RGD Reference Report - Serum interleukin-6 concentrations are elevated and associated with elevated tumor necrosis factor-alpha and immunoglobulin G and A concentrations in children with HIV infection.

General

Serum interleukin-6 concentrations are elevated and associated with elevated tumor necrosis factor-alpha and immunoglobulin G and A concentrations in children with HIV infection.
Authors:	Rautonen, J Rautonen, N Martin, NL Philip, R Wara, DW
Citation:	Rautonen J, etal., AIDS. 1991 Nov;5(11):1319-25.
RGD ID:	10449449
Pubmed:	PMID:1768380 (View Abstract at PubMed)
Hypergammaglobulinemia is one of the most consistent, and usually the first observable abnormality in infants vertically infected with HIV. We have analyzed serum interleukin (IL)-4, IL-6, tumor necrosis factor (TNF)-alpha, and immunoglobulin (Ig) concentrations in 23 HIV-infected and 21 uninfected children. IL-6 and TNF-alpha concentrations in HIV-infected children were significantly higher than those in uninfected children, and mutually correlated. No differences in serum IL-4 levels between infected and uninfected children were observed. There was a correlation between serum IL-6 and IgG and between IL-6 and IgA concentrations. Furthermore, during follow-up changes in IL-6 levels were usually accompanied by corresponding changes in IgG levels. Our data indicate an association between HIV, IL-6, TNF-alpha and hypergammaglobulinemia. Regardless of the source and initial stimulus, continued production of IL-6 and TNF-alpha may result in augmentation in an auto-feedback manner, accompanied by increases in Ig synthesis and, more importantly, HIV replication. Thus, elucidation of the mechanisms responsible for overproduction of these two cytokines in HIV-infected patients is not only interesting from a biologic point of view, but is likely to have important clinical implications as well.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
human immunodeficiency virus infectious disease		IEP		10449449; 10449449	protein:increased expression:serum	RGD
human immunodeficiency virus infectious disease		ISO	IL6 (Homo sapiens)	10449449; 10449449	protein:increased expression:serum	RGD
human immunodeficiency virus infectious disease		ISO	TNF (Homo sapiens)	10449449; 10449449	protein:increased expression:serum	RGD

Objects Annotated

Genes (Rattus norvegicus)

Il6 (interleukin 6)

Tnf (tumor necrosis factor)

Genes (Mus musculus)

Il6 (interleukin 6)

Tnf (tumor necrosis factor)

Genes (Homo sapiens)

IL6 (interleukin 6)

TNF (tumor necrosis factor)

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Serum interleukin-6 concentrations are elevated and associated with elevated tumor necrosis factor-alpha and immunoglobulin G and A concentrations in children with HIV infection.