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Gene: THAP1 (THAP domain containing 1) Homo sapiens
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Symbol: THAP1
Name: THAP domain containing 1
Description: Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity; protein homodimerization activity; and zinc ion binding activity. Involved in several processes, including endothelial cell proliferation; negative regulation of transcription by RNA polymerase II; and transcription, DNA-templated. Localizes to the fibrillar center and nucleoplasm. Implicated in torsion dystonia 6.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 4833431A01Rik; dystonia 6, torsion (autosomal dominant); DYT6; FLJ10477; MGC33014; nuclear proapoptotic factor; THAP domain containing, apoptosis associated protein 1; THAP domain protein 1; THAP domain-containing protein 1
Orthologs:
Mus musculus (house mouse) : Thap1 (THAP domain containing, apoptosis associated protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Thap1 (THAP domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thap1 (THAP domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : THAP1 (THAP domain containing 1)
Canis lupus familiaris (dog) : THAP1 (THAP domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thap1 (THAP domain containing 1)
Sus scrofa (pig) : THAP1 (THAP domain containing 1)
Chlorocebus sabaeus (green monkey) : THAP1 (THAP domain containing 1)
Heterocephalus glaber (naked mole-rat) : Thap1 (THAP domain containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl842,836,674 - 42,843,325 (-)Ensembl
GRCh38842,836,674 - 42,843,331 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,691,817 - 42,698,474 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,810,974 - 42,817,631 (-)NCBINCBI36hg18NCBI36
Celera841,639,814 - 41,646,471 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef841,214,132 - 41,220,749 (-)NCBIHuRef
CHM1_1842,738,710 - 42,745,365 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on THAP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316870
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.