CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: astemizole
Accession: CHEBI:2896
browse the term
Definition: A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Synonyms: exact_synonym: 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
related_synonym: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole; 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole; Astemison; Formula=C28H31FN4O; InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31); InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N; SMILES=COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1; astemizol; astemizolum
xref: Beilstein:4830190; CAS:68844-77-9; DrugBank:DB00637; Drug_Central:249; KEGG:C06832; KEGG:D00234; LINCS:LSM-5502
xref_mesh: MESH:D016589
xref: Patent:EP5318; Patent:US4219559
G
Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases activity
ISO
Astemizole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Astemizole results in decreased activity of ABCB11 protein
CTD
PMID:24014644
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Ak3
adenylate kinase 3
increases expression
EXP
Astemizole results in increased expression of AK3 mRNA
CTD
PMID:20221588
NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
G
Alas2
5'-aminolevulinate synthase 2
increases expression
EXP
Astemizole results in increased expression of ALAS2 mRNA
CTD
PMID:20221588
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
G
Angpt2
angiopoietin 2
increases expression
EXP
Astemizole results in increased expression of ANGPT2 mRNA
CTD
PMID:20221588
NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
G
Atf3
activating transcription factor 3
increases expression
ISO
Astemizole results in increased expression of ATF3 mRNA
CTD
PMID:32661532
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Atp1b1
ATPase Na+/K+ transporting subunit beta 1
increases expression
EXP
Astemizole results in increased expression of ATP1B1 mRNA
CTD
PMID:20221588
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
G
Atp1b2
ATPase Na+/K+ transporting subunit beta 2
decreases expression
EXP
Astemizole results in decreased expression of ATP1B2 mRNA
CTD
PMID:20221588
NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933
G
Atp5f1e
ATP synthase F1 subunit epsilon
increases expression
EXP
Astemizole results in increased expression of ATP5F1E mRNA
CTD
PMID:20221588
NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
G
Bcl2
BCL2, apoptosis regulator
decreases expression
EXP
Astemizole results in decreased expression of BCL2 mRNA
CTD
PMID:20221588
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bmp1
bone morphogenetic protein 1
decreases expression
EXP
Astemizole results in decreased expression of BMP1 mRNA
CTD
PMID:20221588
NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776
G
Camk2d
calcium/calmodulin-dependent protein kinase II delta
decreases expression
EXP
Astemizole results in decreased expression of CAMK2D mRNA
CTD
PMID:20221588
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
G
Cat
catalase
increases expression
EXP
Astemizole results in increased expression of CAT mRNA
CTD
PMID:20221588
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl7
C-C motif chemokine ligand 7
decreases expression
EXP
Astemizole results in decreased expression of CCL7 mRNA
CTD
PMID:20221588
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
G
Cebpb
CCAAT/enhancer binding protein beta
increases expression
EXP
Astemizole results in increased expression of CEBPB mRNA
CTD
PMID:20221588
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
G
Cebpg
CCAAT/enhancer binding protein gamma
decreases expression
EXP
Astemizole results in decreased expression of CEBPG mRNA
CTD
PMID:20221588
NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
G
Cfh
complement factor H
decreases expression
EXP
Astemizole results in decreased expression of CFH mRNA
CTD
PMID:20221588
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
G
Colec12
collectin sub-family member 12
decreases expression
EXP
Astemizole results in decreased expression of COLEC12 mRNA
CTD
PMID:20221588
NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
G
Cox6c-ps1
cytochrome c oxidase subunit VIc, pseudogene
increases expression
EXP
Astemizole results in increased expression of COX6C-PS1 mRNA
CTD
PMID:20221588
NCBI chr19:52,192,612...52,193,470
Ensembl chr19:52,192,612...52,193,470
G
Crh
corticotropin releasing hormone
multiple interactions
EXP
Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]
CTD
PMID:18835572
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
G
Cxcl3
C-X-C motif chemokine ligand 3
decreases expression
EXP
Astemizole results in decreased expression of CXCL3 mRNA
CTD
PMID:20221588
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
G
Cxcl9
C-X-C motif chemokine ligand 9
decreases expression
EXP
Astemizole results in decreased expression of CXCL9 mRNA
CTD
PMID:20221588
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
G
Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
multiple interactions increases metabolic processing decreases methylation
ISO
Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]; ebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole] CYP2J2 protein results in increased metabolism of Astemizole
CTD
PMID:12386130 PMID:15861034 PMID:17162467
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases degradation
ISO
CYP3A4 protein results in increased degradation of Astemizole
CTD
PMID:15684493
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Eaf1
