Gene: IL13 (interleukin 13)  Homo sapiens Symbol: IL13 Name: interleukin 13 Description: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] Type: protein-coding RefSeq Status: REVIEWED Also known as: allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness-1 (bronchial asthma); IL-13; interleukin-13; MGC116786; MGC116788; MGC116789; OTTHUMP00000066048; P600 Orthologs: Mus musculus : Il13 (interleukin 13)  MGI Rattus norvegicus : Il13 (interleukin 13) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 132,270,711 - 132,273,647 + NCBI Human Genome Assembly HuRef 5 127,186,169 - 127,189,105 + NCBI Human Genome Assembly GRCh37 5 131,993,865 - 131,996,801 + NCBI Human Genome Assembly Build 36 5 132,021,764 - 132,024,700 + NCBI Human Cytogenetic Map 5 q31   NCBI Human Genome Assembly 5 132,021,763 - 132,024,700   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Alveolitis, Extrinsic Allergic   ISS RGD:69009 5128548 mRNA:increased expression:lung RGD   Alveolitis, Extrinsic Allergic   ISS RGD:68949 4145650   RGD   Arthritis, Experimental   ISS RGD:69008 4889497   RGD   Arthritis, Experimental   IED   4889497   RGD   Asthma Severity IEP   4145777 protein:increased expression:sputum RGD   Asthma   IEA   7240710   OMIM   Asthma Susceptibility IAGP   4321828 DNA:polymorphism: :p. R110Q (human) RGD   Asthma Susceptibility IAGP   4145775 DNA:polymorphism: :c. 1923C>T (human) RGD   Asthma Susceptibility IAGP   4220633 DNA:polymorphism:promoter:c. -1055C>T (human) RGD   Asthma   IAGP   4145776 DNA:polymorphism: :c. 2044G>A (human) RGD   Asthma No_Association IAGP   4763761 DNA:polymorphism:cds:p.R130Q (human) RGD   Asthma Severity IEP   4763153 protein:increased expression:serum RGD   Asthma   ISS RGD:69009 4145508   RGD   Asthma Severity ISS RGD:69009 4145639   RGD   Asthma   IAGP   4146241 DNA:SNP: :c. -646A>G (human) RGD   Asthma   ISS RGD:69009 4206706   RGD   Asthma   ISS RGD:68949 4145453   RGD   Asthma Susceptibility IAGP   4145601 DNA:polymorphisms:promoters,exon4: rs1881457, rs1800925, rs20541 (human) RGD   Asthma Severity IAGP   4145593 DNA:polymorphism: :c.-1055C>T (human) RGD   Asthma   IAGP   4892639 DNA:polymorphism: :-1512A>C, -1112C>T, 2044G>A (human) RGD   Asthma Susceptibility IAGP   4765128 DNA:polymorphism:3'utr:c.4738G>A (human) RGD   Asthma   ISS RGD:68949 2301686   RGD   Asthma   ISS RGD:68949 2307110 mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid RGD   Asthma   ISS RGD:69009 4145664   RGD   Asthma Susceptibility IAGP   4145534 DNA:polymorphisms: :rs20541, rs1295685(human) RGD   Bronchial Hyperreactivity   ISS RGD:69008 4761594   RGD   Bronchial Hyperreactivity Susceptibility IAGP   4765128 DNA:polymorphism:promoter:c.-111C>T (human) RGD   Bronchiolitis Obliterans   IEP   4146242 protein:increased expression:bronchoalveolar lavage fluid RGD   Bronchiolitis Obliterans   ISS RGD:69009 4146242   RGD   Bronchitis, Chronic   IEP   4759835 protein:increased expression:Respiratory Mucosa RGD   Chlamydia Infections   ISS RGD:69009 5684365   RGD   Cystic Fibrosis   IEP   4312589 mRNA:increased expression:bronchoalveolar lavage fluid RGD   Dermatitis, Atopic   IAGP   5684364 DNA:SNPs: :rs3091307, rs20541 (human) RGD   Encephalomyelitis, Autoimmune, Experimental   IPM   5684367   RGD   Encephalomyelitis, Autoimmune, Experimental Severity ISS RGD:69009 5684366   RGD   Esophagitis   ISS RGD:69009 4145528   RGD   Esophagitis, Peptic   ISS RGD:68949 2307110 associated with asthma; more ... RGD   Food Hypersensitivity   ISS RGD:69009 5684372 mRNA:increased expression:small intestine RGD   Hepatitis, Alcoholic   ISS RGD:68949 1581860 mRNA:increased expression:liver RGD   Hypertension, Pulmonary   IEP   4145600 associated with sclerosis; more ... RGD   Influenza, Human   IEP   4888530 protein:increased expression:serum RGD   Kidney Diseases   ISS RGD:68949 2290347   RGD   Lung Diseases   ISS RGD:69009 4145647 acute lung injury RGD   Lung Diseases   IEP   4145526 associated with Behcet Syndrome; more ... RGD   Lung Diseases   ISS RGD:68949 4145512 acute lung injury; more ... RGD   Lung Diseases, Fungal   ISS RGD:69009 4145474 protein:increased expression:lung RGD   Lung Diseases, Fungal   ISS RGD:68949 4145506 protein:increased expression:lung RGD   Malaria, Falciparum   IEP   5684362 protein:increased expression:plasma RGD   Mucocutaneous Lymph Node Syndrome   ISS RGD:69009 5684363   RGD   Multiple Sclerosis   IEP   5684368 protein:increased expression:serum RGD   Ovarian Neoplasms   IEP   2290344 mRNA,protein:increased expression:tumor,ascites:mRNA increased relative to normal ovary, protein increased in tumor tissue/cancer ascites relative to normal ovary/ascites RGD   Pancreatic Neoplasms Disease_progression IEP   2317669 protein:increased expression:pancreas RGD   Pancreatic Neoplasms   IPM   2317670   RGD   Pancreatitis   ISS RGD:68949 4145466 protein:increased expression:pancreas RGD   Pancreatitis   IEP   4145466 protein:increased expression:pancreas RGD   Pneumonia   IEP   4145774 associated with Respiratory Distress Syndrome, Newborn; more ... RGD   Pneumonia, Mycoplasma   IEP   4145765 protein:increased expression:serum RGD   Prostatic Hyperplasia   ISS RGD:68949 5684375 mRNA:increased expression:prostate gland RGD   Pseudomonas Infections   IEP   4145500 associated with Cystic Fibrosis RGD   Pulmonary Disease, Chronic Obstructive Susceptibility IAGP   4145596 DNA:polymorphism:promoter:c.-1055C>T (human) RGD   Pulmonary Disease, Chronic Obstructive Susceptibility IAGP   4145668 DNA:polymorphism: :c. 1103C>T (human) RGD   Pulmonary Disease, Chronic Obstructive Susceptibility IAGP   4145601 DNA:polymorphisms:intron1,exon4s: rs2066960, rs20541, rs1295685 (human) RGD   Pulmonary Disease, Chronic Obstructive No_Association IAGP   4145714 DNA:SNP:promoter:c.-1055 C>T (human) RGD   Pulmonary Edema   IED   4145737 aosciated with Enterovirus Infections RGD   Pulmonary Emphysema   ISS RGD:69009 4145652   RGD   Pulmonary Fibrosis   ISS RGD:68949 RGD:69009 2314537 mRNA:increased expression:lung RGD   Pulmonary Fibrosis   IEP   4145627 idiopathic pulmonary fibrosis RGD   Pulmonary Fibrosis   ISS RGD:69009 4888529   RGD   Radiation Pneumonitis Susceptibility IAGP   5131286 associated with carcinoma, non-small-cell lung; more ... RGD   Reperfusion Injury   ISS RGD:68949 2301685 protein:decreased expression:plasma RGD   Reperfusion Injury   IED   2301685   RGD   Respiratory Hypersensitivity   ISS RGD:69009 4145637 mRNA:increased expression:lung RGD   Respiratory Sounds   IEP   4145779 associated with Bronchiolitis; more ... RGD   Respiratory Syncytial Virus Infections   ISS RGD:69009 4145641   RGD   Respiratory Tract Infections   IEP   4145665 Severe Acute Respiratory Syndrome RGD   Rhinitis Disease_progression ISS RGD:69009 4159171   RGD   Rhinitis   ISS RGD:68949 4145454 mRNA:increased expression:nose