Gene:	Tnf ( Rattus norvegicus ) tumor necrosis factor (TNF superfamily, member 2)
Description:	acts as a cytokine; binds TNF receptors; plays a role in regulation of cell proliferation, induction of apoptosis, and inflammatory response
Synonyms:	RATTNF; Tnfa; tumor necrosis factor superfamily member 2; Tumor necrosis factor, alpha (cachetin); MGC124630; Tumor necrosis factor alpha (cachetin); TNF-alpha; tumor necrosis factor superfamily, member 2; TNF; tumor necrosis factor superfamily, member 2;  (details...)
ArrayIDs:	6282531; E02468cds_s_at; GE19895; 1391384_at; L00981mRNA#2_at; 6152199; A_43_P11513; 5941644; GE22167; GE1101079; A_43_P10946; 1387691_at; 6568107; 6688613; A_44_P553535; 6162712;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Edcs3 - Endometrial carcinoma susceptibility QTL3
Markers:	D20Kyo1 D20UW1 D20Wox2 D20Wox3 D20Ztm1
primer pair:	635237 704339
Homologs
Homo sapiens: TNF     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Tnf     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Tnf genome assembly 3.1 20 3661370 - 3663010     RH 3.4 20 51.4     RH 3.4 20 51.3     Rat Celera Assembly 20 4400860 - 4403478     RGSC genome assembly v3.4 20 3661000 - 3663618     Cytogenetic 20 p12 Mus musculus Tnf Mouse genome assembly build 36.1 17 35336335 - 35338941     Cytogenetic 17 17 B1 Homo sapiens TNF human genome assembly 6 31651328 - 31654091     Human genome assembly build 36.2 6 31651329 - 31654091     Cytogenetic 6 p21.3   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Other Map Data:	Associated SSLP Map Locations No mapping information currently available in RGD for D20Kyo1 STS D20UW1 genome assembly 3.1 20 3660865 - 3661007     RH 3.4 20 44.5     FHH x ACI 20 .16     RH 2.0 20 28.3     SHRSP x BN 20 0     RGSC genome assembly v3.4 20 3660638 - 3660780 STS D20Wox2 RH 3.4 20 48.4     RH 2.0 20 33.3 STS D20Wox3 Rat cytogenetic map 20     genome assembly 3.1 20 3660872 - 3660987 STS D20Ztm1 Rat cytogenetic map 20
Annotation
Molecular Function	Note Reference cytokine 625679, 628388 Gene Ontology tumor necrosis factor receptor binding,  identical protein binding,  cytokine activity (details...)
Biological Process	Note Reference involved in host defense, cell proliferation, differentiation and death 625679 plays a role in initiating and regulating the cytosine cascade 625679 involved in body temperature response to endotoxin 61505 inhibits protein synthesis and myogenesis in myoblasts, activates nuclear facotr-kappa B in the myotubes 628388 decreases viability of anterior pituitary cells in females and induces apoptosis in somatotope and lactotrope cells from female rats 628388 proinflammatory cytokine responsible for muscle catabolism 628388 Tnfr1 (p60) and Tnfr2 (p80) mediated transcytosis an inflammatory response in blood-brain barrier, takes place under native conditions 628388 activates the ubiquitin-proteasome pathway 628388 proinflammatory cytokine acting as a signalling molecule in immune-neuro-endocrine network 628388 Gene Ontology positive regulation of vitamin D biosynthetic process,  leukocyte migration,  positive regulation of heterotypic cell-cell adhesion ...  (details...)
Cellular Component	Gene Ontology phagocytic cup,  extracellular space,  membrane raft ...  (details...)
Disease	Note Reference cosegregates with various cardiovascular phenotypes and body mass in GH x BN F2 hybrids 1357163 may be involved in insulin resistance; coadministration with insulin mimics human type II diabetes 1358946 Ontology Schizophrenia,  Pre-Eclampsia,  Insulin Resistance ...  (details...)
Phenotype	Ontology increased blood pressure,  dilated heart left ventricle,  decreased vasodilation ...  (details...)
Expression	Note Reference expression increases after endotoxin administration resulting in decrease in body temperature 70589 expressed in brain, somatotropes and neurointermediate lobes of pituitary 628388 estrogen induces apoptotic function and may be involved in regulation of anterior pituitary cell renewal during estrous cylce 628388
Pathway	Ontology p38 MAPK signaling pathway,  c-Jun N-terminal kinases MAPK signaling pathway,  tumor necrosis factor mediated signaling pathway ...  (details...)
