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formononetin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:formononetin
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Accession:CHEBI:18088 term browser browse the term
Definition:A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.
Synonyms:related_synonym: 4'-O-methyldaidzein;   7-Hydroxy-3-(4-methoxyphenyl)-4-benzopyrone;   7-Hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one;   7-Hydroxy-4'-methoxyisoflavone;   7-hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one;   Formula=C16H12O4;   InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3;   InChIKey=HKQYGTCOTHHOMP-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1)-c1coc2cc(O)ccc2c1=O;   biochanin B;   formononetol
 alt_id: CHEBI:14279;   CHEBI:18194;   CHEBI:24086;   CHEBI:5146
 xref: Beilstein:1288158;   CAS:485-72-3;   HMDB:HMDB0005808;   KEGG:C00858;   KNApSAcK:C00002525;   LINCS:LSM-19000;   LIPID_MAPS_instance:LMPK12050037
 xref_mesh: MESH:C007768
 xref: MetaCyc:FORMONONETIN;   PMID:16108819;   PMID:24023812;   Reaxys:237979;   Wikipedia:Formononetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:77688

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formononetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects activity
increases expression
decreases activity 		ISO Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
formononetin affects the activity of ABCB1 protein
formononetin results in decreased activity of ABCB1 protein 		CTD PMID:15796199 PMID:23867903 PMID:27996361 PMID:34217736 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects activity
multiple interactions
decreases expression 		ISO formononetin affects the activity of ABCC1 protein
Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA] 		CTD PMID:15796199 PMID:23867903 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression 		ISO
EXP 		Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]
formononetin promotes the reaction [Cisplatin results in increased expression of ABCC2 mRNA] 		CTD PMID:23867903 PMID:28414026 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions EXP formononetin promotes the reaction [Cisplatin results in increased expression of ABCC4 mRNA] CTD PMID:28414026 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO formononetin inhibits the reaction [Streptozocin results in increased activity of ACP5 protein]; formononetin inhibits the reaction [Streptozocin results in increased expression of ACP5 mRNA] CTD PMID:35315182 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity 		ISO fulvestrant promotes the reaction [formononetin results in increased activity of AHR protein] CTD PMID:28985473 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO formononetin results in increased expression of AKR1B10 mRNA CTD PMID:37793997 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation 		ISO formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]
formononetin decreases phosphorylation of AKT1 protein in lung 		CTD
RGD		 PMID:34077701 PMID:32276600 RGD:151357000 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP 		formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]
formononetin inhibits the reaction [Cisplatin results in increased expression of BAX protein] 		CTD PMID:23867903 PMID:28414026 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO
EXP 		formononetin results in decreased expression of BCL2 mRNA
formononetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]
formononetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] 		CTD PMID:23867903 PMID:28414026 PMID:34077701 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression 		ISO
EXP 		Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP3 mRNA]; formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]
formononetin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]
formononetin increases activity of CASP3 protein in lung 		CTD
RGD		 PMID:23867903 PMID:28414026 PMID:34077701 PMID:32276600 RGD:151357000 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO formononetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP7 protein] CTD PMID:34077701 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
increases expression 		ISO Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA] CTD PMID:23867903 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression 		ISO Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP9 mRNA]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP9 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA] CTD PMID:23867903 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions 		ISO
EXP 		formononetin results in increased expression of CCNB1 protein
XI-006 inhibits the reaction [formononetin results in increased expression of CCNB1 protein] 		CTD PMID:28414026 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions 		EXP
ISO 		formononetin results in increased expression of CCND1 protein
XI-006 inhibits the reaction [formononetin results in increased expression of CCND1 protein] 		CTD PMID:28414026 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO formononetin results in increased expression of CPT1A mRNA CTD PMID:37793997 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of CTSK protein] CTD PMID:35315182 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydroxylation
decreases methylation
multiple interactions
increases expression 		ISO CYP1A1 protein results in increased hydroxylation of formononetin
CYP1A1 protein results in decreased methylation of formononetin
fulvestrant promotes the reaction [formononetin results in increased expression of CYP1A1 mRNA] 		CTD PMID:15479032 PMID:28985473 PMID:37793997 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO
EXP 		formononetin results in decreased activity of CYP1A2 protein CTD PMID:26278343 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases methylation
increases expression 		ISO CYP1B1 protein results in decreased methylation of formononetin
formononetin results in increased expression of CYP1B1 mRNA 		CTD PMID:15479032 PMID:28985473 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO formononetin results in decreased activity of CYP2D6 protein CTD PMID:26278343 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO formononetin decreases phosphorylation of EGFR protein in lung RGD PMID:32276600 RGD:151357000 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Epo erythropoietin increases expression ISO formononetin results in increased expression of EPO mRNA CTD PMID:21309574 PMID:37348668 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions 		ISO formononetin binds to ESR1 protein
formononetin binds to and results in increased activity of ESR1 protein
[Lipopolysaccharides co-treated with formononetin] results in increased expression of ESR1 protein 		CTD PMID:9751507 PMID:16076101 PMID:16773531 PMID:37269934 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding 		ISO formononetin binds to and results in increased activity of ESR2 protein
formononetin binds to ESR2 protein 		CTD PMID:9751507 PMID:12224631 PMID:16076101 PMID:16773531 PMID:19913605 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO formononetin inhibits the reaction [Streptozocin results in increased expression of FOS mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of FOS protein] CTD PMID:35315182 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [formononetin co-treated with Hydrogen Peroxide] results in increased expression of GCLM protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]] CTD PMID:34077701 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP formononetin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] CTD PMID:28414026 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions 		ISO formononetin results in increased expression of HIF1A mRNA; formononetin results in increased expression of HIF1A protein
formononetin results in decreased degradation of and results in increased expression of HIF1A protein modified form; formononetin results in increased expression of and results in decreased degradation of HIF1A protein 		CTD PMID:21309574 PMID:37348668 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP 		[formononetin co-treated with Hydrogen Peroxide] results in increased expression of HMOX1 protein; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]
