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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:15366
Term: acetic acid
Definition: A simple monocarboxylic acid containing two carbons.
Chemical ID: MESH:D019342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDAcetic Acid results in increased expression of TNF; Acetic Acid results in increased expression of TNF proteinPMID:10898763 PMID:11376495 PMID:21463646 PMID:23810507 PMID:26276312 PMID:29187079 PMID:29518435 PMID:30408459 PMID:30594690 PMID:35122774 PMID:35595039
Tnfmultiple interactionsEXP 6480464CTDAspirin promotes the reaction [Acetic Acid results in increased expression of TNF protein]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; huperzine A inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Indomethacin promotes the reaction [Acetic Acid results in increased expression of TNF protein]; Linagliptin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Mesalamine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Acetic Acid results in increased expression of TNF protein]; Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Plant Extracts inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Resveratrol promotes the reaction [Acetic Acid results in increased expression of TNF protein]; rofecoxib promotes the reaction [Acetic Acid results in increased expression of TNF protein]; sangre de grado inhibits the reaction [Acetic Acid results in increased expression of TNF]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]PMID:10898763 PMID:11376495 PMID:23810507 PMID:26276312 PMID:29187079 PMID:29518435 PMID:30408459 PMID:30594690 PMID:35122774 PMID:35595039
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDAcetic Acid results in increased expression of TNF proteinPMID:33002459 PMID:33171134
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDAcetic Acid results in increased expression of and results in increased secretion of TNF protein; cavidine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]; hesperidin methylchalcone inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Melitten inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]PMID:26102009 PMID:33002459 PMID:33171134
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