CCL11 (C-C motif chemokine ligand 11) - Rat Genome Database

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Gene: CCL11 (C-C motif chemokine ligand 11) Homo sapiens
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Symbol: CCL11
Name: C-C motif chemokine ligand 11
RGD ID: 1351854
HGNC Page HGNC:10610
Description: Enables CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including eosinophil chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular region. Implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Biomarker of several diseases, including cystic fibrosis; hyperglycemia; lung disease (multiple); nephrotic syndrome type 1; and ureteral obstruction.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-C motif chemokine 11; chemokine (C-C motif) ligand 11; eosinophil chemotactic protein; eotaxin; eotaxin-1; MGC22554; SCYA11; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); small-inducible cytokine A11
RGD Orthologs
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,285,742 - 34,288,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,285,742 - 34,288,334 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,612,761 - 32,615,353 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,636,800 - 29,639,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,636,799 - 29,639,312NCBI
Celera1729,522,500 - 29,525,011 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,797,991 - 28,800,502 (+)NCBIHuRef
CHM1_11732,676,549 - 32,679,061 (+)NCBICHM1_1
T2T-CHM13v2.01735,232,017 - 35,234,610 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
CCL11Humanacute kidney failure  ISOCcl11 (Mus musculus)7247739protein:increased expression:kidneyRGD 
CCL11Humanallergic conjunctivitis  ISOCcl11 (Rattus norvegicus)2307196mRNA:increased expression:conjunctivaRGD 
CCL11Humanallergic rhinitis treatmentISOCcl11 (Rattus norvegicus)7248414 RGD 
CCL11Humanasthma treatmentISOCcl11 (Rattus norvegicus)7248416 RGD 
CCL11Humanasthma  ISOCcl11 (Mus musculus)4145451 RGD 
CCL11Humanasthma  ISOCcl11 (Mus musculus)4891485 RGD 
CCL11Humanasthma  IEP 5130930protein:increased expression:plasmaRGD 
CCL11Humanasthma  ISOCcl11 (Rattus norvegicus)4145461 RGD 
CCL11Humanasthma  ISOCcl11 (Mus musculus)4145392mRNA:increased expression:lungRGD 
CCL11Humanasthma susceptibilityIAGP 4145457DNA:polymorphism: :p.A23T (human)RGD 
CCL11Humanasthma severityIEP 4145387 RGD 
CCL11HumanBronchial Hyperreactivity  ISOCcl11 (Mus musculus)4145432associated with Gastrointestinal DiseasesRGD 
CCL11Humanbronchiolitis severityISOCcl11 (Mus musculus)4145415associated with Respiratory Syncytial Virus InfectionsRGD 
CCL11Humanbronchiolitis  IEP 4145460protein:increased expression:nasal mucusRGD 
CCL11Humancataract  ISOCcl11 (Rattus norvegicus)7248415associated with Diabetes Mellitus more ...RGD 
CCL11HumanChronic Bronchitis  IEP 4145442 RGD 
CCL11Humanchronic obstructive pulmonary disease severityIEP 4145389 RGD 
CCL11Humancystic fibrosis  IEP 4145455protein:increased expression:paranasal sinusRGD 
CCL11HumanDiabetic Nephropathies  IEP 5683918associated with Diabetes Mellitus and Type 2RGD 
CCL11Humanendometriosis  ISOCcl11 (Rattus norvegicus)2307108 RGD 
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CCL11Humanhuman immunodeficiency virus infectious disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Human immunodeficiency virus type 1 and susceptibility toClinVarPMID:14571188
CCL11HumanNeurodevelopmental Disorders  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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CCL11Humanallergic disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544
CCL11Humanasthma  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
CCL11Humanatopic dermatitis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18249437
CCL11Humanbrain ischemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15829914
CCL11Humandrug allergy  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:14616128
CCL11Humanendometriosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:30579999
CCL11Humanhuman immunodeficiency virus infectious disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
CCL11HumanInflammation  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23707484
CCL11Humanpneumonia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544
CCL11HumanPolyomavirus Infections  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25162674
CCL11Humanpulmonary fibrosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16314464 and PMID:17620002
CCL11Humanrespiratory allergy  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17085522
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CCL11Humanasthma  IAGP 7240710 OMIM 
CCL11Humanhuman immunodeficiency virus infectious disease  IAGP 7240710 OMIM 