RGD   Rhinitis   ISS RGD:69009 4206706   RGD   Rhinitis Susceptibility IAGP   4145767 associated with asthma; more ... RGD   Rhinitis Susceptibility IAGP   4145534 DNA:polymorphism: :rs1800925 (human) RGD   Rhinitis, Allergic, Perennial   IEP   4782826 mRNA, protein:increased expression:nasal mucosa RGD   Scleroderma, Systemic   ISS RGD:69009 5684370 mRNA, protein:increased expression:skin RGD   Scleroderma, Systemic   IEP   5684371 protein:increased expression:serum RGD   Scleroderma, Systemic   IAGP   5684369 DNA:SNPs: :rs1800925, rs2243204 (human) RGD   Sepsis   ISS RGD:69009 4145654   RGD   Sinusitis Susceptibility IAGP   4145767 associated with asthma; more ... RGD   Tuberculosis, Pulmonary   IEP   4145649 mRNA:increased expression:Leukocytes, Mononuclear RGD   Uveitis   IED   4145496   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) 1,1-dichloroethene decreases expression ISO RGD:69009 6480464 vinylidene chloride results in decreased expression of IL13 protein CTD PMID:16879906 1,1-dichloroethene increases expression ISO RGD:69009 6480464 vinylidene chloride results in increased expression of IL13 protein CTD PMID:16879906 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:69009 6480464 Dinitrochlorobenzene results in increased expression of IL13 mRNA CTD PMID:23200891 1-chloro-2,4-dinitrobenzene multiple interactions ISO RGD:69009 6480464 Biological Agents inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 mRNA] CTD PMID:23200891 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:69009 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased secretion of IL13 protein] CTD PMID:21804081 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:69009 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IL13 promoter] CTD PMID:19654925 4,4'-diaminodiphenylmethane decreases expression ISO RGD:69009 6480464 4,4'-diaminodiphenylmethane results in decreased expression of IL13 mRNA CTD PMID:18648102 4-tolyl isocyanate increases expression ISO RGD:69009 6480464 4-tolyl isocyanate results in increased expression of IL13 mRNA CTD PMID:15664275 9-cis-retinoic acid increases expression EXP   6480464 alitretinoin results in increased expression of IL13 mRNA; more ... CTD PMID:17118196 acetone multiple interactions EXP   6480464 [Acetone co-treated with olive oil] results in increased expression of IL13 mRNA CTD PMID:21252390 acetylsalicylic acid affects response to substance EXP   6480464 IL13 polymorphism affects the susceptibility to Aspirin CTD PMID:22123380 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of IL13 mRNA; more ... CTD PMID:17118196 aluminium hydroxide increases expression ISO RGD:69009 6480464 Aluminum Hydroxide results in increased expression of IL13 mRNA CTD PMID:9328138 ammonium chloride affects expression ISO RGD:68949 6480464 Ammonium Chloride affects the expression of IL13 mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression ISO RGD:69009 6480464 Benzo(a)pyrene results in decreased expression of IL13 mRNA CTD PMID:22228805 bis(2-chloroethyl) sulfide multiple interactions EXP   6480464 TNF protein affects the reaction [Mustard Gas affects the expression of IL13 mRNA] CTD PMID:16173061 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:68949 6480464 ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein] CTD PMID:18852015 bis(2-chloroethyl) sulfide increases expression ISO RGD:68949 6480464 Mustard Gas results in increased expression of IL13 protein CTD PMID:18852015 bleomycin A2 decreases response to substance ISO RGD:69009 6480464 IL13 gene mutant form results in decreased susceptibility to Bleomycin CTD PMID:15322207 bleomycin A2 multiple interactions ISO RGD:69009 6480464 IL13 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA] CTD PMID:15322207 bucladesine decreases expression EXP   6480464 Bucladesine results in decreased expression of IL13 mRNA CTD PMID:16083514 bucladesine decreases secretion EXP   6480464 Bucladesine results in decreased secretion of IL13 protein CTD PMID:16083514 cadmium dichloride increases expression EXP   6480464 Cadmium Chloride results in increased expression of IL13 mRNA CTD PMID:12160620 calcium atom multiple interactions ISO RGD:69009 6480464 IL13 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium] CTD PMID:12110441 calcium(0) multiple interactions ISO RGD:69009 6480464 IL13 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium] CTD PMID:12110441 capsaicin multiple interactions ISO RGD:68949 6480464 Naproxen inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; more ... CTD PMID:22150557 capsaicin increases expression ISO RGD:68949 6480464 Capsaicin results in increased expression of IL13 protein CTD PMID:22150557 chlorobenzene increases expression EXP   6480464 chlorobenzene results in increased expression of IL13 protein CTD PMID:18514500 chlorobenzene multiple interactions EXP   6480464 CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein] CTD PMID:18514500 chloroform increases expression ISO RGD:69009 6480464 Chloroform results in increased expression of IL13 protein CTD PMID:16879906 chlorpyrifos increases expression EXP   6480464 Chlorpyrifos results in increased expression of IL13 mRNA CTD PMID:22265773 D-penicillamine decreases expression ISO RGD:68949 6480464 Penicillamine results in decreased expression of IL13 mRNA CTD PMID:19575532 D-penicillamine increases expression ISO RGD:68949 6480464 Penicillamine results in increased expression of IL13 mRNA CTD PMID:19575532 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [IL13 protein results in increased secretion of CSF2 protein]; more ... CTD PMID:12077271 dexamethasone increases expression ISO RGD:69009 6480464 Dexamethasone results in increased expression of IL13 mRNA; more ... CTD PMID:22842586 dexamethasone decreases expression ISO RGD:69009 6480464 Dexamethasone results in decreased expression of IL13 protein CTD PMID:19056934 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of IL13 mRNA CTD PMID:19080345 diarsenic trioxide decreases secretion EXP   6480464 arsenic trioxide results in decreased secretion of IL13 protein CTD PMID:19080345 diarsenic trioxide multiple interactions EXP   6480464 arsenic trioxide inhibits the reaction [GATA3 protein binds to IL13 promoter] CTD PMID:19080345 dichlorine increases expression ISO RGD:69009 6480464 Chlorine results in increased expression of IL13 protein CTD PMID:23146759 dicyclohexylmethane-4,4'-diisocyanate increases expression ISO RGD:69009 6480464 methylene bis(4-cyclohexylisocyanate) results in increased expression of IL13 mRNA CTD PMID:16940033 diphenylmethane-4,4'-diisocyanate increases expression ISO RGD:69009 6480464 4,4'-diphenylmethane diisocyanate results in increased expression of IL13 mRNA CTD PMID:16940033 emodin multiple interactions ISO RGD:69009 6480464 Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:22484343 epinastine decreases expression EXP   6480464 epinastine results in decreased expression of IL13 protein; more ... CTD PMID:16534218 fisetin multiple interactions EXP   6480464 fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein]; more ... CTD PMID:12789233 formaldehyde increases expression ISO RGD:69009 6480464 Formaldehyde results in increased expression of IL13 mRNA CTD PMID:12161283 gadodiamide hydrate increases expression EXP   6480464 gadodiamide results in increased expression of IL13 mRNA; more ... CTD PMID:19404939 gadolinium trichloride increases expression EXP   6480464 gadolinium chloride results in increased expression of IL13 mRNA CTD PMID:19404939 genistein multiple interactions ISO RGD:68949 6480464 [Genistein co-treated with Methoxychlor] results in decreased expression of IL13 mRNA CTD PMID:21782745 glutathione multiple interactions EXP   6480464 Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein] CTD PMID:17079650 glutathione multiple interactions EXP   6480464 [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein CTD PMID:18214930 hexamethylene diisocyanate increases secretion ISO RGD:69009 6480464 1,6-hexamethylene diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 hydroxyurea affects expression ISO RGD:69009 6480464 Hydroxyurea affects the expression of IL13 protein CTD PMID:15927844 isophorone diisocyanate increases secretion ISO RGD:69009 6480464 isophorone diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 leukotriene B4 increases abundance ISO RGD:68949 6480464 IL13 protein results in increased abundance of Leukotriene B4 CTD PMID:12654629 leukotriene B4 multiple interactions ISO RGD:68949 6480464 zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4] CTD PMID:12654629 leukotriene C4 increases expression ISO RGD:69009 6480464 Leukotriene C4 results in increased expression of IL13 mRNA CTD PMID:12388339 leukotriene C4 multiple interactions ISO RGD:68949 6480464 [IL13 protein results in increased abundance of Leukotriene C4] which results in increased secretion of MUC5AC protein CTD PMID:12654629 leukotriene C4 increases abundance ISO RGD:68949 6480464 IL13 protein results in increased abundance of Leukotriene C4 CTD PMID:12654629 leukotriene D4 increases abundance ISO RGD:68949 6480464 IL13 protein results in increased abundance of Leukotriene D4 CTD PMID:12654629 leukotriene D4 multiple interactions ISO RGD:68949 6480464 [IL13 protein results in increased abundance of Leukotriene D4] which results in increased secretion of MUC5AC protein CTD PMID:12654629 leukotriene E4 increases abundance ISO RGD:68949 6480464 IL13 protein results in increased abundance of Leukotriene E4 CTD PMID:12654629 lidocaine decreases expression ISO RGD:69009 6480464 Lidocaine results in decreased expression of IL13 protein CTD PMID:18382663 luteolin multiple interactions ISO RGD:68949 6480464 Luteolin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:17950587 mercury dichloride decreases expression ISO RGD:69009 6480464 Mercuric Chloride results in decreased expression of IL13 protein CTD PMID:21984480 methotrexate affects expression ISO RGD:69009 6480464 Methotrexate affects the expression of IL13 mRNA CTD PMID:18502557 methoxychlor multiple interactions ISO RGD:69009 6480464 [Methoxychlor co-treated with Antigens, Dermatophagoides] affects the expression of IL13 protein CTD PMID:21864637 methoxychlor multiple interactions ISO RGD:68949 6480464 [Genistein co-treated with Methoxychlor] results in decreased expression of IL13 mRNA CTD PMID:21782745 methoxychlor increases expression ISO RGD:69009 6480464 Methoxychlor results in increased expression of IL13 protein CTD PMID:22842586 morphine increases expression ISO RGD:69009 6480464 Morphine results in increased expression of IL13 protein CTD PMID:16210602 mycophenolic acid increases expression ISO RGD:69009 6480464 Mycophenolic Acid results in increased expression of IL13 mRNA CTD PMID:19818335 N-ethyl-5'-carboxamidoadenosine increases secretion EXP   6480464 Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of IL13 protein CTD PMID:17696452 naproxen multiple interactions ISO RGD:68949 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; more ... CTD PMID:22150557 nitrososulfamethoxazole increases secretion EXP   6480464 4-nitrososulfamethoxazole results in increased secretion of IL13 protein CTD PMID:22331489 ozone multiple interactions ISO RGD:69009 6480464 IL13 protein affects the reaction [Ozone results in increased expression of CXCL1 mRNA]; more ... CTD PMID:18417511 ozone increases response to substance ISO RGD:69009 6480464 IL13 protein results in increased susceptibility to Ozone CTD PMID:18417511 paracetamol increases expression ISO RGD:69009 6480464 Acetaminophen results in increased expression of IL13 protein CTD PMID:17439248 PMID:11826401 paracetamol increases response to substance ISO RGD:69009 6480464 IL13 gene mutant form results in increased susceptibility to Acetaminophen CTD PMID:22107450 paracetamol increases expression ISO RGD:69009 6480464 Acetaminophen results in increased expression of IL13 protein CTD PMID:11826401 PMID:17439248 paracetamol decreases response to substance ISO RGD:69009 6480464 IL13 protein results in decreased susceptibility to Acetaminophen CTD PMID:17439248 paraquat increases expression ISO RGD:69009 6480464 Paraquat results in increased expression of IL13 mRNA CTD PMID:17215068 paraquat decreases expression ISO RGD:68949 6480464 Paraquat results in decreased expression of IL13 mRNA CTD PMID:17077588 parathion multiple interactions ISO RGD:69009 6480464 [Parathion co-treated with Antigens, Dermatophagoides] affects the expression of IL13 protein CTD PMID:21864637 parathion increases expression ISO RGD:69009 6480464 Parathion results in increased expression of IL13 mRNA; more ... CTD PMID:22842586 phenobarbital increases expression ISO RGD:68949 6480464 Phenobarbital results in increased expression of IL13 mRNA CTD PMID:19162173 phorbol 13-acetate 12-myristate increases expression EXP   6480464 Tetradecanoylphorbol Acetate results in increased expression of IL13 mRNA CTD PMID:10428506 phosmet increases expression EXP   6480464 Phosmet results in increased expression of IL13 mRNA CTD PMID:22265773 phthalaldehyde increases expression ISO RGD:69009 6480464 o-Phthalaldehyde results in increased expression of IL13 mRNA CTD PMID:21785612 phthalic anhydride increases expression EXP   6480464 phthalic anhydride results in increased expression of IL13 mRNA CTD PMID:21252390 phthalic anhydride increases expression ISO RGD:69009 6480464 phthalic anhydride results in increased expression of IL13 protein CTD PMID:20219652 phthalic anhydride increases expression ISO RGD:69009 6480464 phthalic anhydride results in increased expression of IL13 mRNA CTD PMID:14599759 