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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:53076
Term: 4-(ethoxymethylene)-2-phenyloxazol-5-one
Definition: A 1,3-oxazole compound having a phenyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position. It is a chemical allergen used for immunological experiments, particularly for experiments on delayed type hypersensitivity.
Chemical ID: MESH:D010081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDOxazolone results in increased expression of TNF mRNA; Oxazolone results in increased expression of TNF proteinPMID:11851881 PMID:16557482 PMID:19622729 PMID:19647056 PMID:22200888 PMID:24205293 PMID:28826779
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDClofibrate inhibits the reaction [Oxazolone results in increased expression of TNF protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; SSTR4 gene mutant form promotes the reaction [Oxazolone results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]PMID:11851881 PMID:16557482 PMID:19622729 PMID:22200888
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