RGD Reference Report - Tumor necrosis factor signaling. - Rat Genome Database

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Tumor necrosis factor signaling.

Authors: Wajant, H  Pfizenmaier, K  Scheurich, P 
Citation: Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
RGD ID: 2292150
Pubmed: PMID:12655295   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.cdd.4401189   (Journal Full-text)

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50,000 articles providing one or the other information about this pleiotropic cytokine or its relatives. This demonstrates the enormous scientific and clinical interest in elucidating the biology of a molecule (or rather a large family of molecules), which began now almost 30 years ago with the description of a cytokine able to exert antitumoral effects in mouse models. Although our understanding of the multiple functions of TNF in vivo and of the respective underlying mechanisms at a cellular and molecular level has made enormous progress since then, new aspects are steadily uncovered and it appears that still much needs to be learned before we can conclude that we have a full comprehension of TNF biology. This review shortly covers some general aspects of this fascinating molecule and then concentrates on the molecular mechanisms of TNF signal transduction. In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Adam17  (ADAM metallopeptidase domain 17)
Bag4  (BAG cochaperone 4)
Chuk  (component of inhibitor of nuclear factor kappa B kinase complex)
Fadd  (Fas associated via death domain)
Ikbkb  (inhibitor of nuclear factor kappa B kinase subunit beta)
Ikbkg  (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma)
Ripk1  (receptor interacting serine/threonine kinase 1)
Tnf  (tumor necrosis factor)
Tnfrsf1a  (TNF receptor superfamily member 1A)
Tnfrsf1b  (TNF receptor superfamily member 1B)
Tradd  (TNFRSF1A-associated via death domain)
Traf2  (Tnf receptor-associated factor 2)

Genes (Mus musculus)
Adam17  (a disintegrin and metallopeptidase domain 17)
Bag4  (BCL2-associated athanogene 4)
Chuk  (conserved helix-loop-helix ubiquitous kinase)
Fadd  (Fas associated via death domain)
Ikbkb  (inhibitor of kappaB kinase beta)
Ikbkg  (inhibitor of kappaB kinase gamma)
Ripk1  (receptor (TNFRSF)-interacting serine-threonine kinase 1)
Tnf  (tumor necrosis factor)
Tnfrsf1a  (tumor necrosis factor receptor superfamily, member 1a)
Tnfrsf1b  (tumor necrosis factor receptor superfamily, member 1b)
Tradd  (TNFRSF1A-associated via death domain)
Traf2  (TNF receptor-associated factor 2)

Genes (Homo sapiens)
ADAM17  (ADAM metallopeptidase domain 17)
BAG4  (BAG cochaperone 4)
CHUK  (component of inhibitor of nuclear factor kappa B kinase complex)
FADD  (Fas associated via death domain)
IKBKB  (inhibitor of nuclear factor kappa B kinase subunit beta)
IKBKG  (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma)
RIPK1  (receptor interacting serine/threonine kinase 1)
TNF  (tumor necrosis factor)
TNFRSF1A  (TNF receptor superfamily member 1A)
TNFRSF1B  (TNF receptor superfamily member 1B)
TRADD  (TNFRSF1A associated via death domain)
TRAF2  (TNF receptor associated factor 2)


Additional Information