RGD Reference Report - Levels of tumor necrosis factor alpha/cachectin (TNF alpha) in sera from patients with sickle cell disease. - Rat Genome Database

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Levels of tumor necrosis factor alpha/cachectin (TNF alpha) in sera from patients with sickle cell disease.

Authors: Malave, I  Perdomo, Y  Escalona, E  Rodriguez, E  Anchustegui, M  Malave, H  Arends, T 
Citation: Malave I, etal., Acta Haematol. 1993;90(4):172-6.
RGD ID: 10449460
Pubmed: PMID:8140855   (View Abstract at PubMed)

Serum levels of tumor necrosis factor alpha/cachectin (TNF alpha) were studied in a group of adult patients with sickle cell disease (SCD), which include 31 patients with homozygous SS hemoglobinopathy and 10 patients bearing double heterozygous SC hemoglobinopathy and in their matched normal controls. All patients tested did not show any form of crisis for at least 4 weeks prior to the extraction of the sample. The amount of TNF alpha in serum was quantitated by means of an immunoenzymatic assay with a lower limit of detection of 25 pg/ml. The percentage of sera with detectable levels of TNF alpha was significantly increased in SCD patients as compared with the normal controls. Mean TNF alpha values in individuals with detectable levels of the cytokine were also significantly higher in the whole group of SCD patients and in patients bearing either SS or SC hemoglobinopathies than in the control group. An inverse correlation was observed between the percentages of Hb F and the levels of TNF alpha found in the sera from the patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sickle cell anemia  IEP 10449460protein:increased expression:serumRGD 
sickle cell anemia  ISOTNF (Homo sapiens)10449460; 10449460protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information