RGD Reference Report - Multiplex bead analysis of urinary cytokines of type 2 diabetic patients with normo- and microalbuminuria. - Rat Genome Database

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Multiplex bead analysis of urinary cytokines of type 2 diabetic patients with normo- and microalbuminuria.

Authors: Liu, J  Zhao, Z  Willcox, MD  Xu, B  Shi, B 
Citation: Liu J, etal., J Immunoassay Immunochem. 2010 Oct;31(4):279-89.
RGD ID: 5683918
Pubmed: PMID:21113841   (View Abstract at PubMed)
DOI: DOI:10.1080/15321819.2010.524860   (Journal Full-text)

Renal damage of diabetic patients is linked to chronic low-grade inflammation. The aim of this study was to analyze urinary concentrations of 27 cytokines in type 2 diabetic patients with normo- and microalbuminuria by multiplex bead immunoassay. Urinary levels of IL-8, IP-10, MCP-1, G-CSF, EOTAXIN, RANTES, and TNF-alpha in microalbuminuric patients were significantly increased compared to those in normoalbuminuric patients (p < 0.05) or controls (p < 0.05). GM-CSF, MIP-1alpha, and MIP-1beta levels were more elevated in microalbuminuric patients than in controls (both p < 0.05). IP-10 and MCP-1 levels were correlated with urinary albumin excretion rate (r = 0.668 and 0.544, both p < 0.01), and estimated glomerular filtration rate (r = -0.454 and -0.418, both p < 0.05). EOTAXIN, GM-CSF, IP-10, MCP-1, and RANTES levels were correlated with HbA1c (r = 0.457, 0.466, 0.678, 0.567, 0.542, respectively, p

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Albuminuria  IEP 5683918associated with Diabetes Mellitus more ...RGD 
Albuminuria  ISOCCL4 (Homo sapiens)5683918; 5683918associated with Diabetes Mellitus more ...RGD 
Diabetic Nephropathies  IEP 5683918associated with Diabetes Mellitus and Type 2RGD 
Diabetic Nephropathies  ISOCCL11 (Homo sapiens)5683918; 5683918associated with Diabetes Mellitus and Type 2RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl11  (C-C motif chemokine ligand 11)
Ccl4  (C-C motif chemokine ligand 4)

Genes (Mus musculus)
Ccl11  (C-C motif chemokine ligand 11)
Ccl4  (C-C motif chemokine ligand 4)

Genes (Homo sapiens)
CCL11  (C-C motif chemokine ligand 11)
CCL4  (C-C motif chemokine ligand 4)


Additional Information