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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TNF mRNA; Estradiol inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of TNF mRNA]; Estradiol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]PMID:21127968 PMID:29425760 PMID:32741896
Tnfdecreases activityISOTnf (Mus musculus)6480464CTDEstradiol results in decreased activity of TNF proteinPMID:20962747
Tnfdecreases expressionISOTNF (Homo sapiens)6480464CTDEstradiol results in decreased expression of TNF proteinPMID:20130130
Tnfdecreases secretionISOTnf (Mus musculus)6480464CTDEstradiol results in decreased secretion of TNF proteinPMID:12538720
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDEstradiol results in increased expression of TNF mRNAPMID:11473722 PMID:17089059
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDEstradiol results in increased expression of TNF; Estradiol results in increased expression of TNF mRNAPMID:19153601 PMID:20056579 PMID:23373633
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[Estradiol results in increased susceptibility to CpG ODN 1826] which results in increased expression of TNF protein; bu-zhong-yi-qi-tang inhibits the reaction [Estradiol results in increased expression of TNF mRNA]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; Estradiol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of and results in increased secretion of TNF protein]; Estradiol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Estradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Estradiol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]]; Fulvestrant inhibits the reaction [Estradiol results in decreased activity of TNF protein]; Genistein inhibits the reaction [Estradiol results in increased expression of TNF mRNA]PMID:11063824 PMID:11473722 PMID:12860292 PMID:15256495 PMID:17089059 PMID:20962747 PMID:21501669 PMID:23943137 PMID:28811679 PMID:29718165 PMID:35537655
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of MCP1 mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of MCP1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of MMP9 mRNA]; [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; [[IL6 protein co-treated with IL1B protein co-treated with TNF protein] affects the susceptibility to [Testosterone co-treated with Estradiol co-treated with Progesterone]] which affects the abundance of Lipids; [[IL6 protein co-treated with IL1B protein co-treated with TNF protein] affects the susceptibility to [Testosterone co-treated with Estradiol co-treated with Progesterone]] which affects the abundance of Reactive Oxygen Species; [[IL6 protein co-treated with IL1B protein co-treated with TNF protein] affects the susceptibility to [Testosterone co-treated with Estradiol co-treated with Progesterone]] which affects the expression of ALB protein; [[Testosterone co-treated with Estradiol co-treated with Progesterone] affects the susceptibility to [IL6 protein co-treated with IL1B protein co-treated with TNF protein]] which affects the abundance of Lipids; [[Testosterone co-treated with Estradiol co-treated with Progesterone] affects the susceptibility to [IL6 protein co-treated with IL1B protein co-treated with TNF protein]] which affects the abundance of Reactive Oxygen Species; [[Testosterone co-treated with Estradiol co-treated with Progesterone] affects the susceptibility to [IL6 protein co-treated with IL1B protein co-treated with TNF protein]] which affects the expression of ALB protein; [Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased secretion of TNF protein; [Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein; [Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA; [Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein; [Estradiol co-treated with TNF protein] results in increased expression of MCP1 mRNA; [Estradiol co-treated with TNF protein] results in increased expression of MCP1 protein; [Estradiol co-treated with TNF protein] results in increased expression of MMP9 mRNA; [Estradiol co-treated with TNF protein] results in increased expression of TIMP1 mRNA; [IL6 protein co-treated with IL1B protein co-treated with TNF protein] affects the susceptibility to [Testosterone co-treated with Estradiol co-treated with Progesterone]; [Lipopolysaccharides co-treated with Estradiol] results in increased secretion of TNF protein; [Progesterone co-treated with Estradiol] inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of TNF protein]; [Testosterone co-treated with Estradiol co-treated with Progesterone] affects the susceptibility to [IL6 protein co-treated with IL1B protein co-treated with TNF protein]; Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; CREBBP mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]; ESR1 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Estradiol affects the reaction [TNF protein promotes the reaction [KAT2B protein binds to IL6 promoter]]; Estradiol inhibits the reaction [TNF protein inhibits the reaction [NCOA3 protein binds to IL6 promoter]]; Estradiol inhibits the reaction [TNF protein inhibits the reaction [RCOR1 protein binds to IL6 promoter]]; Estradiol inhibits the reaction [TNF protein promotes the reaction [EP300 protein binds to IL6 promoter]]; Estradiol inhibits the reaction [TNF protein promotes the reaction [RELA protein modified form binds to IL6 promoter]]; Estradiol inhibits the reaction [TNF protein promotes the reaction [SIRT1 protein binds to IL6 promoter]]; Estradiol inhibits the reaction [TNF protein promotes the reaction [SIRT2 protein binds to IL6 promoter]]; Estradiol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Estradiol inhibits the reaction [TNF protein results in increased activity of RELA protein]; Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Estradiol inhibits the reaction [TNF protein results in increased expression of PTGER4 mRNA]; Estradiol inhibits the reaction [TNF protein results in increased expression of ROCK1 mRNA]; Estradiol inhibits the reaction [TNF protein results in increased expression of TNFRSF11B mRNA]; Estradiol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estradiol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; Estradiol inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of TNF protein]; Estradiol promotes the reaction [ESR1 protein results in increased expression of TNF mRNA]; Estradiol promotes the reaction [Poly I-C results in increased expression of TNF protein]; Estradiol promotes the reaction [TNF protein promotes the reaction [CREBBP protein binds to IL6 promoter]]; Estradiol promotes the reaction [TNF protein promotes the reaction [NCOA2 protein binds to IL6 promoter]]; Estradiol promotes the reaction [TNF protein promotes the reaction [NMNAT1 protein binds to IL6 promoter]]; Estradiol promotes the reaction [TNF protein results in increased activity of MMP2 protein]; Estradiol promotes the reaction [TNF protein results in increased activity of NFKB1 protein]; Estradiol promotes the reaction [TNF protein results in increased activity of RELA protein]; Estradiol promotes the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Estradiol promotes the reaction [TNF protein results in increased expression of CXCL8 protein]; Estradiol promotes the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Estradiol results in increased expression of and results in increased secretion of TNF protein; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of and results in increased secretion of TNF protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of TNF]; GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased expression of CXCL8 protein]]; GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; Mifepristone inhibits the reaction [Progesterone inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]]; Mifepristone inhibits the reaction [Progesterone inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]]; NCOA2 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; NCOA3 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; NMNAT1 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Progesterone inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; Progesterone inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Progesterone inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]; RCOR1 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]; TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estradiol]PMID:12547825 PMID:12574206 PMID:15866426 PMID:15866594 PMID:16030167 PMID:20056579 PMID:20130130 PMID:20621171 PMID:21734263 PMID:23733894 PMID:24039973 PMID:24771768 PMID:30017638 PMID:32328699 PMID:36142876
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