ELL associated factor 1
increases expression
EXP
Astemizole results in increased expression of EAF1 mRNA
CTD
PMID:20221588
NCBI chr16:6,698,322...6,713,071
Ensembl chr16:6,698,322...6,713,071
G
Egln1
egl-9 family hypoxia-inducible factor 1
increases expression
EXP
Astemizole results in increased expression of EGLN1 mRNA
CTD
PMID:20221588
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
G
Eif4a1
eukaryotic translation initiation factor 4A1
increases expression
EXP
Astemizole results in increased expression of EIF4A1 mRNA
CTD
PMID:20221588
NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
G
Errfi1
ERBB receptor feedback inhibitor 1
decreases expression
EXP
Astemizole results in decreased expression of ERRFI1 mRNA
CTD
PMID:20221588
NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
G
Etv5
ETS variant transcription factor 5
decreases expression
EXP
Astemizole results in decreased expression of ETV5 mRNA
CTD
PMID:20221588
NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215
G
Fam124a
family with sequence similarity 124 member A
increases expression
EXP
Astemizole results in increased expression of FAM124A mRNA
CTD
PMID:20221588
NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683
G
Fcer1a
Fc epsilon receptor Ia
multiple interactions
EXP
Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]
CTD
PMID:9088877
NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
G
Gdf10
growth differentiation factor 10
increases expression
EXP
Astemizole results in increased expression of GDF10 mRNA
CTD
PMID:20221588
NCBI chr16:9,237,182...9,250,537
Ensembl chr16:9,237,261...9,249,343
G
Gimap1
GTPase, IMAP family member 1
increases expression
EXP
Astemizole results in increased expression of GIMAP1 mRNA
CTD
PMID:20221588
NCBI chr 4:77,687,581...77,691,468
Ensembl chr 4:77,682,171...77,691,866
G
Gpm6b
glycoprotein m6b
increases expression
EXP
Astemizole results in increased expression of GPM6B mRNA
CTD
PMID:20221588
NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211
G
Gpx4
glutathione peroxidase 4
increases expression
EXP
Astemizole results in increased expression of GPX4 mRNA
CTD
PMID:20221588
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
G
Hexb
hexosaminidase subunit beta
increases secretion multiple interactions
EXP
Astemizole results in increased secretion of HEXB protein Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]
CTD
PMID:9088877
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
G
Hmox1
heme oxygenase 1
increases expression
ISO
Astemizole results in increased expression of HMOX1 mRNA
CTD
PMID:32661532
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hrh1
histamine receptor H 1
multiple interactions
ISO
[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]
CTD
PMID:12147327 PMID:16129921
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
G
Hsp90ab1
heat shock protein 90 alpha family class B member 1
decreases expression
EXP
Astemizole results in decreased expression of HSP90AB1 mRNA
CTD
PMID:20221588
NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
G
Hspa8
heat shock protein family A (Hsp70) member 8
increases expression
EXP
Astemizole results in increased expression of HSPA8 mRNA
CTD
PMID:20221588
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Hspb8
heat shock protein family B (small) member 8
increases expression
EXP
Astemizole results in increased expression of HSPB8 mRNA
CTD
PMID:20221588
NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
G
Hsph1
heat shock protein family H (Hsp110) member 1
decreases expression
EXP
Astemizole results in decreased expression of HSPH1 mRNA
CTD
PMID:20221588
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]
CTD
PMID:17517105
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
decreases expression
EXP
Astemizole results in decreased expression of IFIT3 mRNA
CTD
PMID:20221588
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
G
Igf1
insulin-like growth factor 1
multiple interactions
ISO
Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]
CTD
PMID:17520698
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igsf6
immunoglobulin superfamily, member 6
decreases expression
EXP
Astemizole results in decreased expression of IGSF6 mRNA
CTD
PMID:20221588
NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722
G
Il1b
interleukin 1 beta
multiple interactions
ISO
Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
CTD
PMID:17517105
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il36rn
interleukin 36 receptor antagonist
increases expression
EXP
Astemizole results in increased expression of IL36RN mRNA
CTD
PMID:20221588
NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
G
Il7r
interleukin 7 receptor
decreases expression
EXP
Astemizole results in decreased expression of IL7R mRNA
CTD
PMID:20221588
NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
G
Itga8
integrin subunit alpha 8
increases expression
EXP
Astemizole results in increased expression of ITGA8 mRNA
CTD
PMID:20221588
NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510
G
Kcnh1
potassium voltage-gated channel subfamily H member 1
multiple interactions decreases activity affects binding
ISO
Astemizole binds to and results in decreased activity of KCNH1 protein; Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] Astemizole results in decreased activity of KCNH1 protein Astemizole binds to KCNH1 protein
CTD
PMID:14985237 PMID:16816845 PMID:17520698 PMID:18471075 PMID:18497958 PMID:20050851 PMID:32533968 More...
NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions affects binding decreases activity affects localization
ISO EXP
Astemizole binds to and results in decreased activity of KCNH2 protein; Astemizole inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Astemizole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]; Potassium promotes the reaction [Astemizole binds to KCNH2 protein] Astemizole binds to KCNH2 gene polymorphism; Astemizole binds to KCNH2 protein Astemizole affects the localization of KCNH2 protein mutant form
CTD
PMID:8641472 PMID:9658196 PMID:10376921 PMID:10422790 PMID:10531299 PMID:10828461 PMID:11040061 PMID:11082114 PMID:11705456 PMID:11741928 PMID:12388285 PMID:15272206 PMID:15671647 PMID:15740727 PMID:16723379 PMID:18701618 PMID:19139152 PMID:19583963 PMID:21158687 PMID:24052561 PMID:24200993 PMID:28521025 More...
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kcnq2
potassium voltage-gated channel subfamily Q member 2
multiple interactions
ISO
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]
CTD
PMID:12147327
NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071
G
Kcnq3
potassium voltage-gated channel subfamily Q member 3
multiple interactions
ISO
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]
CTD
PMID:12147327
NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653
G
Maoa
monoamine oxidase A
decreases expression
EXP
Astemizole results in decreased expression of MAOA mRNA
CTD
PMID:20221588
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
G
Mapt
microtubule-associated protein tau
affects binding
ISO
Astemizole binds to MAPT protein alternative form
CTD
PMID:20110603
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
G
Mmp2
matrix metallopeptidase 2
decreases expression
EXP
Astemizole results in decreased expression of MMP2 mRNA
CTD
PMID:20221588
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Ms4a6a
membrane spanning 4-domains A6A
decreases expression
EXP
Astemizole results in decreased expression of MS4A6A mRNA
CTD
PMID:20221588
NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758
G
Mt2A
metallothionein 2A
increases expression
ISO
Astemizole results in increased expression of MT2A mRNA
CTD
PMID:32661532
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Mtf1
metal-regulatory transcription factor 1
multiple interactions
ISO
MTF1 protein affects the reaction [Astemizole results in increased expression of MT1M mRNA]
CTD
PMID:32661532
NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
G
Mtus1
microtubule associated scaffold protein 1
decreases expression
EXP
Astemizole results in decreased expression of MTUS1 mRNA
CTD
PMID:20221588
NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793
G
Myh6
myosin heavy chain 6
increases expression
EXP
Astemizole results in increased expression of MYH6 mRNA
CTD
PMID:20221588
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
G
Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
increases expression
EXP
Astemizole results in increased expression of NDUFS7 mRNA
CTD
PMID:20221588
NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
G
Ndufv2
NADH:ubiquinone oxidoreductase core subunit V2
increases expression
EXP
Astemizole results in increased expression of NDUFV2 mRNA
CTD
PMID:20221588
NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
G
Necab1
N-terminal EF-hand calcium binding protein 1
decreases expression
EXP
Astemizole results in decreased expression of NECAB1 mRNA
CTD
PMID:20221588
NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642 Ensembl chr 5:28,357,859...28,578,642
G
Nr4a3
nuclear receptor subfamily 4, group A, member 3
increases expression
EXP
Astemizole results in increased expression of NR4A3 mRNA
CTD
PMID:20221588
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
G
Oasl
2'-5'-oligoadenylate synthetase-like
decreases expression
EXP
Astemizole results in decreased expression of OASL1 mRNA
CTD
PMID:20221588
NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
G
Osbpl3
oxysterol binding protein-like 3
increases expression
EXP
Astemizole results in increased expression of OSBPL3 mRNA
CTD
PMID:20221588
NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393
