GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of TNF protein | PMID:24348802 PMID:36850985 | Tnf | multiple interactions | EXP | | 6480464 | CTD | [calcium arsenate results in increased abundance of Arsenic] which results in increased secretion of TNF protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF protein; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF protein]; Arsenic inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of TNF protein]; nobiletin inhibits the reaction [Arsenic results in increased expression of TNF protein]; Succimer inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF mRNA] | PMID:24348802 PMID:32402895 PMID:36822304 PMID:36850985 PMID:7537211 | Tnf | affects expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Arsenic affects the expression of TNF protein | PMID:20940111 | Tnf | affects response to substance | ISO | TNF (Homo sapiens) | 6480464 | CTD | TNF gene SNP affects the susceptibility to Arsenic; TNF promoter polymorphism affects the susceptibility to Arsenic | PMID:21357384 PMID:29028684 | Tnf | decreases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Arsenic results in decreased expression of TNF protein | PMID:27289040 | Tnf | decreases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Arsenic results in decreased expression of TNF mRNA; Arsenic results in decreased expression of TNF protein | PMID:16835338 PMID:19962721 PMID:24924402 PMID:27838757 | Tnf | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Arsenic results in increased expression of TNF protein | PMID:10828279 PMID:19654921 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Arsenic results in increased expression of TNF mRNA | PMID:36861143 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in increased expression of TNF protein; [APOE protein affects the susceptibility to Arsenic] which results in increased expression of TNF mRNA; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of TNF protein; CD200R1 protein affects the reaction [MIR129 mRNA affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of TNF protein]]; MIR129 mRNA affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of TNF protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] | PMID:22719926 PMID:31238026 PMID:32226249 PMID:33049506 PMID:34952004 PMID:35777461 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [Arsenic co-treated with Fluorides] results in decreased expression of TNF mRNA; [ATF3 protein affects the susceptibility to Arsenic] which affects the expression of TNF mRNA; [ATF3 protein affects the susceptibility to Arsenic] which affects the secretion of TNF protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF mRNA; Arsenic results in increased expression of and results in increased secretion of TNF protein; TNF gene SNP affects the reaction [Arsenic results in increased expression of and results in increased secretion of TNF protein] | PMID:19962721 PMID:29028684 PMID:34364923 PMID:36669534 | | ||||||||||||||||||||||
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