Regulation	Note Reference production increased on enhanced activation of ERK1/2 and Egr-1 by LPS after chronic ethanol feeding 70589 expression was decreased in cerebellum from F344 animals (20-month-old) on 6 weeks of a spinach-enriched diet 628388
Drugs	Note Reference injection of endotoxin, a lipopolysaccaride, increases the mRNA level in muscles 628388 ebselen,a seleno-organic compound, significantly reduces mRNA and protein levels in lung and cronchoalveolar lavage 628388
Mapping	Note Reference found in the major histocompatibility RT1 complex 1300431
External Links
Databases	DATABASE ID SOURCE SMART: TNF IPI PROSITE: TNF_2 IPI PROSITE: TNF_1 IPI UNIPARC: UPI000004368F IPI KEGG Report: rno:24835 ENTREZGENE HomoloGene Group ID: 496 ENTREZGENE Germonline: 3876 Pfam: TNF IPI KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04940 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04350 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05322 ENTREZGENE KEGG Pathway: 04622 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 05410 ENTREZGENE KEGG Pathway: 04640 ENTREZGENE KEGG Pathway: 05332 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04060 ENTREZGENE KEGG Pathway: 05310 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 05014 ENTREZGENE KEGG Pathway: 05010 ENTREZGENE KEGG Pathway: 05330 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE InterPro: Tumour_necrosis_fac-like. IPI InterPro: TNF_family. IPI InterPro: TNF_alpha. IPI InterPro: TNF_a/b/c. IPI Ensembl Protein: ENSRNOP00000001110 IPI IPI: IPI00213948 IPI Gene3D-CATH: Tumour_necrosis_fac-like IPI Entrez Gene: Tnf ENTREZGENE IMAGE_CLONE: IMAGE:7938033 IMAGE-MGC_LOAD MGC_CLONE: MGC:124630 IMAGE-MGC_LOAD Ensembl Genes: ENSRNOG00000000837 IPI UniProt: TNFA_RAT IPI RatMap: 34493 ENTREZGENE Superfamily-SCOP: TNF_like IPI PRINTS: TNFALPHA. IPI PRINTS: TNECROSISFCT. IPI
Sequences	Nucleotide: AF329982 Get FASTA Search GEO Profiles Nucleotide: BC107671 Get FASTA Search GEO Profiles Nucleotide: AJ002278 Get FASTA Search GEO Profiles Nucleotide: AF269160 Get FASTA Search GEO Profiles Nucleotide: AF269159 Get FASTA Search GEO Profiles Nucleotide: L19123 Get FASTA Search GEO Profiles Nucleotide: L00981 Get FASTA Search GEO Profiles Nucleotide: D00475 Get FASTA Search GEO Profiles Nucleotide: CH474121 Get FASTA Search GEO Profiles Nucleotide: BX883046 Get FASTA Search GEO Profiles Nucleotide: AY427675 Get FASTA Search GEO Profiles Nucleotide: AY427674 Get FASTA Search GEO Profiles Nucleotide: AY427673 Get FASTA Search GEO Profiles Nucleotide: AF329987 Get FASTA Search GEO Profiles Nucleotide: AF329986 Get FASTA Search GEO Profiles Nucleotide: AF329985 Get FASTA Search GEO Profiles Nucleotide: AF329984 Get FASTA Search GEO Profiles Nucleotide: AF329983 Get FASTA Search GEO Profiles Nucleotide: X66539 Get FASTA Search GEO Profiles Nucleotide: NM_012675 Get FASTA Search GEO Profiles (View all 20 Nucleotide Accessions) Protein: P16599 Get FASTA Protein: CAA47146 Get FASTA Protein: AAI07672 Get FASTA Protein: CAA05290 Get FASTA Protein: AAF82568 Get FASTA Protein: AAF82567 Get FASTA Protein: AAA42255 Get FASTA Protein: AAA16275 Get FASTA Protein: BAA00367 Get FASTA Protein: EDL83548 Get FASTA Protein: EDL83547 Get FASTA Protein: CAE84003 Get FASTA Protein: AAR91626 Get FASTA Protein: AAR91625 Get FASTA Protein: AAR91624 Get FASTA Protein: AAK53573 Get FASTA Protein: AAK53572 Get FASTA Protein: AAK53571 Get FASTA Protein: AAK53570 Get FASTA Protein: AAK53569 Get FASTA Protein: AAK53568 Get FASTA Protein: NP_036807 Get FASTA (View all 22 Protein Accessions)
Clusters	UniGene: 2275
References
Curated References	84 references in RGD related to Tnf
Other References	321 other references at PubMed related to Tnf
Database Information
RGD ID	3876
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 30-MAR-06: Tnf tumor necrosis factor (TNF superfamily, member 2) tumor necrosis factor superfamily, member 2 APPROVED Name updated 1299863 14-DEC-04: Tnf tumor necrosis factor superfamily, member 2 tumor necrosis factor superfamily, member 2 APPROVED Symbol and Name status set to approved 1299863 10-JUN-02: Tnf tumor necrosis factor superfamily, member 2 PROVISIONAL Name updated 70585