZGENE
UniProt Secondary P50877 UniProtKB/Swiss-Prot
  Q92490 UniProtKB/Swiss-Prot
  Q92491 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL11  C-C motif chemokine ligand 11  CCL11  chemokine (C-C motif) ligand 11  Symbol and/or name change 5135510 APPROVED