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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects methylationEXP 6480464CTDAtrazine affects the methylation of TNF genePMID:28931070
Tnfdecreases expressionEXP 6480464CTDAtrazine results in decreased expression of TNF proteinPMID:34090108
Tnfincreases expressionEXP 6480464CTDAtrazine results in increased expression of TNF mRNA; Atrazine results in increased expression of TNF proteinPMID:34624533 PMID:34994930
Tnfdecreases expressionISOTnf (Mus musculus)6480464CTDAtrazine results in decreased expression of TNF proteinPMID:12504806
Tnfdecreases expressionISOTNF (Homo sapiens)6480464CTDAtrazine results in decreased expression of TNF proteinPMID:10883730
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDAtrazine results in increased expression of TNF mRNA; Atrazine results in increased expression of TNF proteinPMID:26256823 PMID:36216167
Tnfincreases secretionISOTnf (Mus musculus)6480464CTDAtrazine results in increased secretion of TNF proteinPMID:34624533
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDLycopene inhibits the reaction [Atrazine results in increased expression of TNF mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of TNF protein]PMID:36216167
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