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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:74023
Term: dioscin
Definition: A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Chemical ID: MESH:C019357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 15090820RGDdioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver] 
Tnfmultiple interactionsEXP 6480464CTDdioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]PMID:24146112 PMID:28082111
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDdioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF proteinPMID:22334414 PMID:29990575 PMID:33359023
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDdioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]PMID:24146112 PMID:35481609
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