pioglitazone multiple interactions ISO RGD:69009 6480464 pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein] CTD PMID:17015710 piperonyl butoxide increases expression ISO RGD:69009 6480464 Piperonyl Butoxide results in increased expression of IL13 mRNA CTD PMID:22842586 prednisone decreases expression EXP   6480464 Prednisone results in decreased expression of IL13 protein CTD PMID:15523430 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:68949 6480464 Pregnenolone Carbonitrile results in increased expression of IL13 mRNA CTD PMID:19162173 prostaglandin E2 increases secretion EXP   6480464 Dinoprostone results in increased secretion of IL13 protein CTD PMID:15788148 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [IL13 protein results in increased expression of CCL11 mRNA]; more ... CTD PMID:22254182 resveratrol decreases expression ISO RGD:69009 6480464 resveratrol results in decreased expression of IL13 protein CTD PMID:22962611 resveratrol decreases response to substance EXP   6480464 resveratrol results in decreased susceptibility to IL13 protein CTD PMID:22254182 rolipram decreases expression EXP   6480464 Rolipram results in decreased expression of IL13 mRNA CTD PMID:16083514 rolipram decreases secretion EXP   6480464 Rolipram results in decreased secretion of IL13 protein CTD PMID:16083514 rosiglitazone multiple interactions ISO RGD:69009 6480464 rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein] CTD PMID:17015710 serotonin affects response to substance ISO RGD:69009 6480464 IL13 protein affects the susceptibility to Serotonin CTD PMID:12370375 simvastatin decreases expression ISO RGD:69009 6480464 Simvastatin results in decreased expression of IL13 mRNA; more ... CTD PMID:17169357 sterigmatocystin increases expression ISO RGD:69009 6480464 Sterigmatocystin results in increased expression of IL13 mRNA CTD PMID:19818335 sumatriptan multiple interactions ISO RGD:68949 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; more ... CTD PMID:22150557 tetrachloromethane increases expression ISO RGD:69009 6480464 Carbon Tetrachloride results in increased expression of IL13 mRNA CTD PMID:18263696 tetrachloromethane multiple interactions ISO RGD:69009 6480464 IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL13 protein] CTD PMID:17412915 tetrachloromethane increases expression ISO RGD:69009 6480464 Carbon Tetrachloride results in increased expression of IL13 protein CTD PMID:17412915 theophylline decreases expression EXP   6480464 Theophylline results in decreased expression of IL13 mRNA; more ... CTD PMID:16083514 theophylline decreases secretion EXP   6480464 Theophylline results in decreased secretion of IL13 protein CTD PMID:16083514 thimerosal multiple interactions EXP   6480464 Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein] CTD PMID:17079650 titanium dioxide increases expression EXP   6480464 titanium dioxide results in increased expression of IL13 mRNA CTD PMID:19695317 toluene 2,4-diisocyanate multiple interactions ISO RGD:69009 6480464 BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; more ... CTD PMID:17015710 toluene 2,4-diisocyanate increases secretion ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA CTD PMID:11243917 more ... toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 protein CTD PMID:20219652 more ... toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA CTD PMID:15590890 more ... toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA CTD PMID:16940033 more ... toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 protein CTD PMID:17015710 more ... toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA CTD PMID:17641053 more ... toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA CTD PMID:17641053 more ... toluene 2,4-diisocyanate multiple interactions ISO RGD:69009 6480464 CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA] CTD PMID:15590890 toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA CTD PMID:11243917 more ... toluene 2,4-diisocyanate increases expression ISO RGD:69009 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL13 protein CTD PMID:20219652 PMID:17015710 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [IL13 protein results in increased expression of CCL11 mRNA]; more ... CTD PMID:22254182 trans-resveratrol decreases expression ISO RGD:69009 6480464 resveratrol results in decreased expression of IL13 protein CTD PMID:22962611 trans-resveratrol decreases response to substance EXP   6480464 resveratrol results in decreased susceptibility to IL13 protein CTD PMID:22254182 triclosan multiple interactions EXP   6480464 Triclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA] CTD PMID:20507366 trimellitic anhydride increases expression ISO RGD:69009 6480464 trimellitic anhydride results in increased expression of IL13 mRNA CTD PMID:14599759 trimellitic anhydride increases expression ISO RGD:69009 6480464 trimellitic anhydride results in increased expression of IL13 protein CTD PMID:20219652 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell-cell signaling   IC GO:0005125 2290271 PMID:10725748 UniProtKB PMID:10725748 cellular component movement   TAS   2290271 PMID:10725748 PINC PMID:10725748 cellular response to cytokine stimulus   IEA Ensembl:ENSMUSP00000020650 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to mechanical stimulus   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 immune response   IEA InterPro:IPR001325|InterPro:IPR018096 2290271 GO_REF:0000002 InterPro GO_REF:0000002 inflammatory response   TAS   2290271 PMID:8096327 PINC PMID:8096327 negative regulation of lung ciliated cell differentiation   NAS   2290271 PMID:20539013 BHF-UCL PMID:20539013 negative regulation of transforming growth factor beta production   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of B cell proliferation   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of connective tissue growth factor production   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of immunoglobulin production   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of lung goblet cell differentiation   NAS   2290271 PMID:20539013 BHF-UCL PMID:20539013 positive regulation of macrophage activation   IEA Ensembl:ENSMUSP00000020650 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of pancreatic stellate cell proliferation   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of protein secretion   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of release of sequestered calcium ion into cytosol   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of smooth muscle cell proliferation   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of tyrosine phosphorylation of Stat6 protein   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of proton transport   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to ethanol   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to lipopolysaccharide   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to nicotine   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 signal transduction   NAS   2290271 PMID:10725748 PINC PMID:10725748 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytoplasm   IEA Ensembl:ENSMUSP00000020650 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 external side of plasma membrane   IEA Ensembl:ENSMUSP00000020650 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 extracellular region   IDA   2290271 PMID:20041150 BHF-UCL PMID:20041150 extracellular space   ISS UniProtKB:P20109 2290271 PMID:16275384 UniProtKB PMID:16275384 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine activity   IEA UniProtKB-KW:KW-0202 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 interleukin-13 receptor binding   IEA Ensembl:ENSRNOP00000010121 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 protein binding   IPI UniProtKB:P78552 2290271 PMID:18243101 IntAct PMID:18243101 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) asthma disease pathway   IEA RGD:69008 6907045   KEGG hsa:05310 Jak-Stat signaling pathway   IEA RGD:69008 6907045   KEGG hsa:04630 measles infection pathway   IEA RGD:69008 6907045   KEGG hsa:05162 External Database Links KEGG Pathway Asthma Cytokine-cytokine receptor interaction Fc epsilon RI signaling pathway Jak-STAT signaling pathway Measles Pathway Interaction Database Glucocorticoid receptor regulatory network (PID:200091) IL12 signaling mediated by STAT4 (PID:200229) Disease Annotations Alveolitis, Extrinsic Allergic  (ISS) Arthritis, Experimental  (IED,ISS) Asthma  (IAGP,IEA,IEP,ISS) Bronchial Hyperreactivity  (IAGP,ISS) Bronchiolitis Obliterans  (IEP,ISS) Bronchitis, Chronic  (IEP) Chlamydia Infections  (ISS) Cystic Fibrosis  (IEP) Dermatitis, Atopic  (IAGP) Encephalomyelitis, Autoimmune, Experimental  (IPM,ISS) Esophagitis  (ISS) Esophagitis, Peptic  (ISS) Food Hypersensitivity  (ISS) Hepatitis, Alcoholic  (ISS) Hypertension, Pulmonary  (IEP) Influenza, Human  (IEP) Kidney Diseases  (ISS) Lung Diseases  (IEP,ISS) Lung Diseases, Fungal  (ISS) Malaria, Falciparum  (IEP) Mucocutaneous Lymph Node Syndrome  (ISS) Multiple Sclerosis  (IEP) Ovarian Neoplasms  (IEP) Pancreatic Neoplasms  (IEP,IPM) Pancreatitis  (IEP,ISS) Pneumonia  (IEP) Pneumonia, Mycoplasma  (IEP) Prostatic Hyperplasia  (ISS) Pseudomonas Infections  (IEP) Pulmonary Disease, Chronic Obstructive  (IAGP) Pulmonary Edema  (IED) Pulmonary Emphysema  (ISS) Pulmonary Fibrosis  (IEP,ISS) Radiation Pneumonitis  (IAGP) Reperfusion Injury  (IED,ISS) Respiratory Hypersensitivity  (ISS) Respiratory Sounds  (IEP) Respiratory Syncytial Virus Infections  (ISS) Respiratory Tract Infections  (IEP) Rhinitis  (IAGP,ISS) Rhinitis, Allergic, Perennial  (IEP) Scleroderma, Systemic  (IAGP,IEP,ISS) Sepsis  (ISS) Sinusitis  (IAGP) Tuberculosis, Pulmonary  (IEP) Uveitis  (IED) Gene-Chemical Interaction Annotations 1,1-dichloroethene  (ISO) 1-chloro-2,4-dinitrobenzene  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 4,4'-diaminodiphenylmethane  (ISO) 4-tolyl isocyanate  (ISO) 9-cis-retinoic acid  (EXP) acetone  (EXP) acetylsalicylic acid  (EXP) all-trans-retinoic acid  (EXP) aluminium hydroxide  (ISO) ammonium chloride  (ISO) benzo[a]pyrene  (ISO) bis(2-chloroethyl) sulfide  (EXP,ISO) bleomycin A2  (ISO) bucladesine  (EXP) cadmium dichloride  (EXP) calcium atom  (ISO) calcium(0)  (ISO) capsaicin  (ISO) chlorobenzene  (EXP) chloroform  (ISO) chlorpyrifos  (EXP) D-penicillamine  (ISO) dexamethasone  (EXP,ISO) diarsenic trioxide  (EXP) dichlorine  (ISO) dicyclohexylmethane-4,4'-diisocyanate  (ISO) diphenylmethane-4,4'-diisocyanate  (ISO) emodin  (ISO) epinastine  (EXP) fisetin  (EXP) formaldehyde  (ISO) gadodiamide hydrate  (EXP) gadolinium trichloride  (EXP) genistein  (ISO) glutathione  (EXP) hexamethylene diisocyanate  (ISO) hydroxyurea  (ISO) isophorone diisocyanate  (ISO) leukotriene B4  (ISO) leukotriene C4  (ISO) leukotriene D4  (ISO) leukotriene E4  (ISO) lidocaine  (ISO) luteolin  (ISO) mercury dichloride  (ISO) methotrexate  (ISO) methoxychlor  (ISO) morphine  (ISO) mycophenolic acid  (ISO) N-ethyl-5'-carboxamidoadenosine  (EXP) naproxen  (ISO) nitrososulfamethoxazole  (EXP) ozone  (ISO) paracetamol  (ISO) paraquat  (ISO) parathion  (ISO) phenobarbital  (ISO) phorbol 13-acetate 12-myristate  (EXP) phosmet  (EXP) phthalaldehyde  (ISO) phthalic anhydride  (EXP,ISO) pioglitazone  (ISO) piperonyl butoxide  (ISO) prednisone  (EXP) pregnenolone 16alpha-carbonitrile  (ISO) prostaglandin E2  (EXP) resveratrol  (EXP,ISO) rolipram  (EXP) rosiglitazone  (ISO) serotonin  (ISO) simvastatin  (ISO) sterigmatocystin  (ISO) sumatriptan  (ISO) tetrachloromethane  (ISO) theophylline  (EXP) thimerosal  (EXP) titanium dioxide  (EXP) toluene 2,4-diisocyanate  (ISO) trans-resveratrol  (EXP,ISO) triclosan  (EXP) trimellitic anhydride  (ISO) Gene Ontology Annotations Biological Process cell-cell signaling  (IC) cellular component movement  (TAS) cellular response to cytokine stimulus  (IEA) cellular response to mechanical stimulus  (IEA) immune response  (IEA) inflammatory response  (TAS) negative regulation of lung ciliated cell differentiation  (NAS) negative regulation of transforming growth factor beta production  (IEA) positive regulation of B cell proliferation  (IEA) positive regulation of connective tissue growth factor production  (IEA) positive regulation of immunoglobulin production  (IEA) positive regulation of lung goblet cell differentiation  (NAS) positive regulation of macrophage activation  (IEA) positive regulation of pancreatic stellate cell proliferation  (IEA) positive regulation of protein secretion  (IEA) positive regulation of release of sequestered calcium ion into cytosol  (IEA) positive regulation of smooth muscle cell proliferation  (IEA) positive regulation of tyrosine phosphorylation of Stat6 protein  (IEA) regulation of proton transport  (IEA) response to ethanol  (IEA) response to lipopolysaccharide  (IEA) response to nicotine  (IEA) signal transduction  (NAS) Cellular Component cytoplasm  (IEA) external side of plasma membrane  (IEA) extracellular region  (IDA) extracellular space  (ISS) Molecular Function cytokine activity  (IEA) interleukin-13 receptor binding  (IEA) protein binding  (IPI) Molecular Pathway Annotations asthma disease pathway  (IEA) Jak-Stat signaling pathway  (IEA) measles infection pathway  (IEA) External Database Links KEGG Pathway Asthma Cytokine-cytokine receptor interaction Fc epsilon RI signaling pathway Jak-STAT signaling pathway Measles Pathway Interaction Database Glucocorticoid receptor regulatory network (PID:200091) IL12 signaling mediated by STAT4 (PID:200229) References - curated 1. 