MIR205 (microRNA 205) - Rat Genome Database
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Gene: MIR205 (microRNA 205) Homo sapiens
Analyze
Symbol: MIR205
Name: microRNA 205
RGD ID: 1350430
HGNC Page HGNC
Description: Predicted to be involved in several processes, including cellular response to leukemia inhibitory factor; positive regulation of cell population proliferation; and positive regulation of protein kinase B signaling.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-205; MIRN205
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1209,432,133 - 209,432,242 (+)EnsemblGRCh38hg38GRCh38
GRCh381209,432,133 - 209,432,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371209,605,478 - 209,605,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361207,672,100 - 207,672,209 (+)NCBINCBI36hg18NCBI36
Celera1182,836,332 - 182,836,441 (+)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1180,280,840 - 180,280,949 (+)NCBIHuRef
CHM1_11210,877,809 - 210,877,918 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12624257   PMID:16381832   PMID:17604727   PMID:17616659   PMID:18320040   PMID:18376396   PMID:18719201   PMID:19033458   PMID:19144710   PMID:19190970   PMID:19238171   PMID:19244118  
PMID:19665999   PMID:19839716   PMID:20167074   PMID:20428818   PMID:20436283   PMID:20530248   PMID:20588024   PMID:20889907   PMID:21037258   PMID:21237487   PMID:21263248   PMID:21330408  
PMID:21363915   PMID:21368878   PMID:21372198   PMID:21426561   PMID:21453382   PMID:21454583   PMID:21787752   PMID:22159356   PMID:22223089   PMID:22294324   PMID:22356767   PMID:22374676  
PMID:22391564   PMID:22514717   PMID:22525428   PMID:22555458   PMID:22578566   PMID:22631664   PMID:22782668   PMID:22859986   PMID:22869146   PMID:22870299   PMID:22871739   PMID:22890556  
PMID:22949650   PMID:22987275   PMID:23041061   PMID:23056551   PMID:23125283   PMID:23212344   PMID:23239884   PMID:23297865   PMID:23447575   PMID:23571738   PMID:23574937   PMID:23589079  
PMID:23612742   PMID:23683741   PMID:23800974   PMID:23856247   PMID:23881177   PMID:23924028   PMID:23950153   PMID:23994666   PMID:24084898   PMID:24098490   PMID:24129185   PMID:24147037  
PMID:24166197   PMID:24167554   PMID:24173237   PMID:24223734   PMID:24297308   PMID:24314651   PMID:24339740   PMID:24370341   PMID:24434435   PMID:24462768   PMID:24525843   PMID:24576478  
PMID:24763883   PMID:24911147   PMID:24929707   PMID:24935592   PMID:25012146   PMID:25137071   PMID:25292031   PMID:25308719   PMID:25422181   PMID:25427583   PMID:25476932   PMID:25597268  
PMID:25613953   PMID:25695220   PMID:25701838   PMID:25720086   PMID:25917317   PMID:25956054   PMID:25973003   PMID:26045795   PMID:26059417   PMID:26129839   PMID:26181203   PMID:26230475  
PMID:26239614   PMID:26252115   PMID:26275944   PMID:26380287   PMID:26397843   PMID:26446417   PMID:26469956   PMID:26554762   PMID:26586569   PMID:26633009   PMID:26646931   PMID:26708425  
PMID:26711784   PMID:26715266   PMID:26781079   PMID:26813458   PMID:26864590   PMID:26880795   PMID:26916073   PMID:27035764   PMID:27082508   PMID:27153322   PMID:27271572   PMID:27278159  
PMID:27279345   PMID:27283988   PMID:27362808   PMID:27379838   PMID:27498834   PMID:27574009   PMID:27651436   PMID:27753010   PMID:27885248   PMID:27929537   PMID:27943259   PMID:27974696  
PMID:28078305   PMID:28145479   PMID:28199217   PMID:28304186   PMID:28346474   PMID:28350117   PMID:28431233   PMID:28476165   PMID:28501009   PMID:28536008   PMID:28627687   PMID:28634901  
PMID:28651495   PMID:28653600   PMID:28671039   PMID:28740544   PMID:28766230   PMID:28792704   PMID:28987942   PMID:28990808   PMID:29115451   PMID:29150940   PMID:29196733   PMID:29345288  
PMID:29352232   PMID:29393341   PMID:29413049   PMID:29461593   PMID:29464002   PMID:29488611   PMID:29548280   PMID:29556360   PMID:29667486   PMID:29845281   PMID:29964204   PMID:30021798  
PMID:30174230   PMID:30194772   PMID:30244390   PMID:30334817   PMID:30459436   PMID:30659180   PMID:30741252   PMID:30853343   PMID:30909190   PMID:30923833   PMID:30961681   PMID:30992394  
PMID:30997877   PMID:31049956   PMID:31074018   PMID:31150646   PMID:31158447   PMID:31283712   PMID:31292168   PMID:31351249   PMID:31366492   PMID:31391772   PMID:31441592   PMID:31444971  
PMID:31486497   PMID:31545453   PMID:31547870   PMID:31552595   PMID:31578772   PMID:31633295   PMID:31640854   PMID:31799678   PMID:31847864   PMID:31886244   PMID:32046433   PMID:32277654  
PMID:32354230  


