RGD Reference Report - [Studies on the expression of mRNA of anti- and pro-inflammatory cytokines in acute lung injury induced by lipopolysaccharide in rat] - Rat Genome Database

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[Studies on the expression of mRNA of anti- and pro-inflammatory cytokines in acute lung injury induced by lipopolysaccharide in rat]

Authors: Zhang, Q  Li, Q  Mao, BL  Qian, GS  Xu, JC  Chen, ZT 
Citation: Zhang Q, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Oct;16(10):585-8.
RGD ID: 4145512
Pubmed: PMID:15461830   (View Abstract at PubMed)

OBJECTIVE: To study the role of pro-inflammatory cytokines including tumor necrosis factor-alpha(TNF-alpha), interleukin-1beta(IL-1beta), IL-6, and anti-inflammatory cytokines including IL-4, IL-10, and IL-13 in acute lung injury(ALI). METHODS: Reverse transcription-polymerase chain reaction(RT-PCR) were used to assess the expressions of mRNA of TNF-alpha, IL-1beta, IL-6, IL-4, IL-10 and IL-13 in the lung tissue after lipopolysaccharide challenge. RESULTS: The expression of TNF-alpha mRNA was seen to peak at 1 hour and IL-6 mRNA at 4 hours in lung tissue after the challenge. The highest expression of mRNA of other cytokines, such as IL-1beta, IL-4, IL-10 and IL-13 in lung tissue appeared 2 hours after LPS-induced lung injury. CONCLUSION: TNF-alpha is an early presenting cytokine in ALI, and IL-6 may play an important role in delayed development of ALI. The over-expression of anti-inflammatory cytokines IL-4, IL-10 and IL-13 may act as promoters rather than protectors in amplification of inflammatory process.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Acute Lung Injury  ISOIl13 (Rattus norvegicus)4145512; 4145512mRNA:increased expression:lungRGD 
Acute Lung Injury  IEP 4145512mRNA:increased expression:lungRGD 
lung disease  ISOTnf (Rattus norvegicus)4145512; 4145512acute lung injury and mRNA:increased expression:lungRGD 
lung disease  IEP 4145512acute lung injury and mRNA:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Il13  (interleukin 13)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
IL13  (interleukin 13)
TNF  (tumor necrosis factor)


Additional Information