RGD Reference Report - A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. - Rat Genome Database

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A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia.

Authors: Katoh, S  Matsumoto, N  Kawakita, K  Tominaga, A  Kincade, PW  Matsukura, S 
Citation: Katoh S, etal., J Clin Invest. 2003 May;111(10):1563-70.
RGD ID: 4145437
Pubmed: PMID:12750406   (View Abstract at PubMed)
PMCID: PMC155042   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI16583   (Journal Full-text)

Previous studies established that IL-5-producing CD4(+) T cells play a pivotal role in allergic respiratory inflammation. It was also reported that CD4(+) T cells express higher levels of CD44 in the airway than in peripheral blood of patients with allergic respiratory diseases. We have used experimental pulmonary eosinophilia induced in mice by Ascaris suum (Asc) extract to investigate the role of CD44 in the development of allergic respiratory inflammation. Intraperitoneal administration of anti-CD44 mAb prevented both lymphocyte and eosinophil accumulation in the lung. Anti-CD44 mAb also blocked antigen-induced elevation of Th2 cytokines as well as chemokines (CCL11, CCL17) in bronchoalveolar lavage fluid (BALF). Treatment with anti-CD44 mAb inhibited the increased levels of hyaluronic acid (HA) and leukotriene concentrations in BALF that typically result from antigen challenge. Anti-CD44 mAb also blocked antigen-induced airway hyperresponsiveness. An anti-CD44 mAb (IM7) inhibited the HA-binding ability of splenocytes associated with decreased levels of CD44. Soluble CD44 levels in serum were increased in Asc-challenged IM7-treated mice, but not in KM201-treated mice, compared with Asc-challenged rat IgG-treated mice. Ab's that block CD44-HA binding reduced allergic respiratory inflammation by preventing lymphocyte and eosinophil accumulation in the lung. Thus, CD44 may be critical for development of allergic respiratory inflammation.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Ccl11  (C-C motif chemokine ligand 11)
Cd44  (CD44 molecule)

Genes (Mus musculus)
Ccl11  (C-C motif chemokine ligand 11)
Cd44  (CD44 antigen)

Genes (Homo sapiens)
CCL11  (C-C motif chemokine ligand 11)
CD44  (CD44 molecule (IN blood group))


Additional Information