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Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data IL13   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 132,270,711 - 132,273,647 + NCBI Human Genome Assembly HuRef 5 127,186,169 - 127,189,105 + NCBI Human Genome Assembly GRCh37 5 131,993,865 - 131,996,801 + NCBI Human Genome Assembly Build 36 5 132,021,764 - 132,024,700 + NCBI Human Cytogenetic Map 5 q31   NCBI Human Genome Assembly 5 132,021,763 - 132,024,700   NCBI Il13   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 11 53,631,323 - 53,634,702 - NCBI Mouse cM Map 11 31.98   NCBI Mouse Celera Assembly 11 58,210,849 - 58,214,228 - NCBI Mouse Genome Assembly Build 37 11 53,444,825 - 53,448,204 - NCBI Mouse Genome Assembly Build 36.1 11 53,444,826 - 53,448,204 - NCBI Mouse Cytogenetic Map 11 B1.3   NCBI Il13   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 10 q22   NCBI RGSC Genome Assembly v5.0 10 38,764,639 - 38,767,196 - NCBI RGSC Genome Assembly v3.4 10 39,093,512 - 39,096,069 - NCBI Rat Celera Assembly 10 37,134,342 - 37,136,897 - NCBI Genome Assembly 3.1 10 39,102,758 - 39,105,316 - NCBI Position Markers D4S2394   Map Chr Position Strand Source Human deCODE Assembly Map 4 128.08   UniSTS Human Genome Assembly HuRef 4 126,028,047 - 126,028,288   UniSTS Human Genome Assembly GRCh37 4 130,297,833 - 130,298,080   UniSTS Human Celera Assembly 4 127,679,285 - 127,679,525   RGD Human Genome Assembly Build 36 4 130,517,283 - 130,517,530   RGD D4S1651   Map Chr Position Strand Source Human Whitehead-YAC Contig Map 4     UniSTS Human Whitehead-RH Map 4 570.0   UniSTS Human deCODE Assembly Map 4 115.68   UniSTS Human Genome Assembly HuRef 4 107,863,843 - 107,864,042   UniSTS Human Genome Assembly GRCh37 4 112,132,472 - 112,132,671   UniSTS Human Celera Assembly 4 109,425,906 - 109,426,105   RGD Human Genome Assembly Build 36 4 112,351,921 - 112,352,120   RGD Marshfield Human Genetic Map 4 117.06   RGD Marshfield Human Genetic Map 4 117.06   UniSTS D5S2410   Map Chr Position Strand Source Human GeneMap99-G3 RH Map 5 5063.0   UniSTS Human Whitehead-YAC Contig Map 5     UniSTS Human Whitehead-RH Map 5 415.5   UniSTS Human GeneMap99-GB4 RH Map 5 510.1   UniSTS Human Stanford-G3 RH Map 5 4975.0   UniSTS Human Genome Assembly HuRef 5 127,188,698 - 127,189,040   UniSTS Human Genome Assembly GRCh37 5 131,996,394 - 131,996,736   UniSTS Human Celera Assembly 5 128,126,524 - 128,126,866   RGD Human Genome Assembly Build 36 5 132,024,293 - 132,024,635   RGD Human Cytogenetic Map 5 q31   UniSTS PMC356970P3   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,187,424 - 127,188,406   UniSTS Human Genome Assembly GRCh37 5 131,995,120 - 131,996,102   UniSTS Human Celera Assembly 5 128,125,250 - 128,126,232   RGD Human Genome Assembly Build 36 5 132,023,019 - 132,024,001   RGD Human Cytogenetic Map 5 q31   UniSTS IL13_148   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,188,368 - 127,189,142   UniSTS Human Genome Assembly GRCh37 5 131,996,064 - 131,996,838   UniSTS Human Celera Assembly 5 128,126,194 - 128,126,968   RGD Human Genome Assembly Build 36 5 132,023,963 - 132,024,737   RGD ECD00324   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,187,078 - 127,187,991   UniSTS Human Genome Assembly GRCh37 5 131,994,774 - 131,995,687   UniSTS Human Celera Assembly 5 128,124,904 - 128,125,817   RGD Human Genome Assembly Build 36 5 132,022,673 - 132,023,586   RGD Human Cytogenetic Map 5 q31   UniSTS ECD05278   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,184,574 - 127,185,314   UniSTS Human Genome Assembly GRCh37 5 131,992,270 - 131,993,010   UniSTS Human Celera Assembly 5 128,122,400 - 128,123,140   RGD Human Genome Assembly Build 36 5 132,020,169 - 132,020,909   RGD Human Cytogenetic Map 5 q31   UniSTS ECD09780   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,188,843 - 127,189,463   UniSTS Human Genome Assembly GRCh37 5 131,996,539 - 131,997,159   UniSTS Human Celera Assembly 5 128,126,669 - 128,127,289   RGD Human Genome Assembly Build 36 5 132,024,438 - 132,025,058   RGD Human Cytogenetic Map 5 q31   UniSTS ECD09846   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,188,133 - 127,188,751   UniSTS Human Genome Assembly GRCh37 5 131,995,829 - 131,996,447   UniSTS Human Celera Assembly 5 128,125,959 - 128,126,577   RGD Human Genome Assembly Build 36 5 132,023,728 - 132,024,346   RGD Human Cytogenetic Map 5 q31   UniSTS ECD09979   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,185,527 - 127,186,141   UniSTS Human Genome Assembly GRCh37 5 131,993,223 - 131,993,837   UniSTS Human Celera Assembly 5 128,123,353 - 128,123,967   RGD Human Genome Assembly Build 36 5 132,021,122 - 132,021,736   RGD Human Cytogenetic Map 5 q31   UniSTS ECD10847   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,186,199 - 127,186,788   UniSTS Human Genome Assembly GRCh37 5 131,993,895 - 131,994,484   UniSTS Human Celera Assembly 5 128,124,025 - 128,124,614   RGD Human Genome Assembly Build 36 5 132,021,794 - 132,022,383   RGD Human Cytogenetic Map 5 q31   UniSTS REN71151   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,184,328 - 127,184,593   UniSTS Human Genome Assembly GRCh37 5 131,992,024 - 131,992,289   UniSTS Human Celera Assembly 5 128,122,154 - 128,122,419   RGD Human Genome Assembly Build 36 5 132,019,923 - 132,020,188   RGD Human Cytogenetic Map 5 q31   UniSTS REN71152   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,184,573 - 127,184,801   UniSTS Human Genome Assembly GRCh37 5 131,992,269 - 131,992,497   UniSTS Human Celera Assembly 5 128,122,399 - 128,122,627   RGD Human Genome Assembly Build 36 5 132,020,168 - 132,020,396   RGD Human Cytogenetic Map 5 q31   UniSTS REN71153   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,184,726 - 127,184,974   UniSTS Human Genome Assembly GRCh37 5 131,992,422 - 131,992,670   UniSTS Human Celera Assembly 5 128,122,552 - 128,122,800   RGD Human Genome Assembly Build 36 5 132,020,321 - 132,020,569   RGD Human Cytogenetic Map 5 q31   UniSTS REN71154   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,184,972 - 127,185,208   UniSTS Human Genome Assembly GRCh37 5 131,992,668 - 131,992,904   UniSTS Human Celera Assembly 5 128,122,798 - 128,123,034   RGD Human Genome Assembly Build 36 5 132,020,567 - 132,020,803   RGD Human Cytogenetic Map 5 q31   UniSTS REN71155   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,185,184 - 127,185,409   UniSTS Human Genome Assembly GRCh37 5 131,992,880 - 131,993,105   UniSTS Human Celera Assembly 5 128,123,010 - 128,123,235   RGD Human Genome Assembly Build 36 5 132,020,779 - 132,021,004   RGD Human Cytogenetic Map 5 q31   UniSTS REN71156   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,185,377 - 127,185,643   UniSTS Human Genome Assembly GRCh37 5 131,993,073 - 131,993,339   UniSTS Human Celera Assembly 5 128,123,203 - 128,123,469   RGD Human Genome Assembly Build 36 5 132,020,972 - 132,021,238   RGD Human Cytogenetic Map 5 q31   UniSTS REN71157   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,185,622 - 127,185,876   UniSTS Human Genome Assembly GRCh37 5 131,993,318 - 131,993,572   UniSTS Human Celera Assembly 5 128,123,448 - 128,123,702   RGD Human Genome Assembly Build 36 5 132,021,217 - 132,021,471   RGD Human Cytogenetic Map 5 q31   UniSTS REN71158   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,185,854 - 127,186,099   UniSTS Human Genome Assembly GRCh37 5 131,993,550 - 131,993,795   UniSTS Human Celera Assembly 5 128,123,680 - 128,123,925   RGD Human Genome Assembly Build 36 5 132,021,449 - 132,021,694   RGD Human Cytogenetic Map 5 q31   UniSTS REN71159   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,186,073 - 127,186,320   UniSTS Human Genome Assembly GRCh37 5 131,993,769 - 131,994,016   UniSTS Human Celera Assembly 5 128,123,899 - 128,124,146   RGD Human Genome Assembly Build 36 5 132,021,668 - 132,021,915   RGD Human Cytogenetic Map 5 q31   UniSTS REN71160   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,186,318 - 127,186,556   UniSTS Human Genome Assembly GRCh37 5 131,994,014 - 131,994,252   UniSTS Human Celera Assembly 5 128,124,144 - 128,124,382   RGD Human Genome Assembly Build 36 5 132,021,913 - 132,022,151   RGD Human Cytogenetic Map 5 q31   UniSTS REN71161   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,186,528 - 127,186,786   UniSTS Human Genome Assembly GRCh37 5 131,994,224 - 131,994,482   UniSTS Human Celera Assembly 5 128,124,354 - 128,124,612   RGD Human Genome Assembly Build 36 5 132,022,123 - 132,022,381   RGD Human Cytogenetic Map 5 q31   UniSTS REN71162   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,186,763 - 127,187,026   UniSTS Human Genome Assembly GRCh37 5 131,994,459 - 131,994,722   UniSTS Human Celera Assembly 5 128,124,589 - 128,124,852   RGD Human Genome Assembly Build 36 5 132,022,358 - 132,022,621   RGD Human Cytogenetic Map 5 q31   UniSTS REN71163   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,187,012 - 127,187,267   UniSTS Human Genome Assembly GRCh37 5 131,994,708 - 131,994,963   UniSTS Human Celera Assembly 5 128,124,838 - 128,125,093   RGD Human Genome Assembly Build 36 5 132,022,607 - 132,022,862   RGD Human Cytogenetic Map 5 q31   UniSTS REN71164   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,187,245 - 127,187,485   UniSTS Human Genome Assembly GRCh37 5 131,994,941 - 131,995,181   UniSTS Human Celera Assembly 5 128,125,071 - 128,125,311   RGD Human Genome Assembly Build 36 5 132,022,840 - 132,023,080   RGD Human Cytogenetic Map 5 q31   UniSTS REN71165   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,187,460 - 127,187,723   UniSTS Human Genome Assembly GRCh37 5 131,995,156 - 131,995,419   UniSTS Human Celera Assembly 5 128,125,286 - 128,125,549   RGD Human Genome Assembly Build 36 5 132,023,055 - 132,023,318   RGD Human Cytogenetic Map 5 q31   UniSTS REN71166   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,187,703 - 127,187,929   UniSTS Human Genome Assembly GRCh37 5 131,995,399 - 131,995,625   UniSTS Human Celera Assembly 5 128,125,529 - 128,125,755   RGD Human Genome Assembly Build 36 5 132,023,298 - 132,023,524   RGD Human Cytogenetic Map 5 q31   UniSTS REN71167   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,187,900 - 127,188,159   UniSTS Human Genome Assembly GRCh37 5 131,995,596 - 131,995,855   UniSTS Human Celera Assembly 5 128,125,726 - 128,125,985   RGD Human Genome Assembly Build 36 5 132,023,495 - 132,023,754   RGD Human Cytogenetic Map 5 q31   UniSTS REN71168   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,188,156 - 127,188,409   UniSTS Human Genome Assembly GRCh37 5 131,995,852 - 131,996,105   UniSTS Human Celera Assembly 5 128,125,982 - 128,126,235   RGD Human Genome Assembly Build 36 5 132,023,751 - 132,024,004   RGD Human Cytogenetic Map 5 q31   UniSTS REN71169   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,188,386 - 127,188,642   UniSTS Human Genome Assembly GRCh37 5 131,996,082 - 131,996,338   UniSTS Human Celera Assembly 5 128,126,212 - 128,126,468   RGD Human Genome Assembly Build 36 5 132,023,981 - 132,024,237   RGD Human Cytogenetic Map 5 q31   UniSTS REN71170   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,188,620 - 127,188,860   UniSTS Human Genome Assembly GRCh37 5 131,996,316 - 131,996,556   UniSTS Human Celera Assembly 5 128,126,446 - 128,126,686   RGD Human Genome Assembly Build 36 5 132,024,215 - 132,024,455   RGD Human Cytogenetic Map 5 q31   UniSTS REN71171   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,188,842 - 127,189,099   UniSTS Human Genome Assembly GRCh37 5 131,996,538 - 131,996,795   UniSTS Human Celera Assembly 5 128,126,668 - 128,126,925   RGD Human Genome Assembly Build 36 5 132,024,437 - 132,024,694   RGD Human Cytogenetic Map 5 q31   UniSTS REN71172   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,189,077 - 127,189,322   UniSTS Human Genome Assembly GRCh37 5 131,996,773 - 131,997,018   UniSTS Human Celera Assembly 5 128,126,903 - 128,127,148   RGD Human Genome Assembly Build 36 5 132,024,672 - 132,024,917   RGD Human Cytogenetic Map 5 q31   UniSTS REN71173   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,189,294 - 127,189,540   UniSTS Human Genome Assembly GRCh37 5 131,996,990 - 131,997,236   UniSTS Human Celera Assembly 5 128,127,120 - 128,127,366   RGD Human Genome Assembly Build 36 5 132,024,889 - 132,025,135   RGD Human Cytogenetic Map 5 q31   UniSTS stSG601426   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,184,926 - 127,186,372   UniSTS Human Genome Assembly GRCh37 5 131,992,622 - 131,994,068   UniSTS Human Celera Assembly 5 128,122,752 - 128,124,198   RGD Human Genome Assembly Build 36 5 132,020,521 - 132,021,967   RGD stSG601427   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,186,374 - 127,187,571   UniSTS Human Genome Assembly GRCh37 5 131,994,070 - 131,995,267   UniSTS Human Celera Assembly 5 128,124,200 - 128,125,397   RGD Human Genome Assembly Build 36 5 132,021,969 - 132,023,166   RGD stSG601428   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,187,656 - 127,188,750   UniSTS Human Genome Assembly GRCh37 5 131,995,352 - 131,996,446   UniSTS Human Celera Assembly 5 128,125,482 - 128,126,576   RGD Human Genome Assembly Build 36 5 132,023,251 - 132,024,345   RGD stSG601429   Map Chr Position Strand Source Human Genome Assembly HuRef 5 127,188,737 - 127,188,956   UniSTS Human Genome Assembly GRCh37 5 131,996,433 - 131,996,652   UniSTS Human Celera Assembly 5 128,126,563 - 128,126,782   RGD Human Genome Assembly Build 36 5 132,024,332 - 132,024,551   RGD Human Cytogenetic Map 5 q31   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1357383 BW61_H Body weight QTL 61 (human) 2.4 .0004 Body weight BMI after exercise training 5 34952160 147315481 Human 1357331 AASTH10_H Allergic/atopic asthma related QTL 10 (human) 1.23 Reversible airflow obstruction ETS positive 5 81673046 155668491 Human 1559217 SCL48_H Serum cholesterol level QTL 48 (human) 2.4 Lipid level HDL cholesterol 5 106101774 132101774 Human 1643519 BW263_H Body Weight QTL 263 (human) 1.5 .00394 Body weight body mass index 5 106101774 132101774 Human 2292833 MYI25_H Myocardial infarction susceptibility QTL 25 (human) Myocardial infarction susceptibility early-onset 5 106101774 132101774 Human 2292894 MYI26_H Myocardial infarction susceptibility QTL 26 (human) Myocardial infarction susceptibility early-onset 5 106101774 132101774 Human 1331659 AASTH4_H Allergic/atopic asthma related QTL 4 (human) 2.73 .0002 Reversible airflow obstruction post-bronchodilator FEV1 5 118041132 144041132 Human 1643241 BW129_H Body Weight QTL 129 (human) .93 .019 Body weight body mass index 5 119101646 135301752 Human 1358844 MULTSCL15_H Multiple sclerosis susceptibility QTL 15 (human) Multiple sclerosis susceptibility 5 122301631 148301631 Human 2316336 GLUCO233_H Glucose level QTL 233 (human) 2.41 Glucose level 5 122301631 148301631 Human 2316337 GLUCO226_H Glucose level QTL 226 (human) .84 .02 Glucose level 5 122301631 148301631 Human 1357309 AASTH55_H Allergic/atopic asthma related QTL 5 (human) .0001 Atopy reversible airflow obstruction 5 122701420 148701420 Human 2289311 BW380_H Body weight QTL 380 (human) 2.06 .00104 Body fat amount abdominal 5 127373052 153373052 Human 2289319 BW381_H Body weight QTL 381 (human) 1.84 .00179 Body fat amount abdominal 5 127373052 153373052 Human 1357301 AASTH17_H Allergic/atopic asthma related QTL 17 (human) 2.18 .0007 Reversible airflow obstruction atopy score 5 128191539 152549542 Human 1298472 BP21_H Blood pressure QTL 21 (human) .0785 Blood pressure hypertension susceptibility 5 131143833 157143833 Human 1357317 AASTH19_H Allergic/atopic asthma related QTL 19 (human) .98 Reversible airflow obstruction post-bronchodilator FEV1 5 131143833 157143833 Human 1357329 AASTH46_H Allergic/atopic asthma related QTL 46 (human) .0079 Reversible airflow obstruction 5 131143833 157143833 Human 2289309 BW382_H Body weight QTL 382 (human) 1.87 .00169 Body fat amount abdominal 5 131143833 157143833 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_012090 (Get FASTA) Search GEO for Microarray Profiles   NM_002188 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide ABBA01068803 (Get FASTA) Search GEO for Microarray Profiles   AC004039 (Get FASTA) Search GEO for Microarray Profiles   AF043334 (Get FASTA) Search GEO for Microarray Profiles   AF172149 (Get FASTA) Search GEO for Microarray Profiles   AF172150 (Get FASTA) Search GEO for Microarray Profiles   AF193838 (Get FASTA) Search GEO for Microarray Profiles   AF193839 (Get FASTA) Search GEO for Microarray Profiles   AF193840 (Get FASTA) Search GEO for Microarray Profiles   AF377331 (Get FASTA) Search GEO for Microarray Profiles   AF416600 (Get FASTA) Search GEO for Microarray Profiles   AMYH01015616 (Get FASTA) Search GEO for Microarray Profiles   AY008331 (Get FASTA) Search GEO for Microarray Profiles   AY008332 (Get FASTA) Search GEO for Microarray Profiles   BC096138 (Get FASTA) Search GEO for Microarray Profiles   BC096139 (Get FASTA) Search GEO for Microarray Profiles   BC096140 (Get FASTA) Search GEO for Microarray Profiles   BC096141 (Get FASTA) Search GEO for Microarray Profiles   CH471062 (Get FASTA) Search GEO for Microarray Profiles   HI573912 (Get FASTA) Search GEO for Microarray Profiles   L06801 (Get FASTA) Search GEO for Microarray Profiles   L13029 (Get FASTA) Search GEO for Microarray Profiles   L42079 (Get FASTA) Search GEO for Microarray Profiles   L42080 (Get FASTA) Search GEO for Microarray Profiles   U10307 (Get FASTA) Search GEO for Microarray Profiles   U31120 (Get FASTA) Search GEO for Microarray Profiles   X69079 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_002188 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_002179 Peptide Label: precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 132,270,711 - 132,273,647 + NCBI Human Genome Assembly HuRef 5 127,186,169 - 127,189,105 + ENTREZGENE Human Genome Assembly GRCh37 5 131,993,865 - 131,996,801 + ENTREZGENE Human Genome Assembly Build 36 5 132,021,764 - 132,024,700 + NCBI Archive Protein Sequences Protein RefSeqs NP_002179 (Get FASTA) GenBank Protein AAA36107 (Get FASTA)   AAA83738 (Get FASTA)   AAB01681 (Get FASTA)   AAC03535 (Get FASTA)   AAH96138 (Get FASTA)   AAH96139 (Get FASTA)   AAH96140 (Get FASTA)   AAH96141 (Get FASTA)   AAK53823 (Get FASTA)   CAA48823 (Get FASTA)   CAA48824 (Get FASTA)   CBX47445 (Get FASTA)   EAW62324 (Get FASTA)   EAW62325 (Get FASTA)   EAW62326 (Get FASTA)   EAW62327 (Get FASTA)   P35225 (Get FASTA) Promoters RGD ID: 6802795 Promoter ID: HG_KWN:51060 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell,   Lymphoblastoid Transcripts: OTTHUMT00000132565,   OTTHUMT00000132779,   OTTHUMT00000132783,   OTTHUMT00000132784,   OTTHUMT00000132785 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 5 132,019,566 - 132,020,207 - MPROMDB RGD ID: 6803266 Promoter ID: HG_KWN:51061 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell Transcripts: OTTHUMT00000132782,   OTTHUMT00000315744 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 5 132,021,826 - 132,023,027 + MPROMDB Additional Information External Database Links Database Acc Id Source(s) COSMIC IL13 COSMIC Ensembl Genes ENSG00000169194 ENTREZGENE Ensembl Protein ENSP00000304915 ENTREZGENE Ensembl Transcript ENST00000304506 ENTREZGENE Entrez Gene 3596 ENTREZGENE Gene3D-CATH 4_helix_cytokine_core UniProtKB/Swiss-Prot Germonline ENSG00000169194 HGNC ID 5973 ENTREZGENE HomoloGene Group ID 1649 ENTREZGENE HPRD ID 00981 ENTREZGENE InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot   4_helix_cytokine_core UniProtKB/Swiss-Prot   Interleukin-13 UniProtKB/Swiss-Prot   Interleukin-4/-13_CS UniProtKB/Swiss-Prot   Interleukin-4/13 UniProtKB/Swiss-Prot KEGG Report hsa:3596 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 147683 OMIM   600807 OMIM PANTHER Interleukin_13 UniProtKB/Swiss-Prot Pfam IL13 UniProtKB/Swiss-Prot PharmGKB IL13 RGD, PharmGKB PRINTS INTRLEUKIN13 UniProtKB/Swiss-Prot PROSITE INTERLEUKIN_4_13 UniProtKB/Swiss-Prot SMART IL4_13 UniProtKB/Swiss-Prot Superfamily-SCOP 4_helix_cytokine UniProtKB/Swiss-Prot UniGene Hs.845 ENTREZGENE UniProt IL13_HUMAN UniProtKB/Swiss-Prot   Q4VB53_HUMAN UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 IL13  interleukin 13  IL13  interleukin 13  Symbol and/or name change 39860 APPROVED

More on IL13 Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 69008 Created: 2001-11-06 Species: Homo sapiens Last Modified: 2013-05-14 Status: ACTIVE