GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of TNF protein | PMID:16987042 | Tnf | multiple interactions | EXP | | 6480464 | CTD | [Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein]; tempol inhibits the reaction [Copper results in increased expression of TNF protein] | PMID:16987042 PMID:25813056 PMID:34577062 | Tnf | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Copper results in increased expression of TNF mRNA | PMID:21765606 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Copper results in increased expression of TNF mRNA | PMID:2107032 | Tnf | increases secretion | ISO | TNF (Homo sapiens) | 6480464 | CTD | Copper results in increased secretion of TNF protein | PMID:2107032 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid inhibits the reaction [Copper results in increased expression of TNF mRNA]; [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Copper promotes the reaction [APP protein modified form results in increased expression of and results in increased secretion of TNF protein]; GSK0660 promotes the reaction [Copper results in increased expression of TNF mRNA] | PMID:21765606 PMID:23690655 PMID:27122238 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [Copper binds to Tobramycin] inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; [diglycyl-histidine co-treated with Copper] inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Copper inhibits the reaction [Lead results in increased expression of and results in increased secretion of TNF protein]; Copper promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Lipopolysaccharides promotes the reaction [Copper results in increased secretion of TNF protein] | PMID:12633744 PMID:2107032 PMID:23072509 PMID:23285694 PMID:29028684 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |