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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:2030
Term: 5-aminoimidazole-4-carboxamide
Definition: An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.
Chemical ID: MESH:D000620
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDAminoimidazole Carboxamide analog results in increased expression of TNF proteinPMID:19853624
Tnfmultiple interactionsEXP 6480464CTD[dorsomorphin co-treated with Aminoimidazole Carboxamide analog] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Aminoimidazole Carboxamide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:19853624
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