RGD Reference Report - [Exploration of the theory of "Fei and Dachang being interior-exteriorly related" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats].

General

[Exploration of the theory of "Fei and Dachang being interior-exteriorly related" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats].
Authors:	Yan, X Wang, XY Sheng, YH Zhu, L Zhang, LD Zang, Q
Citation:	Yan X, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Apr;34(4):455-9.
RGD ID:	10450593
Pubmed:	PMID:24812904 (View Abstract at PubMed)
OBJECTIVE: To explore the theory of "Fei and Dachang being interior-exteriorly related" and the pathogenesis of lung injury by observing changes of inflammatory cytokines and oxygen free radicals in ulcerative colitis (UC) rats. METHODS: Totally 50 healthy male Wistar rats were randomly divided into two groups, the normal control group and the model group, 25 rats in each group. The UC model was established by allergizing colon mucosa combined with TNBS-alcohol (50%) enema. Another 25 rats were recruited as the normal control group. At week 2 and 4 after modeling, the pathomorphological changes of the lung were observed. Furthermore, the contents of tumor necrosis factor alpha (TNF-alpha) and IL-1beta were determined by ELISA. The activities of superoxide dismutase (SOD) and malondialdehyde (MDA) were evaluated with colorimetry. RESULTS: Compared with the normal control group, the pathomorphology of the lung tissue in the model group appeared abnormal at week 2 and 4. Compared with the normal control group, levels of TNF-alpha, IL-1beta, and MDA in the lung tissue significantly increased in the model group (P < 0. 01) and the activities of SOD significantly decreased (P < 0.05, P < 0.01). CONCLUSION: TNF-alpha, IL-1beta, SOD, and MDA might be common material bases for the large intestine involved in lung disease of UC patients, thus providing a modern scientific basis for the theory of Fei and Dachang being interior-exteriorly related.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
ulcerative colitis		ISO	Il1b (Rattus norvegicus)	10450593; 10450593	protein:increased expression:lung	RGD
ulcerative colitis		IEP		10450593; 10450593	protein:increased expression:lung	RGD
ulcerative colitis		ISO	Tnf (Rattus norvegicus)	10450593; 10450593	protein:increased expression:lung	RGD

Objects Annotated

Genes (Rattus norvegicus)

Il1b (interleukin 1 beta)

Tnf (tumor necrosis factor)

Genes (Mus musculus)

Il1b (interleukin 1 beta)

Tnf (tumor necrosis factor)

Genes (Homo sapiens)

IL1B (interleukin 1 beta)

TNF (tumor necrosis factor)

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[Exploration of the theory of "Fei and Dachang being interior-exteriorly related" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats].