RGD Reference Report - Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. - Rat Genome Database

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Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease.

Authors: Sen, A  Paine, SK  Chowdhury, IH  Mondal, LK  Mukherjee, A  Biswas, A  Chowdhury, S  Bhattacharya, S  Bhattacharya, B 
Citation: Sen A, etal., Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):171-8. doi: 10.1167/iovs.10-5885.
RGD ID: 7364860
Pubmed: PMID:20720222   (View Abstract at PubMed)
DOI: DOI:10.1167/iovs.10-5885   (Journal Full-text)

PURPOSE: Eales' disease (ED) is an idiopathic retinal vasculitis characterized by capillary nonperfusion and neovascularization. Previous reports on ED demonstrated that T-cell-mediated immunoresponse and differential cytokine production in inflammatory and angiogenic stage seem to influence the extent and severity of this disease. Therefore, the purpose of this study is to investigate the influence of cytokine gene polymorphisms on occurrence and severity of ED. METHODS: One hundred twenty-one patients with ED were recruited from an Eastern Indian population and compared with 223 matched healthy control subjects. Genotyping of IFN-gamma, IL-10, and TNF-alpha were performed by amplification refractory mutation system polymerase chain reaction (ARMS-PCR). RESULTS: A statistically significant association was found between the IL-10 -1082AA (P = 0.002), TNF-alpha -308AA (P = 0.0017) genotypes and the IL-10 ATA haplotype (P = 0.0123) and the occurrence of ED. In addition IL-10 -1082GG (P = 0.0005), TNF-alpha -308GG (P < 0.0001) genotype were found to be protective against disease occurrence. A synergistically low IL-10/high TNF-alpha genotype increased the risk of development (P < 0.0001) and the severity (P = 0.019) of ED. CONCLUSIONS: These data suggest that a low IL-10-expressing and high TNF-alpha-expressing genotype of the host can influence the occurrence and severity of outcome of ED.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Eales Disease  IAGP 7364860; 7364860DNA:SNP and haplotype:promoterRGD 
Eales Disease  ISOIL10 (Homo sapiens)7364860; 7364860DNA:SNP and haplotype:promoterRGD 
Eales Disease  ISOTNF (Homo sapiens)7364860; 7364860DNA:SNP and haplotype:promoterRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Il10  (interleukin 10)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
IL10  (interleukin 10)
TNF  (tumor necrosis factor)


Additional Information