GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | multiple interactions | EXP | | 6480464 | CTD | [Metformin co-treated with Rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with Rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with Rosiglitazone] promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein; Ezetimibe inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Metformin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Valsartan inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein] | PMID:16865780 PMID:26695085 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | 2-acetoxy-5-(2-4-(trifluoromethyl)phenethylamino)benzoic acid inhibits the reaction [[Choline deficiency co-treated with Ethionine] results in increased expression of TNF protein]; 5-(3-methoxy-5-(4-methoxystyryl)phenoxy)-2,2-dimethylpentanoic acid analog inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein; [Choline deficiency co-treated with Ethionine] results in increased expression of TNF protein; [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of TNF mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in increased expression of TNF mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] promotes the reaction [cyanoginosin LR results in increased expression of TNF protein]; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of TNF protein; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNF mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of TNF mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; fuzheng huayu inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; NLRP3 protein affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] promotes the reaction [cyanoginosin LR results in increased expression of TNF protein]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]]; obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]; Resveratrol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Smoke affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of TNF protein]; Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; tianhuang inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA] | PMID:18513333 PMID:18952117 PMID:19593819 PMID:20697377 PMID:20938992 PMID:22575522 PMID:22915297 PMID:23038002 PMID:25712622 PMID:26498332 PMID:27984176 PMID:28100771 PMID:28133511 PMID:28163111 PMID:28973532 PMID:29127188 PMID:30745416 PMID:31678261 PMID:34416350 PMID:37023836 PMID:38042390 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of TNF mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of TNF protein; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA] | PMID:25712622 PMID:30116142 | | ||||||||||||||||||||||
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