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CCL11Human1,4-benzoquinone increases expressionEXP 6480464quinone results in increased expression of CCL11 proteinCTDPMID:17572062
CCL11Human1-chloro-2,4-dinitrobenzene multiple interactionsISOCcl11 (Mus musculus)6480464Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA] and Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA]CTDPMID:23133493
CCL11Human1-chloro-2,4-dinitrobenzene increases expressionISOCcl11 (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of CCL11 mRNACTDPMID:23133493
CCL11Human1-naphthyl isothiocyanate increases expressionISOCcl11 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of CCL11 mRNACTDPMID:30723492
CCL11Human17alpha-ethynylestradiol affects expressionISOCcl11 (Mus musculus)6480464Ethinyl Estradiol affects the expression of CCL11 mRNACTDPMID:17555576
CCL11Human17alpha-ethynylestradiol increases expressionISOCcl11 (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of CCL11 mRNACTDPMID:12655037 more ...
CCL11Human17alpha-ethynylestradiol multiple interactionsISOCcl11 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL11 mRNACTDPMID:17942748
CCL11Human17alpha-ethynylestradiol increases expressionISOCcl11 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of CCL11 mRNACTDPMID:17942748
CCL11Human17beta-estradiol affects expressionISOCcl11 (Mus musculus)6480464Estradiol affects the expression of CCL11 mRNACTDPMID:15598610
CCL11Human17beta-estradiol multiple interactionsISOCcl11 (Rattus norvegicus)6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CCL11 mRNACTDPMID:32741896
CCL11Human17beta-estradiol increases expressionISOCcl11 (Rattus norvegicus)6480464Estradiol results in increased expression of CCL11 mRNACTDPMID:26945725
CCL11Human17beta-estradiol increases expressionISOCcl11 (Mus musculus)6480464Estradiol results in increased expression of CCL11 mRNACTDPMID:23144751
CCL11Human17beta-estradiol 3-benzoate multiple interactionsISOCcl11 (Rattus norvegicus)6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CCL11 mRNACTDPMID:32741896
CCL11Human2,2',5,5'-tetrachlorobiphenyl decreases expressionEXP 64804642 more ...CTDPMID:36804509
CCL11Human2,2',5,5'-tetrachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:36804509
CCL11Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCcl11 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL11 mRNA and Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased secretion of CCL11 protein]CTDPMID:17942748 and PMID:21858153
CCL11Human2,4-D increases expressionISOCcl11 (Mus musculus)64804642 and 4-Dichlorophenoxyacetic Acid results in increased expression of CCL11 proteinCTDPMID:19467290
CCL11Human2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOCcl11 (Mus musculus)64804642 more ...CTDPMID:38648751
CCL11Human3,3',4,4',5-pentachlorobiphenyl multiple interactionsISOCcl11 (Rattus norvegicus)6480464[AHR gene mutant form affects the susceptibility to 3 more ...CTDPMID:34256052
CCL11Human3-chlorophenol increases expressionEXP 64804643-chlorophenol results in increased expression of CCL11 mRNACTDPMID:18486366

