|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions affects activity increases expression decreases activity |
ISO |
Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] formononetin affects the activity of ABCB1 protein formononetin results in decreased activity of ABCB1 protein |
CTD |
PMID:15796199 PMID:23867903 PMID:27996361 PMID:34217736 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects activity decreases expression multiple interactions |
ISO |
formononetin affects the activity of ABCC1 protein formononetin results in decreased expression of ABCC1 mRNA Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA] |
CTD |
PMID:15796199 PMID:23867903 |
|
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions decreases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA] formononetin promotes the reaction [Cisplatin results in increased expression of ABCC2 mRNA] |
CTD |
PMID:23867903 PMID:28414026 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
EXP |
formononetin promotes the reaction [Cisplatin results in increased expression of ABCC4 mRNA] |
CTD |
PMID:28414026 |
|
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283
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G |
Acp5 |
acid phosphatase 5, tartrate resistant |
multiple interactions |
ISO |
formononetin inhibits the reaction [Streptozocin results in increased activity of ACP5 protein]; formononetin inhibits the reaction [Streptozocin results in increased expression of ACP5 mRNA] |
CTD |
PMID:35315182 |
|
NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:20,663,985...20,667,929
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions increases activity |
ISO |
fulvestrant promotes the reaction [formononetin results in increased activity of AHR protein] |
CTD |
PMID:28985473 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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|
G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases expression |
ISO |
formononetin results in increased expression of AKR1B10 mRNA |
CTD |
PMID:37793997 |
|
NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
formononetin decreases phosphorylation of AKT1 protein in lung formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]] |
CTD RGD |
PMID:34077701 PMID:32276600 |
RGD:151357000 |
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO EXP |
formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA] formononetin inhibits the reaction [Cisplatin results in increased expression of BAX protein] |
CTD |
PMID:23867903 PMID:28414026 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
formononetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein] formononetin results in decreased expression of BCL2 mRNA formononetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] |
CTD |
PMID:23867903 PMID:28414026 PMID:34077701 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP3 mRNA]; formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA] formononetin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form] formononetin increases activity of CASP3 protein in lung |
CTD RGD |
PMID:23867903 PMID:28414026 PMID:34077701 PMID:32276600 |
RGD:151357000 |
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP7 protein] |
CTD |
PMID:34077701 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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|
G |
Casp8 |
caspase 8 |
increases activity increases expression multiple interactions |
ISO |
formononetin results in increased activity of CASP8 protein formononetin results in increased expression of CASP8 mRNA Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA] |
CTD |
PMID:23867903 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity increases expression multiple interactions |
ISO |
formononetin results in increased activity of CASP9 protein formononetin results in increased expression of CASP9 mRNA Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP9 mRNA]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP9 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA] |
CTD |
PMID:23867903 |
|
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccnb1 |
cyclin B1 |
increases expression multiple interactions |
ISO EXP |
formononetin results in increased expression of CCNB1 protein XI-006 inhibits the reaction [formononetin results in increased expression of CCNB1 protein] |
CTD |
PMID:28414026 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
increases expression multiple interactions |
EXP ISO |
formononetin results in increased expression of CCND1 protein XI-006 inhibits the reaction [formononetin results in increased expression of CCND1 protein] |
CTD |
PMID:28414026 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
formononetin results in increased expression of CPT1A mRNA |
CTD |
PMID:37793997 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
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G |
Ctsk |
cathepsin K |
multiple interactions |
ISO |
formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK protein] |
CTD |
PMID:35315182 |
|
NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases hydroxylation decreases methylation multiple interactions increases expression |
ISO |
CYP1A1 protein results in increased hydroxylation of formononetin CYP1A1 protein results in decreased methylation of formononetin fulvestrant promotes the reaction [formononetin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:15479032 PMID:28985473 PMID:37793997 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO EXP |
formononetin results in decreased activity of CYP1A2 protein |
CTD |
PMID:26278343 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases methylation increases expression |
ISO |
CYP1B1 protein results in decreased methylation of formononetin formononetin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:15479032 PMID:28985473 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
formononetin results in decreased activity of CYP2D6 protein |
CTD |
PMID:26278343 |
|
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation |
ISO |
formononetin decreases phosphorylation of EGFR protein in lung |
RGD |
PMID:32276600 |
RGD:151357000 |
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
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|