Genomics

Comparative Map Data
MIR205
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1209,432,133 - 209,432,242 (+)EnsemblGRCh38hg38GRCh38
GRCh381209,432,133 - 209,432,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371209,605,478 - 209,605,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361207,672,100 - 207,672,209 (+)NCBINCBI36hg18NCBI36
Celera1182,836,332 - 182,836,441 (+)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1180,280,840 - 180,280,949 (+)NCBIHuRef
CHM1_11210,877,809 - 210,877,918 (+)NCBICHM1_1
Mir205
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391193,189,771 - 193,189,838 (-)NCBIGRCm39mm39
GRCm381193,507,463 - 193,507,530 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,507,463 - 193,507,530 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,333,657 - 195,333,724 (-)NCBIGRCm37mm9NCBIm37
Celera1200,390,095 - 200,390,162 (-)NCBICelera
Cytogenetic Map1H6NCBI
Mir205
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.013112,233,283 - 112,233,390 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13112,233,283 - 112,233,390 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013116,787,618 - 116,787,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13104,464,695 - 104,464,802 (-)NCBICelera
Cytogenetic Map13q27NCBI
MIR205
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl78,090,511 - 8,090,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.178,090,511 - 8,090,579 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR205
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9133,517,078 - 133,517,146 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19133,517,078 - 133,517,146 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29146,808,292 - 146,808,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
A006A02  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371209,605,682 - 209,605,822UniSTSGRCh37
Build 361207,672,305 - 207,672,445RGDNCBI36
Celera1182,836,536 - 182,836,676RGD
Cytogenetic Map1q32.2UniSTS
HuRef1180,281,044 - 180,281,184UniSTS
TNG Radiation Hybrid Map1125838.0UniSTS
GeneMap99-GB4 RH Map1691.06UniSTS
NCBI RH Map11868.8UniSTS
G20640  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371209,605,682 - 209,605,822UniSTSGRCh37
Build 361207,672,305 - 207,672,445RGDNCBI36
Celera1182,836,536 - 182,836,676RGD
Cytogenetic Map1q32.2UniSTS
HuRef1180,281,044 - 180,281,184UniSTS
RH68246  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q32.2UniSTS
HuRef1180,281,050 - 180,281,246UniSTS
GeneMap99-GB4 RH Map1691.06UniSTS
NCBI RH Map11870.1UniSTS

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
LRP1hsa-miR-205-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19665999
ZEB1hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI18376396
ZEB1hsa-miR-205-5pMirtarbaseexternal_infoqRT-PCR;OtherFunctional MTI (Weak)19502803
MED1hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20065103
INPPL1hsa-miR-205-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assay//Northern Functional MTI19033458
INPPL1hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20065103
E2F5hsa-miR-205-5pMirtarbaseexternal_infoReporter assayFunctional MTI21454583
E2F1hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22578566
ERBB3hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI19238171
ERBB3hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20065103
ERBB3hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19276373
ERBB3hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI20864407
ZEB2hsa-miR-205-5pMirtarbaseexternal_infoimmunoblot//qRT-PCRFunctional MTI (Weak)19244118
VEGFAhsa-miR-205-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayNon-Functional MTI18320040
VEGFAhsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI19238171
IL24hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20737563
IL24hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23212344
TP73hsa-miR-205-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22871739
ERBB2hsa-miR-205-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI21787752
LRRK2hsa-miR-205-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23125283
YES1hsa-miR-205-5pMirtarbaseexternal_infoReporter assayFunctional MTI21330408
SRChsa-miR-205-5pTarbaseexternal_infoReporter GenePOSITIVE
ZEB1hsa-miR-205-5pTarbaseexternal_infoqPCRPOSITIVE
ZEB1hsa-miR-205-5pTarbaseexternal_infoOtherPOSITIVE
INPPL1hsa-miR-205-5pTarbaseexternal_infoWesternblitPOSITIVE
ZEB2hsa-miR-205-5pMirecordsexternal_infoNANA18376396
VEGFAhsa-miR-205-5pMirecordsexternal_infoNANA18320040
INPPL1hsa-miR-205-5pMirecordsexternal_infoNANA19033458
VEGFAhsa-miR-205-5pMirecordsexternal_infoNANA19238171
ZEB2hsa-miR-205-5pMirecordsexternal_info{changed}NA19244118
ERBB3hsa-miR-205-5pMirecordsexternal_infoNANA19276373
MED1hsa-miR-205-5pMirecordsexternal_infoNANA20065103
CCN1hsa-miR-205-5pOncomiRDBexternal_infoNANA23056551
ZEB1hsa-miR-205-5pOncomiRDBexternal_infoNANA22949650
BCL2hsa-miR-205-5pOncomiRDBexternal_infoNANA22871739
MED1hsa-miR-205-5pOncomiRDBexternal_infoNANA22869146
E2F1hsa-miR-205-5pOncomiRDBexternal_infoNANA22578566
ZEB2hsa-miR-205-5pOncomiRDBexternal_infoNANA22525428
PTENhsa-miR-205-5pOncomiRDBexternal_infoNANA22374676
CCN1hsa-miR-205-5pMirtarbaseexternal_infoWestern blotFunctional MTI23056551
TRAF2hsa-miR-205-5pOncomiRDBexternal_infoNANA22167321
VEGFAhsa-miR-205-5pOncomiRDBexternal_infoNANA22159356
E2F1hsa-miR-205-5pOncomiRDBexternal_infoNANA21454583
ZEB2hsa-miR-205-5pOncomiRDBexternal_infoNANA21426561
SRChsa-miR-205-5pOncomiRDBexternal_infoNANA21330408
BCL2L2hsa-miR-205-5pOncomiRDBexternal_infoNANA21368878
LRP1hsa-miR-205-5pOncomiRDBexternal_infoNANA19665999
ERBB3hsa-miR-205-5pOncomiRDBexternal_infoNANA19276373
PRKCEhsa-miR-205-5pOncomiRDBexternal_infoNANA19244118
ERBB3hsa-miR-205-5pOncomiRDBexternal_infoNANA19238171
INPPL1hsa-miR-205-5pOncomiRDBexternal_infoNANA19033458
ZEB1hsa-miR-205-5pOncomiRDBexternal_infoNANA18376396