G
Osgepl1
O-sialoglycoprotein endopeptidase-like 1
increases expression
EXP
Astemizole results in increased expression of OSGEPL1 mRNA
CTD
PMID:20221588
NCBI chr 9:48,214,995...48,229,440
Ensembl chr 9:48,215,402...48,229,388
G
Park7
Parkinsonism associated deglycase
increases expression
EXP
Astemizole results in increased expression of PARK7 mRNA
CTD
PMID:20221588
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
G
Pcdh17
protocadherin 17
decreases expression
EXP
Astemizole results in decreased expression of PCDH17 mRNA
CTD
PMID:20221588
NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999
G
Peli2
pellino E3 ubiquitin protein ligase family member 2
increases expression
EXP
Astemizole results in increased expression of PELI2 mRNA
CTD
PMID:20221588
NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106
G
Prl8a3
prolactin family 8, subfamily A, member 3
decreases expression
EXP
Astemizole results in decreased expression of PRL8A3 mRNA
CTD
PMID:20221588
NCBI chr17:37,508,328...37,514,832
Ensembl chr17:37,508,328...37,514,825
G
Psmb5
proteasome 20S subunit beta 5
increases expression
EXP
Astemizole results in increased expression of PSMB5 mRNA
CTD
PMID:20221588
NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
G
Ptgs1
prostaglandin-endoperoxide synthase 1
decreases expression
EXP
Astemizole results in decreased expression of PTGS1 mRNA
CTD
PMID:20221588
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
G
Pycr3
pyrroline-5-carboxylate reductase 3
increases expression
EXP
Astemizole results in increased expression of PYCR3 mRNA
CTD
PMID:20221588
NCBI chr 7:107,603,543...107,608,831
Ensembl chr 7:107,581,930...107,608,799
G
Pygm
glycogen phosphorylase, muscle associated
increases expression
EXP
Astemizole results in increased expression of PYGM mRNA
CTD
PMID:20221588
NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368
G
S100a8
S100 calcium binding protein A8
increases expression
EXP
Astemizole results in increased expression of S100A8 mRNA
CTD
PMID:20221588
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
G
S100b
S100 calcium binding protein B
decreases expression
EXP
Astemizole results in decreased expression of S100B mRNA
CTD
PMID:20221588
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
G
Sik1
salt-inducible kinase 1
decreases expression
EXP
Astemizole results in decreased expression of SIK1 mRNA
CTD
PMID:20221588
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
G
Slc1a1
solute carrier family 1 member 1
increases expression
EXP
Astemizole results in increased expression of SLC1A1 mRNA
CTD
PMID:20221588
NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
G
Sod2
superoxide dismutase 2
increases expression
EXP
Astemizole results in increased expression of SOD2 mRNA
CTD
PMID:20221588
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Sqstm1
sequestosome 1
increases expression
EXP
Astemizole results in increased expression of SQSTM1 mRNA
CTD
PMID:20221588
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Tf
transferrin
decreases expression
EXP
Astemizole results in decreased expression of TF mRNA
CTD
PMID:20221588
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
G
Tgfb2
transforming growth factor, beta 2
increases expression
EXP
Astemizole results in increased expression of TGFB2 mRNA
CTD
PMID:20221588
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
G
Tlr2
toll-like receptor 2
decreases expression
EXP
Astemizole results in decreased expression of TLR2 mRNA
CTD
PMID:20221588
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tlr7
toll-like receptor 7
decreases expression
EXP
Astemizole results in decreased expression of TLR7 mRNA
CTD
PMID:20221588
NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
G
Tmod1
tropomodulin 1
increases expression
EXP
Astemizole results in increased expression of TMOD1 mRNA
CTD
PMID:20221588
NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
CTD
PMID:17517105
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
G
Vcan
versican
decreases expression
EXP
Astemizole results in decreased expression of VCAN mRNA
CTD
PMID:20221588
NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all