G |
Epo |
erythropoietin |
increases expression |
ISO |
formononetin results in increased expression of EPO mRNA |
CTD |
PMID:21309574 PMID:37348668 |
|
NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
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G |
Esr1 |
estrogen receptor 1 |
affects binding multiple interactions |
ISO |
formononetin binds to ESR1 protein formononetin binds to and results in increased activity of ESR1 protein [Lipopolysaccharides co-treated with formononetin] results in increased expression of ESR1 protein |
CTD |
PMID:9751507 PMID:16076101 PMID:16773531 PMID:37269934 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects binding |
ISO |
formononetin binds to and results in increased activity of ESR2 protein formononetin binds to ESR2 protein |
CTD |
PMID:9751507 PMID:12224631 PMID:16076101 PMID:16773531 PMID:19913605 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
formononetin inhibits the reaction [Streptozocin results in increased expression of FOS mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of FOS protein] |
CTD |
PMID:35315182 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of GCLM protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]] |
CTD |
PMID:34077701 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
formononetin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] |
CTD |
PMID:28414026 |
|
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases expression |
ISO |
formononetin results in decreased degradation of and results in increased expression of HIF1A protein modified form; formononetin results in increased expression of and results in decreased degradation of HIF1A protein formononetin results in increased expression of HIF1A mRNA; formononetin results in increased expression of HIF1A protein |
CTD |
PMID:21309574 PMID:37348668 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP ISO |
formononetin inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA] [formononetin co-treated with Hydrogen Peroxide] results in increased expression of HMOX1 protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]] |
CTD |
PMID:34077701 PMID:37944786 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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|
G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
formononetin promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA] |
CTD |
PMID:25583575 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
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G |
Il4 |
interleukin 4 |
increases expression |
ISO |
formononetin results in increased expression of IL4 mRNA; formononetin results in increased expression of IL4 protein |
CTD |
PMID:16108819 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] |
CTD |
PMID:37269934 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
formononetin inhibits the reaction [Streptozocin results in increased expression of JUN mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of JUN protein] |
CTD |
PMID:35315182 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:34077701 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:34077701 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:34077701 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G |
Matn3 |
matrilin 3 |
decreases expression |
ISO |
formononetin results in decreased expression of MATN3 mRNA |
CTD |
PMID:37793997 |
|
NCBI chr 6:37,467,729...37,487,776
Ensembl chr 6:31,748,474...31,768,101
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
formononetin decreases expression of MCL1 protein in lung |
RGD |
PMID:32276600 |
RGD:151357000 |
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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|
G |
Mdm2 |
MDM2 proto-oncogene |
increases expression |
EXP |
formononetin results in increased expression of MDM2 protein |
CTD |
PMID:28414026 |
|
NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
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|
G |
Mdm4 |
MDM4 regulator of p53 |
increases expression |
EXP |
formononetin results in increased expression of MDM4 protein |
CTD |
PMID:28414026 |
|
NCBI chr13:46,922,236...47,068,241
Ensembl chr13:44,406,213...44,474,226
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 protein] |
CTD |
PMID:35315182 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 protein] |
CTD |
PMID:35315182 |
|
NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 mRNA; formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]] formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] |
CTD |
PMID:34077701 PMID:37269934 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
formononetin inhibits the reaction [CXCL8 protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:22387535 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G |
Ngf |
nerve growth factor |
multiple interactions |
EXP |
formononetin inhibits the reaction [Glucose results in decreased expression of NGF mRNA]; formononetin inhibits the reaction [Glucose results in decreased secretion of and results in decreased expression of NGF protein] |
CTD |
PMID:37944786 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA] |
CTD |
PMID:37269934 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G |
Nos3 |
nitric oxide synthase 3 |
increases expression multiple interactions |
EXP |
formononetin results in increased expression of NOS3 mRNA formononetin results in increased phosphorylation of and results in increased activity of NOS3 protein |
CTD |
PMID:19570671 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA] |
CTD |
PMID:34077701 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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|
G |
Pgc |
progastricsin |
decreases expression |
ISO |
formononetin results in decreased expression of PGC mRNA |
CTD |
PMID:37793997 |
|
NCBI chr 9:20,755,002...20,763,220
Ensembl chr 9:13,257,462...13,265,682
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|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein] |
CTD |
PMID:37944786 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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|
G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
increases phosphorylation multiple interactions |
ISO |
formononetin results in increased phosphorylation of PRKAA1 protein Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA1 protein] |
CTD |
PMID:37269934 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978
|
|
G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
multiple interactions increases phosphorylation |
ISO |
Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA2 protein] |
CTD |
PMID:37269934 |
|
NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543
|
|
G |
Prkacb |
protein kinase cAMP-activated catalytic subunit beta |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of PRKACB protein |
CTD |
PMID:37269934 |
|
NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:235,636,885...235,726,198
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|
G |
Ptgr1 |
prostaglandin reductase 1 |
increases expression |
ISO |
[Formononetin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells |
RGD |
PMID:26265982 |
RGD:401959214 |
NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:73,784,009...73,802,666
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] |
CTD |
PMID:37269934 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
|
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] |
CTD |
PMID:37944786 |
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NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
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G |
Sirt3 |
sirtuin 3 |
affects binding multiple interactions |
EXP |
formononetin binds to SIRT3 protein formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 protein] |
CTD |
PMID:37944786 |
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NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:195,942,073...195,964,808
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G |
Slc22a2 |
solute carrier family 22 member 2 |
decreases expression |
EXP |
formononetin results in decreased expression of SLC22A2 mRNA |
CTD |
PMID:28414026 |
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NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc6a14 |
solute carrier family 6 member 14 |
decreases expression |
ISO |
formononetin results in decreased expression of SLC6A14 mRNA |
CTD |
PMID:37793997 |
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NCBI chr X:117,109,063...117,169,522
Ensembl chr X:112,314,691...112,375,096
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 protein] |
CTD |
PMID:37944786 |
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NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 protein] |
CTD |
PMID:37944786 |
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NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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G |
Stk11 |
serine/threonine kinase 11 |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of STK11 protein |
CTD |
PMID:37269934 |
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NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315
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G |
Tagln |
transgelin |
decreases expression |
ISO |
formononetin results in decreased expression of TAGLN mRNA |
CTD |
PMID:37793997 |
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NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:46,222,472...46,230,668
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G |
Tfam |
transcription factor A, mitochondrial |
multiple interactions |
EXP |
formononetin inhibits the reaction [Glucose results in decreased expression of TFAM mRNA] |
CTD |
PMID:37944786 |
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NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292
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G |
Tfb2m |
transcription factor B2, mitochondrial |
multiple interactions |
EXP |
formononetin inhibits the reaction [Glucose results in decreased expression of TFB2M mRNA] |
CTD |
PMID:37944786 |
|
NCBI chr13:93,810,859...93,828,678
Ensembl chr13:91,278,898...91,296,657
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] |
CTD |
PMID:37269934 |
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NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G |
Tp53 |
tumor protein p53 |
multiple interactions decreases expression |
EXP ISO |
formononetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] XI-006 inhibits the reaction [formononetin results in decreased expression of TP53 protein] |
CTD |
PMID:28414026 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Trpv5 |
transient receptor potential cation channel, subfamily V, member 5 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV5 mRNA] |
CTD |
PMID:35315182 |
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NCBI chr 4:71,503,085...71,531,134
Ensembl chr 4:70,536,440...70,562,745
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G |
Trpv6 |
transient receptor potential cation channel, subfamily V, member 6 |
multiple interactions |
ISO |
formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV6 mRNA] |
CTD |
PMID:35315182 |
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NCBI chr 4:71,474,006...71,489,667
Ensembl chr 4:70,507,348...70,523,017
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G |
Txnip |
thioredoxin interacting protein |
increases expression |
ISO |
formononetin results in increased expression of TXNIP mRNA |
CTD |
PMID:37793997 |
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NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886
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G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
ISO |
[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA] |
CTD |
PMID:34077701 |
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NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation increases expression |
ISO |
UGT1A1 protein results in increased glucuronidation of formononetin formononetin results in increased expression of UGT1A1 mRNA |
CTD |
PMID:14557274 PMID:37793997 |
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NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of formononetin |
CTD |
PMID:14557274 |
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NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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