formononetin inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA] 		CTD PMID:34077701 PMID:37944786 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO formononetin promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA] CTD PMID:25583575 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il4 interleukin 4 increases expression ISO formononetin results in increased expression of IL4 mRNA; formononetin results in increased expression of IL4 protein CTD PMID:16108819 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:37269934 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO formononetin inhibits the reaction [Streptozocin results in increased expression of JUN mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of JUN protein] CTD PMID:35315182 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:34077701 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] CTD PMID:34077701 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO formononetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] CTD PMID:34077701 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Matn3 matrilin 3 decreases expression ISO formononetin results in decreased expression of MATN3 mRNA CTD PMID:37793997 NCBI chr 6:31,748,517...31,768,564
Ensembl chr 6:31,748,474...31,768,101 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO formononetin decreases expression of MCL1 protein in lung RGD PMID:32276600 RGD:151357000 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP formononetin results in increased expression of MDM2 protein CTD PMID:28414026 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mdm4 MDM4 regulator of p53 increases expression EXP formononetin results in increased expression of MDM4 protein CTD PMID:28414026 NCBI chr13:46,922,236...47,068,241
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of MMP9 protein] CTD PMID:35315182 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 mRNA]; formononetin inhibits the reaction [Streptozocin results in increased expression of NFATC1 protein] CTD PMID:35315182 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [formononetin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 mRNA; formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]]
formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] 		CTD PMID:34077701 PMID:37269934 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO formononetin inhibits the reaction [CXCL8 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:22387535 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP formononetin inhibits the reaction [Glucose results in decreased expression of NGF mRNA]; formononetin inhibits the reaction [Glucose results in decreased secretion of and results in decreased expression of NGF protein] CTD PMID:37944786 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA] CTD PMID:37269934 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions 		EXP formononetin results in increased expression of NOS3 mRNA
formononetin results in increased phosphorylation of and results in increased activity of NOS3 protein 		CTD PMID:19570671 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA] CTD PMID:34077701 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pgc progastricsin decreases expression ISO formononetin results in decreased expression of PGC mRNA CTD PMID:37793997 NCBI chr 9:13,257,462...13,265,682
Ensembl chr 9:13,257,462...13,265,682 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein] CTD PMID:37944786 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions 		ISO formononetin results in increased phosphorylation of PRKAA1 protein
Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA1 protein] 		CTD PMID:37269934 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions
increases phosphorylation 		ISO Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA2 protein] CTD PMID:37269934 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta multiple interactions ISO [Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of PRKACB protein CTD PMID:37269934 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO [Formononetin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells RGD PMID:26265982 RGD:401959214 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:37269934 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] CTD PMID:37944786 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt3 sirtuin 3 affects binding
multiple interactions 		EXP formononetin binds to SIRT3 protein
formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 protein] 		CTD PMID:37944786 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases expression EXP formononetin results in decreased expression of SLC22A2 mRNA CTD PMID:28414026 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc6a14 solute carrier family 6 member 14 decreases expression ISO formononetin results in decreased expression of SLC6A14 mRNA CTD PMID:37793997 NCBI chr  X:112,314,643...112,375,412
Ensembl chr  X:112,314,691...112,375,096 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD1 protein] CTD PMID:37944786 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of SOD2 protein] CTD PMID:37944786 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO [Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of STK11 protein CTD PMID:37269934 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tagln transgelin decreases expression ISO formononetin results in decreased expression of TAGLN mRNA CTD PMID:37793997 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP formononetin inhibits the reaction [Glucose results in decreased expression of TFAM mRNA] CTD PMID:37944786 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tfb2m transcription factor B2, mitochondrial multiple interactions EXP formononetin inhibits the reaction [Glucose results in decreased expression of TFB2M mRNA] CTD PMID:37944786 NCBI chr13:91,278,889...91,296,709
Ensembl chr13:91,278,898...91,296,657 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO formononetin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:37269934 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression 		EXP
ISO 		formononetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
XI-006 inhibits the reaction [formononetin results in decreased expression of TP53 protein] 		CTD PMID:28414026 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 multiple interactions ISO formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV5 mRNA] CTD PMID:35315182 NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745 		JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 multiple interactions ISO formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV6 mRNA] CTD PMID:35315182 NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO formononetin results in increased expression of TXNIP mRNA CTD PMID:37793997 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA] CTD PMID:34077701 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
increases expression 		ISO UGT1A1 protein results in increased glucuronidation of formononetin
formononetin results in increased expression of UGT1A1 mRNA 		CTD PMID:14557274 PMID:37793997 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of formononetin CTD PMID:14557274 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        pharmaceutical 20413
          drug 20413
            antineoplastic agent 18066
              daidzein 281
                formononetin 75
                  2'-hydroxyformononetin 0
                  formononetin 7-O-glucoside-6''-O-malonate 0
                  formononetin 7-O-rutinoside 0
                  ononin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  oxacycle 18292
                                    benzopyran 12079
                                      1-benzopyran 11825
                                        isoflavonoid 3900
                                          isoflavones 3882
                                            hydroxyisoflavone 3815
                                              7-hydroxyisoflavones 3792
                                                daidzein 281
                                                  formononetin 75
                                                    2'-hydroxyformononetin 0
                                                    formononetin 7-O-glucoside-6''-O-malonate 0
                                                    formononetin 7-O-rutinoside 0
                                                    ononin 0
paths to the root