RGD Reference Report - Polymorphisms of tumour necrosis factors A and B in breast cancer. - Rat Genome Database

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Polymorphisms of tumour necrosis factors A and B in breast cancer.

Authors: Park, KS  Mok, JW  Ko, HE  Tokunaga, K  Lee, MH 
Citation: Park KS, etal., Eur J Immunogenet. 2002 Feb;29(1):7-10.
RGD ID: 8548791
Pubmed: PMID:11841482   (View Abstract at PubMed)

We assayed for germline single nucleotide polymorphisms (SNPs) in the TNFB and TNFA genes in patients with breast cancer. SNPs were observed in the first intron of TNFB (G/A) and at -1031 (T/C), -863 (C/A), -857 (C/T) and -308 (G/A) in the promoter region of TNFA from peripheral leucocytes in 95 breast cancer patients and 190 healthy subjects as controls. The TNFB*G/TNFB*G homozygote (23.2% vs. 5.8%, P= 0.001) was predominant in patients, while the TNFB*A/TNFB*A homozygote was less frequent in patients (34.7% vs. 46.3%, P = 0.041) than in the control subjects. Breast cancer was not associated with SNPs in the TNFA promoters. Although the TNFB SNP failed to associate with any clinicopathological parameter of breast cancer, a substantial difference in pathology among tumour stages for the -857 SNP in TNFA was detected. These results indicate that TNFB has both tumorigenic and antitumorigenic capabilities depending on the genotype: the TNFB SNP TNFB*G/TNFB*G genotype gave an increased risk for breast cancer and that of TNFB*A/TNFB*A gave resistance to breast cancer (OR = 5.3395%; CI: 2.33-12.19). The results suggest that the TNFB*G allele plays some role in the tumorigenesis or activation of dormant tumour cells, but the TNFB*A allele induces some function(s) leading to the inhibition of tumorigenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer susceptibilityIAGP 8548791DNA:SNP:intronRGD 
breast cancer susceptibilityISOLTA (Homo sapiens)8548791; 8548791DNA:SNP:intronRGD 
breast cancer no_associationIAGP 8548791DNA:SNPs:promoter:multipleRGD 
breast cancer no_associationISOTNF (Homo sapiens)8548791; 8548791DNA:SNPs:promoter:multipleRGD 

Objects Annotated

Genes (Rattus norvegicus)
Lta  (lymphotoxin alpha)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Lta  (lymphotoxin A)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
LTA  (lymphotoxin alpha)
TNF  (tumor necrosis factor)


Additional Information