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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionISOTnf (Mus musculus)6480464CTDDDT metabolite results in decreased expression of TNF mRNA; DDT results in decreased expression of TNF mRNAPMID:12007859
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDDDT results in increased expression of TNF mRNAPMID:15603917 PMID:20865247 PMID:31521043
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[DDT co-treated with o,p'-DDT] results in decreased expression of TNF mRNAPMID:12007859
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of TNF mRNA]; DDT inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; SB 203580 inhibits the reaction [DDT results in increased expression of TNF mRNA]PMID:15603917 PMID:20865247 PMID:28412309
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