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Biological Process
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CCL11Humanactin filament organization involved_inIEAUniProtKB:P97545 and ensembl:ENSRNOP00000009756150520179 EnsemblGO_REF:0000107
CCL11Humanactin filament organization  ISOCcl11 (Rattus norvegicus)9068941 RGDPMID:12413953 and REF_RGD_ID:4145648
CCL11Humanantimicrobial humoral immune response mediated by antimicrobial peptide involved_inIDA 150520179 PMID:12949249UniProtPMID:12949249
CCL11Humanantimicrobial humoral immune response mediated by antimicrobial peptide involved_inIBAPANTHER:PTN000245709 more ...150520179 GO_CentralGO_REF:0000033
CCL11Humanbranching involved in mammary gland duct morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P48298 and ensembl:ENSMUSP00000000342150520179 EnsemblGO_REF:0000107
CCL11Humancell adhesion involved_inTAS 150520179 PMID:10201960PINCPMID:10201960
CCL11Humanchemokine-mediated signaling pathway involved_inIDA 150520179 PMID:19525930BHF-UCLPMID:19525930
CCL11Humanchemokine-mediated signaling pathway involved_inIBAMGI:1349183 more ...150520179 GO_CentralGO_REF:0000033
CCL11Humanchemotaxis involved_inIEAUniProtKB-KW:KW-0145150520179 UniProtGO_REF:0000043
CCL11Humanchemotaxis involved_inTAS 150520179 PMID:10706854PINCPMID:10706854
CCL11Humanchronic inflammatory response involved_inIEAUniProtKB:P97545 and ensembl:ENSRNOP00000009756150520179 EnsemblGO_REF:0000107
CCL11Humanchronic inflammatory response  ISOCcl11 (Rattus norvegicus)9068941 RGDPMID:10861753 and REF_RGD_ID:4145481
CCL11Humancytoskeleton organization involved_inIDA 150520179 PMID:10072545UniProtPMID:10072545
CCL11Humaneosinophil chemotaxis involved_inIEAUniProtKB:P97545 and ensembl:ENSRNOP00000009756150520179 EnsemblGO_REF:0000107
CCL11Humaneosinophil chemotaxis involved_inIBAPANTHER:PTN008532501 more ...150520179 GO_CentralGO_REF:0000033
CCL11Humaneosinophil chemotaxis involved_inIDA 150520179 PMID:10072545UniProtPMID:10072545
CCL11Humaneosinophil chemotaxis  ISOCcl11 (Rattus norvegicus)9068941 RGDPMID:9458816 more ...
CCL11HumanERK1 and ERK2 cascade involved_inIEAUniProtKB:P97545 and ensembl:ENSRNOP00000009756150520179 EnsemblGO_REF:0000107
CCL11HumanERK1 and ERK2 cascade  ISORac1 (Rattus norvegicus)9068941 RGDPMID:12413953 and REF_RGD_ID:4145648
CCL11Humanimmune response involved_inIEAInterPro:IPR000827 more ...150520179 InterProGO_REF:0000002
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Cellular Component
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Original Reference(s)
CCL11Humanextracellular region located_inIEAInterPro:IPR000827 more ...150520179 InterProGO_REF:0000002
CCL11Humanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
CCL11Humanextracellular region located_inIDA 150520179 PMID:20041150BHF-UCLPMID:20041150
CCL11Humanextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
CCL11Humanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-443986 and Reactome:R-HSA-6793978
CCL11Humanextracellular space located_inIEAUniProtKB:P97545 and ensembl:ENSRNOP00000009756150520179 EnsemblGO_REF:0000107
CCL11Humanextracellular space is_active_inIBAMGI:101878 more ...150520179 GO_CentralGO_REF:0000033
CCL11Humanextracellular space located_inIEAUniProtKB-KW:KW-0202150520179 UniProtGO_REF:0000043
CCL11Humanextracellular space  ISOCcl11 (Rattus norvegicus)9068941 RGDPMID:9458816 and REF_RGD_ID:69985
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Molecular Function
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Imported Annotations - KEGG (archival)

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CCL11Humanasthma pathway  IEA 6907045 KEGGhsa:05310

Imported Annotations - PID (archival)

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CCL11Humaninterleukin-4 signaling pathway  EXP 6484113 PIDPID:200022

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#
Reference Title
Reference Citation
1. Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy. Andres-Hernando A, etal., Nephrol Dial Transplant. 2012 Dec;27(12):4339-47. doi: 10.1093/ndt/gfs256. Epub 2012 Jul 9.
2. Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis. Bocchino V, etal., Allergy. 2002 Jan;57(1):17-22.
3. Eotaxin and capping protein in experimental vasculopathy. Chen J, etal., Am J Pathol. 1998 Jul;153(1):81-90.
4. The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines/chemokines in uncomplicated type 1 diabetes: a pilot study. Cherney DZ, etal., Diabetes Care. 2011 Jan;34(1):177-80. doi: 10.2337/dc10-1219. Epub 2010 Sep 14.
5. The effect of aliskiren on urinary cytokine/chemokine responses to clamped hyperglycaemia in type 1 diabetes. Cherney DZ, etal., Diabetologia. 2013 Jul 28.
6. Intrinsic expression of Th2 cytokines in urothelium of congenital ureteropelvic junction obstruction. Chiou YY, etal., Kidney Int. 2005 Feb;67(2):638-46.
7. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. Chiu BC, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):106-16. Epub 2003 Jan 10.
8. Eosinophil and T cell markers predict functional decline in COPD patients. D'Armiento JM, etal., Respir Res. 2009 Nov 19;10:113.
9. Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. Emad A and Emad Y, J Clin Immunol. 2007 Nov;27(6):605-12. Epub 2007 Jul 10.
10. Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. Firoved AM, etal., Am J Pathol. 2005 Nov;167(5):1309-20.
11. T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice. Forbes E, etal., Gastroenterology. 2004 Jul;127(1):105-18.
12. A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Fulkerson PC, etal., Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16418-23. Epub 2006 Oct 23.
13. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
14. Eotaxin expression in Sephadex-induced lung injury in rats. Guo RF, etal., Am J Pathol. 1999 Dec;155(6):2001-8.
15. Regulatory effects of eotaxin on acute lung inflammatory injury. Guo RF, etal., J Immunol. 2001 Apr 15;166(8):5208-18.
16. mRNA differential display analysis of nephrotic kidney glomeruli. Haltia A, etal., Exp Nephrol. 1999 Jan-Feb;7(1):52-8.
17. Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate. Harris MT, etal., Prostate. 2000 Jun 15;44(1):19-25.
18. Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Huaux F, etal., Am J Pathol. 2005 Dec;167(6):1485-96.
19. Quantitative expression levels of regulated on activation, normal T cell expressed and secreted and eotaxin transcripts in toluene diisocyanate-induced allergic rats. Im GJ, etal., Acta Otolaryngol. 2005 Apr;125(4):370-7.
20. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. Jahnsen FL, etal., J Immunol. 1999 Aug 1;163(3):1545-51.
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PMID:8597956   PMID:8609214   PMID:8631813   PMID:8642344   PMID:8674119   PMID:8676064   PMID:8780731   PMID:9169149   PMID:9299399   PMID:9405404   PMID:9558100   PMID:9578468  
PMID:9712872   PMID:10072545   PMID:10201960   PMID:10477718   PMID:10642580   PMID:10706854   PMID:10708591   PMID:10734104   PMID:11264152   PMID:11390394   PMID:11425309   PMID:11742272  
PMID:11884459   PMID:11966763   PMID:12065904   PMID:12082592   PMID:12192108   PMID:12193745   PMID:12234713   PMID:12370400   PMID:12392390   PMID:12393570   PMID:12477932   PMID:12884299  
PMID:12915771   PMID:12916705   PMID:12949249   PMID:14571188   PMID:14725564   PMID:14733956   PMID:15067078   PMID:15186951   PMID:15207712   PMID:15223611   PMID:15389872   PMID:15489334  
PMID:15537425   PMID:15661912   PMID:16029496   PMID:16169070   PMID:16184405   PMID:16391516   PMID:16461130   PMID:16510147   PMID:16517749   PMID:16864713   PMID:16872505   PMID:16874958  
PMID:16879311   PMID:17016617   PMID:17220216   PMID:17438849   PMID:17438850   PMID:17541284   PMID:17672898   PMID:17703412   PMID:17827376   PMID:18055844   PMID:18203973   PMID:18275857  
PMID:18312459   PMID:18312691   PMID:18380907   PMID:18398743   PMID:18515987   PMID:18523302   PMID:18699931   PMID:18712274   PMID:18714023   PMID:18844613   PMID:18950617   PMID:18971287  
PMID:18974840   PMID:18981162   PMID:19028820   PMID:19056482   PMID:19131662   PMID:19247692   PMID:19258923   PMID:19263529   PMID:19264973   PMID:19338989   PMID:19351767   PMID:19423540  
PMID:19479237   PMID:19522186   PMID:19525930   PMID:19559392   PMID:19578796   PMID:19729601   PMID:19913121   PMID:19937162   PMID:19948975   PMID:20041150   PMID:20056178   PMID:20227754  
PMID:20236835   PMID:20237496   PMID:20306659   PMID:20406964   PMID:20438785   PMID:20444156   PMID:20503287   PMID:20505746   PMID:20536507   PMID:20603037   PMID:20628086   PMID:20628624  
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CCL11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,285,742 - 34,288,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,285,742 - 34,288,334 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,612,761 - 32,615,353 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,636,800 - 29,639,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,636,799 - 29,639,312NCBI
Celera1729,522,500 - 29,525,011 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,797,991 - 28,800,502 (+)NCBIHuRef
CHM1_11732,676,549 - 32,679,061 (+)NCBICHM1_1
T2T-CHM13v2.01735,232,017 - 35,234,610 (+)NCBIT2T-CHM13v2.0
Ccl11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,948,658 - 81,953,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,948,649 - 81,953,781 (+)EnsemblGRCm39 Ensembl
GRCm381182,057,832 - 82,062,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,057,823 - 82,062,955 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,871,334 - 81,876,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,874,117 - 81,879,148 (+)NCBIMGSCv36mm8
Celera1191,671,281 - 91,676,404 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1149.84NCBI
Ccl11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,525,975 - 67,530,576 (+)NCBIGRCr8
mRatBN7.21067,028,328 - 67,032,929 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,028,328 - 67,032,926 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,649,521 - 71,654,122 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,154,872 - 71,159,475 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,615,995 - 66,620,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,434,965 - 69,439,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,434,941 - 69,439,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,069,783 - 69,074,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,279,161 - 70,283,762 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11070,292,783 - 70,297,384 (+)NCBI
Celera1065,975,844 - 65,980,445 (+)NCBICelera
Cytogenetic Map10q26NCBI
LOC100980531
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21930,175,125 - 30,195,199 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11732,056,452 - 32,076,467 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01722,495,737 - 22,515,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,806,311 - 22,808,330 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,806,076 - 22,808,345 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl1722,787,541 - 22,791,604 (-)Ensemblpanpan1.1panPan2
LOC101968920
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,957,463 - 37,971,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538847,464 - 848,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936538835,859 - 837,710 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538835,436 - 848,907 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,779,173 - 40,782,893 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,779,906 - 40,782,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,424,321 - 42,427,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,792,699 - 27,796,437 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,794,033 - 27,796,460 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660752,223,450 - 2,226,274 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in CCL11
12 total Variants

1 to 10 of 35 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NC_000017.11:g.34284427= single nucleotide variant Susceptibility to HIV infection [RCV000008872] Chr17:34284427 [GRCh38]
Chr17:32611446 [GRCh37]
Chr17:17q12
pathogenic|protective
NC_000017.11:g.34274816GAGAAG[9] microsatellite Inherited susceptibility to asthma [RCV000008873] Chr17:34274815..34274816 [GRCh38]
Chr17:32601834..32601835 [GRCh37]
Chr17:17q12
risk factor
GRCh38/hg38 17q12(chr17:33642695-34549211)x3 copy number gain See cases [RCV000054013] Chr17:33642695..34549211 [GRCh38]
Chr17:31969714..32876230 [GRCh37]
Chr17:28993827..29900343 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33670906-34596087)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|See cases [RCV000054042] Chr17:33670906..34596087 [GRCh38]
Chr17:31997925..32923106 [GRCh37]
Chr17:29022038..29947219 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33715517-34301601)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|See cases [RCV000054043] Chr17:33715517..34301601 [GRCh38]
Chr17:32042536..32628620 [GRCh37]
Chr17:29066649..29652733 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33777728-34301601)x3 copy number gain See cases [RCV000135956] Chr17:33777728..34301601 [GRCh38]
Chr17:32104747..32628620 [GRCh37]
Chr17:29128860..29652733 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33671097-34595982)x3 copy number gain See cases [RCV000139003] Chr17:33671097..34595982 [GRCh38]
Chr17:31998116..32923001 [GRCh37]
Chr17:29022229..29947114 [NCBI36]
Chr17:17q12
likely benign
GRCh38/hg38 17q12(chr17:33671106-34595887)x3 copy number gain See cases [RCV000140285] Chr17:33671106..34595887 [GRCh38]
Chr17:31998125..32922906 [GRCh37]
Chr17:29022238..29947019 [NCBI36]
Chr17:17q12
likely benign
GRCh37/hg19 17q12(chr17:31982779-32917705)x3 copy number gain See cases [RCV000449299] Chr17:31982779..32917705 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000445952] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12
uncertain significance
1 to 10 of 35 rows

