MIR205 (microRNA 205) - Rat Genome Database

Name: MIR205
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MIR205 (microRNA 205) Homo sapiens

Analyze

Symbol:

MIR205

Name:

microRNA 205

Description:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Type:

ncrna

RefSeq Status:

PROVISIONAL

Also known as:

mir-205; MIRN205

Orthologs:

Mus musculus (house mouse) : Mir205 (microRNA 205) MGI
Rattus norvegicus (Norway rat) : Mir205 (microRNA 205) Alliance
Canis lupus familiaris (dog) : MIR205 (microRNA mir-205)
Sus scrofa (pig) : MIR205 (microRNA mir-205)

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	209,432,133 - 209,432,242 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	209,605,478 - 209,605,587 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	207,672,100 - 207,672,209 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	1	182,836,332 - 182,836,441 (+)	NCBI
Cytogenetic Map	1	q32.2	NCBI
HuRef	1	180,280,840 - 180,280,949 (+)	NCBI		HuRef
CHM1_1	1	210,877,809 - 210,877,918 (+)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

References - curated

References - uncurated

Genomics

Comparative Map Data

Position Markers

miRNA Target Status

Confirmed Targets

Gene Target	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
LRP1	hsa-miR-205-5p	Mirtarbase	external_info	qRT-PCR//Luciferase reporter assay//Western blot	Functional MTI	19665999
ZEB1	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//Microarray//Western blo	Functional MTI	18376396
ZEB1	hsa-miR-205-5p	Mirtarbase	external_info	qRT-PCR;Other	Functional MTI (Weak)	19502803
MED1	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//Western blot	Functional MTI	20065103
INPPL1	hsa-miR-205-5p	Mirtarbase	external_info	Western blot//Luciferase reporter assay//Northern	Functional MTI	19033458
INPPL1	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay	Non-Functional MTI	20065103
E2F5	hsa-miR-205-5p	Mirtarbase	external_info	Reporter assay	Functional MTI	21454583
E2F1	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	22578566
ERBB3	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//Reporter assay;Other	Functional MTI	19238171
ERBB3	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	20065103
ERBB3	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	19276373
ERBB3	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//Microarray//Western blo	Functional MTI	20864407
ZEB2	hsa-miR-205-5p	Mirtarbase	external_info	immunoblot//qRT-PCR	Functional MTI (Weak)	19244118
VEGFA	hsa-miR-205-5p	Mirtarbase	external_info	ELISA//Luciferase reporter assay	Non-Functional MTI	18320040
VEGFA	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//Reporter assay	Functional MTI	19238171
IL24	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	20737563
IL24	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23212344
TP73	hsa-miR-205-5p	Mirtarbase	external_info	qRT-PCR//Western blot	Functional MTI	22871739
ERBB2	hsa-miR-205-5p	Mirtarbase	external_info	qRT-PCR//Western blot	Functional MTI	21787752
LRRK2	hsa-miR-205-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23125283
YES1	hsa-miR-205-5p	Mirtarbase	external_info	Reporter assay	Functional MTI	21330408
SRC	hsa-miR-205-5p	Tarbase	external_info	Reporter Gene	POSITIVE
ZEB1	hsa-miR-205-5p	Tarbase	external_info	qPCR	POSITIVE
ZEB1	hsa-miR-205-5p	Tarbase	external_info	Other	POSITIVE
INPPL1	hsa-miR-205-5p	Tarbase	external_info	Westernblit	POSITIVE
ZEB2	hsa-miR-205-5p	Mirecords	external_info	NA	NA	18376396
VEGFA	hsa-miR-205-5p	Mirecords	external_info	NA	NA	18320040
INPPL1	hsa-miR-205-5p	Mirecords	external_info	NA	NA	19033458
VEGFA	hsa-miR-205-5p	Mirecords	external_info	NA	NA	19238171
ZEB2	hsa-miR-205-5p	Mirecords	external_info	{changed}	NA	19244118
ERBB3	hsa-miR-205-5p	Mirecords	external_info	NA	NA	19276373
MED1	hsa-miR-205-5p	Mirecords	external_info	NA	NA	20065103
CCN1	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	23056551
ZEB1	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	22949650
BCL2	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	22871739
MED1	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	22869146
E2F1	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	22578566
ZEB2	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	22525428
PTEN	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	22374676
CCN1	hsa-miR-205-5p	Mirtarbase	external_info	Western blot	Functional MTI	23056551
TRAF2	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	22167321
VEGFA	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	22159356
E2F1	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	21454583
ZEB2	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	21426561
SRC	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	21330408
BCL2L2	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	21368878
LRP1	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	19665999
ERBB3	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	19276373
PRKCE	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	19244118
ERBB3	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	19238171
INPPL1	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	19033458
ZEB1	hsa-miR-205-5p	OncomiRDB	external_info	NA	NA	18376396

Predicted Targets

	Summary Value
Count of predictions:	34631
Count of gene targets:	10403
Count of transcripts:	22527
Interacting mature miRNAs:	hsa-miR-205-3p, hsa-miR-205-5p
Prediction methods:	Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences

Clinical Variants

Additional Information

External Database Links

More on MIR205
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: hg19 hg38
	HGNC Report
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1350430
Created:	2005-03-08
Species:	Homo sapiens
Last Modified:	2019-10-29
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - CTD