Predicted Targets
Summary Value
Count of predictions:36353
Count of gene targets:11860
Count of transcripts:24117
Interacting mature miRNAs:hsa-miR-205-3p, hsa-miR-205-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 2 1 1
Low 1 1 1 5 5 364 1 2 2 92 8 5 3 193
Below cutoff 1 7 61 1 4 10 7 35

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384891
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1209,432,133 - 209,432,242 (+)Ensembl
RefSeq Acc Id: NR_029622
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381209,432,133 - 209,432,242 (+)NCBI
GRCh371209,605,478 - 209,605,587 (+)ENTREZGENE
HuRef1180,280,840 - 180,280,949 (+)ENTREZGENE
CHM1_11210,877,809 - 210,877,918 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh38/hg38 1q32.1-32.2(chr1:204990129-210220258)x3 copy number gain See cases [RCV000051859] Chr1:204990129..210220258 [GRCh38]
Chr1:204959257..210572305 [GRCh37]
Chr1:203225880..208638928 [NCBI36]
Chr1:1q32.1-32.2
pathogenic
GRCh38/hg38 1q32.2-32.3(chr1:208063461-211907812)x1 copy number loss See cases [RCV000138122] Chr1:208063461..211907812 [GRCh38]
Chr1:208236806..212081154 [GRCh37]
Chr1:206303429..210147777 [NCBI36]
Chr1:1q32.2-32.3
likely benign
GRCh38/hg38 1q32.2(chr1:207583527-210159181)x1 copy number loss See cases [RCV000139025] Chr1:207583527..210159181 [GRCh38]
Chr1:207756872..210332526 [GRCh37]
Chr1:205823495..208399149 [NCBI36]
Chr1:1q32.2
pathogenic
GRCh38/hg38 1q32.1-42.12(chr1:204764914-225408698)x3 copy number gain See cases [RCV000142054] Chr1:204764914..225408698 [GRCh38]
Chr1:204734042..225596400 [GRCh37]
Chr1:203000665..223663023 [NCBI36]
Chr1:1q32.1-42.12
pathogenic
GRCh38/hg38 1q32.2-44(chr1:207346642-248930485)x3 copy number gain See cases [RCV000143727] Chr1:207346642..248930485 [GRCh38]
Chr1:207519987..249224684 [GRCh37]
Chr1:205586610..247191307 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q32.1-32.3(chr1:204682513-212815646) copy number loss Global developmental delay [RCV000626524] Chr1:204682513..212815646 [GRCh37]
Chr1:1q32.1-32.3
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
GRCh37/hg19 1q32.1-32.3(chr1:206329070-213263817)x3 copy number gain not provided [RCV000848713] Chr1:206329070..213263817 [GRCh37]
Chr1:1q32.1-32.3
uncertain significance
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2
not provided
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q32.1-44(chr1:204045948-249218992)x3 copy number gain See cases [RCV001007407] Chr1:204045948..249218992 [GRCh37]
Chr1:1q32.1-44
pathogenic
GRCh37/hg19 1q32.2(chr1:208703835-210154164)x3 copy number gain not provided [RCV001259105] Chr1:208703835..210154164 [GRCh37]
Chr1:1q32.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31583 AgrOrtholog
COSMIC MIR205 COSMIC
Ensembl Genes ENSG00000284485 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384891 ENTREZGENE
GTEx ENSG00000284485 GTEx
HGNC ID HGNC:31583 ENTREZGENE
Human Proteome Map MIR205 Human Proteome Map
miRBase MI0000285 ENTREZGENE
NCBI Gene 406988 ENTREZGENE
OMIM 613147 OMIM
PharmGKB PA164722581 PharmGKB
RNAcentral URS0000016914 RNACentral
  URS000038727B RNACentral
  URS0000446722 RNACentral