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:240
Interacting mature miRNAs:252
Transcripts:ENST00000305869
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298406BP16_HBlood pressure QTL 16 (human)0.0004Blood pressurehypertension susceptibility171477864740778647Human

RH75873  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,614,722 - 32,614,954UniSTSGRCh37
Build 361729,638,835 - 29,639,067RGDNCBI36
Celera1729,524,535 - 29,524,766RGD
Cytogenetic Map17q21.1-q21.2UniSTS
HuRef1728,800,026 - 28,800,257UniSTS
CCL11_2928  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,614,555 - 32,615,115UniSTSGRCh37
Build 361729,638,668 - 29,639,228RGDNCBI36
Celera1729,524,368 - 29,524,927RGD
HuRef1728,799,859 - 28,800,418UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
819 2316 1348 1496 1565 1137 1565 2 412 640 339 885 4453 3997 8 1267 734 1294 968 75


1 to 19 of 19 rows
RefSeq Transcripts NG_012212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB063614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB063616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI446061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF197516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U46572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U46573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z69291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z75668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z75669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z92709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENST00000305869   ⟹   ENSP00000302234
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,285,742 - 34,288,334 (+)Ensembl
RefSeq Acc Id: NM_002986   ⟹   NP_002977
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,285,742 - 34,288,334 (+)NCBI
GRCh371732,612,687 - 32,615,199 (+)ENTREZGENE
Build 361729,636,800 - 29,639,312 (+)NCBI Archive
HuRef1728,797,991 - 28,800,502 (+)ENTREZGENE
CHM1_11732,676,549 - 32,679,061 (+)NCBI
T2T-CHM13v2.01735,232,017 - 35,234,610 (+)NCBI
Sequence:
RefSeq Acc Id: NP_002977   ⟸   NM_002986
- Peptide Label: precursor
- UniProtKB: Q92490 (UniProtKB/Swiss-Prot),   P50877 (UniProtKB/Swiss-Prot),   Q92491 (UniProtKB/Swiss-Prot),   P51671 (UniProtKB/Swiss-Prot),   Q6I9T4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000302234   ⟸   ENST00000305869
Name Modeler Protein Id AA Range Protein Structure
AF-P51671-F1-model_v2 AlphaFold P51671 1-97 view protein structure

RGD ID:7234587
Promoter ID:EPDNEW_H23039
Type:multiple initiation site
Name:CCL11_1
Description:C-C motif chemokine ligand 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,285,742 - 34,285,802EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
COSMIC CCL11 COSMIC
Ensembl Genes ENSG00000172156 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000305869 ENTREZGENE
  ENST00000305869.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000172156 GTEx
HGNC ID HGNC:10610 ENTREZGENE
Human Proteome Map CCL11 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:6356 UniProtKB/Swiss-Prot
NCBI Gene 6356 ENTREZGENE
OMIM 601156 OMIM
PANTHER EOTAXIN UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35543 PharmGKB
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CCL11_HUMAN UniProtKB/Swiss-Prot
  P50877 ENTREZGENE
  P51671 ENTREZGENE
  Q6I9T4 ENTREZGENE, UniProtKB/TrEMBL
  Q92490 ENTREZGENE
  Q92491 ENTREZGENE
UniProt Secondary P50877 UniProtKB/Swiss-Prot
  Q92490 UniProtKB/Swiss-Prot
  Q92491 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL11  C-C motif chemokine ligand 11  CCL11  chemokine (C-C motif) ligand 11  Symbol and/or name change 5135510 APPROVED