RGD Reference Report - Cytokine levels in nasal secretions in asthmatic and nonasthmatic patients with nasal polyposis. - Rat Genome Database

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Cytokine levels in nasal secretions in asthmatic and nonasthmatic patients with nasal polyposis.

Authors: Peric, A  Vojvodic, D  Radulovic, V  Miljanovic, O 
Citation: Peric A, etal., Kulak Burun Bogaz Ihtis Derg. 2010 May-Jun;20(3):111-7.
RGD ID: 4143369
Pubmed: PMID:20465535   (View Abstract at PubMed)

OBJECTIVES: The aim of this study was to compare the cytokine levels of subjects with nasal polyps (NP) and comorbid asthma and NP patients without asthma. PATIENTS AND METHODS: Thirty patients with NP (15 asthmatic and 15 nonasthmatic) were included in this prospective study. Nasal secretion samples were collected from the nasal cavities of all subjects. The levels of eleven cytokines (TNF-alpha, TNF-beta, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IFN-gamma) were measured using flow cytometric method. RESULTS: The concentrations of Th2 cytokines IL-5, IL-6 and IL-10 were significantly higher in patients with NP and asthma compared with subjects with NP without asthma. IFN-gamma, IL-4, IL-6 and IL-10 levels were found significantly higher in allergic patients with NP and asthma compared with those without asthma. In nonallergic patients with NP and asthma, the concentrations of TNF-alpha, IL-5 and IL-6 were significantly higher than in nonallergic patients with NP without asthma. CONCLUSION: Our results showed that the presence of Th2 cytokines, especially IL-5 and IL-6 in patients with NP and asthma is a prominent feature that relates to increased eosinophilic inflammation. We also found significant influence of asthma and allergy on the cytokine profiles in nasal secretions of patients with NP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma  IEP 4143369associated with nasal polys and protein:increased expression:noseRGD 
asthma  ISOTNF (Homo sapiens)4143369; 4143369associated with nasal polys and protein:increased expression:noseRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information