GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | cobaltous chloride results in increased expression of TNF protein | PMID:31362009 | Tnf | increases secretion | EXP | | 6480464 | CTD | cobaltous chloride results in increased secretion of TNF protein | PMID:21925238 | Tnf | multiple interactions | EXP | | 6480464 | CTD | cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]; Gallic Acid inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; Luteolin inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; Protein Kinase Inhibitors inhibits the reaction [cobaltous chloride results in increased secretion of TNF protein] | PMID:18635243 PMID:19278353 PMID:21296072 PMID:21925238 PMID:31362009 | Tnf | decreases secretion | ISO | TNF (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in decreased secretion of TNF protein | PMID:17291400 | Tnf | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | cobaltous chloride results in increased expression of TNF mRNA; cobaltous chloride results in increased expression of TNF protein | PMID:20511350 PMID:22472292 PMID:23684559 PMID:25820916 PMID:25966675 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in increased expression of TNF protein | PMID:20974702 PMID:23840602 PMID:25803856 | Tnf | increases secretion | ISO | Tnf (Mus musculus) | 6480464 | CTD | cobaltous chloride results in increased secretion of TNF protein | PMID:23384249 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of TNF mRNA]; [cobaltous chloride co-treated with chromic chloride] results in increased expression of TNF mRNA; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of TNF mRNA; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; BAY 11-7085 inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; cobaltous chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cobaltous chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; HIF1A promotes the reaction [cobaltous chloride results in increased expression of TNF protein]; NOS2 protein promotes the reaction [cobaltous chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of TNF protein] | PMID:20511350 PMID:22472292 PMID:25820916 PMID:25966675 PMID:32408695 PMID:8975779 | | ||||||||||||||||||||||
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